TY - JOUR A1 - Pangerl, Jonas A1 - Müller, Max A1 - Rück, Thomas A1 - Weigl, Stefan A1 - Bierl, Rudolf T1 - Characterizing a sensitive compact mid-infrared photoacoustic sensor for methane, ethane and acetylene detection considering changing ambient parameters and bulk composition (N2, O2 and H2O) JF - Sensors and Actuators B: Chemical N2 - We present a sensitive and compact interband cascade laser (ICL) based photoacoustic setup for the detection of gaseous hydrocarbons and discuss its applicability towards trace gas analysis. We investigated the performance of the sensor for trace concentrations of methane, ethane and acetylene diluted in nitrogen. The excitation of methane and ethane was accomplished using one tunable diode laser, covering a range from 3360 to 3372 nm, which was replaced by a separate ICL at 3025 nm for acetylene detection. The influence of ambient parameters such as temperature, flow rate and pressure as well as potential cross-sensitivities towards O2 and H2O have been examined in terms of methane and acetylene detection. A series of simulations proved several of these influences to be attributed to relaxation effects. With a 3σ limit of detection (LoD) of 6.8 parts per billion (ppbV) in case of methane, 2.3 ppbV regarding ethane and 3.6 ppbV in terms of acetylene, the sensor demonstrates a great potential for applications in the field of trace gas analysis. KW - Acetylene KW - Cross-sensitivities KW - Ethane KW - Interband cascade laser KW - Methane KW - Photoacoustic spectroscopy KW - Relaxation effects Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-25868 N1 - Corresponding author: Jonas Pangerl VL - 352,1 SP - 1 EP - 12 PB - Elsevier ER - TY - CHAP A1 - Scherer, Leo A1 - Vitzthumecker, Thomas A1 - Bierl, Rudolf ED - Uhl, Christian ED - Walter, Michael ED - Stiehl, Annika T1 - Capacitive PCB sensor for the detection of insects in intelligent traps T2 - Applied Research Conference 2022 Conference Proceedings: 4th July 2022, University of Applied Sciences Ansbach (Onsite Conference) N2 - Reliable and fast detection of pest in the food processing and pharmaceutical industry is crucial to ensure hygienically safe, pure and healthy products. This is why intelligent traps, that are able to detect insects automatically are needed. For this, a capacitive PCB sensor is developed and tested, which could be a simplistic, low power solution to the problem. This includes design, footprint generation and simulation as well as testing different types of capacitve sensing against noise immunity and sensitivity to Blattella germanica, the German cockroach. It is shown that a single specimen can very well and reliably be detected by the developed sensor. KW - PCB layout generation KW - insect monitoring KW - pest detection KW - Capacitive sensing Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-55837 SP - 519 EP - 523 PB - Hochschule Ansbach CY - Ansbach ER - TY - GEN A1 - van der Weerd, Bastiaan A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - A Conductivity Probe for Determination of the Carbon Dioxide Tension at the Oxygenator Exhaust Outlet during Extracorporeal Membrane Oxygenation (ECMO) T2 - Proceedings of the 9th ISC Modern Analytical Chemistry 2013, Prag Y1 - 2013 UR - https://www.gdch.de/fileadmin/downloads/Veranstaltungen/Tagungen/2014_Tagungen/analytica/poster_abstracts/sens03_vanderweerd_5860.pdf ER - TY - GEN A1 - Rück, Thomas A1 - Hofmann, Matthias A1 - Bierl, Rudolf T1 - Development of a miniaturized photoacoustic multigas sensing system for trace gas measurement T2 - 17th International Conference on Photoacoustic and Photothermal Phenomena, Oct. 20-24, 2013, Suzhou China Y1 - 2013 UR - https://www.gdch.de/fileadmin/downloads/Veranstaltungen/Tagungen/2014_Tagungen/analytica/poster_abstracts/sens05_rueck_5925.pdf ER - TY - GEN A1 - Rück, Thomas A1 - Matysik, Frank-Michael A1 - Bierl, Rudolf T1 - Development of a miniaturized photoacoustic multigas sensing system for trace gas measurement T2 - analytica conference 2014, 1. bis 4. April, München Y1 - 2014 UR - https://www.gdch.de/fileadmin/downloads/Veranstaltungen/Tagungen/2014_Tagungen/analytica/poster_abstracts/sens05_rueck_5925.pdf ER - TY - JOUR A1 - Escher, Lukas A1 - Rück, Thomas A1 - Jobst, Simon A1 - Pangerl, Jonas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Photodissociation-Driven Photoacoustic Spectroscopy with UV-LEDs for Ozone Detection JF - Photoacoustics N2 - This study presents the development and evaluation of a UV-LED based photoacoustic (PA) measurement system for ozone (O3) detection to demonstrate its potential for low-cost and accurate sensing while for the first time addressing the importance of photodissociation for PA signal generation for O3 in the UV range. With a detection limit of 7.9 ppbV, the system exhibits a significant advancement over state-of-the-art UV-PA O3 detection and is on par with laser-based setups. Following a novel discussion of the PA signal arising from photodissociation and its products, cross-sensitivity effects due to environmental factors such as temperature and gas composition were systematically analyzed. A digital twin driven compensation for these influences was implemented and evaluated. Despite the challenges associated with modeling the effects of H2O and CO2, the PA system shows considerable potential, though further studies in real world applications must be conducted. KW - Photoacoustic spectroscopy KW - UV-LED KW - Ozone KW - Photodissociation KW - Cross-sensitivity Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-80076 SN - 2213-5979 N1 - Corresponding author der OTH Regensburg: Lukas Escher VL - 43 PB - Elsevier BV ER - TY - JOUR A1 - Hausler, Peter A1 - Holzner, Lukas A1 - Ehrnsperger, Matthias A1 - Bierl, Rudolf T1 - Evaluation of the creep strength of samples produced by fused deposition modeling JF - Open Engineering N2 - Data sheets for 3D printing materials typically include softening temperature, impact strength, tensile strength, and stiffness. However, creep strength, an important parameter for components used over an extended period, is usually not included. Nevertheless, this parameter is of significant importance for components that are used over an extended period of time.This study compares the long-term creep behavior of a selection of materials that are commonly used in fused deposition modeling 3D printing. The materials under investigation are acrylonitrile butadiene styrene, acrylonitrile styrene acrylate, polylactic acid, and polycarbonate. In addition, the influence of fiber reinforcements on these materials is also examined. A simple, reproducible test procedure is proposed for users to determine and compare creep resistance of materials. This enables developers to select materials suitable for their own requirements on creep resistance and allows 3D-printing users to compare different materials. Results suggest that fiber reinforcement generally improves creep stability in 3D-printing materials, with GreenTEC Pro Carbon and add:north PC Blend HT LCF showing the most promise in this study. Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-79760 N1 - Corresponding author der OTH Regensburg: Peter Hausler VL - 14 IS - 1 PB - de Gruyter ER - TY - JOUR A1 - Reinker, Lukas A1 - Bläsing, Dominic A1 - Bierl, Rudolf A1 - Ulbricht, Sabina A1 - Dendorfer, Sebastian T1 - Correlation of Acceleration Curves in Gravitational Direction for Different Body Segments during High-Impact Jumping Exercises JF - sensors N2 - Osteoporosis is a common disease of old age. However, in many cases, it can be very well prevented and counteracted with physical activity, especially high-impact exercises. Wearables have the potential to provide data that can help with continuous monitoring of patients during therapy phases or preventive exercise programs in everyday life. This study aimed to determine the accuracy and reliability of measured acceleration data at different body positions compared to accelerations at the pelvis during different jumping exercises. Accelerations at the hips have been investigated in previous studies with regard to osteoporosis prevention. Data were collected using an IMU-based motion capture system (Xsens) consisting of 17 sensors. Forty-nine subjects were included in this study. The analysis shows the correlation between impacts and the corresponding drop height, which are dependent on the respective exercise. Very high correlations (0.83–0.94) were found between accelerations at the pelvis and the other measured segments at the upper body. The foot sensors provided very weak correlations (0.20–0.27). Accelerations measured at the pelvis during jumping exercises can be tracked very well on the upper body and upper extremities, including locations where smart devices are typically worn, which gives possibilities for remote and continuous monitoring of programs. KW - osteoporosis KW - inertial measurement units KW - wearable motion-tracking sensors KW - high-impact exercisess Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-58217 N1 - Corresponding author: Lukas Reinker N1 - This work was supported by the Bavarian Academic Forum [BayWISS-Verbundkolleg Gesundheit] and the DHZK fond for behavioral cardiovascular diseases [Behaviorale kardiovaskuläre Erkrankungen; grand number: 81Z0400105]. VL - 23 IS - 4 PB - MDPI CY - Basel ER - TY - CHAP A1 - Bierl, Rudolf A1 - Boehm, M. A1 - Fraunhoffer, Judith A1 - Gardeia, Armin A1 - Mottok, Jürgen A1 - Schneider, Ralph A1 - Streubel, J. T1 - “Regensburger Modell zu den P-Seminaren” – Ein Konzept zur Gestaltung der Schnittstelle Gymnasium – Hochschule und zur Praxis einer kooperativen Lehr-Lern-Didaktik für Informationstechnik T2 - 3rd Embedded Software Engineering Congress, 7. bis 9. Dezember, Sindelfingen Y1 - 2010 PB - Vogel Business Media CY - Würzburg ER - TY - JOUR A1 - Weigl, Stefan A1 - Feldmeier, Florian A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Photoacoustic detection of acetone in N2 and synthetic air using a high power UV LED JF - Sensors Actuators B Chemical N2 - The performance of a photoacoustic trace gas sensor for the detection of acetone in N2 and synthetic air is reported. The sensor system utilises an amplitude modulated UV LED. The light source has an emission maximum at 278 nm and a maximum CW output power of 300 mW according to the datasheet. Three different collimating and focusing approaches have been investigated to guide the highly divergent LED light into the acoustic resonator of the photoacoustic measurement cell. A 3D printed aluminium cell was designed to optimize light coupling by simultaneously minimizing the photoacoustic background signal generation. Hence, the diameter of the resonator was set to a comparable large diameter of 10 mm and the inner walls of the resonator were mirror polished. The additive manufacturing procedure allowed for integration of a spirally formed gas channel, enabling gas heating prior to detection. The sensor performance was investigated by measuring acetone in N2 and synthetic air at different concentrations. The UV LED current was set to 86 % of the maximum value according to the datasheet of the light source in order to increase the lifetime and thermal stability. An Allan-Werle deviation analysis validates a stable sensor performance. The limit of detection (LoD) was determined at a 3σ noise level with a 10 s lock-in amplifier time constant by sampling data points over 