TY - CHAP A1 - Richter, Stefanie ED - Middendorf, Tim ED - Parchow, Alexander T1 - (Er)Leben älterer Menschen in Alten-, Pflegeheimen und Wohnstiften : Zukunftsunsicherheit, Übergänge und Lebensalltag T2 - Ältere Menschen in prekären Lebenslagen : Theorien, Handlungsfelder und Fragestellungen für die Soziale Arbeit Y1 - 2025 SN - 978-3-7799-9123-6 U6 - https://doi.org/10.3262/978-3-7799-9123-6 SP - 467 EP - 481 PB - Beltz Juventa CY - Weinheim ER - TY - JOUR A1 - Winter, Lina A1 - Artinger, Annalena A1 - Böck, Hendrik A1 - Ramakrishnan, Vignesh A1 - Reible, Bruno A1 - Albin, Jan A1 - Schüffler, Peter J. A1 - Raptis, Georgios A1 - Brochhausen, Christoph T1 - Developing a smart and scalable tool for histopathological education—PATe 2.0 JF - Journal of Pathology Informatics N2 - Digital microscopy plays a crucial role in pathology education, providing scalable and standardized access to learning resources. In response, we present PATe 2.0, a scalable redeveloped web-application of the former PATe system from 2015. PATe 2.0 was developed using an agile, iterative process and built on a microservices architecture to ensure modularity, scalability, and reliability. It integrates a modern web-based user interface optimized for desktop and tablet use and automates key workflows such as whole-slide image uploads and processing. Performance tests demonstrated that PATe 2.0 significantly reduces tile request times compared to PATe, despite handling larger tiles. The platform supports open formats like DICOM and OpenSlide, enhancing its interoperability and adaptability across institutions. PATe 2.0 represents a robust digital microscopy solution in pathology education enhancing usability, performance, and flexibility. Its design enables future integration of research algorithms and highlights it as a pivotal tool for advancing pathology education and research. Y1 - 2026 U6 - https://doi.org/10.1016/j.jpi.2025.100535 SN - 2153-3539 VL - 20 PB - Elsevier ER - TY - CHAP A1 - Greiner, Nina A1 - Currle, Edda A1 - Bahr, Gudrun A1 - Weber, Karsten ED - Weber, Karsten ED - Haug, Sonja ED - Lauer, Norina ED - Mohr, Christa ED - Pfingsten, Andrea ED - Raptis, Georgios ED - Bahr, Gudrun T1 - Die Rekrutierung von Proband*innen im Projekt DeinHaus 4.0 Oberpfalz BT - Prozess, Herausforderungen und Bewertung T2 - Digitale Technik für ambulante Pflege und Therapie III - Nutzung, Akzeptanz, Wirkung und Lebensqualität N2 - Beschrieben wird der Rekrutierungsprozess im Projekt DeinHaus 4.0. Hierbei werden die spezifischen Herausforderungen bei der Akquise von Schlaganfallbetroffenen aufgezeigt und diskutiert. T3 - Regensburger Beiträge zur Digitalisierung des Gesundheitswesens - 4 KW - Rekrutierung KW - Schlaganfallpatient KW - Forschungsprojekt KW - Telerehabilitation KW - Herausforderungen Y1 - 2024 SN - 978-3-8394-6728-2 U6 - https://doi.org/10.14361/9783839467282-004 SP - 29 EP - 61 PB - transcript CY - Bielefeld ER - TY - CHAP A1 - Bugl, Benedikt A1 - Schneider, Viola I. A1 - Sehr, Armin T1 - Vertical Sound Localization: Precision and Robustness to Reverberation in a Large-Scale Study T2 - Proceedings of the 11th Convention of the European Acoustics Association Forum Acusticum / EuroNoise 2025 // Málaga, Spain ; 23-26. June 2025 N2 - Vertical sound localization, the ability to perceive the elevation of a sound source, is a fundamental aspect of human auditory perception, yet it remains far less understood than horizontal localization. Existing studies rely on small sample sizes, limiting the generalizability of findings. The presented study bridges that gap by examining vertical sound localization and precision in a cohort exceeding 150 participants, making it the largest investigation of its kind to date.Participants were exposed to broadband noise stimuli from various elevations under controlled anechoic conditions. The elevation localization error was measured by comparing perceived sound source elevations to actual positions of speakers of a curved array. Azimuth angles of arrival were altered between 0°, 45° and 90°. For a small group the experiment was repeated in echoic conditions, to gain insight in reverberation and reflection robustness of vertical sound localization.This large-scale study establishes benchmarks for vertical sound localization precision and robustness, advancing our understanding of human auditory spatial perception. These findings have implications for audio technology development, such as spatial audio rendering and hearing aid design, and lay the groundwork for further exploration into the neural and anatomical underpinnings of vertical localization. Y1 - 2025 SN - 978-84-87985-35-5 U6 - https://doi.org/10.61782/fa.2025.0953 SP - 3431 EP - 3434 PB - European Acoustics Association ER - TY - JOUR A1 - Ginster, Vinzenz A1 - Weigert, Alexander A1 - Heym, Maximilian Klaus A1 - Beier, Christoph Jürgen Anton A1 - Schiebahn, Alexander A1 - Galka, Stefan T1 - Factory simulation of adhesive bonding processes considering pot-life-induced waste JF - Journal of Advanced Joining Processes N2 - The simulation of production systems in the planning phase is an established tool for evaluating system performance under dynamic conditions (Da Silva et al., 2018). When planning a production system that includes time-critical processes such as adhesive bonding, exceeding time constraints (e.g., excessive lead times relative to the adhesive pot-life) can lead to product rejection and scrap. These risks should be analyzed by means of simulation, as it enables the consideration of stochastic effects such as random machine breakdowns, which significantly influence product lead times. This study focuses on the production of adhesively bonded electrolyzer-cells. Due to the cell design, several handling and stacking operations must be carried out between adhesive application and final joining, so that immediate joining is not feasible and pot-life-induced scrap becomes a critical risk factor. We therefore conducted an exploratory investigation that combines experimental pot-life characterization with discrete-event simulation of a planned electrolyzer-cell production system. A two-component epoxy adhesive was characterized using differential scanning calorimetry with kinetic analysis, rotational rheometry, and 90° peel tests on application-representative joints. Based on these tests, an application-specific pot-life was derived and implemented as a time-dependent quality criterion in the discrete-event simulation model. A full-factorial simulation study with varied buffer size and mean time to repair at a station availability of 98 % was carried out. The results demonstrated a pronounced trade-off between throughput and pot-life-induced waste and identified a buffer capacity of one and short repair times as the most favorable configuration. Extending pot-life due to different processing temperatures substantially reduced scrap, highlighting the benefit of integrating curing kinetics and dynamic simulation in early-stage production system design for time-critical adhesive processes. KW - Digital Twin, Simulation, Logistics Y1 - 2026 U6 - https://doi.org/10.1016/j.jajp.2026.100375 SN - 2666-3309 VL - 13 PB - Elsevier ER - TY - CHAP A1 - Galka, Stefan A1 - Meißner, Sebastian T1 - Simulation-Based Digital Twins for Internal Transport Systems T2 - Procedia Computer Science N2 - The increasing complexity of internal transport systems in industrial applications poses significant challenges for operational decision-making. This paper presents a simulation-based Digital Twin framework developed within the research project TwinTraSys to support the control of such systems. The framework is specifically tailored to the constraints of real-world IT infrastructures, requiring minimal transaction data, while enabling predictive analysis and dynamic scenario evaluation. It consists of a modular architecture divided into four core components: data provision, data preparation, simulation, and decision support. A dedicated simulation framework enables the automated generation of structural models and the integration of real-world operational control systems. The proposed approach has been validated in industrial settings and has demonstrated its ability to support resource planning and transport resource allocation through simulation-based experimentation and multi-criteria evaluation. This paper contributes to the practical advancement of Digital Twin applications in intralogistics by bridging the gap between theoretical models and real-world constraints. KW - Digital Twin KW - Intralogistics KW - Logistics KW - Operational Control KW - Simulation KW - Simulation-based Decision Support Y1 - 2025 U6 - https://doi.org/10.1016/j.procs.2025.12.016 N1 - Corresponding author der OTH Regensburg: Stefan Galka VL - 274 SP - 161 EP - 170 PB - Elsevier ER - TY - JOUR A1 - Krüger, Tom A1 - Mauerer, Wolfgang T1 - Out of the Loop: Structural Approximation of Optimisation Landscapes and non-Iterative Quantum Optimisation JF - Quantum N2 - The Quantum Approximate Optimisation Algorithm (QAOA) is a widely studied quantum-classical iterative heuristic for combinatorial optimisation. While QAOA targets problems in complexity class NP, the classical optimisation procedure required in every iteration is itself known to be NP-hard. Still, advantage over classical approaches is suspected for certain scenarios, but nature and origin of its computational power are not yet satisfactorily understood. By