TY - JOUR A1 - Geith, Markus A. A1 - Swidergal, Krzysztof A1 - Hochholdinger, Bernd A1 - Schratzenstaller, Thomas A1 - Wagner, Marcus A1 - Holzapfel, Gerhard A. T1 - On the importance of modeling balloon folding, pleating, and stent crimping: An FE study comparing experimental inflation tests JF - International Journal for Numerical Methods in Biomedical Engineering N2 - Finite element (FE)–based studies of preoperative processes such as folding,pleating, and stent crimping with a comparison with experimental inflation tests are not yet available. Therefore, a novel workflow is presented in which residual stresses of balloon folding and pleating, as well as stent crimping, and the geometries of all contact partners were ultimately implemented in an FE code to simulate stent expansion by using an implicit solver. The numerical results demonstrate that the incorporation of residual stresses and strains experienced during the production step significantly increased the accuracy of the subsequent simulations, especially of the stent expansion model. During the preoperative processes, stresses inside the membrane and the stent material also reached a rather high level. Hence, there can be no presumption that balloon catheters or stents are undamaged before the actual surgery. The implementation of the realistic geometry, in particular the balloon tapers, and the blades of the process devices improved the simulation of the expansion mech-anisms, such as dogboning, concave bending, or overexpansion of stent cells. This study shows that implicit solvers are able to precisely simulate the mentioned preoperative processes and the stent expansion procedure without a preceding manipulation of the simulation time or physical mass. KW - Catheter KW - Coronary KW - Crimping KW - Finite element KW - Stent KW - Stent KW - Implantation KW - Simulation KW - Finite-Elemente-Methode Y1 - 2019 U6 - https://doi.org/10.1002/cnm.3249 N1 - This study was funded by the Bavarian Research Foundation within the project “PIZ‐225‐18” VL - 35 IS - 11 PB - Wiley ER - TY - JOUR A1 - Aurbach, Maximilian A1 - Spicka, Jan A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Evaluation of musculoskeletal modelling parameters of the shoulder complex during humeral abduction above 90° JF - Journal of Biomechanics N2 - Based on electromyographic data and force measurements within the shoulder joint, there is an indication that muscle and resulting joint reaction forces keep increasing over an abduction angle of 90°. In inverse dynamics models, no single parameter could be attributed to simulate this force behaviour accordingly. The aim of this work is to implement kinematic, kinetic and muscle model modifications to an existing model of the shoulder (AnyBody™) and assess their single and combined effects during abduction up to 140° humeral elevation. The kinematics and the EMG activity of 10 test subjects were measured during humeral abduction. Six modifications were implemented in the model: alternative wrapping of the virtual deltoid muscle elements, utilization of a three element Hill model, strength scaling, motion capture driven clavicle elevation/protraction, translation of the GH joint in dependency of the acting forces and an alteration of the scapula/clavicle rhythm. From the six modifications, 16 different combinations were considered. Parameter combinations with the Hill model changed the resultant GH joint reaction force and led to an increase in force during abduction of the humerus above 90°. Under the premise of muscle activities and forces within the GH joint rising after 90° of humeral abduction, we propose that the Hill type muscle model is a crucial parameter for accurately modelling the shoulder. Furthermore, the outcome of this study indicates that the Hill model induces the co-contraction of the muscles of the shoulder without the need of an additional stability criterion for an inverse dynamics approach. KW - Shoulder joint KW - Musculoskeletal modelling KW - EMG KW - Glenohumeral joint reaction force KW - Muscle model KW - Schultergelenk KW - Bewegungsapparat KW - Biomechanik KW - Simulation Y1 - 2020 U6 - https://doi.org/10.1016/j.jbiomech.2020.109817 VL - 106 IS - June PB - Elsevier ER - TY - JOUR A1 - Weber, Karsten T1 - Simulationen in den Sozialwissenschaften JF - Journal for General Philosophy of Science N2 - Computer simulation—hereafter just called ‘simulation’— more and more is getting an important tool in scientific research and development. Simulations provide powerful means for quite different scientific disciplines, for instance for cosmology as well as for economics, and it seems that they can help to extend the borderline of science. However, from a methodological point of view, besides their benefits one can identify several theoretical problems which can