20 s with a data acquisition rate of 5 Hz. LoDs of 80.8 ppbV and 19.6 ppbV were obtained for acetone in N2 and synthetic air, respectively. KW - Acetone detection KW - Photoacoustic spectroscopy KW - High power UV LED KW - UV LED collimation system KW - Acetone breath analysis Y1 - 2020 U6 - https://doi.org/10.1016/j.snb.2020.128109 N1 - Corresponding author at: Sensorik-Applikationszentrum (SappZ) der Ostbayerischen Technischen Hochschule Regensburg VL - 316 IS - August SP - 1 EP - 11 PB - Elsevier ER - TY - JOUR A1 - Weigl, Stefan A1 - Wittmann, Elisabeth A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Effects of ambient parameters and cross-sensitivities from O2, CO2 and H2O on the photoacoustic detection of acetone in the UV region JF - Sensors Actuators B Chemical N2 - We present a sensitive UV LED photoacoustic setup for the detection of gaseous acetone and discuss its applicability towards breath analysis. We investigated the performance of the sensor for low acetone concentrations down to 0.1 parts per million (ppmV). The influences of temperature, flow, pressure, optical power and LED duty cycle on the measured signal have been examined. To gain a better understanding of the different effects on the photoacoustic signal, correlation analysis was applied and feature importance was determined using a large measured dataset. Furthermore, the cross-sensitivities towards O2, CO2 and H2O have been studied extensively. Finally, the sensor’s performance to detect acetone between 0.1–1 ppmV within gas mixtures simulating breath exhale conditions has been investigated, too. With a limit of detection (LoD) of 12.5 parts per billion (ppbV) (3σ) measured under typical breath exhale gas mixture conditions, the sensor demonstrated a high potential for the application of acetone detection in human breath analysis. KW - Acetone detection KW - Photoacoustic spectroscopy KW - High power UV LED KW - Cross-sensitivities KW - Acetone breath analysis Y1 - 2021 U6 - https://doi.org/10.1016/j.snb.2020.129001 SN - 0925-4005 N1 - Corresponding authors: Stefan Weigl, Elisabeth Wittmann, Thomas Rück, Rudolf Bierl, Frank-Michael Matysik N1 - Corrigendum to “Effects of ambient parameters and cross-sensitivities from O2, CO2 and H2O on the photoacoustic detection of acetone in the UV region” [Sens. Actuators B: Chem. 328 (February 2021) (2020) 129001]; https://doi.org/10.1016/j.snb.2020.129392 IS - 328 PB - Elsevier ER - TY - CHAP A1 - Hausler, Peter A1 - Jobst, Simon A1 - Fischer, Johannes A1 - Roth, Carina A1 - Bierl, Rudolf T1 - Homogeneous Light Source for Surface Plasmon Resonance Imaging T2 - PHOTOPTICS 2020: proceedings of the 8th International Conference on Photonics, Optics and Laser Technology, Valletta, Malta, February 27-29, 2020 N2 - We describe how to build a homogeneous light source for Surface Plasmon Resonance Imaging (SPRi) which mainly finds its applications in pharmaceutical screening and biotechnology so far. SPR spectroscopy is a label-free, non-destructive and highly sensitive measurement principle for detecting changes in the refractive index in close vicinity of a gold surface. A transfer of this technology to a miniaturized sensor will broaden the range of possible applications. Commercial SPR assays are mainly working with a small number of sensing spots. In contrast, the SPR imaging system shown here will allow the use of an array of many sensing spots. In combination with chemical receptors designed as an artificial nose or an electronic tongue, the simultaneous detection of many analytes is envisioned. So far, lasers or other inhomogeneous light sources were used to illuminate the sensing surface, which is decreasing the systems sensitivity. We show a compact ( 300mm2) homogeneous top hat profile. The combination of a high bit-resolution camera with our new light source enables a reflectivity based surface plasmon resonance imaging system with a high refractive index unit (RIU) resolution. KW - Surface Plasmon Resonance Spectroscopy KW - Sensor KW - SPR-imaging KW - Miniaturization KW - Micro-opto-electro-mechanical Systems Y1 - 2020 U6 - https://doi.org/10.5220/0009168701630167 SP - 163 EP - 167 PB - SCITEPRESS - Science and Technology Publications ER - TY - CHAP A1 - Gschossmann, Andreas A1 - Jobst, Simon A1 - Mottok, Jürgen A1 - Bierl, Rudolf T1 - A Measure of Confidence of Artificial Neural Network Classifiers T2 - ARCS Workshop 2019; 32nd International Conference on Architecture of Computing Systems, 20-21 May 2019, Copenhagen, Denmark N2 - Confidence in results of an Artificial Neural Networks (ANNs) is increased by preferring to reject data, that is not trustful, instead of risking a misclassification. For this purpose a model is proposed that is able to recognize data, which differs significantly from the training data, during inference. The proposed model observes all activations of the hidden layers, as well as input and output layers of an ANN in a grey-box view. To make ANNs more robust in safety critical applications, this model can be used to reject flawed data, that is suspected to decrease the accuracy of the model. If this information is logged during inference, it can be used to improve the model, by training it specifically with the missing information. An experiment on the MNIST dataset is conducted and its results are discussed. Y1 - 2019 UR - https://ieeexplore.ieee.org/document/8836211 SP - 153 EP - 157 PB - VDE-Verlag CY - Berlin ER - TY - CHAP A1 - Romano, Marco A1 - Micklitz, Matthias A1 - Olbrich, Florian A1 - Bierl, Rudolf A1 - Ehrlich, Ingo A1 - Gebbeken, Norbert T1 - Experimental investigation of damping properties of unidirectionally and fabric reinforces plastics by the free decay method T2 - Proceeding of the 15th International Materials Symposium (IMSP´2014), Pamukkale University (Denizli, Turkey), 15./17. October 2014 Y1 - 2014 SP - 665 EP - 679 ER - TY - JOUR A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - NO2 trace gas monitoring in air using off-beam quartz enhanced photoacoustic spectroscopy (QEPAS) and interference studies towards CO2, H2O and acoustic noise JF - Sensors and Actuators B: Chemical N2 - We present the development and characterization as well as comprehensive interference studies of a photoacoustic NO2 trace gas detection system. The system is based on an off-beam quartz enhanced photoacoustic scheme (off-beam QEPAS) and signal generation was initiated by amplitude modulating a low-cost diode laser emitting at 450 nm. The QEPAS sensor element features double-resonant amplification, still it is only ∼ 5 × 5 × 2.5 mm in size. The individual and combined resonance characteristics were investigated and specified to 52 dB amplification, adding up 15 dB acoustic- and 37 dB mechanical-resonance amplification. The linearity of the photoacoustic signal dependency on the analyte concentration was verified from 200 ppbV to 100 ppmV NO2 in synthetic air. The detection limit (3σ) was determined to 1.8 ppbV using a lock-in time constant of 10 s and an averaging time of 20 s. The normalized noise equivalent absorption coefficient was specified to 2.5·10−8 W cm−1 Hz−0.5. The stability of the signal was investigated over time and a slight drift by 1‰ was observed after 30 min without temperature stabilizing the photoacoustic cell (PAC). Noise analysis was performed by means of Allan deviation and the inverse dependency of response time and precision of the system on the lock-in time constant was outlined. We performed interference analyses towards N2, O2, CO2, H2O and acoustic noise, respectively. Although neither spectral interferences nor losses due to slow NO2 VT-relaxation were observed, O2 was identified to cause a 15% signal drop due to VVNO2-O2-relaxation. Changing H2O concentrations were found to cause acoustic detuning, which cannot be compensated by adjusting the frequency of modulation, because of the double-resonant feature of the PAC. However, alternative approaches of compensation were discussed. Finally, we carried out heavy traffic noise simulations and determined the QEPAS setup to be 46 times less susceptible towards ambient noise compared to standard microphone-based photoacoustic setups. Y1 - 2018 U6 - https://doi.org/10.1016/j.snb.2017.09.039 VL - 255 IS - Part 3, February SP - 2462 EP - 2471 PB - Elsevier ER - TY - JOUR A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Development and characterization of a laboratory setup for photoacoustic NO2 determination based on the excitation of electronic 2B2 and 2B1 states using a low-cost semiconductor laser JF - Sensors and Actuators A: Physical N2 - This work gives a detailed characterization of a laboratory setup for photoacoustic NO2 trace gas detection at the ppb level. The signal generation is based on the excitation of electronic 2B2 and 2B1 states using a low-cost semiconductor laser emitting at 450 nm. An acoustic resonator was used for signal amplification and the modulation frequency of the laser was determined to 3395 Hz in order to gain maximum signal amplification. The quality of resonant amplification was determined to 7.9. The gas samples were NO2 calibration gases diluted with pure nitrogen. The signal-to-noise ratio (SNR) dependency on the flow rate Q and the lock-in time constant τLIA was investigated, respectively, and the optimum values were specified to Q = 500 mL/min and τLIA = 2 s. In case of ambient noise, increasing τLIA to 10 s was evaluated as sufficient for SNR preservation. The noise level was measured in the absence of NO2 and it was determined to be composed of 51% electronic noise and 49% gas flow noise. With the analyte concentration ranging from 300 ppbV to 100 ppmV, the linear dependency of the photoacoustic amplitude on the NO2 concentration was specified, the sensitivity was determined to 110 μV/ppmV and the maximum measurement error was calculated to ±0.8%. The detection limit was determined to 2.0 ppbV. Furthermore, the stability of the signal was investigated and a maximum drift of ±1% was observed within a measuring period of 30 min. The response time τ90 was specified to 58 s. All results considered, this photoacoustic measuring system, which is based on low-cost signal generation and detection units, provides an excellent basis in view of developing a portable device for photoacoustic trace gas detection. Y1 - 2017 U6 - https://doi.org/10.1016/j.sna.2017.03.024 VL - 258 SP - 193 EP - 200 PB - Elsevier CY - Amsterdam, Niederlande ER - TY - JOUR A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Low-cost photoacoustic NO2 trace gas monitoring at the pptV-level JF - Sensors and Actuators A: Physical N2 - We present the development and the characterization of a photoacoustic NO2 trace gas detection system. The system is based on the implementation of low-cost components, i.e. a mass-produced blue diode laser and a standard MEMS microphone which is commonly built into smartphones, for example. An optimized cell design was realized by means of 3D printing. The linearity of the photoacoustic signal dependency on the analyte concentration was verified from 200 ppbV to 100 ppmV NO2. The detection limit (1σ) was determined to 33 pptV and the normalized noise equivalent absorption coefficient was calculated to 7.0 ∙ 10−10 W cm−1 Hz−1/2. The dynamic range of the system was verified to be linear over three magnitudes of order and the sensitivity was calculated to 814 μV/ppmV. The system was characterized in