introducing means of efficiently and accurately approximating the QAOA optimisation landscape from solution space structures, we derive a new algorithmic variant of unit-depth QAOA for two-level Hamiltonians (including all problems in NP): Instead of performing an iterative quantum-classical computation for each input instance, our non-iterative method is based on a quantum circuit that is instance-independent, but problem-specific. It matches or outperforms unit-depth QAOA for key combinatorial problems, despite reduced computational effort. Our approach is based on proving a long-standing conjecture regarding instance-independent structures in QAOA. By ensuring generality, we link existing empirical observations on QAOA parameter clustering to established approaches in theoretical computer science, and provide a sound foundation for understanding the link between structural properties of solution spaces and quantum optimisation. Y1 - 2025 U6 - https://doi.org/10.22331/q-2025-11-06-1903 N1 - Die Preprint-Version ist ebenfalls in diesem Repositorium verzeichnet unter: https://opus4.kobv.de/opus4-oth-regensburg/frontdoor/index/index/start/2/rows/10/sortfield/score/sortorder/desc/searchtype/simple/query/Out+of+the+Loop/docId/7938 VL - 9 PB - Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften ER - TY - CHAP A1 - Schönberger, Manuel A1 - Trummer, Immanuel A1 - Mauerer, Wolfgang T1 - Large-Scale Multiple Query Optimisation with Incremental Quantum(-Inspired) Annealing T2 - Proceedings of the ACM on Management of Data N2 - Multiple-query optimization (MQO) seeks to reduce redundant work across query batches. While MQO offers opportunities for dramatic performance improvements, the problem is NP-hard, limiting the sizes of problems that can be solved on generic hardware. We propose to leverage specialized hardware solvers for optimization, such as Fujitsu's Digital Annealer (DA), to scale up MQO to problem sizes formerly out of reach. We present a novel incremental processing approach that combines classical computation with DA acceleration. By efficiently partitioning MQO problems into sets of partial problems, and by applying a dynamic search steering strategy that reapplies initially discarded information to incrementally process individual problems, our method overcomes capacity limitations, and scales to extremely large MQO instances (up to νm1000 queries). A thorough and comprehensive empirical evaluation finds our method substantially outperforms existing approaches. Our generalisable framework lays the ground for other database use-cases on quantum-inspired hardware, and bridges towards future quantum accelerators. Y1 - 2025 U6 - https://doi.org/10.1145/3749171 VL - 3 IS - 4 PB - ACM ER - TY - CHAP A1 - Dünnweber, Jan A1 - Lorenz, Marcel A1 - Bräu, Fabian A1 - Saito, Hiroshi A1 - Melzer, Matthias T1 - Driving out the Bears from the Suburbs by Means of Location Theory and Intelligent Agents T2 - Proceedings of the ACM 12th International Conference on Animal-Computer Interaction, ACI 2025: The International Conference on Animal-Computer Interaction ; Indiana USA ; 01-04.12.2025 N2 - Due to the recent surge in bear attacks, affected municipalities have taken various measures to drive out the intruders. Political considerations include, in many places, the expansion of shooting permits. More and more regional governmental authorities invest in technologies for efficient bear hunting, such as IP cameras and computer vision. From an ecological perspective, such procedures, which are all solely aimed at decreasing the bear population, are questionable, since ecosystems can benefit from a peaceful coexistence of bears with humans: Bears remove animal carcasses and thus return vital nutrients to the soil and prevent the spread of diseases. Moreover, the bears keep the deer population in check, which is advantageous for the forest vegetation. Conflicts start, once the bears intrude populated areas, which are often rural villages and suburbs with a low population density. Naturally, bears do not see humans as prey and respect their size. When the animal attacks, this happens rather for territorial or protective reasons, e. g., after an unexpected encounter with humans unsettled it. In this work, we analyze means to eradicate the danger: We dynamically apply Weiszfeld’s algorithm for finding the shifting geometric median between time-windowed black bear sightings and use the results for implementing an early warning system. In addition, we weigh the spotted locations and predict the expected migration behavior between bear habitats using a simulation with intelligent agents. As a case study, we apply our software to data from Romania and Fukushima and identify the positions where bear repelling facilities should be placed most effectively. Y1 - 2025 SN - 9798400721236 U6 - https://doi.org/10.1145/3768539.3768546 PB - ACM CY - New York, NY, USA ER - TY - JOUR A1 - Korzec, Dariusz A1 - Freund, Florian A1 - Doelfs, Isabelle A1 - Zacherl, Florian A1 - Kudala, Lucas A1 - Rabl, Hans-Peter T1 - Low-Current High-Voltage Pulsed Atmospheric Arc Plasma Jet: Nanoparticle Emission from the Cathodic Spot JF - Plasma N2 - The atmospheric pressure plasma jet (APPJ) is a popular type of cold atmospheric plasma (CAP). APPJs based on a pulsed atmospheric arc (PAA) are widely spread in industrial processing. A plasma jet of this type, PlasmaBrush PB3 (PB3), is a subject of diverse research activities. The characteristic feature of PB3 is the generation of a low-current (300 mA), high-voltage (1500 V) pulsed (54 kHz) atmospheric arc. A gas flow vortex is used to stabilize the arc and to sustain the circular motion of the cathodic arc foot. During long periods of operation, nozzles acting as arc discharge cathodes erode. Part of the eroded material is emitted as nanoparticles (NPs). These NPs are not wanted in many processing applications. Knowledge of the number, type, and size distribution of emitted NPs is essential to minimize their emissions. In this study, NPs in the size range of 6 to 220 nm, emitted from four different nozzles operated with PB3, are investigated. The differences between the nozzles are in the eroded surface material (copper, tungsten, and nickel), the diameter of the nozzle orifice, the length of the discharge channel, and the position of the cathodic arc foot. Significant differences in the particle size distribution (PSD) and particle mass distribution (PMD) of emitted NPs are observed depending on the type and condition of the nozzle and their operating time. Monomodal and bimodal PMD models are used to approximate emissions from the nozzles with tungsten and copper cores, respectively. The skew-normal distribution function is deemed suitable. The results of this study can be used to control NP emissions, both to avoid them and to utilize them intentionally. KW - arc discharge KW - atmospheric pressure plasma jet (APPJ) KW - cathode erosion KW - cathodic spot KW - electrode erosion KW - low-current high-voltage pulsed atmospheric arc KW - nanoparticles KW - particle mass distribution (PMD) KW - particle number distribution (PND) KW - pulsed atmospheric arc (PAA) Y1 - 2025 U6 - https://doi.org/10.3390/plasma8040044 N1 - This article belongs to the Special Issue Feature Papers in Plasma Sciences 2025 VL - 8 IS - 4 PB - MDPI ER - TY - JOUR A1 - Wolfgramm, Alex A1 - Abb, Valerius A1 - Samp, Artur A1 - Samp, Rafal A1 - Hoffmann, Jens Christoph A1 - Müller, Rainer A1 - Kammler, Martin T1 - Structural and functional evolution of HKUST-1 nanoparticles induced by ball milling JF - Next Materials N2 - In this study, the effect of post-synthetic ball milling on the structural and functional properties of as-synthesized nanoparticles of the copper-based metal-organic framework (MOF) HKUST-1 was investigated for the first time. Nanoparticles were synthesized using sodium formate as a capping agent. The crystalline particles were subjected to a controlled ball milling process, which induced significant structural changes. Powder X-ray diffraction (PXRD) revealed a reduction in crystallite size from 91 nm to 21 nm and the introduction of microstrain, partially disrupting the MOF's long-range crystalline order, as evidenced by peak broadening and the diminished intensity of high-angle reflections. Particle morphology pre- and post-milling was further studied with scanning electron microscopy (SEM) imaging, verifying a narrow particle size distribution of ± 22 nm after milling. Fourier-transform infrared spectroscopy (FTIR) indicated protonation of carboxylate groups in the larger pores of the framework, likely due to moisture incorporation during milling. Brunauer-Emmett-Teller (BET) surface area analysis showed a substantial decrease in specific surface area from 521 m²/g to 226 m²/g, suggesting a partial collapse of the porous framework. We discuss the applicability of ball milling as a versatile means of post-synthetic approach to reduce MOF particle sizes, a key element in the preparation of MOF-based thin films using inks or polymers. KW - Ball milling KW - Copper-based metal-organic framework KW - HKUST-1 KW - Nitrogen adsorption Y1 - 2026 U6 - https://doi.org/10.1016/j.nxmate.2025.101544 N1 - Corresponding author der OTH Regensburg: Alex Wolfgramm VL - 10 PB - Elsevier ER - TY - JOUR A1 - Heinz, Florian A1 - Schildgen, Johannes T1 - Experience Report: Hey LLM, Generate SQL! JF - Datenbank-Spektrum N2 - Large Language Models have advanced