occur in the process of scientific research. Some of these problems shall be discussed and consequences of these problems for the use of simulations shall be outlined. KW - Instrumentalismus KW - Realismus KW - Simulation KW - Theorieprütung Y1 - 2007 U6 - https://doi.org/10.1007/s10838-006-9011-8 VL - 38 IS - 1 SP - 111 EP - 126 ER - TY - CHAP A1 - Jungtäubl, Dominik A1 - Schmitz, Paul A1 - Gross, Simon A1 - Dendorfer, Sebastian ED - Badnjevic, Almir T1 - FEA of the transiliacal internal fixator as an osteosynthesis of pelvic ring fractures T2 - CMBEBIH 2017, Proceedings of the International Conference on Medical and Biological Engineering 2017 N2 - Common Schanz screw systems can be used to stabilize pelvic ring fractures. In order to accommodate for different patient’s requirements, implants can be placed in cranio-caudal direction into the os ilium (T1), or into the supraacetabular bone canal, and thus, in dorso-ventral direction (T2). Whereas both techniques are currently used, no data of the biomechanical behavior is available up to this date. The aim of this study is to analyze, whether T2 shows biomechanical advantages with respect to tissue and implant stresses due to the enlarged bone-implant interface. Forces acting on the pelvis were analyzed using motion capture data of a gait cycle obtained by the utilization of a musculoskeletal simulation program. A three dimensional finite element (FE) model of the pelvis with grayscale-based material properties was generated. The muscle and joint reaction forces at toe-off were applied to the FE model and instable pelvis fractures were implemented. The osteosynthesis systems were positioned within the model in order to enable the comparison between the two different surgical techniques. Stresses and displacements were analyzed for bone tissue, fracture zone and implant. T2 lead to approx. 30% larger displacements in the fracture zone. Von-Mises stresses were larger for T2 in the implant (80 MPa vs. 227 MPa), whereas T1 leads to larger stresses in the bone tissue (200 MPa vs. 140 MPa). Both implantation techniques showed a good biomechanical behavior. Differences could be found with respect to tissue strains and deformations in the fracture zone. If bone quality or fracture healing are of concern, T2 or T1 should be used, respectively. However, both techniques seem to be applicable for cases with no special requirements. Further analyses aim to investigate the behavior under cyclic loading. KW - Finite element analysis KW - Musculoskeletal simulation KW - Internal fixator KW - Pelvic ring fracture KW - Beckenbruch KW - Operationstechnik KW - Finite-Elemente-Methode KW - Biomechanik KW - Simulation Y1 - 2017 SN - 978-981-10-4165-5 U6 - https://doi.org/10.1007/978-981-10-4166-2_32 SP - 212 EP - 217 PB - Springer CY - Singapore ER - TY - CHAP A1 - Weber, Tim A. A1 - Dendorfer, Sebastian A1 - Dullien, Silvia A1 - Grifka, Joachim A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias T1 - Measuring functional outcome after total hip replacement with subject-specific hip joint loading T2 - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine N2 - Total hip replacement is an often-performed orthopedic surgical procedure; the amount of procedures undertaken will increase since our life expectancy is growing. In order to optimize function, hip biomechanics should be restored to as near normal as possible. The goal of this pilot study was to determine whether or not it is feasible to compute the vectorial hip reaction force pathways on the head of the prosthesis and the force angles relative to the cup of the prosthesis that occur during gait in total hip replacement patients, serving as an objective measurement of the functional outcome following hip replacement. A three-dimensional gait analysis, measuring ground reaction forces and kinematics, was performed. The data retrieved from the gait analysis was used as the input for the musculoskeletal model to compute vectorial joint reaction forces for data processing. To evaluate the position and orientation of the joint reaction forces, the force path, as well as the force angles for the operated and non-operated joint, has been calculated during the stance phase of the specific leg. The force path for subject 2 on the non-operated side is only located in the posterior-lateral quarter, as is the force path for subject 1. In contrast to this subject, the force path for subject 2 at the operated hip joint can be found only within the anterior quarter of the head of the implant, where it is nearly equally distributed in the medio-lateral half of the prosthesis head. The force-inclination angles on the cup of subject 1, with respect to the plane of the socket face, indicates that the force vector is mainly positioned in the same quadrant when compared with