view of optimal operating parameters, i.e. lock-in time constant τLIA and total mass flow rate, optical performance and signal stability. The mass flow dependend response time of the system was specified to 19 s and an idealized step response to a quasi-Heaviside step function was quantified as a function of τLIA. The quality factor of acoustic resonance was determined to 21.9 and an empirical expression regarding acoustic node shifting is provided. The expression takes into account the radius of the resonator pipe and the radius of the hole, which was drilled into the pipe for microphone coupling. Furthermore, we studied the cross-sensitivity of the photoacoustic signal towards H2O and CO2, respectively. Y1 - 2017 U6 - https://doi.org/10.1016/j.sna.2017.06.036 VL - 263 SP - 501 EP - 509 PB - Elsevier CY - Amsterdam, Niederlande ER - TY - GEN A1 - Weigl, Stefan A1 - Matysik, Frank-Michael A1 - Bierl, Rudolf T1 - Development of a sensor system for analysis of human breath exhale T2 - BayWISS Herbstakademie 2018, Plankstetten N2 - Atemgasanalyse ist ein junges und vielversprechendes Feld im Bereich der diagnostischen Medizin. Der Ansatz verspricht einfach zugängliche und leicht wiederholbare Probennahme die zum einen non-invasiv ist und zugleich Rückschlüsse auf Vorgänge im menschlichen Körper und bspw. dessen Gesundheitszustand zulässt. Seit Ende des 20. Jahrhunderts gibt es Massenspektrometer die es ermöglicht haben mehrere Tausend verschiedene Stoffe in der Ausatemluft nachzuweisen. Diese Technologien verbessern sich stetig und ermöglichen es die Vorgänge und Zusammenhänge zwischen Zusammensetzung der Ausatemluft und systemischen Prozessen besser zu verstehen. Die bei Studien mit Massenspektrometern ermittelten Biomarker, deren qualitative und quantitative Detektion Gesundheitsdiagnosen ermöglichen, haben aber noch nicht den Weg in den klinischen Alltag gefunden. Das Problem sind meistens die hohen Anschaffungskosten, komplizierte Datenauswertung und zumeist geringe Verfügbarkeit und Immobilität dieser Messgeräte. Die photoakustische Spektroskopie ist eine selektive und hochsensitive Messmethode, die es ermöglichen soll den Biomarker „Aceton“, der grundsätzlich die Metabolisierung von Fetten widerspiegelt, schnell und reproduzierbar quantitativ zu detektieren. Dabei müssen Hindernisse wie Querempfindlichkeiten, ausgelöst durch die komplexe Zusammensetzung der Messmatrix Atemgas, bei gleichzeitig kleine Aceton Konzentrationen (200-800 parts-per-billion) überwunden werden. Verschiedene Wellenlängenbereiche mit unterschiedlichen Lichtquellen, akustisch resonante sowie innovative Messzellendesigns und anspruchsvolle Datenauswertung mittels komplexer Algorithmik sind nötig um das Ziel, die Entwicklung eines kompakten, günstigen und zuverlässigen Acetonsensors, zu erreichen. Y1 - 2018 ER - TY - CHAP A1 - Roth, Carina A1 - Hausler, Peter A1 - Bierl, Rudolf T1 - Einbindung eines 2D-Photodetektors in einen hochintegrierten SPR-Imaging-Sensor T2 - 118. Jahrestagung der deutschen Gesellschaft für angewandte Optik (DGaO), 6.-10. Juni 2017, Dresden N2 - Mit der Oberflächenplasmonenresonanzspektroskopie (SPR) können Brechungsindexänderungen eines Analyten von bis zu 10-6 RIU detektiert werden. Das SPR-Imaging bietet heute gegenüber der konventionellen SPR-Analyse die Möglichkeit, mehrere einzelne Messungen parallel durchführen zu können. Mit Hilfe eines zweidimensionalen Sensorchips und einer leistungsfähigen Boardlevelkamera können die Abbildungen des Chips direkt an einen Rechner übertragen und dort verarbeitet werden. Aufgrund unterschiedlicher Winkelstellungen und der Geometrie des Aufbaus entstehen Stauchungen und Streckungen des abgebildeten Sensorchips, die mit verschiedenen Ansätzen aus der Bildverarbeitung ausgeglichen werden, um die Bilder miteinander vergleichen zu können. Zudem wird die Güte der Referenz- und Messbereiche des Chips bestimmt. Diese Algorithmen sind nur möglich aufgrund der heutigen, leistungsfähigen Rechner und der immer größer werdenden Durchsatzraten der Kameras. Dabei kommt in dieser Anwendung der relativ neue Kamerastandard USB3 Vision zum Einsatz. Dieser zeichnet sich zusätzlich durch das Plug and Play und seinen Standardstecker, der an (fast) jedem Rechner vorhanden ist, aus. KW - Bildverarbeitung KW - Messtechnik KW - Optische Informationsverarbeitung Y1 - 2017 ER - TY - CHAP A1 - Zhou, Qi A1 - Landgraf, Ferdinand A1 - Rück, Thomas A1 - Bierl, Rudolf T1 - Resonance frequency tuning and process design of a micromechanical capacitive cantilever in a photoacoustic trace-gas sensing device T2 - 7. MikroSystemTechnik Kongress "MEMS, Mikroelektronik, Systeme", 23.-25. Oktober 2017, München N2 - Photoacoustic spectroscopy is an efficient method to detect the concentration of trace gases with following advantages: short response time, high sensitivity, continuous and real-time monitoring and the option of miniaturization without the need of complex mirror-based multi-pass cell designs. A micromechanical cantilever is used as a key component in a two-part "Cantilever-Resonator" system that detects the weak photoacoustic signal. The resonance frequency of cantilever needs to be tuned to match the resonance frequency of resonator in order to achieve the maximum vibration amplitude of the "Cantilever-Resonator" system. This paper reports a post-fabrication method to tune the resonance frequency of cantilevers via focused ion beam (FIB) and a capacitive solution for the cantilever to transform the acoustic signal to electrical signal. Y1 - 2017 SN - 978-3-8007-4491-6 PB - VDE-Verlag CY - Berlin ER - TY - JOUR A1 - van der Weerd, Bastiaan A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Trends in Electrochemical Sensing of Blood Gases JF - Bioanalytical Reviews N2 - The monitoring of partial pressures of the blood gases carbon dioxide (pCO2) and oxygen (pO2) is of great importance in clinical diagnostics. The measure of pCO2 and pO2 provides essential information about the patient’s metabolism, gas exchange, ventilation, and acid–base homeostasis. The conventional electrochemical methods for clinical blood gas analysis are based on the potentiometric Severinghaus sensor for carbon dioxide and the amperometric Clark sensor for oxygen. These techniques are well established and are only shortly discussed in this overview. However, in recent years a variety of modifications of these classical sensor concepts and new approaches of electrochemical sensing of pCO2 and pO2 have been introduced. This review summarizes recent developments in this field and discusses the potential for future applications in clinical blood gas analysis. KW - Blood gas analysis KW - Noninvasive blood gas sensor KW - Electrochemical sensor KW - Clinical analysis Y1 - 2016 U6 - https://doi.org/10.1007/11663_2016_1 VL - 6 SP - 263 EP - 280 PB - Springer CY - Berlin ER - TY - CHAP A1 - Rück, Thomas A1 - Läpple, I. A1 - Bierl, Rudolf T1 - Photoakustische Spurengasanalytik von NO2 im ppt-Bereich (10^-12) bei Verwendung kostengünstiger Einzelkomponenten T2 - 7. MikroSystemTechnik Kongress "MEMS, Mikroelektronik, Systeme", 23.-25. Oktober 2017, München KW - Elektroniksystem KW - Industrie 4.0 KW - Mikrosystemtechnik KW - Mikrofluidik KW - Mikroaktorik Y1 - 2017 SN - 978-3-8007-4491-6 PB - VDE-Verlag CY - Berlin ER - TY - JOUR A1 - Zagler, Andreas A1 - Landgraf, Ferdinand A1 - Rück, Thomas A1 - Bierl, Rudolf T1 - Entwicklung eines mikromechanischen kapazitiven Schalldetektors im resonanten Betrieb für die photoakustische Spurengasanalyse JF - 7. MikroSystemTechnik Kongress "MEMS, Mikroelektronik, Systeme", 23.-25. Oktober 2017, München Y1 - 2017 PB - VDE-Verlag CY - Berlin ER - TY - CHAP A1 - Gaida, Peter A1 - Weigl, Stefan A1 - Rück, Thomas A1 - Bierl, Rudolf T1 - Portable photoakustische Messeinheit zur NO2 Detektion im Spurenbereich T2 - 7. MikroSystemTechnik Kongress "MEMS, Mikroelektronik, Systeme", 23.-25. Oktober 2017, München Y1 - 2017 SN - 978-3-8007-4491-6 PB - VDE-Verlag CY - Berlin ER - TY - CHAP A1 - Fischer, Johannes T1 - Miniaturisierter plasmonischer Sensor für das Monitoring von Weichmachern in Gewässerproben T2 - 7. MikroSystemTechnik Kongress "MEMS, Mikroelektronik, Systeme", 23.-25. Oktober 2017, München Y1 - 2017 SN - 978-3-8007-4491-6 PB - VDE-Verlag CY - Berlin ER - TY - GEN A1 - Hausler, Peter A1 - Roth, Carina A1 - Vitzthumecker, Thomas A1 - Fischer, Johannes A1 - Bierl, Rudolf T1 - Motionless SPR-angle scan with a miniaturized device T2 - Europtrode XIV, Naples, 25-28 March 2018 Y1 - 2018 ER - TY - CHAP A1 - Weigl, Stefan A1 - Gaida, Peter A1 - Rück, Thomas A1 - Bierl, Rudolf T1 - Portable Measurement Unit for NO2 Trace Gas Detection T2 - PHOTOPTICS 2018, 6th International Conference on Photonics, Optics and Laser Technology, 25 - 27 January 2018, Funchal Madeira Y1 - 2018 ER - TY - RPRT A1 - Unger, J. A1 - Rück, Thomas A1 - Landgraf, Ferdinand A1 - Bierl, Rudolf T1 - Herstellung und Analyse der Resonanzfrequenz eines MEMS Cantilever für das CEPAS Verfahren N2 - Diese Abhandlung beschreibt das Konzept eines mikroeletromechanischen Systems (MEMS), das im Messverfahren der cantilever enhanced photoacoustic spectroscopy (CEPAS) Verwendung finden soll. Es wird die Herstellung eines einseitig eingespannten Biegebalkens aus Silizium mittels deep reactiv ion etching (DRIE) beschrieben. Des Weiteren wird die Resonanzfrequenz dieses Cantilevers mit Hilfe Laservibrometertechnik untersucht. Die resultierenden resonanten Schwingungen 0.Ordnung werden mit den Ergebnissen einer vereinfachten theoretischen Näherung verglichen. Die Messergebnisse stehen in gutem Zusammenhang mit den theoretischen Werten. Solche Cantilever, die aus silicon on insula tor (SOI) Wafer angefertigt wurden, weisen bei einer Zielfrequenz ein mittlere Abweichung von Δf = 118±26Hz (bzw.