to a resourceful tool with many applications. One particularly interesting use case is the LLM-aided generation of ad-hoc database queries and the possibility of subsequent processing of the results in a way suiting the users intents. In this article, practical ways and experiences are described on how to effectively use LLMs to map a natural-language user query to an SQL query conforming to a specific database schema and post-processing the results of this query in order to, for example, create an appealing visualization. Best results are achieved under favorable circumstances, as, for example, a clean and meaningful named database schema. Y1 - 2025 U6 - https://doi.org/10.1007/s13222-025-00512-w N1 - Corresponding author der OTH Regensburg: Florian Heinz VL - 25 IS - 2 SP - 95 EP - 101 PB - Springer CY - Wiesbaden ER - TY - CHAP A1 - Preiß, Niklas A1 - Westner, Markus T1 - From Agents to Copilots: a Systematic Review of Digital Assistant Technology Adoption in Proprietary Productivity Software T2 - Annals of Computer Science and Information Systems N2 - This study provides a systematic review of how the impact and adaptation of digital assistant technologies (DATs) are defined, operationalized, and studied, synthesizing key domains where DATs generate or are expected to generate value. Based on an analysis of 61 articles published since 2013, it identifies five main areas of impact: productivity and efficiency, business development, resource optimization, quality enhancement, and the promotion of learning and creativity. The review highlights DAT adoption across various disciplines and industries, while revealing limited longitudinal research on benefits and adaptation. Key gaps remain in understanding strategic use and sustained impact. Future research should explore longitudinal comparisons of recently introduced generative AI-driven DATs and their organizational implications. This review contributes to information systems research by structuring current knowledge on DAT adoption and outcomes, and by proposing a research agenda to support deeper exploration of their value and long-term integration. KW - Digital Assistant Technology KW - Copilot KW - Generative AI KW - Technology Adoption KW - Productivity Y1 - 2025 U6 - https://doi.org/10.15439/2025F3271 SN - 2300-5963 VL - 43 SP - 565 EP - 576 PB - Polish Information Processing Society ER - TY - JOUR A1 - Käss, Sebastian A1 - Strahringer, Susanne A1 - Westner, Markus T1 - Archetypes, Situations, and Practices : a Guide to Successful Low-Code Adoption JF - Information Resources Management Journal N2 - This paper extends prior work on low-code by explaining when adoption archetypes occur and how to use them. Motivated by information technology (IT) talent shortages and uneven low-code development platform (LCDP) outcomes, the paper seeks practical guidance for post-adoption choices in work systems. Using a multiple mini case study of 36 cases in large German organizations, this study analyzes interviews and context questionnaires with within-/cross-case coding and pattern matching against a 13-factor model. This analysis identifies situations that trigger three adoption archetypes—application development democratizers, synergy realizers, and IT resource shortage mitigators—and one non-adoption archetype, intricacy adversaries. The analysis also maps advantages and disadvantages and distills 12 good practices. Across adoption cases, efficiency is the dominant goal, whereas non-adoption stems from high application sophistication. The results give actionable guidance: align goals to an archetype, stick to LCDP standards, involve IT and foster an open culture, invest in skilling, reuse platform components, and reserve LCDPs for less-complex apps while planning architecture early. KW - Business-managed IT KW - Low-Code Development KW - Citizen Development KW - Shadow IT KW - Multiple Mini Case Studies KW - Work Systems Theory KW - Good Practices Y1 - 2025 U6 - https://doi.org/10.4018/IRMJ.396005 SN - 1040-1628 VL - 38 IS - 1 PB - IGI Global ER - TY - CHAP A1 - Sachenbacher, Martin A1 - Leucker, Martin T1 - Towards Monitoring and Diagnosis of Quantum Digital Twins T2 - Lecture Notes in Informatics (LNI) N2 - As access to larger-scale quantum computers is still limited, it is useful to simulate quantum algorithms on specialized programmable logic hardware such as FPGAs to exploit analogies between quantum and digital circuits, and allow for analysis and efficient debugging of quantum programs. Such simulations can be viewed as digital representations of actual physical systems, commonly referred to as Digital Twins (DTs). In previous work, we applied formal methods from runtime verification to synthesize monitors capable of real-time analysis of conventional DTs. Specifically, these monitors supervise alignment with their physical counterparts and support model-based diagnosis to identify potential root causes of observed deviations. In this short paper, we present ongoing work aimed at adapting and extending our approach to hardware-based simulation and analysis of quantum software on FPGAs, with the objective of improving both accuracy and resilience. Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-87546 VL - P-366 SP - 1767 EP - 1772 PB - Gesellschaft für Informatik e.V. CY - Bonn ER - TY - CHAP A1 - Albrecht, Sophie Viktoria A1 - Thiel, Charlotte A1 - Karamara, Merve T1 - Decoding concrete’s environmental performance: A detailed analysis of global EPDs across the entire life cycle T2 - MATEC Web of Conferences N2 - Environmental Product Declarations (EPDs) for concrete are essential tools to quantify the environmental impact of this versatile building material throughout its life cycle, supporting sustainable choices in construction. Concrete is made up of raw materials like cement, water, aggregates, additives, and admixtures, which can be mixed in diverse ways. This variability often necessitates site-specific EPDs, as emissions and environmental impacts depend greatly on cement type, transport routes, and specific production processes. This study analyses various data sources, focusing on EPDs according to ISO 14025 and EN 15804. The life cycle phases A1-A3, B1-B7, C1-C4 and D are considered and compared. The results demonstrate that factors such as scenario assumptions, methodological choices, and allocation procedures significantly influence concrete’s environmental impact. Transparent EPDs improve assessment reliability, while allocation methods, especially in phases D and end-of-life, significantly influence reported benefits, underscoring the importance of careful allocation for accurate impact evaluations. Improved standardisation, transparency, and alignment with EN 16757 would enhance EPD comparability and reliability. Overall, the study identifies key parameters such as recycling potential, production stage and allocation methods as substantial factors in the environmental performance of concrete. Y1 - 2025 U6 - https://doi.org/10.1051/matecconf/202540913001 VL - 409 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Qiao, Yu A1 - Grad, Marius A1 - Nonn, Aida T1 - Toward an Efficient and Robust Process–Structure Prediction Framework for Filigree L-PBF 316L Stainless Steel Structures JF - Metals N2 - Additive manufacturing (AM), particularly laser powder bed fusion (L-PBF), provides unmatched design flexibility for creating intricate steel structures with minimal post-processing. However, adopting L-PBF for high-performance applications is difficult due to the challenge of predicting microstructure evolution. This is because the process is sensitive to many parameters and has a complex thermal history. Thin-walled geometries present an added challenge because their dimensions often approach the scale of individual grains. Thus, microstructure becomes a critical factor in the overall integrity of the component. This study focuses on applying cellular automata (CA) modeling to establish robust and efficient process–structure relationships in L-PBF of 316L stainless steel. The CA framework simulates solidification-driven grain evolution and texture development across various processing conditions. Model predictions are evaluated against experimental electron backscatter diffraction (EBSD) data, with additional quantitative comparisons based on texture and morphology metrics. The results demonstrate that CA simulations calibrated with relevant process parameters can effectively reproduce key microstructural features, including grain size distributions, aspect ratios, and texture components, observed in thin-walled L-PBF structures. This work highlights the strengths and limitations of CA-based modeling and supports its role in reliably designing and optimizing complex L-PBF components. Y1 - 2025 U6 - https://doi.org/10.3390/met15070812 SN - 2075-4701 VL - 15 IS - 7 PB - MDPI ER - TY - JOUR A1 - Kranz, Michael A1 - Wagner, Maria Stella A1 - Pointner, Daniel A1 - Haus, Moritz A1 - Lubnow, Matthias A1 - Lehle, Karla A1 - Krenkel, Lars T1 - Polymer embedding of membrane lungs for histological investigations of intra-device clot formation JF - Cardiovascular Medicine N2 - Extracorporeal membrane oxygenation (ECMO) is an invasive but potentially lifesaving treatment option for severe cardiac or respiratory failure. Despite its beneficial effect, coagulation-related complications, mainly due to clot formation, excessive bleeding and the accumulation of deposits in the