subject 2 (in a cup-fixed coordinate system). The force-anteversion angle behaves similarly to the force-inclination angle, even when the effects are not as pronounced. The proposed methods in this article are aiming to define two functional outcomes of total hip replacement that are related to wear and rim loading. It is accepted that wear is not only a function of time, but a function of use. Owing to the methods listed in this article, we are able to determine a) the applied force and b) the sliding distance (force pathway) in a subject-specific manner. The computed hip-reaction force angles and the distance to the rim cup are a measurement for cup or rim loading, and occurs in the so-called safe-zones. This method may well give us insight into the biomechanical situation during gait, after receiving total hip replacement, that we need to fully understand the mechanisms acting on a hip joint and to prove a possible increase of functional outcome after receiving total hip replacement. KW - total hip replacement KW - subject-specific musculoskeletal modeling KW - functional outcome KW - force pathways KW - force angles KW - critical hip joint loading KW - rim loading KW - cup loading KW - Hüftgelenkprothese KW - Biomechanik KW - Lastverteilung KW - Ganganalyse KW - Simulation Y1 - 2012 U6 - https://doi.org/10.1177/0954411912447728 VL - 226 IS - 12 SP - 939 EP - 946 ER - TY - JOUR A1 - Dendorfer, Sebastian A1 - Weber, Tim A1 - Kennedy, O. T1 - Musculoskeletal modeling for hip replacement outcome analyses and other applications JF - The Journal of the American Academy of Orthopaedic Surgeons KW - Hüftgelenkprothese KW - Bewegungsapparat KW - Simulation Y1 - 2014 U6 - https://doi.org/10.5435/JAAOS-22-04-268 VL - 22 IS - 4 SP - 268 EP - 269 ER - TY - JOUR A1 - De Pieri, Enrico A1 - Atzori, Federica A1 - Ferguson, Stephen J. A1 - Dendorfer, Sebastian A1 - Leunig, Michael A1 - Aepli, Martin T1 - Contact force path in total hip arthroplasty: effect of cup medialisation in a whole-body simulation JF - HIP International N2 - Background: Cup medialisation down to the true acetabular floor in total hip arthroplasty with a compensatory femoral offset increase seems to be mechanically advantageous for the abductor muscles due to the relocation of the lever arms (body weight lever arm decreased, abductor lever arm increased). However, limited information is currently available about the effects of this reconstruction type at the head cup interface, compared to an anatomical reconstruction that maintains the natural lever arms. Through a whole-body simulation analysis, we compared medialised versus anatomical reconstruction in THA to analyse the effects on: (1) contact force magnitude at the head cup interface; (2) contact force path in the cup; and (3) abductor activity. Methods: Musculoskeletal simulations were performed to calculate the above-mentioned parameters using inverse dynamics analysis. The differences between the virtually implanted THAs were calculated to compare the medialised versus anatomical reconstruction. Results: Cup medialisation with compensatory femoral offset increase led to: (1) a reduction in contact force magnitude at the head cup interface up to 6.6%; (2) a similar contact force path in the cup in terms of sliding distance and aspect ratio; and (3) a reduction in abductor activity up to 17.2% (gluteus medius). Conclusions: In our opinion, these potential biomechanical gains do not generally justify a fully medialised reconstruction, especially in younger patients that are more likely to undergo revision surgery in their lifetime. Cup medialisation should be performed until sufficient press fit and bony coverage of a properly sized and oriented cup can be achieved. KW - Cup medialisation KW - femoral offset KW - hip contact force KW - total hip anthroplasty KW - total hip replacement KW - Hüftgelenkprothese KW - Kontaktkraft KW - Biomechanische Analyse KW - Simulation Y1 - 2020 U6 - https://doi.org/10.1177/1120700020917321 VL - 31 IS - 5 SP - 624 EP - 631 PB - Sage ER - TY - JOUR A1 - Putzer, Michael A1 - Ehrlich, Ingo A1 - Rasmussen, John A1 - Gebbeken, Norbert A1 - Dendorfer, Sebastian T1 - Sensitivity of lumbar spine loading to anatomical parameters JF - Journal of Biomechanics N2 - Musculoskeletal simulations of lumbar spine loading rely on a geometrical representation of the anatomy. However, this data has an inherent inaccuracy. This study evaluates the influence of defined geometrical parameters on lumbar spine loading utilising five parametrised musculoskeletal lumbar spine models for four different postures. The influence of the dimensions of vertebral body, disc, posterior parts of the vertebrae as well as the curvature of the lumbar spine was studied. Additionally, simulations with combinations of selected parameters were conducted. Changes