Δf =0,76±0,17%) auf. Y1 - 2015 ER - TY - CHAP A1 - Holler, Sven A1 - Hausler, Peter A1 - Roth, Carina A1 - Bierl, Rudolf T1 - Gestapelte Au-Al-Au und Au-Ag-Au Schichten als aktive Schichten für die Oberflächenplasmonenresonanzspektroskopie T2 - 5. Landshuter Symposium Mikrosystemtechnik, März 2016 Y1 - 2016 SN - 978-3-9812696-9-7 SP - 192 EP - 198 PB - Fachhochschule Landshut CY - Landshut ER - TY - CHAP A1 - Roth, Carina A1 - Hausler, Peter A1 - Bierl, Rudolf T1 - Einbindung eines CMOS-Detektors in einen hochintegrierten SPR-Sensor T2 - 5. Landshuter Symposium Mikrosystemtechnik, März 2016 Y1 - 2016 SN - 78-3-9812696-9-7 SP - 200 EP - 205 PB - Fachhochschule Landshut CY - Landshut ER - TY - JOUR A1 - Romano, Marco A1 - Micklitz, Matthias A1 - Olbrich, Florian A1 - Bierl, Rudolf A1 - Ehrlich, Ingo A1 - Gebbeken, Norbert T1 - Experimental investigation of damping properties of unidirectionally and fabric reinforced plastics by the free decay method JF - Journal of Achievements in Materials and Manufacturing Engineering N2 - Purpose: of this paper is experimental investigation of damping properties of unidirectionally and fabric reinforced plastics by the free decay method. Design/methodology/approach: For the evaluation of the presumed effect experimental structural dynamic investigations comparing unidirectionally and fabric reinforced plastics are carried out. In detail the free decay behaviour of flat beamlike specimens under fixed-free boundary conditions and relatively constant and reproducible displacement excitation is investigated. Findings: The vibrating structure has been measured by a laser scanning vibrometer PSV 400 from POLYTEC. In both cases evaluation of the results yields enhanced damping properties of the specimens with fabric reinforcement compared to the unidirectionally reinforced specimens. The results justify the presumed acting of a mesomechanic kinematic. Research limitations/implications: The results show that in either case the material damping in terms of the logarithmic decrement of the fabric reinforced material is higher than the material damping in of the unidirectionally reinforced material. Additionally, when the fabric reinforced specimens are addressed, in each case the plain weave reinforced specimens exhibited higher values of the material damping as the twill weave 2/2 reinforced ones. Originality/value: Ondulations in fabrics as a textile semi-finished product are caused by the alternating crossing of warp and fill yarns. In the mesoscopic scale the acting of a mesomechanic kinematic is presumed to enhance the damping properties under cyclic elastic deformation. For the evaluation of the presumed effect experimental structural dynamic investigations comparing unidirectionally and fabric reinforced plastics are carried out. KW - structural vibration KW - damping KW - fibre reinforced plastics KW - mesomechanic scale KW - fabric reinforced layer Y1 - 2014 VL - 63 IS - 2 SP - 65 EP - 80 ER - TY - CHAP A1 - Jobst, Simon A1 - Bierl, Rudolf T1 - A Comparison of Correlation and Zero-Crossing Based Techniques in Ultrasonic Measurement T2 - 10th International Symposium on Applied Reconfigurable Computing (ARC'2014), Vilamoura, Algarve, Portugal, 14 - 16 April, 2014 N2 - Ultrasound measurement technology has advancedin previous decades due to positive developments in computing power and lower cost for the necessary hardware. Correlation-based processing can be advantageous for high-accuracy measurements, especially in noisy environments. Higher computational load makes correlation less attractive for industrialapplications, though, favouring traditional processing techniques. A platform for comparing various processing techniques hasbeen developed. It was found that both zero-crossing detectionas well as correlation can achieve very high accuracy over a hightemperature range but that correlation-based processing can lead to a significant precision bias depending on system bandwidth. Y1 - 2014 ER - TY - CHAP A1 - Hofmann, Matthias A1 - Bierl, Rudolf A1 - Rück, Thomas T1 - Implementation of a dual-phase lock-in amplifier on a TMS320C5515 digital signal processor T2 - Proceedings of the 5th European DSP Education and Research Conference (EDERC), 13-14 Sept. 2012, Amsterdam N2 - A digital dual-phase lock-in amplifier that is capable to run on a low-cost, low-power platform comprising a 16-bit fixed-point digital signal processor was developed. This is achieved by a set of optimised digital filters including an exponential averager to adjust the time constant of the overall filter. The reference frequency is generated using a direct digital synthesis source utilising angle decomposition with a resolution of 1 Hz. The digital lock-in algorithm is described and the performance of the algorithm is analysed. The experimental results show that the developed lock-in amplifier achieves similar performance to a commercially available lock-in amplifier. Y1 - 2012 U6 - https://doi.org/10.1109/EDERC.2012.6532217 ER - TY - CHAP A1 - Rück, Thomas A1 - Landgraf, Ferdinand A1 - Läpple, I. A1 - Unger, J. A1 - Matysik, Frank-Michael A1 - Bierl, Rudolf T1 - Specification of an improved photoacoustic setup for high-sensitive, low-cost NO2 trace gas detection T2 - 18th International Conference on Photoacoustic and Photothermal Phenomena (ICPPP18), 2015, September 6-10, Novi Sad, Serbia Y1 - 2015 ER - TY - CHAP A1 - van der Weerd, Bastiaan A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - A Conductivity Probe for the Determination of Carbon Dioxide Tension at the Oxygenator Exhaust Outlet during Extracorporeal Membrane Oxygenation (ECMO) T2 - analytica Conference 2014, 1. bis 4. April, München Y1 - 2014 ER - TY - CHAP A1 - van der Weerd, Bastiaan A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - A Conductivity Probe for the Determination of Carbon Dioxide Tension at the Oxygenator Exhaust Outlet during Extracorporeal Membrane Oxygenation (ECMO) T2 - Electrochemistry 2014, September 22 - 24, Mainz Y1 - 2014 ER - TY - CHAP A1 - van der Weerd, Bastiaan A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - A Planar Conductivity Probe for CO2 Determination at the Oxygenator Outlet T2 - Doktorandenseminar GDCh Prozessanalytik 2014, Berlin Y1 - 2014 ER - TY - JOUR A1 - Wunderlich, Lukas A1 - Hausler, Peter A1 - Maerkl, Susanne A1 - Bierl, Rudolf A1 - Hirsch, Thomas T1 - Nanoparticle Determination in Water by LED-Excited Surface Plasmon Resonance Imaging JF - Chemosensors N2 - The increasing popularity of nanoparticles in many applications has led to the fact that these persistent materials pollute our environment and threaten our health. An online sensor system for monitoring the presence of nanoparticles in fresh water would be highly desired. We propose a label-free sensor based on SPR imaging. The sensitivity was enhanced by a factor of about 100 by improving the detector by using a high-resolution camera. This revealed that the light source also needed to be improved by using LED excitation instead of a laser light source. As a receptor, different self-assembled monolayers have been screened. It can be seen that the nanoparticle receptor interaction is of a complex nature. The best system when taking sensitivity as well as reversibility into account is given by a dodecanethiol monolayer on the gold sensor surface. Lanthanide-doped nanoparticles, 29 nm in diameter and with a similar refractive index to the most common silica nanoparticles were detected in water down to 1.5 mu g mL(-1). The sensor can be fully regenerated within one hour without the need for any washing buffer. This sensing concept is expected to be easily adapted for the detection of nanoparticles of different size, shape, and composition, and upon miniaturization, suitable for long-term applications to monitor the quality of water. KW - ENGINEERED NANOPARTICLES KW - imaging KW - nanoparticle KW - plasmon resonance KW - REFRACTIVE-INDEX KW - sensor KW - surface Y1 - 2021 U6 - https://doi.org/10.3390/chemosensors9070175 SN - 2227-9040 VL - 9 IS - 7 SP - 1 EP - 9 PB - MDPI ER - TY - CHAP A1 - Hausler, Peter A1 - Roth, Carina A1 - Vitzthumecker, Thomas A1 - Bierl, Rudolf ED - Ribeiro, Paulo ED - Raposo, Maria T1 - Miniaturized Surface Plasmon Resonance Based Sensor Systems BT - Opportunities and Challenges T2 - Optics, Photonics and Laser Technology 2018 N2 - Surface Plasmon Resonance (SPR) is a well-known and established technology in bioanalysis and pharmaceutical sciences. Due to the expensive instrumentation and the need of trained people, it is mainly limited to applications in laboratories. However, there are some areas like environmental monitoring, chemical processing and civil infrastructure, which urgently need new sensor technologies. SPR has the potential to serve these fields. In order to be qualified for a use in these areas SPR has to overcome some hurdles. The instrumentation has to be robust, small in size and cheap. A device, which fits these needs, will be a micro-opto-electro-mechanical system (MOEMS) with integrated intelligent algorithms. In this book chapter, examples of miniaturized SPR devices are introduced, the limitations which have to be overcome as well as the possibilities for future applications are proposed. Due to the manifold advantages of this technology and the dropping prices for imaging sensors, Surface Plasmon Resonance imaging (SPRi) might become one of the leading technologies for SPR smart sensor systems. Y1 - 2019 SN - 978-3-030-30112-5 U6 - https://doi.org/10.1007/978-3-030-30113-2_8 SP - 169 EP - 195 PB - Springer Nature CY - Cham ER - TY - CHAP A1 - Müller, Max A1 - Rück, Thomas A1 - Jobst, Simon A1 - Pangerl, Jonas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Creating a Digital Twin of a Photoacoustic Gas Sensor for Methane Detection in Complex Gas Matrices T2 - Proceedings Optical Sensors and Sensing Congress 2022 (AIS, LACSEA, Sensors, ES): 11–15 July 2022, Vancouver, British Columbia, Canada N2 - We present the calculation results from a digital twin (DT) of our photoacoustic (PA) sensor for methane detection, regarding gas composition, temperature and pressure variations. Y1 - 2022 SN - 978-1-957171-10-4 U6 - https://doi.org/10.1364/LACSEA.2022.LW4D.2 PB - Optica Publishing Group ER - TY - JOUR A1 - Zifarelli, Andrea A1 - Cantatore, Aldo Francesco Pio A1 - Sampaolo, Angelo A1 - Mueller, Max A1 - Rueck, Thomas A1 - Hoelzl, Christine A1 - Rossmadl, Hubert A1 - Patimisco, Pietro A1 - Spagnolo, Vincenzo T1 - Multivariate analysis and digital twin modelling: Alternative approaches to evaluate molecular relaxation in photoacoustic spectroscopy JF - Photoacoustics N2 - A comparative analysis of two different approaches developed to deal with molecular relaxation in photoacoustic spectroscopy is here reported. The first method employs a statistical analysis based on partial least squares regression, while the second method relies on the development of a digital twin of the photoacoustic sensor based on the theoretical modelling of the occurring relaxations. Methane detection within a gas matrix of synthetic air with variable humidity level is selected as case study. An interband cascade laser emitting at 3.345 µm is used to target methane absorption features. Two methane concentration ranges are explored targeting different absorptions, one in the order of part-per-million and one in the order of percent, while water vapor absolute concentration was varied from 0.3 % up to 2 %. The results achieved employing the detection techniques demonstrated the possibility to efficiently retrieve the target gas concentrations with accuracy > 95 % even in the case of strong influence of relaxation effects. KW - digital twin model KW - methane detection over a wide concentration range KW - multivariate analysis KW - Partial Least Squares Regression KW - QEPAS sensor KW - relaxation effects photoacoustic spectroscopy KW - water vapor influence on relaxation Y1 - 2023 U6 - https://doi.org/10.1016/j.pacs.2023.100564 SN - 2213-5979 VL - 33 PB - Elsevier ER - TY - CHAP A1 - Pangerl, Jonas A1 - Wittmann, Elisabeth A1 - Weigl, Stefan A1 - Müller, Max A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Using a Modulated Quantum Cascade Laser for Photoacoustic Spectra Recording of Exhaled Acetone and Main Breath Components T2 - Optical Sensors and Sensing Congress 2022 (AIS, LACSEA, Sensors, ES) N2 - Photoacoustic spectra of main breath components together with acetone are presented demonstrating spectral linearity towards different concentrations and compositions. The acetone 3σ detection limit at 1209 cm−1 is 0.28 ppbV Y1 - 2023 U6 - https://doi.org/10.1364/AIS.2022.ATu3G.1 PB - Optica Publishing Group ER - TY - CHAP A1 - Escher, Lukas A1 - Rück, Thomas A1 - Jobst, Simon A1 - König, Martin A1 - Bierl, Rudolf T1 - Design and Characterization of a Low-Cost Photoacoustic Sensor for NO2 Using Lateral Illumination and Background Suppression T2 - Imaging and Applied Optics Congress 2022 (3D, AOA, COSI, ISA, pcAOP): 11–15 July 2022, Vancouver, British Columbia, Canada N2 - We introduce a low-cost