membrane lung (ML) remain common, causing higher mortality. In this context, the formation of clots and other deposits in the ML is of particular interest. Previous histological examinations of the polymethylpentene fiber mats inside the ML could only be performed in a top view, prohibiting valid quantification and examination of the multi-layered deposits or fiber mat spanning structures. Our objective was the establishment of a polymer embedding to increase the mechanical stability of the deposits and thus enable cross-sectional microtome cutting through the ML hollow-fibers. Clinically used MLs (PLS, Getinge, Rastatt, Germany) were stabilized with a polymer resin (HistoCURE 8100). Specimens were cut out of the embedded MLs and microtome sections with a thickness of 10 µm were performed. In addition to standard histological staining with hematoxylin-eosin (HE) and Pappenheim (May-Grunwald-Giemsa), fluorescence DNA staining for nucleated cells with 4′,6-diamidino-2-phenylindole (DAPI) and SYTOX™ Green as well as immunohistochemical and immunofluorescence staining for the lysosomal enzyme myeloperoxidase (MPO) and von Willebrand factor (vWF) were established. The protocol provides a method for large volume embedding (400 mL). The cellular and extracellular deposits were securely fixed by the polymer scaffold allowing the examination of clots in MLs in native position which was not possible with conventional paraffin embedding. Multi-layered deposits and fiber mat spanning structures are no longer disrupted during specimen extraction and can now be quantified. Staining with HE, Pappenheim, DAPI, SYTOX™ Green, MPO, and vWF was successfully tested with this protocol. This method may be the foundation for new insights into the complex clotting phenomena observed in MLs KW - clot formation KW - ECMO KW - HistoCURE 8100 KW - histology KW - membrane lungs KW - polymer embedding KW - Technovit 8100 Y1 - 2026 U6 - https://doi.org/10.3389/fcvm.2026.1650978 VL - 13 PB - Frontiers CY - Lausanne ER - TY - CHAP A1 - Wagner, Bernd A1 - Hay, Stefan A1 - Neidhart, Thomas A1 - Spirkl, Florian A1 - Ried, Michael A1 - Zrenner, Louis A1 - Weidlich, Ingo A1 - Gabriel, Eugen A1 - Banning, Timo ED - Vanhoudt, Dirk T1 - TFSB as Bedding Material in District Heating Pipe Constructin - Scientifically Proven Long-Term Experience T2 - Proceedings of the 19th International Symposium on District Heating and Cooling; 2025, Genk (Belgium) N2 - Following the explanation of the increasing importance of alternative backfill materials like TFSB, TFSB and their status in terms of science and technology are depicted. Selected results of the research project FW-ZFSV 4.0 are presented: computer-aided static calculation, in situ long term loading of district heating pipes in TFSB and sand, quality assurance and resource conservation. The conclusions provide an overall assessment of the use of TFSB in district heating pipe construction. Y1 - 2026 SN - 9783032098443 U6 - https://doi.org/10.1007/978-3-032-09844-3_10 SP - 99 EP - 108 PB - Springer CY - Cham ER - TY - JOUR A1 - Weber, Karsten T1 - Public images of artificial intelligence: an overview JF - media-culture-social communication N2 - Artificial intelligence (AI) is not only a ubiquitous topic in scholarly debates but in recent years has also received increased media and political attention. Discussions, initially strongly influenced by autonomous vehicles but currently dominated by expectations concerning generative AI such as ChatGPT, have contributed to public awareness. There are debate cycles, often characterized by a significant decline in public attention after a certain period of time, and the issue to a large extent or completely disappears from mass media’s agenda; also, they are often specific to certain countries. In this paper, a cursory cross-country overview concerning studies on media representations and the public perception of AI is provided. The use of AI in healthcare will be particularly highlighted, as there are currently high expectations regarding the benefits of AI, but other areas of application will also be considered. It will be tentatively concluded that in many countries, public perception of and public attitudes toward AI often is based on superficial knowledge and even prejudices. Y1 - 2025 U6 - https://doi.org/10.31648/mcsc.10343 IS - 21 SP - 9 EP - 24 PB - Wydawnictwo Uniwersytetu Warmińsko-Mazurskiego w Olsztynie CY - Olsztyn ER - TY - JOUR A1 - Glavan, Gašper A1 - Belyaeva, Inna A. A1 - Shamonin (Chamonine), Mikhail T1 - Multiferroic Cantilevers Containing a Magnetoactive Elastomer: Magnetoelectric Response to Low-Frequency Magnetic Fields of Triangular and Sinusoidal Waveform JF - Sensors N2 - In this work, multiferroic cantilevers comprise a layer of a magnetoactive elastomer (MAE) and a commercially available piezoelectric polymer-based vibration sensor. The structures are fixed at one end in the horizontal plane and the magnetic field is applied vertically. First, the magnetoelectric (ME) response to uniform, triangle-wave magnetic fields with five different slew rates is investigated experimentally. Time and field dependences of the generated voltage, electric charge, and observed mechanical deflection are obtained and compared for four different thicknesses of the MAE layer. The ME responses to triangular and sinusoidal wave excitations are examined in contrast. Second, the ME response at low frequencies (≤3 Hz) is studied by the standard method of harmonic magnetic field modulation. The highest ME coupling coefficient is observed in the bias magnetic field strength of ≈73 kA/m and it is estimated to be about 3.3 ns/m (ME voltage coefficient ≈ 25 V/A) at theoretically vanishing modulation frequency (f→0 Hz). Presented results demonstrate that the investigated heterostructures are promising for applications as magnetic-field sensors and energy harvesting devices. KW - magnetoactive elastomer KW - piezoelectric polymer KW - multilayer cantilever KW - direct magnetoelectric effect KW - magnetic field sensing Y1 - 2022 U6 - https://doi.org/10.3390/s22103791 N1 - Corresponding authors: Gašper Glavan und Mikhail Shamonin Veröffentlichtes Datenset: https://doi.org/10.5281/zenodo.14651784 VL - 22 IS - 10 SP - 1 EP - 17 PB - MDPI CY - Basel ER - TY - CHAP A1 - Deutel, Mark A1 - Mallah, Maen A1 - Wissing, Julio A1 - Scheele, Stephan ED - Vermesan, Ovidiu ED - Pagani, Alain ED - Meloni, Paolo T1 - Recent Trends in Edge AI: Efficient Design, Training and Deployment of Machine Learning Models T2 - Charting the Intelligence Frontiers – Edge AI Systems Nexus N2 - With a rising demand for ubiquitous smart systems, processing and interpreting large quantities of data generated on the edge at a high velocity is becoming an increasingly important challenge. Machine learning (ML) models such as Deep Neural Networks (DNNs) are an essential tool of today’s artificial intelligence due to their ability to make accurate predictions given complex tasks and environments. However, Deep Learning is computationally complex and energy intensive. This seems to contradict the characteristics of many edge devices, which have only limited memory, computational resources, and energy budget available. To overcome this challenge, an efficient ML model design is crucial that incorporates available optimization techniques from hardware, software, and methodological perspective to enable energy-efficient deployment and operation on the edge. This work comprehensively summarizes recent techniques for training, optimizing, and deploying ML models targeting edge devices. We discuss different strategies for finding deployable ML models, scalable DNN architectures, neural architecture search, and multi-objective optimization approaches, to enable feasible trade-offs considering available resources and latency. Furthermore, we give insight into DNN compression methods such 182as quantization and pruning. We conclude by investigating different forms of cascaded processing, from simple multi-level approaches to highly branched compute graphs and early-exit DNNs. Y1 - 2026 SN - 9788743808862 U6 - https://doi.org/10.1201/9788743808862-9 SP - 181 EP - 220 PB - River Publishers CY - New York ER - TY - JOUR A1 - Glavan, Gašper A1 - Belyaeva, Inna A. A1 - Shamonin (Chamonine), Mikhail T1 - Transient Response of Macroscopic Deformation of Magnetoactive Elastomeric Cylinders in Uniform Magnetic Fields JF - Polymers N2 - Significant deformations of bodies made from compliant magnetoactive elastomers (MAE) in magnetic fields make these materials promising for applications in magnetically controlled actuators for soft robotics. Reported experimental research in this context was devoted to the behaviour in the quasi-static magnetic field, but the transient dynamics are of great practical importance. This paper presents an experimental study of the transient response of apparent longitudinal and transverse strains of a family of isotropic and anisotropic MAE cylinders with six different aspect ratios in time-varying uniform magnetic fields. The time dependence of the magnetic field has a trapezoidal form, where the rate of both legs is varied between 52 and 757 kA/(s·m) and the maximum magnetic field takes three values between 153 and 505 kA/m. It is proposed to introduce four characteristic times: two for the delay of the transient response during increasing and decreasing magnetic field, as well as two for rise and fall times. To facilitate