in L4/L5 resultant joint force were used as outcome variable. Variations of the vertebral body height, disc height, transverse process width and the curvature of the lumbar spine were the most influential. These parameters can be easily acquired from X-rays and should be used to morph a musculoskeletal lumbar spine model for subject-specific approaches with respect to bone geometry. Furthermore, the model was very sensitive to uncommon configurations and therefore, it is advised that stiffness properties of discs and ligaments should be individualised. KW - Musculoskeletal simulation KW - Lumbar spine KW - Parameter study KW - Vertebra KW - Wirbelsäule KW - Belastung KW - Simulation Y1 - 2015 U6 - https://doi.org/10.1016/j.jbiomech.2015.11.003 VL - 49 IS - 6 SP - 953 EP - 958 PB - Elsevier Science ER - TY - JOUR A1 - Lenich, Andreas A1 - Bachmeier, S. A1 - Dendorfer, Sebastian A1 - Mayr, E. A1 - Nerlich, Michael A1 - Füchtmeier, Bernd T1 - Development of a test system to analyze different hip fracture osteosyntheses under simulated walking JF - Biomedizinische Technik. Biomedical engineering N2 - The mechanical complications of osteosyntheses after hip fractures are previously investigated by mostly static or dynamic uniaxial loading test systems. However, the physiologic loading of the hip joint during a normal gait is a multiplanar, dynamic movement. Therefore, we constructed a system to test osteosyntheses for hip fractures under physiologic multiplanar loading representative of normal gait. To evaluate the testing system, 12 femora pairs were tested under 25,000 cycles with two standard osteosyntheses (Proximal Femoral Nail Antirotation/Gamma3 Nail). For angular movement, the varus collapse to cut out (∝CO) (∝CO=4.8°±2.1° for blade and ∝CO=7.8°±3.8° for screw) was the dominant failure mode, and only slight rotational angle shifts (∝Rot) (∝Rot=1.7°±0.4° for blade and ∝Rot=2.4°±0.3° for screw) of the femoral head around the implant axis were observed. Angular displacements in varus direction and rotation were higher in specimens reinforced with screws. Hence, the cut out model and the migration directions showed a distinction between helical blade and hip screw. However, there were no significant differences between the different implants. The new setup is able to create clinical failures and allows to give evidence about the anchorage stability of different implant types under dynamic gait motion pattern. KW - biomechanical implant test KW - dynamic multiplanar loading KW - hip fractureg KW - implant migration KW - patient specific loading KW - Hüftgelenk KW - Knochenbruch KW - Osteosynthese KW - Bewegungsanalyse KW - Simulation Y1 - 2012 U6 - https://doi.org/10.1515/bmt-2011-0999 VL - 57 IS - 2 SP - 113 EP - 119 ER - TY - JOUR A1 - Melzner, Maximilian A1 - Suess, Franz A1 - Dendorfer, Sebastian T1 - The impact of anatomical uncertainties on the predictions of a musculoskeletal hand model – a sensitivity study JF - Computer Methods in Biomechanics and Biomedical Engineering N2 - Outputs of musculoskeletal models should be considered probabilistic rather than deterministic as they are affected by inaccuracies and estimations associated with the development of the model. One of these uncertainties being critical for modeling arises from the determination of the muscles' line of action and the physiological cross-sectional area. Therefore, the aim of this study was to evaluate the outcome sensitivity of model predictions from a musculoskeletal hand model in comparison to the uncertainty of these input parameters. For this purpose, the kinematics and muscle activities of different hand movements (abduction of the fingers, abduction of the thumb, and flexion of the thumb) were recorded. One thousand simulations were calculated for each movement using the Latin hypercube sampling method with a corresponding variation of the muscle origin/insertion points and the cross-sectional area. Comparing the standard hand to simulations incorporating uncertainties of input parameters shows no major deviations in on- and off-set time point of muscle activities. About 60% of simulations are located within a ± 30% interval around the standard model concerning joint reaction forces. The comparison with the variation of the input data leads to the conclusion that the standard hand model is able to provide not over-scattered outcomes and, therefore, can be considered relatively stable. These results are of practical importance to the personalization of a musculoskeletal model with subject-specific bone geometries and hence changed muscle line of action. KW - Biomechanik KW - Simulation Y1 - 2021 U6 - https://doi.org/10.1080/10255842.2021.1940974 SN - 1476-8259 N1 - Corresponding author: Maximilian Melzner VL - 25 IS - 2 SP - 156 EP - 164 PB - Taylor & Francis ER -