photoacoustic NO2 sensor based on lateral LED illumination and optical background signal compensation. The 3σ limit of detection (LOD) was identified to be 24 ppbV. Y1 - 2022 SN - 978-1-957171-09-8 U6 - https://doi.org/10.1364/3D.2022.JTu2A.10 PB - Optica Publishing Group ER - TY - INPR A1 - Pangerl, Jonas A1 - Sukul, Pritam A1 - Rück, Thomas A1 - Escher, Lukas A1 - Miekisch, Wolfram A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Photoacoustic Trace-Analysis of Breath Isoprene and Acetone Via Interband- and Quantum Cascade Lasers N2 - This research presents two laser-based photoacoustic approaches for analyzing exhaled breath isoprene and acetone. The integration of a PTR-ToF-MS as a reference device ensured the reliability and accuracy of the PAS systems that is based on an ICL for isoprene and a QCL for acetone detection. The calibration yielded limits of detection of 26.9 ppbV and 1.7 ppbV, respectively, and corresponding normalized noise equivalent absorption coefficients (NNEAs) of 5.0E-9 Wcm-1Hz-0.5 and 4.9E-9 Wcm-1Hz-0.5. Laboratory as well as real breath sample measurements from alveolar breath revealed a robust system performance, with only one outlier within the static isoprene measurements. However, discrepancies emerged under dynamic breath sampling conditions, emphasizing the need for further optimization. Especially by knowing the dynamic nature and endogenous origin of exhaled isoprene our findings highlight the potential of breath analysis for non-invasive physio-metabolic and pathophysiological monitoring towards point-of-care devices. KW - photoacoustic spectroscopy KW - breath analysis/profiling KW - real-time mass spectroscopy KW - isoprene KW - acetone Y1 - 2024 U6 - https://doi.org/10.2139/ssrn.4834735 PB - Elsevier / SSRN ER - TY - JOUR A1 - Pangerl, Jonas A1 - Sukul, Pritam A1 - Rück, Thomas A1 - Escher, Lukas A1 - Miekisch, Wolfram A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Photoacoustic trace-analysis of breath isoprene and acetone via interband- and Quantum Cascade Lasers JF - Sensors and Actuators: B. Chemical N2 - This research presents two laser-based photoacoustic approaches for analyzing exhaled breath isoprene and acetone. The integration of a PTR-ToF-MS as a reference device ensured the reliability and accuracy of the photoacoustic systems that is based on an ICL for isoprene and a QCL for acetone detection. The calibration yielded limits of detection of 26.9 ppbV and 1.7 ppbV, respectively, and corresponding normalized noise equivalent absorption coefficients (NNEAs) of 5.0E-9 Wcm 1Hz 0.5 and 4.9E-9 Wcm 1Hz 0.5. Laboratory as well as real breath sample measurements from alveolar breath revealed a robust system performance, with only one outlier within the static isoprene measurements. However, discrepancies emerged under dynamic breath sampling conditions, emphasizing the need for further optimization. Especially by knowing the dynamic nature and endogenous origin of exhaled isoprene our findings highlight the potential of breath analysis for non-invasive physio-metabolic and pathophysiological monitoring towards point-of-care devices KW - Photoacoustic spectroscopy KW - Breath analysis/profiling KW - Real-time mass spectrometry KW - Isoprene KW - Acetone Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-77024 N1 - Corresponding author der OTH Regensburg: Jonas Pangerl VL - 424 PB - Elsevier ER - TY - CHAP A1 - Escher, Lukas A1 - Müller, Max A1 - Rück, Thomas A1 - Jobst, Simon A1 - Bierl, Rudolf T1 - Digitaler Zwilling photoakustischer Spurengassensoren zur Prozessüberwachung T2 - 16. Dresdner Sensor-Symposium 2022: Vorträge N2 - Stickstoffdioxid (NO2) wird hauptsächlich durch anthropogene Verbrennungsprozesse in Verkehr und Industrie in die Umgebungsluft eingebracht [1]. Die stark reaktive, oxidative Wirkung von NO2 kann bei Exposition mit höheren Konzentrationen Reizungen und allergische Reaktionen in den Atemwegen hervorrufen. Weiter führt NO2 zur Bildung von saurem Regen, Smog und Ozon (O3) die sich ebenso negativ auf die menschliche Gesundheit und Umwelt auswirken [2,3]. Aufgrund dieser Effekte wird die Spurengaskonzentration von NO2 in der Luft in Deutschland an ausgewählten, verkehrsreichen Orten gemessen. Y1 - 2022 SN - 978-3-9819376-7-1 U6 - https://doi.org/10.5162/16dss2022/3.3 PB - AMA (Association for Sensors + Measurement) ER - TY - JOUR A1 - Rück, Thomas A1 - Pangerl, Jonas A1 - Escher, Lukas A1 - Jobst, Simon A1 - Müller, Max A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Kinetic cooling in mid-infrared methane photoacoustic spectroscopy: A quantitative analysis via digital twin verification JF - Photoacoustics N2 - This study presents a detailed quantitative analysis of kinetic cooling in methane photoacoustic spectroscopy, leveraging the capabilities of a digital twin model. Using a quantum cascade laser tuned to 1210.01 cm⁻¹, we investigated the effects of varying nitrogen-oxygen matrix compositions on the photoacoustic signals of 15 ppmV methane. Notably, the photoacoustic signal amplitude decreased with increasing oxygen concentration, even falling below the background signal at oxygen levels higher than approximately 6 %V. This phenomenon was attributed to kinetic cooling, where thermal energy is extracted from the surrounding gas molecules rather than added, as validated by complex vector analysis using a previously published digital twin model. The model accurately reproduced complex signal patterns through simulations, providing insights into the underlying molecular mechanisms by quantifying individual collision contributions. These findings underscore the importance of digital twins in understanding the fundamentals of photoacoustic signal generation at the molecular level. Y1 - 2024 U6 - https://doi.org/10.1016/j.pacs.2024.100652 VL - 40 PB - Elsevier ER - TY - JOUR A1 - Jobst, Simon A1 - Recum, Patrick A1 - Écija-Arenas, Ángela A1 - Moser, Elisabeth A1 - Bierl, Rudolf A1 - Hirsch, Thomas T1 - Semi-Selective Array for the Classification of Purines with Surface Plasmon Resonance Imaging and Deep Learning Data Analysis JF - ACS sensors N2 - In process analytics or environmental monitoring, the real-time recording of the composition of complex samples over a long period of time presents a great challenge. Promising solutions are label-free techniques such as surface plasmon resonance (SPR) spectroscopy. They are, however, often limited due to poor reversibility of analyte binding. In this work, we introduce how SPR imaging in combination with a semi-selective functional surface and smart data analysis can identify small and chemically similar molecules. Our sensor uses individual functional spots made from different ratios of graphene oxide and reduced graphene oxide, which generate a unique signal pattern depending on the analyte due to different binding affinities. These patterns allow four purine bases to be distinguished after classification using a convolutional neural network (CNN) at concentrations as low as 50 μM. The validation and test set classification accuracies were constant across multiple measurements on multiple sensors using a standard CNN, which promises to serve as a future method for developing online sensors in complex mixtures. KW - surface plasmon resonance imaging KW - functional surface KW - graphene oxide KW - reduced graphene oxide KW - 2D materials KW - pattern recognition KW - small-molecule sensing Y1 - 2023 U6 - https://doi.org/10.1021/acssensors.3c01114 VL - 8 IS - 9 SP - 3530 EP - 3537 PB - American Chemical Society ER - TY - CHAP A1 - Hausler, Peter A1 - Wunderlich, Lukas A1 - Fischer, Johannes A1 - Pfab, Christina A1 - Heckscher, Simon A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - Surface plasmon resonance imaging for detection of drug metabolites in water T2 - Proceedings of SPIE, Optical Sensors 2019, 1 - 4 April 2019, Prague, Czech Republic N2 - The analysis of surface water, groundwater, drinking water as well as sewage is important to get information about the contamination of the water cycle. Currently, these time-consuming investigations require special equipment, like for example hyphenated mass spectrometry. Surface plasmon resonance (SPR) is a faster alternative as it is highly sensitive to changes in the dielectric medium next to a thin metal layer and makes it a quasi-universal detector. Therefore, and due to the labelfree nature, SPR is a widely used sensing tool for real‐time monitoring of molecular interactions of various analytes. SPR imaging (SPRi) has several advantages to standard surface plasmon resonance, as it allows to observe many analytes in parallel as well as the integration of referencing technologies. However, the homogenous illumination of a large area (several millimeters) with a small light source is challenging and demands new approaches. Allopurinol, a drug used to lower the blood concentration of urate and hence decrease the affection of gout, gets metabolized to oxipurinol in the body and dropped out almost entirely by urinary excretion. After wastewater treatment, concentrations of oxipurinol up to 21.7 μg•L-1 are detected. Further tracking of oxipurinol in the urban water cycle showed its presence in rivers and streams or even in groundwater. Therefore, the high biological stability of oxipurinol allows this molecule to be used as a marker for domestic wastewater in the environment. For the detection of oxipurinol by SPR graphene was used as receptive layer, as the analyte can bind via π-stacking to this surface. An SPRi technique was developed and compared to conventional SPR system for the detection of oxipurinol. Y1 - 2019 U6 - https://doi.org/10.1117/12.2522324 SN - 0277-786X VL - Vol. 11028 ER - TY - CHAP A1 - Hausler, Peter A1 - Roth, Carina A1 - Aumer, F. A1 - Vitzthumecker, Thomas A1 - Genslein, Christa A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - Miniaturisiertes Sensorsystem zur Oberflächenplasmonenresonanzspektroskopie T2 - 118. Jahrestagung der deutschen Gesellschaft für angewandte Optik (DGaO), 6.