the comparison between different magnetic field rates, these characteristic times are further normalized on the rise time of the magnetic field ramp. The dependence of the normalized characteristic times on the aspect ratio, the magnetic field slew rate, maximum magnetic field values, initial internal structure (isotropic versus anisotropic specimens) and weight fraction of the soft-magnetic filler are obtained and discussed in detail. The normalized magnetostrictive hysteresis loop is introduced, and used to explain why the normalized delay times vary with changing experimental parameters. KW - magnetoactive elastomer KW - magnetorheological elastomer KW - macroscopic deformation KW - magnetostriction KW - time-varying magnetic field Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-71067 SN - 2073-4360 N1 - Corresponding author der OTH Regensburg: Gašper Glavan Zugehöriges Datenset: doi:10.5281/zenodo.10679499 VL - 16 IS - 5, Special Issue Magnetic Polymer Composites: Design and Application II PB - MDPI CY - Basel, Schweiz ER - TY - JOUR A1 - Ortner, Martina A1 - Kökten, Rabia T1 - Rechtsextremismus transnational betrachtet : das Forschungsprojekt zur Ülkücü-Bewegung in Bayern stellt sich vor JF - RadiX – Zeitschrift für Radikalisierungsforschung und Prävention N2 - Deutschland ist eine postmigrantische Gesellschaft. Die damit einhergehende Pluralität beschränkt sich nicht nur auf Herkünfte und Biografien, sondern spiegelt sich auch in Lebensentwürfen und politischen Einstellungen wider, die nicht nur demokratisch, sondern menschenverachtend-völkisch und antidemokratisch sein können. Im Projekt ReTra geht es darum, mehr über Strukturen, Akteur:innen und Aktivitäten von türkischen extrem rechten Organisationen in Bayern zu erfahren. Dabei wird der Einfluss von politischen Veränderungen in der Türkei miteinbezogen. Das Projekt leistet einen Beitrag zur Rechtsextremismusforschung unter Berücksichtigung sich aufspannender transnationaler sozialer Räume. Die qualitative Studie wird ergänzt durch einen partizipativen Forschungsansatz, in dem zivilgesellschaftlich Aktive als Co-Forschende einbezogen werden. Fortlaufend wird die Fachdiskussion mit einschlägigen Wissenschaftler:innen geführt. So entsteht ein Netzwerk, durch das ein kontinuierlicher Forschungs-Praxis Austausch ermöglicht wird. Durch eine Handreichung leistet das Projekt einen Beitrag für die zivilgesellschaftliche Praxis und darüber hinaus für ein demokratisches Miteinander. Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-84211 SN - 2944-1382 N1 - Online First-Beitrag VL - 1 IS - 2 PB - Verlag Barbara Budrich ER - TY - JOUR A1 - Kraus, Richard A1 - Knipfer, Maximilian A1 - Jacob, Matthias A1 - Kienninger, Baerbel A1 - Alikhani, Jasmine A1 - Ghamsary, Parham Heydarzadeh A1 - Reinker, Lukas A1 - Adler, Ina A1 - Dendorfer, Sebastian A1 - Kieninger, Martin T1 - Effectiveness and safety of techniques for cervical spine immobilization in mountain rescue JF - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine N2 - Background Cervical spine injuries in alpine sports require immediate immobilization at the site of the accident to avoid possible secondary damage caused by transportation. Using special sensor technology, this study investigated whether a cervical spine orthosis (cervical collar, Stifneck collar (Laerdal Medical GmbH, Puchheim, Germany)) provides greater stability than a vacuum mattress alone. Methods Using one male test person, we simulated transporting a patient with a spinal injury in steep alpine terrain. A wireless motion capture system (Xsens Technologies, Movella™ Inc., Henderson, USA) was used to record motion in three-dimensional space within a standardized environment. All tests were performed on a set course by the Bavarian Mountain Rescue Service. The test person lay on a mountain rescue stretcher and was immobilized with a vacuum mattress, either with or without a cervical orthosis. The axes of cervical spine movements were analyzed separately. Results There were no significant differences between immobilization with and without a cervical orthosis with regard to lateral flexion (max. 3.7° compared to 3.0°) in the frontal plane and maximum excursion in flexion (max. 1.6° compared to 2.8°) or extension (max. -1.6° compared to -1.7°). There was significantly greater rotation movement around the craniocaudal axis without an orthosis (max. 2.4° compared to 1.3°). Conclusion During mountain rescues, the cervical spine can be immobilized without a rigid cervical spine orthosis. Future research should explore the fundamental benefits of cervical spine immobilization, while the findings of this work contribute to the safe care of patients by avoiding the disadvantages associated with rigid cervical orthoses. KW - Mountain rescue KW - Orthosis KW - Cervical spine KW - Immobilization KW - Vacuum mattress Y1 - 2026 U6 - https://doi.org/10.1186/s13049-025-01530-z VL - 34 PB - Springer ER - TY - JOUR A1 - Schiek, Roland A1 - Solntsev, Alexander S. A1 - Neshev, Dragomir N. T1 - Measurement of the cubic nonlinear susceptibility in lithium niobate JF - Optical Materials Express N2 - We measured the cubic nonlinear susceptibility tensor elements ( χ(3)) for polarization along the primary crystallographic axis in titanium-indiffused lithium niobate waveguides, assessed through self-phase modulation using picosecond-duration pulses at telecommunication wavelengths. A dominant, highly temperature- and wavelength-dependent contribution from a cascaded second-order nonlinearity is observed. Through careful extraction of the cascaded effect, we quantify the intrinsic third-order susceptibility tensor elements as χ(3) zzzz(ω; ω, ω, −ω) = (5.2 ± 1.3) × 10−21 m2 V2 and χ(3) xxxx(ω; ω, ω, −ω) = χ(3) yyyy(ω; ω, ω, −ω) = (3.6 ± 0.8) × 10−21 m2 V2 . These measurements underscore the substantial impact of the cascaded nonlinearity in enhancing the effective cubic nonlinearity in lithium niobate and offer precise values essential for the design of nonlinear photonic devices. Y1 - 2025 U6 - https://doi.org/10.1364/OME.557516 SN - 2159-3930 N1 - Corresponding author der OTH Regensburg: Schiek, Roland VL - 15 IS - 5 SP - 1100 EP - 1117 PB - Optica Publishing Group ER - TY - JOUR A1 - Dobler, Barbara A1 - Walter, Cornelia A1 - Knopf, Antje A1 - Fabri, Daniella A1 - Löschel, Rainer A1 - Polednik, Martin A1 - Schneider, Frank A1 - Wenz, Frederik A1 - Lohr, Frank T1 - Optimization of extracranial stereotactic radiation therapy of small lung lesions using accurate dose calculation algorithms JF - Radiation Oncology N2 - BACKGROUND The aim of this study was to compare and to validate different dose calculation algorithms for the use in radiation therapy of small lung lesions and to optimize the treatment planning using accurate dose calculation algorithms. METHODS A 9-field conformal treatment plan was generated on an inhomogeneous phantom with lung mimics and a soft tissue equivalent insert, mimicking a lung tumor. The dose distribution was calculated with the Pencil Beam and Collapsed Cone algorithms implemented in Masterplan (Nucletron) and the Monte Carlo system XVMC and validated using Gafchromic EBT films. Differences in dose distribution were evaluated. The plans were then optimized by adding segments to the outer shell of the target in order to increase the dose near the interface to the lung. RESULTS The Pencil Beam algorithm overestimated the dose by up to 15% compared to the measurements. Collapsed Cone and Monte Carlo predicted the dose more accurately with a maximum difference of -8% and -3% respectively compared to the film. Plan optimization by adding small segments to the peripheral parts of the target, creating a 2-step fluence modulation, allowed to increase target coverage and homogeneity as compared to the uncorrected 9 field plan. CONCLUSION The use of forward 2-step fluence modulation in radiotherapy of small lung lesions allows the improvement of tumor coverage and dose homogeneity as compared to non-modulated treatment plans and may thus help to increase the local tumor control probability. While the Collapsed Cone algorithm is closer to measurements than the Pencil Beam algorithm, both algorithms are limited at tissue/lung interfaces, leaving Monte-Carlo the most accurate algorithm for dose prediction. Y1 - 2006 U6 - https://doi.org/10.1186/1748-717X-1-45 VL - 1 PB - BMC ; Springer ER - TY - JOUR A1 - Broll, Alexander A1 - Rosentritt, Martin A1 - Schlegl, Thomas A1 - Goldhacker, Markus T1 - A data-driven approach for the partial reconstruction of individual human molar teeth using generative deep learning JF - Frontiers in Artificial Intelligence N2 - Background and objectiveDue to the high prevalence of dental caries, fixed dental restorations are regularly required to restore compromised teeth or replace missing teeth while retaining function and aesthetic appearance. The fabrication of dental restorations, however, remains challenging due to the complexity of the human masticatory system as well as the unique morphology of each individual dentition. Adaptation and reworking are frequently required during the insertion of fixed dental prostheses (FDPs), which increase cost and treatment time. This article proposes a data-driven approach for the partial reconstruction of occlusal surfaces based on a data set that comprises 92 3D mesh files of full dental crown restorations.MethodsA Generative Adversarial Network (GAN) is considered for the given task in view of its ability to represent extensive data sets in an unsupervised manner with a wide variety of applications. Having demonstrated good capabilities in terms of image quality and training stability, StyleGAN-2 has been chosen as the main network for generating the occlusal surfaces. A 2D projection method is proposed in order to generate 2D representations of the provided 3D tooth data set for integration with the StyleGAN architecture. The reconstruction capabilities of the trained network are demonstrated by means of 4 common inlay types using a Bayesian Image Reconstruction method. This involves pre-processing the data in order to extract the necessary information of the tooth preparations required for the used method as well as the modification of the initial reconstruction loss.ResultsThe reconstruction process yields satisfactory visual and quantitative results for all preparations with a root mean square error (RMSE) ranging from 0.02 mm to 0.18 mm. When compared against a clinical procedure for CAD inlay fabrication, the group of dentists preferred the GAN-based restorations for 3 of the total 4 inlay geometries.ConclusionsThis article shows the effectiveness of the StyleGAN architecture with a downstream optimization process for the reconstruction of 4 different inlay geometries. The independence of the reconstruction process and the initial training of the GAN enables the application of the method for arbitrary inlay geometries without time-consuming retraining of the GAN. KW - inlay restoration KW - dental prosthesis design KW - StyleGAN KW - machine learning KW - digital dentistry Y1 - 2024 U6 - https://doi.org/10.3389/frai.2024.1339193 SN - 2624-8212 VL - 7 PB - Frontiers Media SA ER - TY - JOUR A1 - Ott, Christian A1 - Rosengarth, Katharina A1 - Doenitz, Christian A1 - Hoehne, Julius A1 - Wendl, Christina A1 - Dodoo-Schittko, Frank A1 - Lang, Elmar Wolfgang A1 - Schmidt, Nils Ole A1 - Goldhacker, Markus T1 - Preoperative Assessment of Language Dominance through Combined Resting-State and Task-Based Functional Magnetic Resonance Imaging JF - Journal of personalized medicine N2 - Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years, the resting-state fMRI (RS-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere. Twenty patients suffering from brain lesions close to supposed language-relevant cortical areas were included. RS-fMRI and task-based (TB-fMRI) were performed for the purpose of preoperative language assessment. TB-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language-critical and language-supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the TB-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice index. Thereby, the RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly. In general, the results suggest that determining language dominance in the human brain is feasible both with TB-fMRI and RS-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits. KW - resting-state fMRI KW - task-based fMRI KW - brain mapping KW - language assessment KW - data-driven analysis Y1 - 2021 U6 - https://doi.org/10.3390/jpm11121342 VL - 11 IS - 12 PB - MDPI ER - TY - GEN A1 - Ott, Christian A1 - Rosengarth, K. A1 - Doenitz, Christian A1 - Hoehne, Julius A1 - Wendl, C. A1 - Dodoo-Schittko, Frank A1 - Lang, Elmar Wolfgang A1 - Schmidt, Nils Ole A1 - Goldhacker, Markus T1 - Preoperative assessment of language dominance through combined resting-state and task-based functional magnetic resonance imaging T2 - Brain and Spine N2 - Background: Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years the resting-state fMRI (rs-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere. Methods: Twenty patients suffering from brain lesions close to supposed language relevant cortical areas were included. Rs-fMRI and task-based (tb-fMRI) were performed for the purpose of preoperative language assessment. Tb-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language critical and language supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the tb-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice-index. Results: The RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly. Conclusion: In general, the results suggest that determining language dominance in the human brain is feasible both with tb-fMRI and rs-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits. Y1 - 2021 U6 - https://doi.org/10.1016/j.bas.2021.100523 VL - 1 IS - Suppl. 2 PB - Elsevier ER - TY - JOUR A1 - Goldhacker, Markus A1 - Tomé, Ana Maria A1 - Greenlee, Mark W. A1 - Lang, Elmar Wolfgang T1 - Frequency-Resolved Dynamic Functional Connectivity Reveals Scale-Stable Features of Connectivity-States JF - Frontiers in Human Neuroscience N2 - Investigating temporal variability of functional connectivity is an emerging field in connectomics. Entering dynamic functional connectivity by applying sliding window techniques on resting-state fMRI (rs-fMRI) time courses emerged from this topic. We introduce frequency-resolved dynamic functional connectivity (frdFC) by means of multivariate empirical mode decomposition (MEMD) followed up by filter-bank investigations. In general, we find that MEMD is capable of generating time courses to perform frdFC and we discover that the structure of connectivity-states is robust over frequency scales and even becomes more evident with decreasing frequency. This scale-stability varies with the number of extracted clusters when applying k-means. We find a scale-stability drop-off from k = 4 to k = 5 extracted connectivity-states, which is corroborated by null-models, simulations, theoretical considerations, filter-banks, and scale-adjusted windows. Our filter-bank studies show that filter design is more delicate in the rs-fMRI than in the simulated case. Besides offering a baseline for further frdFC research, we suggest and demonstrate the use of scale-stability as a possible quality criterion for connectivity-state and model selection. We present first evidence showing that connectivity-states are both a multivariate, and a multiscale phenomenon. A data repository of our frequency-resolved time-series is provided. Y1 - 2018 U6 - https://doi.org/10.3389/fnhum.2018.00253 SN - 1662-5161 VL - 12 SP - 1 EP - 16 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Fellner, Marie-Christin A1 - Volberg, Gregor A1 - Wimber, Maria A1 - Goldhacker, Markus A1 - Greenlee, Mark W. A1 - Hanslmayr, Simon T1 - Spatial mnemonic encoding: Theta power decreases and medial temporal lobe BOLD increases co-occur during the usage of the method of loci JF - eNeuro N2 - The method of loci is one, if not the most, efficient mnemonic encoding strategy. This spatial mnemonic combines the core cognitive processes commonly linked to medial temporal lobe (MTL) activity: spatial and associative memory processes. During such processes, fMRI studies consistently demonstrate MTL activity, while electrophysiological studies have emphasized the important role of theta oscillations (3–8 Hz) in the MTL. However, it is still unknown whether increases or decreases in theta power co-occur with increased BOLD signal in the MTL during memory encoding. To investigate this question, we recorded EEG and fMRI separately, while human participants used the spatial method of loci or the pegword method, a similarly associative but nonspatial mnemonic. The more effective spatial mnemonic induced a pronounced theta power decrease source localized to the left MTL compared with the nonspatial associative mnemonic strategy. This effect was mirrored by BOLD signal increases in the MTL. Successful encoding, irrespective of the strategy used, elicited decreases in left temporal theta power and increases in MTL BOLD activity. This pattern of results suggests a negative relationship between theta power and BOLD signal changes in the MTL during memory encoding and spatial processing. The findings extend the well known negative relation of alpha/beta oscillations and BOLD signals in the cortex to theta oscillations in the MTL. KW - EEG KW - fMRI KW - memory encoding KW - method of loci KW - mnemonics KW - theta oscillations Y1 - 2016 U6 - https://doi.org/10.1523/ENEURO.0184-16.2016 SN - 2373-2822 VL - 3 IS - 6 SP - 1 EP - 16 PB - Society for Neuroscience CY - Washington, DC ER - TY - JOUR A1 - Plank, Tina A1 - Rosengarth, Katharina A1 - Schmalhofer, Carolin A1 - Goldhacker, Markus A1 - Brandl-Rühle, Sabine A1 - Greenlee, Mark W. T1 - Perceptual learning in patients with macular degeneration JF - Frontiers in psychology N2 - Patients with age-related macular degeneration (AMD) or hereditary macular dystrophies (JMD) rely on an efficient use of their peripheral visual field. We trained eight AMD and five JMD patients to perform a texture-discrimination task (TDT) at their preferred retinal locus (PRL) used for fixation. Six training sessions of approximately one hour duration were conducted over a period of approximately 3 weeks. Before, during and after training twelve patients and twelve age-matched controls (the data from two controls had to be discarded later) took part in three functional magnetic resonance imaging (fMRI) sessions to assess training-related changes in the BOLD response in early visual cortex. Patients benefited from the training measurements as indexed by significant decrease (p = 0.001) in the stimulus onset asynchrony (SOA) between the presentation of the texture target on background and the visual mask, and in a significant location specific