-10. Juni 2017, Dresden N2 - Die Oberflächenplasmonenresonanzspektroskopie (SPR) wird aufgrund ihrer Vorzüge der zerstörungs- und markierungsfreien Messung, sowie der hohen Sensitivität sehr erfolgreich im Labormaßstab eingesetzt. Aufgrund der hohen Kosten geschieht dies bislang hauptsächlich in der Bioanalytik und dem Wirkstoffscreening. Gezeigt wird ein Ansatz, mit dem diese Technologie auf ein ultrakompaktes, kostengünstiges Sensorsystem übertragen wird, welches in der Lage ist, hoch-sensitiv Änderungen im Brechungsindex von 10-6 Einheiten (RIU) zu detektieren. Für Wasser bewirkt eine Temperaturschwankung von 1 K bereits eine Änderung von 1 mRIU. Daher wird durch ein integriertes Referenzsystem, sowie die Miniaturisierung erreicht, dass das System gegenüber Temperaturschwankungen, weitestgehend stabil ist. In dem MOEMS wird anstatt der konventionellen 1-Punkt bzw. 2-Punkt Messung ein bildgebendes Verfahren angewendet. Die Sensorfläche von 15 x 15 mm wird dabei mit einem handelsüblichen 4 Mio. Pixel CMOS Sensor ausgewertet. Um verlässliche Datenpunkte zu erhalten benötigt man eine Fläche von 10 x 10 Pixel. Demzufolge können auf dem Sensor theoretisch bis zu 40.000 Sensorspots parallel ausgewertet werden. KW - Messtechnik KW - Optische Systeme KW - Spektroskopie Y1 - 2017 ER - TY - CHAP A1 - Hausler, Peter A1 - Genslein, Christa A1 - Roth, Carina A1 - Vitzthumecker, Thomas A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - Miniaturized Surface Plasmon Resonance based Sensor System T2 - Proceedings of the 6th International Conference on Photonics, Optics and Laser Technology - PHOTOPTICS, Funchal, Madeira, Portugal N2 - We describe the miniaturization of the Surface Plasmon Resonance (SPR) technology which mainly finds its applications in pharmaceutical screening and biotechnology so far. SPR spectroscopy is a label-free, non-destructive and highly sensitive measurement principle detecting changes in the refractive index in striking distance to a gold surface. A transfer of this technology to a miniaturized sensor will broaden the range of possible applications. A promising feature which is included in the miniaturized system is the angle-dependent recording of the SPR signals without moving parts. Commercial SPR assays are mainly working with a small number of sensing spots. In contrast, the SPR imaging system shown here will allow to use an array of many sensing spots. In combination with chemical receptors designed as an artificial nose, the simultaneous detection of many analytes is envisioned for future applications. KW - Surface Plasmon Resonance Spectroscopy KW - Sensor KW - SPR-imaging KW - Miniaturization KW - Micro-Opto-Electro-Mechanical Systems Y1 - 2018 SN - 978-989-758-286-8 U6 - https://doi.org/10.5220/0006555400630066 SP - 63 EP - 66 PB - SciTePress ER - TY - CHAP A1 - Hausler, Peter A1 - Genslein, Christa A1 - Roth, Carina A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - Mikro-Opto-Elektro-Mechanisches Sensorsystem zur Oberflächenplasmonenresonanzspektroskopie T2 - MikroSystemTechnik Kongress 2017 : MEMS, Mikroelektronik, Systeme 23.-25. Oktober 2017 in München N2 - Gezeigt wird die Miniaturisierung eines Messsystems für Oberflächenplasmonenresonanzspektroskopie (SPR), einer markierungs-, sowie zerstörungsfreien als auch hoch sensitiven Technologie. Aufgrund der hohen Kosten klassischer SPR-Geräte wird sie bisher jedoch vornehmlich in der Bio- und Medizintechnik eingesetzt. Das Messprinzip ermöglicht die Erfassung von Brechungsindexänderungen nahe einer Oberfläche. Der Transfer dieser Technologie von Laborgeräten hin zu einem miniaturisierten Sensorsystem senkt die Kosten, macht das System robuster und ermöglicht so ein wesentlich breiteres Anwendungsspektrum. Ein sehr vielversprechendes Merkmal des hier vorgestellten Systems ist die Möglichkeit den SPR-Effekt winkelabhängig zur Lichtquelle ohne bewegliche Bauteile zu verfolgen. The miniaturization of Surface Plasmon Resonance (SPR) technology, which mainly finds its applications in pharmaceutical screening and biotechnology so far, is described. SPR spectroscopy is a label-free, non destructive and highly sensitive measurement principle which is capable of detecting changes in the refractive index in striking distance to a gold surface. A transfer of this technology to a miniaturized sensor will broaden the range of possible applications. A promising feature which is included in the miniaturized system is the angle-dependent recording of the SPR signals without moving parts. KW - Bewegungselement KW - Biotechnik KW - Brechungsindex KW - Goldoberfläche KW - Laborgerät KW - Lichtquelle KW - Medizintechnik KW - Messprinzip KW - Messsystem KW - Miniaturisierung KW - Oberflächenplasmon KW - Oberflächenplasmonenresonanzspektroskopie KW - pharmazeutisches Screening KW - Sensorsystem KW - Spektroskopie Y1 - 2017 SN - 978-3-8007-4491-6 IS - CD-ROM SP - 645 EP - 647 PB - VDE-Verlag CY - Berlin ER - TY - CHAP A1 - Genslein, Christa A1 - Hauser, Peter A1 - Kirchner, Eva-Maria A1 - Bierl, Rudolf A1 - Baeumner, Antje J. A1 - Hirsch, Thomas T1 - Detection of small molecules with surface plasmon resonance by synergistic plasmonic effects of nanostructured surfaces and graphene T2 - SPIE Proceedings, Plasmonics in Biology and Medicine XIV, 2017, San Francisco, California N2 - Surface plasmon resonance depends on the dielectric medium at the vicinity and makes it a quasi-universal detector. Therefore, and due to the label-free nature, SPR is a widely used sensing tool for real‐time monitoring molecular interactions of various analytes. However, detection of highly diluted analytes and small molecules (< 400 Da) is still challenging. Gold nanohole arrays provide plasmonic hotspots with improved surface sensitivity and 2D carbon nanomaterials enable binding near the surface. Both effects together are promising in the development of SPR sensors for the efficient determination of small molecules. Graphene is known for efficient binding of molecules with delocalized aromatic π-systems. Additionally, the electromagnetic field is locally enhanced and modulated by the interaction of graphene photonics with the plasmonics of metal nanostructures. The advantages of chemical vapor deposition (CVD) graphene over reduced graphene oxide (rGO) is illustrated by a proof of concept study. In comparison to substrates consisting of a continuous film the surface sensitivity is enhanced for a nanohole arrays and further improved for CVD graphene functionalization in contrast to rGO. The feasibility of the sensor was demonstrated for the detection of adenine down to a concentration of 0.9 μM. Y1 - 2017 U6 - https://doi.org/10.1117/12.2252256 VL - 10080 IS - 1008001F ER - TY - CHAP A1 - Hausler, Peter A1 - Holler, Sven A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - High integrated miniaturized sensor based on Surface Plasmon Resonance T2 - International Biosensor Conference, 11th Workshop on Biosensors & Bioanalytical Microtechniques in Environmental, Food & Clinical Analysis, BBMEC 11, 26.-30. September 2015, Regensburg, Germany Y1 - 2015 ER - TY - CHAP A1 - Hausler, Peter A1 - Holler, Sven A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - Miniaturisierte Oberflächenplasmonenresonanz Sensorplattform T2 - MEMS, Mikroelektronik, Systeme, MikroSystemTechnik Kongress 2015, 26.- 28. Oktober 2015, Karlsruhe, proceedings Y1 - 2015 SN - 978-3-8007-4100-7 PB - VDE Verlag CY - Berlin ER - TY - JOUR A1 - Pangerl, Jonas A1 - Moser, Elisabeth A1 - Müller, Max A1 - Weigl, Stefan A1 - Jobst, Simon A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - A sub-ppbv-level Acetone and Ethanol Quantum Cascade Laser Based Photoacoustic Sensor– Characterization and Multi-Component Spectra Recording in Synthetic Breath JF - Photoacoustics N2 - Trace gas analysis in breath is challenging due to the vast number of different components. We present a highly sensitive quantum cascade laser based photoacoustic setup for breath analysis. Scanning the range between 8263 and 8270 nm with a spectral resolution of 48 pm, we are able to quantify acetone and ethanol within a typical breath matrix containing water and CO2. We photoacoustically acquired spectra within this region of mid-infra-red light and prove that those spectra do not suffer from non-spectral interferences. The purely additive behavior of a breath sample spectrum was verified by comparing it with the independently acquired single component spectra using Pearson and Spearman correlation coefficients. A previously presented simulation approach is improved and an error attribution study is presented. With a 3σ detection limit of 6.5 ppbv in terms of ethanol and 250 pptv regarding acetone, our system is among the best performing presented so far. KW - Acetone KW - Breath analysis KW - Photoacoustic spectroscopy KW - Quantum cascade laser KW - Spectral simulation Y1 - 2023 U6 - https://doi.org/10.1016/j.pacs.2023.100473 SN - 2213-5979 N1 - Corresponding author: Jonas Pangerl VL - 30 SP - 1 EP - 12 PB - Elsevier ER - TY - PAT A1 - Olbrich, Florian A1 - Pongratz, Christian A1 - Bierl, Rudolf A1 - Ehrlich, Ingo T1 - Method and System for Evaluating a Structural Integrity of an Aerial Vehicle T2 - Europäisches Patentblatt (09.12.2020) zur Anmeldung: OTH Regensburg, Anmeldenummer: 19179054.2, Patentnummer 1001/3748327, Veröffentlichungsnummer: 3 748 327 Y1 - 2020 SP - 395 EP - 396 ER - TY - CHAP A1 - Hausler, Peter A1 - Fischer, Johannes A1 - Wunderlich, Lukas A1 - Recum, Patrick A1 - Peller, Sebastian A1 - Hirsch, Thomas A1 - Bierl, Rudolf T1 - Miniaturisierte Sensoren basierend auf Oberflächenplasmonenresonanz, Chancen und Herausforderungen T2 - DGaO-Proceedings 2021 N2 - Derzeit gibt es zahlreiche Bereiche, wie Umwelt Monitoring und zivile Infrastruktur in denen geeignete Sensoren für die Überwachung der Systeme fehlen. SPR-basierte Sensoren haben das Potential diese Lücke zu schließen. Um für den Einsatz in der Umwelt tauglich zu werden, müssen die Sensoren noch robuster werden. Hier wird eine mögliche Lösung gezeigt. Y1 - 2021 UR - https://www.dgao-proceedings.de/download/122/122_a21.pdf PB - Dt. Gesellschaft für angewandte Optik CY - Erlangen-Nürnberg ER - TY - JOUR A1 - Moser, Elisabeth A1 - Jobst, Simon A1 - Bierl, Rudolf A1 - Jenko, Frank T1 - A Deep Learning System to Transform Cross-Section Spectra to Varying Environmental Conditions JF - Vibrational Spectroscopy N2 - Absorption cross-sections provide a basis for many gas sensing applications. Therefore, any error in molecular cross-sections caused by varying environmental conditions propagates to spectroscopic applications. Original molecular cross-sections in varying environmental conditions can only be simulated for some molecules, whereas for most multi-atom molecules, one must rely on high-precision measurements at certain environmental configurations. In this study, a deep learning system trained with simulated absorption cross-sections for predicting cross-sections at a different pressure configuration is presented. The system’s capability to transfer to measured, multi-atom cross-sections is demonstrated. Thus, it provides an alternative to (pseudo-) line lists whenever the required information for simulation is unavailable. The predictive performance of the system was evaluated on validation data via simulation, and its transfer learning capabilities were demonstrated on actual measurement chlorine nitrate data. From the comparison between the system and line lists, the system shows slightly worse performance than pseudo-line lists but its predictive quality is still deemed acceptable with less than 5% relative integral change with a highly localized error around the peak center. This opens a promising way for further research to use deep learning to simulate the effect of varying environmental conditions on absorption cross-sections. KW - Spectroscopy KW - Deep learning KW - Simulation KW - Pressure broadening KW - Pseudo-line lists KW - Transfer learning Y1 - 2022 U6 - https://doi.org/10.1016/j.vibspec.2022.103410 SN - 0924-2031 VL - 122 IS - September PB - Elsevier ER - TY - CHAP A1 - Moser, Elisabeth A1 - Pangerl, Jonas A1 - Jobst, Simon A1 - Weigl, Stefan A1 - Bierl, Rudolf T1 - Modeling the Photoacoustic Spectrum of a Quantum Cascade Laser for Human Breath T2 - Optical Sensors and Sensing Congress 2022 (AIS, LACSEA, Sensors, ES): July 11 - 15, 2022, Vancouver, British Columbia Canada N2 - A modeling approach to create a photoacoustic spectrum from synthetic data is presented and evaluated. The resulting model reaches a MAPE score of 2.7% and can be used to enable data-driven development in future work. KW - Quantenkaskadenlaser KW - Photoakustische Spektrometrie KW - Atemluft Y1 - 2022 SN - 978-1-957171-10-4 U6 - https://doi.org/10.1364/AIS.2022.ATu3G.2 PB - Optica Publishing Group ER - TY - JOUR A1 - Goldschmidt, Jens A1 - Moser, Elisabeth A1 - Nitzsche, Leonard A1 - Bierl, Rudolf A1 - Wöllenstein, Jürgen T1 - Improving the performance of artificial neural networks trained on synthetic data in gas spectroscopy – a study on two sensing approaches JF - tm - Technisches Messen N2 - Artificial neural networks (ANNs) are used in quantitative infrared gas spectroscopy to predict concentrations on multi-component absorption spectra. Training of ANNs requires vast amounts of labelled training data which may be elaborate and time consuming to obtain. Additional data can be gained by the utilization of synthetically generated spectra, but at the cost of systematic deviations to measured data. Here, we present two approaches to train ANNs with a combination of comparatively small, measured data sets and synthetically generated data. For the first approach a neural network is trained hybridly with synthetically generated infrared absorption spectra of mixtures of N2O and CO and measured zero-gas spectra, taken with a mid-infrared dual comb spectrometer. This improves the mean absolute error (MAE) of the network predictions from 0.46 to 0.01 ppmV and 0.24 to 0.01 ppmV for the concentration predictions of N2O and CO respectively for zero-gas measurements which was previously observed for training with purely synthetic data. At the same time a similar performance on spectra from gas mixtures of 0–100 ppmV N2O and 0 to 60 ppmV CO was achieved. For the second approach an ANN pre-trained on synthetic infrared spectra of mixtures of acetone and ethanol is retrained on a small dataset consisting of 26 spectra taken with a mid-infrared photoacoustic spectrometer. In this case the MAE for the concentration predictions of ethanol and acetone are improved by 45 % and 20 % in comparison to purely synthetic training. This shows the capability of using synthetically generated data to train ANNs in combination with small amounts of measured data to further improve neural networks for gas sensing and the transferability between different sensing approaches. N2 - Künstliche neuronale Netze werden in der quantitativen Infrarot-Gasspektroskopie eingesetzt, um Gaskonzentrationen in Multi-Komponenten-Absorptionsspektren vorherzusagen. Das Training von künstlichen neuronalen Netzen benötigt große Mengen an Trainingsdaten, was mit einem hohen Arbeits- und Zeitaufwand verbunden ist. Zusätzliche Trainingsdaten können durch synthetisch generierte Spektren gewonnen werden, sind jedoch mit systematischen Abweichungen zu tatsächlich gemessenen Daten verbunden. In dieser Arbeit werden zwei Ansätze präsentiert, um künstliche neuronale Netze mit einer Kombination aus vergleichsweise kleinen, gemessenen Datensätzen und synthetisch erzeugten Daten zu trainieren. Für den ersten Ansatz wird das neuronale Netz hybrid mit synthetisch erzeugten Infrarot-Absorptionsspektren von Mischungen aus N2O und CO und gemessenen Null-Gas-Spektren trainiert, welche mit einem Doppel-Kamm-Spektrometer im Mittelinfraroten aufgenommen wurden. Dieses Vorgehen verbessert den mittleren, absoluten Fehler der Netzvorhersagen von 0,46 auf 0,01 ppmV und 0,24 auf 0,01 ppmV für N2O bzw. für CO für Null-Gas-Messungen, im Vergleich zu den Vorhersagen des neuronalen Netzes, welches nur mit synthetisch erzeugten Daten trainiert wurde. Gleichzeitig zeigte das hybrid trainierte Netz eine gleichbleibende Performance für Konzentrationsvorhersagen für Spektren aus Gasmischungen von 0 bis 100 ppmV N2O und 0 bis 60 ppmV CO. Für den zweiten Ansatz wird ein neuronales Netz, welches bereits mit synthetischen erzeugten Infrarotspektren von Mischungen aus Aceton und Ethanol trainiert wurde, erneut auf einem kleinen gemessenen Datensatz bestehend aus 26 Spektren trainiert, welche mit einem photoakustischen Spektrometer im mittleren Infrarot aufgenommen wurden. In diesem Fall hat sich der mittlere absolute Fehler der Konzentrationsvorhersage für Ethanol und Aceton um 45 % bzw. 20 % im Vergleich zu einem rein synthetischen Training verbessert. Das zeigt das Potential synthetisch erzeugte Daten für das Training von künstlichen neuronalen Netzen in Kombination mit kleinen gemessenen Datensätzen zu nutzen, um neuronale Netze für den Einsatz im Bereich der Gassensorik zu verbessern und gleichzeitig die Übertragbarkeit der Methodik auf verschiedene Messansätze. Y1 - 2023 U6 - https://doi.org/10.1515/teme-2023-0051 PB - Oldenbourg Wissenschaftsverlag ET - Online veröffentlicht ER - TY - CHAP A1 - Ulreich, Fabian A1 - Moser, Elisabeth A1 - Olbrich, Florian A1 - Ebert, Martin A1 - Bierl, Rudolf A1 - Kaup, André ED - Keil, Rudolf ED - Tschorn, Jan Alexander ED - Tümler, Johannes ED - Altinsoy, Mehmet Ercan T1 - Luminance Simulation in CARLA under Cloud Coverage - Model Validation and Implications T2 - 2023 IEEE International Workshop on Metrology for Automotive (MetroAutomotive), -30 June 2023, Modena, Italy N2 - To decrease the number of kilometers driven during the development of autonomous cars or driving assistance systems, performant simulation tools are necessary. Currently, domain distance effects between simulation and reality are limiting the successful application of rendering engines in data-driven perception tasks. In order to mitigate those domain distance effects, simulation tools have to be as close to reality as possible for the given task. For optical sensors like cameras, the luminance of the scene is essential. We provide within this paper a method to measure the luminance of rendered scenes within CARLA, an often used open-source simulation environment. Thereby, it is possible to validate the environment and weather models by taking real-world measurements with photometric sensors or with the help of open-source weather data, published e.g. by the German federal service for weather data (DWD - "Deutscher Wetterdienst"). Employing our proposed luminance measurement, the domain gap resulting from the simulation can be specified, which makes it possible to evaluate the statements about the safety of the automated driving system determined within the simulation. We show that the ratio between global and diffuse radiation modeled by the default atmosphere models within CARLA are under limited conditions similar to real-world measurements taken by the DWD. Nevertheless, we show, that the ratio’s temporal variability in real-world situations is not modeled by CARLA. KW - Atmospheric measurements KW - Atmospheric modeling KW - Cameras KW - carla KW - Cloud computing KW - cloud coverage KW - Data models KW - luminance KW - meteorology KW - Simulation KW - Soft sensors KW - weather KW - Wind Y1 - 2023 SN - 979-8-3503-2187-6 U6 - https://doi.org/10.1109/MetroAutomotive57488.2023.10219098 SP - 228 EP - 233 PB - IEEE ER - TY - JOUR A1 - Müller, Max A1 - Weigl, Stefan A1 - Müller-Williams, Jennifer A1 - Lindauer, Matthias A1 - Rück, Thomas A1 - Jobst, Simon A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - Comparison of photoacoustic spectroscopy and cavity ring-down spectroscopy for ambient methane monitoring at Hohenpeißenberg JF - Atmospheric Measurement Techniques N2 - With an atmospheric concentration of approximately 2000 parts per billion (ppbV, 10−9), methane (CH4) is the second most abundant greenhouse gas (GHG) in the atmosphere after carbon dioxide (CO2). The task of long-term and spatially resolved GHG monitoring to verify whether climate policy actions are effective is becoming more crucial as climate change progresses. In this paper we report the CH4 concentration readings of our photoacoustic (PA) sensor over a 5 d period at Hohenpeißenberg, Germany. As a reference device, a calibrated cavity ring-down spectrometer, Picarro G2301, from the meteorological observatory of the German Weather Service (DWD) was employed. Trace gas measurements with photoacoustic instruments promise to provide low detection limits at comparably low costs. However, PA devices are often susceptible to cross-sensitivities related to fluctuating environmental conditions, e.g. ambient humidity. The obtained results show that for PA sensor systems non-radiative relaxation effects induced by varying humidity are a non-negligible factor. Applying algorithm compensation techniques, which are capable of calculating the influence of non-radiative relaxation effects on the photoacoustic signal, increase the accuracy of the photoacoustic sensor significantly. With an average relative deviation of 1.11 % from the G2301, the photoacoustic sensor shows good agreement with the reference instrument. Y1 - 2023 U6 - https://doi.org/10.5194/amt-16-4263-2023 SN - 1867-8548 VL - 16 IS - 18 SP - 4263 EP - 4270 PB - Copernicus Publications ER - TY - INPR A1 - Pangerl, Jonas A1 - Moser, Elisabeth A1 - Müller, Max A1 - Weigl, Stefan A1 - Jobst, Simon A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Matysik, Frank-Michael T1 - A Highly Sensitive Acetone and Ethanol Quantum Cascade Laser Based Photoacoustic Sensor: Characterization and Multi-Component Spectra Recording in Synthetic Breath T2 - SSRN Electronic Journal N2 - Trace gas analysis in breath is challenging due to the vast number of different components. We present a highly sensitive quantum cascade laser based photoacoustic setup for breath analysis. Scanning the range between 8260 and 8270 nm with a spectral resolution of 48 pm, we are able to quantify acetone and ethanol within a typical breath matrix containing water and CO2. We photoacoustically acquired spectra within this region of mid-infra-red light and prove that those spectra do not suffer from non-spectral interferences. The purely additive behavior of a breath sample spectrum was verified by comparing it with the independently acquired single component spectra using Pearson and Spearman correlation coefficients. A previously presented simulation approach is improved and an error attribution study is presented. With a 3σ detection limit of 6.5 ppbV in terms of ethanol and 250 pptV regarding acetone, our system is among the best performing presented so far. KW - Photoacoustic spectroscopy KW - quantum cascade laser KW - spectral simulation KW - breath analysis KW - acetone Y1 - 2022 U6 - https://doi.org/10.2139/ssrn.4305376 PB - Elsevier ER - TY - PAT A1 - Olbrich, Florian A1 - Pongratz, Christian A1 - Bierl, Rudolf A1 - Ehrlich, Ingo T1 - Method and System for Evaluating a Structural Integrity of an Aerial Vehicle Y1 - 2024 ER - TY - CHAP A1 - Peller, Sebastian A1 - Zankl, Tobias A1 - Fischer, Christoph A1 - Bierl, Rudolf T1 - Fast sound field characterization of beamforming capable capacitive micromachined ultrasonic transducer (CMUT) arrays by refracto-vibrometry T2 - IEEE IUS 2023, International Ultrasonics Symposium, Montréal, September 3-8, 2023 N2 - We introduce a time-optimized setup based on refracto-vibrometry for the purpose of scanning the sound field of capacitive micromachined ultrasonic transducer (CMUT) arrays primarily for the qualification of their beamforming capability. In comparison to commonly used microphones on a traversing stage the proposed method is substantially faster and consumes only a few minutes of time for a complete two-dimensional sound field containing about 100.000 scan points. T2 - Schnelle Schallfeld-Charakterisierung von CMUT-Arrays mithilfe von Refrakto-Vibrometrie KW - CMUT KW - LDV KW - refracto-vibrometry KW - sound field KW - beamforming Y1 - 2023 SN - 979-8-3503-4645-9 U6 - https://doi.org/10.1109/IUS51837.2023.10308126 SN - 1948-5727 SP - 1 EP - 3 PB - IEEE ER - TY - CHAP A1 - Roth, Carina A1 - Hausler, Peter A1 - Bierl, Rudolf T1 - Einbindung eines 2D-Photodetektors in einen hochintegrierten SPR-Imaging-Sensor T2 - 7. MikroSystemTechnik Kongress "MEMS, Mikroelektronik, Systeme", 23.