effect of the PRL with respect to hit rate (p = 0.014). The following trends were observed: (i) improvement in Vernier acuity for an eccentric line-bisection task; (ii) positive correlation between the development of BOLD signals in early visual cortex and initial fixation stability (r = 0.531); (iii) positive correlation between the increase in task performance and initial fixation stability (r = 0.730). The first two trends were non-significant, whereas the third trend was significant at p = 0.014, Bonferroni corrected. Consequently, our exploratory study suggests that training on the TDT can enhance eccentric vision in patients with central vision loss. This enhancement is accompanied by a modest alteration in the BOLD response in early visual cortex. KW - perceptual learning KW - fMRI BOLD KW - cortical plasticity KW - visual cortex KW - macular degeneration Y1 - 2014 U6 - https://doi.org/10.3389/fpsyg.2014.01189 SN - 1664-1078 VL - 5 SP - 1 EP - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Greenlee, Mark W. A1 - Anstis, Stuart A1 - Rosengarth, Katharina A1 - Goldhacker, Markus A1 - Brandl-Rühle, Sabine A1 - Plank, Tina T1 - Neural correlates of perceptual filling-in: fMRI evidence in the foveal projection zone of patients with central scotoma T2 - Journal of Vision / Vision Sciences Society Annual Meeting Abstract N2 - Patients with juvenile retinal dystrophy often report that they are unaware of their central scotoma, suggesting the presence of perceptual filling-in. We used functional Magnetic Resonance Imaging (fMRI) to determine possible neural correlates of perceptual filling-in in patients with retinal distrophy and clinically established central scotoma in both eyes. The data of 5 patients (Stargardt disease, cone-rod dystrophy; mean age 45 yrs; scotoma diameter 10-20°) and of 5 normally sighted controls were analyzed. Fixation behaviour and perimetry were measured with a Nidek microperimeter. Magnetic resonance imaging was performed using a Siemens 3T Allegra scanner. We stimulated the central visual field (30 deg) with a vertically oriented, low spatial frequency (1 c/deg) high-contrast sinewave grating that was either a) continuous, or b) was interrupted by a central grey disk. The disk was either slightly larger than the scotoma (detectable on 75% of trials) or slightly smaller (detectable on 25% of trials). To control for attention, an eccentric fixation task was performed during scanning. Data were analyzed using SPM8 (GLM with ROI analysis to obtain percent signal change for foveal projection zone). Results: for all patients, the BOLD signal in the foveal projection area was significantly higher for the small disk (i.e., condition leading to complete filling-in) than for the large disk (i.e., no filling-in). This effect was absent in the control subjects. Our findings support the existence of an active neural process that leads to filling-in in patients with central visual field scotomata. Y1 - 2012 U6 - https://doi.org/10.1167/12.9.1303 SN - 1534-7362 VL - 12 IS - 9 PB - ARVO ER - TY - JOUR A1 - Wein, Simon A1 - Tomé, Ana Maria A1 - Goldhacker, Markus A1 - Greenlee, Mark W. A1 - Lang, Elmar Wolfgang T1 - A Constrained ICA-EMD Model for Group Level fMRI Analysis JF - Frontiers in Neuroscience N2 - Independent component analysis (ICA), being a data-driven method, has been shown to be a powerful tool for functional magnetic resonance imaging (fMRI) data analysis. One drawback of this multivariate approach is that it is not, in general, compatible with the analysis of group data. Various techniques have been proposed to overcome this limitation of ICA. In this paper, a novel ICA-based workflow for extracting resting-state networks from fMRI group studies is proposed. An empirical mode decomposition (EMD) is used, in a data-driven manner, to generate reference signals that can be incorporated into a constrained version of ICA (cICA), thereby eliminating the inherent ambiguities of ICA. The results of the proposed workflow are then compared to those obtained by a widely used group ICA approach for fMRI analysis. In this study, we demonstrate that intrinsic modes, extracted by EMD, are suitable to serve as references for cICA. This approach yields typical resting-state patterns that are consistent over subjects. By introducing these reference signals into the ICA, our processing pipeline yields comparable activity patterns across subjects in a mathematically transparent manner. Our approach provides a user-friendly tool to adjust the trade-off between a high similarity across subjects and preserving individual subject features of the independent components. Y1 - 2020 U6 - https://doi.org/10.3389/fnins.2020.00221 SN - 1662-453X SN - 1662-4548 VL - 14 SP - 1 EP - 10 PB - frontiers ER - TY - JOUR A1 - Greenlee, Mark W. A1 - Rosengarth, Katharina A1 - Schmalhofer, Carolin A1 - Goldhacker, Markus A1 - Brandl-Rühle, Sabine A1 - Plank, Tina T1 - Perceptual learning in patients with central scotomata due to hereditary and age-related macular dystrophy JF - Journal of Vision N2 - Hereditary and age-related forms of macular dystrophy (MD) are characterized by loss of cone function in the fovea, leading to central scotomata and eccentric fixation at the so-called preferred retinal locus (PRL). We investigated whether perceptual learning enhances visual abilities at the PRL. We also determined the neural correlates (3-Tesla fMRI) of learning success. Twelve MD patients (eight with age-related macular dystrophy, four with hereditary macular dystrophies) were trained on a texture discrimination task (TDT) over six days. Patients underwent three fMRI sessions (before, during and after training) while performing the TDT (target at PRL or opposite PRL). Reading speed, visual acuity (Vernier task) and contrast sensitivity were also assessed before and after training. With one exception, all patients showed improved performance (i.e. significant decrease in stimulus onset asynchronies and reaction times, significant increase in hit rates) on the TDT. Eight patients also showed moderate increases in reading speed, six patients showed improved thresholds in contrast sensitivity and nine patients showed improved thresholds in a vernier visual acuity task after TDT training. We found an increase in BOLD response in the projections zone of the PRL in the primary visual cortex in nine of twelve patients after training. The change in fMRI signal correlated (r = .8; p = .02) with the patients’ performance enhancements when the target was in the PRL. The results suggest that perceptual learning can enhance eccentric vision and cortical processing in MD patients. Y1 - 2014 U6 - https://doi.org/10.1167/14.10.666 SN - 1468-4233 SN - 0301-0066 VL - 14 IS - 10 PB - ARVO ER - TY - JOUR A1 - Lambert, Jerry A1 - Kraus, Hermann A1 - Doepfert, Markus A1 - He, Miaomiao A1 - Gschossmann, David A1 - Ceruti, Amedeo A1 - Nemeth, Isabell A1 - Brückl, Oliver A1 - Hamacher, Thomas A1 - Spliethoff, Hartmut T1 - Assessing the techno-economic impact of district heating on electrical distribution grid reinforcements JF - Advances in Applied Energy N2 - Enhanced sector coupling across electricity, mobility, and heating sectors leads to higher efforts for distribution grid upgrades. Based on a case study, this paper evaluates the role of district heating networks in reducing electrical distribution grid reinforcements and compares their economic viability against a building-specific heat supply using heat pumps. A detailed energy system model is used to analyze two building energy renovation scenarios: a business-as-usual scenario with a 1 % annual renovation rate and an ambitious scenario with a rate of 2 %. Using a two-step optimization, the impact of different district heating network penetration levels on the distribution grid is evaluated, followed by an ex-post analysis to incorporate a simultaneity factor into district heating networks. Overall, district heating networks can reduce distribution grid reinforcements, but the associated savings alone do not justify their construction, particularly in the ambitious renovation scenario. In the business-as-usual scenario, a district heating network can reduce reinforcement costs by up to 71 %. However, in the ambitious scenario, grid reinforcements are already reduced due to lower heat peak demand, and the maximal reinforcement cost savings only amount to 35 %. Compared economically, district heating networks are cost-competitive with building-specific heating only in the business-as-usual scenario, up to a heat supply share of 70 % and in the ambitious scenario, up to 40 %. In both scenarios, a district heating network can be a robust solution to lower macroeconomic costs for a carbon-neutral heat supply. KW - Energy system optimization KW - Distribution grid KW - Grid reinforcement KW - District heating KW - Benchmark Y1 - 2025 U6 - https://doi.org/10.1016/j.adapen.2025.100251 SN - 2666-7924 VL - 20 PB - Elsevier ER - TY - CHAP A1 - Schönberger, Manuel A1 - Trummer, Immanuel A1 - Mauerer, Wolfgang T1 - Hybrid Mixed Integer Linear Programming for Large-Scale Join Order Optimisation T2 - Proceedings of the VLDB Endowment N2 - Finding optimal join orders is among the most crucial steps to be performed by query optimisers. Though extensively studied in data management research, the problem remains far from solved: While query optimisers rely on exhaustive search methods to determine ideal solutions for small problems, such methods reach their limits once queries grow in size. Yet, large queries become increasingly common in real-world scenarios, and require suitable methods to generate efficient execution plans. While a variety of heuristics have been proposed for large-scale query optimisation, they suffer from degrading solution quality as queries grow in size, or feature highly sub-optimal worst-case behavior, as we will show. We propose a novel method based on the paradigm of mixed integer linear programming (MILP): By deriving a novel MILP model capable of optimising arbitrary bushy tree structures, we address the limitations of existing MILP methods for join ordering, and can rely on highly optimised MILP solvers to derive efficient tree structures that elude competing methods. To ensure optimisation efficiency, we embed our MILP method into a hybrid framework, which applies MILP solvers precisely where they provide the greatest advantage over competitors, while relying on more efficient methods for less complex optimisation steps. Thereby, our approach gracefully scales to extremely large query sizes joining up to 100 relations, and consistently achieves the most robust plan quality among a large variety of competing join ordering methods. Y1 - 2026 U6 - https://doi.org/10.14778/3778092.3778097 VL - 19 IS - 3 SP - 348 EP - 360 PB - VLDB Endowment ER - TY - JOUR A1 - Schmidbauer, Lukas A1 - Lobe, Elisabeth A1 - Schaefer, Ina A1 - Mauerer, Wolfgang T1 - It’s Quick to be Square: Fast Quadratisation for Quantum Toolchains JF - ACM Transactions on Quantum Computing N2 - Many of the envisioned use-cases for quantum computers involve optimisation processes. While there are many algorithmic primitives to perform the required calculations, all eventually lead to quantum gates operating on quantum bits, with an order as determined by the structure of the objective function and the properties of target hardware. When the structure of the problem representation is not aligned with structure and boundary conditions of the executing hardware, various overheads degrading the computation may arise, possibly negating any possible quantum advantage. Therefore, automatic transformations of problem representations play an important role in quantum computing when descriptions (semi-)targeted at humans must be cast into forms that can be “executed” on quantum computers. Mathematically equivalent formulations are known to result in substantially different non-functional properties depending on hardware, algorithm and detail properties of the problem. Given the current state of noisy intermediate-scale quantum (NISQ) hardware, these effects are considerably more pronounced than in classical computing. Likewise, efficiency of the transformation itself is relevant because possible quantum advantage may easily be eradicated by the overhead of transforming between representations. In this paper, we consider a specific class of higher-level representations, that is, PUBOs, and devise novel automatic transformation mechanisms into widely used QUBOs that substantially improve efficiency and versatility over the state of the art. In addition, we conduct a comprehensive investigation of industry-relevant problem formulations and their conversion into a quantum-specific representation, identifying significant obstacles in scaling behaviour and demonstrating how these can be circumvented. KW - Algorithmic optimisation KW - Graphs KW - Performance KW - Pseudo Boolean Function Y1 - 2026 U6 - https://doi.org/10.1145/3800943 N1 - Preprint ebenfalls auf OPUS veröffentlicht: https://opus4.kobv.de/opus4-oth-regensburg/frontdoor/index/index/docId/7937 VL - 7 IS - 2 PB - ACM ER - TY - JOUR A1 - Franz, Maja A1 - Schönberger, Manuel A1 - Strobl, Melvin A1 - Kühn, Eileen A1 - Streit, Achim A1 - Zurita, Pía A1 - Diefenthaler, Markus A1 - Mauerer, Wolfgang T1 - From Hope to Heuristic: Realistic Runtime Estimates for Quantum Optimisation in NHEP JF - EPJ Web of Conferences; 27th International Conference on Computing in High Energy and Nuclear Physics (CHEP 2024) N2 - Noisy Intermediate-Scale Quantum (NISQ) computers, despite their limitations, present opportunities for near-term quantum advantages in Nuclear and High-Energy Physics (NHEP) when paired with specially designed quantum algorithms and processing units. This study focuses on core algorithms that solve optimization problems through the quadratic Ising or Quadratic Unconstrained Binary Optimisation model, specifically Quantum Annealing and the Quantum Approximate Optimisation Algorithm (QAOA). In particular, we estimate runtimes and scalability for the task of particle Track Reconstruction (TR), a key computing challenge in NHEP, and investigate how the classical parameter space in QAOA, along with techniques like a Fourieranalysis based heuristic, can facilitate future quantum advantages. The findings indicate that lower frequency components in the parameter space are crucial for effective annealing schedules, suggesting that heuristics can improve resource efficiency while achieving near-optimal results. Overall, the study highlights the potential of NISQ computers in NHEP and the significance of co-design approaches and heuristic techniques in overcoming challenges in quantum algorithms. Y1 - 2025 U6 - https://doi.org/10.1051/epjconf/202533701282 N1 - Corresponding author der OTH Regensburg: Maja Franz VL - 337 PB - EDP Sciences ER - TY - JOUR A1 - Brunner, Philipp A1 - Vogl, Stefanie T1 - Extracting Product Improvement Insights from Social Media Comments Using Machine Learning: a Case Study in the Automotive Industry JF - Machine Learning and Knowledge Extraction N2 - This paper presents a scalable machine learning pipeline for extracting actionable, product-related insights from user-generated social media comments. Leveraging sentence embeddings from SBERT and unsupervised clustering (k-Means and agglomerative), the approach structures informal and noisy comments from Instagram and YouTube into topic groups intended to support thematic analysis. A case study on feedback regarding BMW vehicles, comprising more than 26,000 comments, illustrates how the pipeline can reveal recurring user concerns, such as design critiques, usability issues, and technology-related expectations, even in short and unstructured social media comments. The proposed pipeline operates without labeled data or manual annotation, enabling scalable application and transferability across product categories and industries. By transforming large-scale, unstructured consumer feedback into interpretable themes, the pipeline provides product teams with an efficient and structured basis for data-driven product development and improvement. KW - social media mining; sentence embeddings; unsupervised clustering; product feedback analysis; SBERT; natural language processing Y1 - 2026 U6 - https://doi.org/10.3390/make8020042 VL - 8 IS - 2 PB - MDPI ER - TY - JOUR A1 - Pointner, Daniel A1 - Kranz, Michael A1 - Wagner, Maria Stella A1 - Haus, Moritz A1 - Lehle, Karla A1 - Krenkel, Lars T1 - Automated deep learning based detection of cellular deposits on clinically used ECMO membrane lungs JF - Frontiers in Bioinformatics N2 - Introduction: Despite the promising application of extracorporeal membrane oxygenation (ECMO) in the treatment of critically ill patients, coagulation-associated technical complications, primarily clot formation and critical bleeding, remain a major challenge during ECMO therapy. The deposition of nucleated cells on the surface has been shown, yet the role of these cells towards complication development is still matter of ongoing research. In particular, the membrane lung (MemL) is prone to clot formation. Therefore, the investigation of nuclear deposits on its hollow-fibers may provide insights for a better understanding of the cellular mechanisms involved in the development of ECMO complications. Methods: To support current research, this study aimed to develop a deep learning–based tool for the automated detection and quantitative analysis of nuclear depositions on MemL hollow-fiber mats. A customized fluorescence microscopy workflow, combined with a semi-automated iterative labeling strategy, was used to generate a high-quality dataset for model training. Results: Six configurations of instance segmentation models were evaluated, with a Mask R-CNN with ResNet 101 backbone using dilated convolution providing the most balanced performance in both nuclei count and area accuracy. Compared with U-Net–based approaches such as Cellpose or StarDist, the proposed model demonstrated superior segmentation of overlapping and low-intensity nuclei, maintaining accuracy even in densely packed cellular regions. Discussion: We present an automated image analysis tool for clinically used MemLs, which exhibit complex three-dimensional hollow-fiber architectures and irregular cellular deposits that challenge conventional tools. A dedicated graphical user interface enables streamlined detection, morphometric analysis, and spatial clustering of nuclei, establishing a reproducible workflow for high-throughput analysis of fluorescence microscopy images. This approach eliminates labor-intensive manual counting and facilitates large-scale studies on cell-fiber interactions and disease-related correlations. Y1 - 2026 U6 - https://doi.org/10.3389/fbinf.2026.1771574 N1 - Corresponding author der OTH Regensburg: Daniel Pointner, Lars Krenkel VL - 6 PB - Frontiers ER -