-25. Oktober 2017, München N2 - Die Oberflächenplasmonenresonanzspektroskopie (SPR) ist eine hochempfindliche Messmethode, die es erlaubt, Gase und Flüssigkeiten zerstörungs- und markierungsfrei in Echtzeit zu analysieren. Bisher vornehmlich im Labormaßstab in der Bioanalytik und dem Wirkstoffscreening eingesetzt, soll diese Technologie nun miniaturisiert und für weitere Anwendungsgebiete zugänglich gemacht werden. Dazu wird ein kompakter Micro-Opto-Electro-Mechanical Systems Sensor (MOEMS) entwickelt, der mit Hilfe des SPR Imaging Änderungen der chemischen Zusammensetzung verschiedener Flüssigkeiten inline messen kann. N2 - Surface plasmon resonance spectroscopy (SPR) is a highly sensitive measurement method which allows the analysis of gases and liquids in real-time in a non-destructive and marking-free manner. Presently SPR is predominantly used for pharmaceutical screening and biotechnical analysis. Now this technology is to be miniaturized and made accessible for further application areas. For this purpose, a compact micro-opto-electro-mechanical system sensor (MOEMS) is developed, which can measure changes in the chemical composition of different fluids using SPR imaging. T2 - Integration of a 2D-photodetector in a SPR-Imaging-Sensor KW - Bildsensor KW - Bioanalytik KW - chemische Zusammensetzung KW - Fotodetektor KW - Labormaßstab KW - Messmethode KW - mikrooptoelektromechanisches System KW - Oberflächenplasmon KW - Oberflächenplasmonenresonanzspektroskopie KW - pharmazeutisches Screening KW - Spektroskopie KW - Wirkstoff Y1 - 2017 SN - 978-3-8007-4491-6 SP - 848 EP - 850 PB - VDE-Verlag CY - München ER - TY - INPR A1 - Fischer, Johannes A1 - Hirsch, Thomas A1 - Reitmeier, Torsten A1 - Bierl, Rudolf T1 - Real-time hardware-based processing of high-precision detector signals for surface plasmon resonance spectroscopy N2 - Surface plasmon resonance (SPR) is limited by small-signal detectability and drift when subtraction occurs in software after digitization. We introduce an SPR detector that performs on-detector amplification and analog differential readout, eliminating moving parts and software-heavy correction. The hardware-native subtraction boosts the usable ADC range and suppresses illumination and environmental noise. In fixed-angle refractive-index steps (NaCl), the platform resolves Δn_min ≈ 1.8 × 10⁻⁷ RIU compared to 4.6–7.2 × 10⁻⁶ RIU on a commercial comparator and improves small-signal SNR by up to ∼5,000-fold, while remaining competitive at high signal levels. In a model IgG–BSA assay, the detector’s low noise floor clarifies early binding and equilibrium transitions. By generating inherently clean raw signals, this hardware-native approach dramatically enhances sensitivity and long-term stability for label-free biosensing and inline process analytics while rendering AI-based or complex post-processing entirely unnecessary. The concept generalizes across platforms and opens a compact route to robust, high-fidelity SPR in complex environments, with a clear path toward multi-wavelength and arrayed detectors for high-throughput chemical monitoring. KW - Drift-free SPR KW - Hardware-native sensing KW - Noise suppression KW - On-detector amplification KW - Small-signal detection KW - Surface plasmon resonance Y1 - 2025 U6 - https://doi.org/10.2139/ssrn.5971170 ER - TY - THES A1 - Weigl, Stefan T1 - Development of a sensor system for human breath acetone analysis based on photoacoustic spectroscopy N2 - The breath analysis section of this thesis outlines the potentials but also emphasises the concomitant challenges of human breath analysis. The section further describes the usefulness of a point-of-care (POC) device for breath acetone detection. In addition, it covers various breath analysis related subjects, which can be useful considering further developments of breath analysers. This includes an extensive summary involving the high abundant endogenous as well as the exogenous breath species present in a clinical environment. Subsequently, a detailed discussion about the theoretical aspects of absorption spectra is provided, forming the basis for the spectral interference chapter. Classical absorption spectroscopy (AS) is compared with photoacoustic spectroscopy (PAS) in view of trace gas analysis. Different modulation schemes for signal generation, i.e. amplitude modulation (AM) and wavelength modulation (WM) are part of the comparison, while the advantages and disadvantages of each technique are highlighted. As a result, PAS is considered superior to AS and hence is selected as the method of choice regarding the development of a sensor for breath acetone detection. A detailed mathematical derivation of the photoacoustic signal generation as well as the signal enhancement by means of acoustic resonance amplification is provided. Moreover, several phenomena causing signal attenuation are outlined, including vibrational-translational (VT) relaxation, vibrational-vibrational (VV) energy transfer mechanism, acoustic detuning and photodissociation. Various simulations regarding spectral interferences in the infra-red (IR) and ultraviolet (UV) region are presented, demonstrating the susceptibility towards spectral cross-sensitivities in the IR region, hence, rather suggesting the UV region for acetone detection. However, this simulation can be easily adopted to other target analytes and serves as a basis for multicomponent analysis approaches in the IR region using tuneable light sources. Ultra sensitive acetone detection employing a high power UV LED is presented and a detailed analysis considering the effects of environmental parameters onto the photoacoustic signal, including temperature, pressure, LED duty cycle and flow rate, is provided. In addition, general cross-sensitivities of the photoacoustic signal towards the high abundant species O2, CO2 and H2O have been investigated and discussed. Moreover, several LED and photoacoustic cell (PAC) combinations have been compared in order to evaluate improvement approaches regarding an enhancement of the system’s sensitivity. Finally, photoacoustic sensor setups employing an interband cascade laser (ICL) or a quantum cascade laser (QCL) have been studied and compared to various UV setups in view of different key performance parameters, including the limits of detection (LOD) and the normalised noise equivalent absorption (NNEA) coefficients. The juxtaposition of the different approaches once more emphasises the extraordinary sensitivity of photoacoustic spectroscopy. To the best of the author’s knowledge, the LODs (3σ) of the UV LED based photoacoustic measurement in typical breath conditions (12.5 ppbV) and the LOD of the QCL measurement (0.79 ppbV) provide two world records. First, regarding photoacoustic acetone detection using an UV LED and second, in view of other published results for photoacoustic acetone detection in general. N2 - Zu Beginn der Arbeit werden zum einen die Potentiale der Analyse des menschlichen Ausatemgases aufgezeigt und zum anderen die damit verbundenen Herausforderungen beschrieben. Dabei wird auch die Nützlichkeit eines Point-of-Care (POC) Gerätes zur Bestimmung des Acetongehalts im Ausatemgas hervorgehoben. Darüber hinaus werden verschiedene mit der Atemgasanalyse zusammenhängende Themen behandelt, die hinsichtlich weiterer Entwicklungen von Atemgasanalysegeräten sehr hilfreich sein können. Dazu gehört u.a. eine ausführliche Analyse der Zusammensetzung des menschlichen Ausatemgases, die sowohl die hauptsächlichen endogenen als auch die im klinischen Umfeld verstärkt vorkommenden, exogenen Bestandteile, aufgelistet. Anschließend werden die theoretischen Grundlagen von Absorptionsspektren detailliert behandelt, da sie die Grundlage für das Kapitel über die spektralen Interferenzen bilden. Des Weiteren werden die klassische Absorptionsspektroskopie (AS), als auch die photoakustische Spektroskopie (PAS), hinsichtlich ihrer Eignung für die Spurengasanalytik verglichen. Verschiedene Modulationsschemata für die Signalerzeugung, d.h. Amplitudenmodulation (AM) und Wellenlängenmodulation (WM), sind Teil des Vergleichs, wobei die Vor- und Nachteile jeder Technik hervorgehoben werden. Als Ergebnis wurde die PAS gegenüber der AS als überlegen angesehen und daher als Methode der Wahl bei der Entwicklung eines Sensors zur Bestimmung des Acetongehalts in der Ausatemluft ausgewählt. Eine detaillierte mathematische Herleitung der photoakustischen Signalerzeugung sowie der Signalverstärkung mittels akustischer Resonanzverstärkung ist ebenso in der Arbeit enthalten. Darüber hinaus werden mehrere Phänomene der Signaldämpfung skizziert, dazu zählen u.a. die Schwingungs-Translation Relaxation, der Schwinungs-Schwingungs Energieübertragungsmechanismus, die Photodissoziation und die akustische Resonanzverschiebung. Es werden verschiedene Simulationen bezüglich spektraler Interferenzen im infraroten (IR) und ultraviolleten (UV) Wellenlängenbereich vorgestellt, die die Anfälligkeit gegenüber spektralen Querempfindlichkeiten im IR-Bereich demonstrieren und somit eher den UV-Bereich für die Acetonbestimmung nahelegen. Die Simulationsergebnisse können leicht auf weitere Zielanalyten übertragen werden und dienen somit als Grundlage für Multikomponenten-Analyseansätze im IR-Bereich mittels durchstimmbarer Lichtquellen. Im Ergebnisteil wird u.a. ein hochempfindliches System zur Acetondetektion unter Verwendung einer Hochleistungs-UV LED vorgestellt. Dieses System wurde außerdem einer detaillierten Analyse unter Berücksichtigung der Auswirkungen von Umgebungsparametern auf das photoakustische Signal, einschließlich Temperatur, Druck, LED-Tastverhältnis und Durchfl ussrate, unterzogen. Zusätzlich wurden Querempfi ndlichkeiten des photoakustischen Systems gegenüber den im Ausatemgas hochkonzentrierten Stoffen O2, CO2 und H2O untersucht und die Ergebnisse diskutiert. Darüber hinaus wurden verschiedene Kombinationen von LEDs und photoakustischen Zellen verglichen, um Verbesserungsansätze hinsichtlich der Empfindlichkeit des Systems zu untersuchen. Abschließend wurden photoakustische Sensorsysteme, die einen Interbandkaskadenlaser (ICL) oder einen Quantenkaskadenlaser (QCL) verwenden, untersucht und mit verschiedenen UV LED Systemen im Hinblick auf unterschiedliche Leistungsparameter, einschließlich der Nachweisgrenzen (NWG) und den normierten, rauschäquivalenten Absorptionskoeffizienten, verglichen. Die Gegenüberstellung der verschiedenen Ansätze unterstreicht einmal mehr die außerordentliche Empfindlichkeit der photoakustischen Spektroskopie. Nach bestem Wissen des Autors stellen die NWGs (3σ) der photoakustischen Messung mit einer UV LED in typischer Atemgaszusammensetzung (12.5 ppbV) und die NWG der QCL-Messungen (0.79 ppbV) zwei Weltrekorde dar. Zum einen gibt es keine Veröffentlichung hinsichtlich einer besseren, photoakustisch ermittelten NWG für Aceton mittels einer UV LED und zum anderen stellt die mit dem QCL photoakustisch gemessene NWG im Allgemeinen die beste, je veröffentlichte photoakustische NWG für Aceton dar. KW - Photoacoustic KW - Breath Analysis KW - Acetone Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:355-epub-447768 ER -