TY - CHAP A1 - Krenkel, Lars A1 - Pennecot, Julien A1 - Lenz, Christian A1 - Feldmann, Daniel A1 - Wagner, Claus ED - Füssel, Jens ED - Koch, Edmund ED - Malberg, Hagen T1 - Optimierung der Hochfrequenz-Oszillationsventilation mittels strömungsmechanischer Methoden und kontrastgasgestützter Magnetresonanztomografie - Teilprojekt: Rekonstruktion von Geometrien aus medizinischen Bilddaten und Erstellung von Modellen für experimentelle Strömungsuntersuchungen T2 - Laseranwendung in der Medizin, Erfassen und Verarbeiten kardiovaskulärer Signale, protektive Beatmungskonzepte : 3. Dresdner Medizintechnik-Symposium - mit DFG-Forschungsschwerpunkt Protektive Beatmungskonzepte, 6. bis 9. Dezember 2010, Dresden N2 - Der vorliegende Artikel skizziert die neu entwickelte Prozesskette für detailgenaue Rekonstruktion von Geometrien anhand medizinischer Bilddaten sowie die Herstellung von transparenten Modellen für experimentelle Untersuchungen mit bildgebenden Strömungsmessverfahren. Die Geometriedaten und Modelle werden für systematische Untersuchungen der komplexen Transportvorgänge in den Atemwegen bei künstlicher Beatmung mittels Hochfrequenzoszillationsventilation (HFOV) verwendet. Y1 - 2010 UR - https://elib.dlr.de/66863/ SN - 978-3-942710-02-2 SP - 107 EP - 114 PB - TUDpress CY - Dresden ER - TY - CHAP A1 - Wiesmaier, Alexander A1 - Lippert, Markus A1 - Karatsiolis, Vangelis A1 - Raptis, Georgios A1 - Buchmann, Johannes T1 - An Evaluated Certification Services System for the German National Root CA - Legally Binding and Trustworthy Transactions in E-Business and E-Government T2 - Proceedings of The 2005 International Conference on E-Business, Enterprise Information Systems, E-Government, and Outsourcing, EEE 2005, Las Vegas, Nevada, USA, June 20-23, 2005 Y1 - 2005 SN - 1-932415-76-9 SP - 103 EP - 108 PB - CSREA Press ER - TY - CHAP A1 - Höh, H. A1 - Raptis, Georgios T1 - Applications of the Erbium: YAG Laser in Ophthalmology - Cataracta-, Glaukoma-, Eyelid-Surgery and pars plana Vitrectomy BT - Symposium on Cataract, IOL, and Refractive Surgery. Boston, 20.05.2000 und 22.05.2000 N2 - Recent developments in lasers have provided us the possibility of laser ocular surgery. The xenon, argon, neodymium:YAG and dye lasers have been successfully used in out-patient clinics. The excimer laser has been attracting researchers' interest in the new application of laser to cornea and lens. The erbium:YAG laser emits a 2.94-microns beam that can ablate the transparent ocular tissues such as lenses and corneas. The author has applied this laser to the cornea, lens, vitreous and other ocular tissues. The erbium:YAG laser beam was directed through a 1.5-meter-long, 200-microns-diameter fiberoptic guide. The radiant energy measured about 50 mJ at the end of the probe. The laser was emitted as a 400-microsecond pulse. Freshly enucleated rabbit eyes were used in this study. Laser burns were applied to the tissue surface at various energy settings. At minimal power, the tissues were coagulated by the erbium:YAG laser application. At a power of more than 636-954 mJ/mm2, tissue began to evaporate; the tissue loss was observed under a surgical light microscope. Corneal photoablation, lens ablation, iridotomy, trabeculotomy, cutting of the vitreous and retinal ablation were easily performed. Like the excimer laser, the erbium:YAG laser is a potential tool for ocular surgery. KW - Augenchirurgie KW - YAG-Laser KW - Erbium-Laser Y1 - 2000 ER - TY - CHAP A1 - Horn, Lars-Christian A1 - Pippig, S. A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Köhler, U. A1 - Hentschel, Bettina A1 - Martin, Rosemarie T1 - Tumorassoziierte Proteolyse beim Zervixkarzinom BT - Vortrag T2 - 87. Tagung der Deutschen Gesellschaft für Pathologie, 14. Juni 2003 KW - Gebärmutterhalskrebs KW - Chirurgie KW - Tumorassoziierte Proteolyse KW - Immuncytochemie KW - Zelladhäsion Y1 - 2003 ER - TY - CHAP A1 - Raptis, Georgios T1 - Empfehlungen der BÄK zum Datenschutz im Praxisalltag, Darstellung unter technischen Aspekten BT - Vortrag im Rahmen der conhIT 2009, Berlin, 22.04.2009, zertifiziert von der Ärztekammer Berlin T2 - conhIT 2009, Berlin, 22.04.2009 KW - Arztpraxis KW - Datenschutz Y1 - 2009 ER - TY - CHAP A1 - Raptis, Georgios T1 - Health Professional eIDs vis-á-vis a Single Market Perspective BT - Vortrag T2 - European Health Telematics Association, Berlin, 25.10.2011 KW - eArztausweis KW - Elektronischer Arztausweis Y1 - 2011 ER - TY - CHAP A1 - Raptis, Georgios T1 - Ein Verfahren zur Lösung des Problems der kryptographischen Langzeitsicherheit medizinischer Daten, die in einer Infrastruktur gespeichert werden T2 - BIOSIG-Konferenz 2007, Darmstadt N2 - Medizinische Daten, die - wie derzeit für die Telematik-Infrastruktur nach §291a SGB V spe-zifiziert - auch außerhalb der physischen Kontrolle der Eigentümer oder Ersteller (also z.B. außerhalb von Arztpraxen oder Klinken) auf Servern kryptographisch verschlüsselt gespeichert werden, müssen sehr lange vertraulich bleiben. Insbesondere darf der technische Betreiber des Servers, der die Daten speichert, keinen Zugriff erlangen. Es kann jedoch keine verlässliche Aussage dahingehend getroffen werden, ob die heute eingesetzten kryp-tographischen Algorithmen in 30 oder 40 Jahren die Vertraulichkeit der medizinischen Daten weiterhin gewährleisten. Es wird ein Verfahren vorgestellt, welches das Problem der langfristigen Sicherheit von verschlüsselt gespeicherten medizinischen Daten aus kryptographischer Sicht löst. Die Anwendung des Verfahrens wird am Beispiel einer nach den derzeit bekannten gematik-Spezifikationen definierten Infrastruktur veranschaulicht. Es wird von einer getrennten Speicherung von verschlüsselten medizinischen Daten und Schlüsselmaterial ausgegangen. Die Daten werden an der Datenquelle (Konnektor, z.B. eines Arztes) mit einem Einmalblock (One Time Pad, OTP) verschlüsselt. Sie sind damit beweisbar sicher verschlüsselt, weil das One-Time-Pad-Verschlüsselungsverfahren beweisbar „perfekt geheim“ ist. Der OTP-Schlüssel wird mit einem symmetrischen Schlüssel verschlüsselt, der wiederum mit den asymmetrischen Schlüsseln aller Zugriffsberechtigten verschlüsselt wird. Die kryptographische, technische und organisatorische Sicherheit des Verfahrens sowie seine Voraussetzungen und Kosten werden analysiert. KW - Gesundheitsinformationssystem KW - Datensicherhung KW - Kryptologie Y1 - 2007 UR - http://www.baek.de/downloads/Raptis_Verfahren-2.pdf ER - TY - CHAP A1 - Raptis, Georgios T1 - Die Konzepte und Mechanismen der elektronischen Gesundheitskarte und des Heilberufsausweises aus der Sicht der Datensicherheit / des Datenschutzes BT - Vortrag T2 - Forschungsseminar med. Informatik an der Universität Heidelberg, 22.06.2006 KW - Elektronische Gesundheitskarte KW - Heilberuf KW - Ausweis KW - Datenschutz KW - Datensicherheit Y1 - 2005 ER - TY - CHAP A1 - Markus Rütten, A1 - Krenkel, Lars A1 - Kessler, Roland T1 - Secondary Flow Effects as Physical Mechanism of Molecular Species Transport in Highly Oscillating Generic-Trachea Flows T2 - 83rd Annual Scientific Conference of the International Association of Applied Mathematics and Mechanics, 26.-30. März 2012, Darmstadt, Germany N2 - The high frequency oscillation artificial respiration technique is often the last hope for patients to survive highly damaged lung tissue. The mortality can significantly be reduced. In comparison to conventional artificial respiration the applied volume flow rate and pressure is significantly lowered in order to avoid further damaging of lung tissue and remaining intact alveolae. However, the physical mechanism of transport of oxygen to the aeriols under high frequency oscillation is not well understood. In the upper part of the lung convection is dominant, in contrast, the gas exchange in the lower parts of the lung is mainly driven by diffusion. It is not clear how associated gradients of concentrations of different molecular species are then achieved. Highly oscillating fluid flows has been a long research topic in fluid dynamics. It is known that oscillating pressure fluctuations are able to induce secondary flows, in particular, in curved ducts and pipes. The question is, whether the trachea enforces the generation of secondary flow by its kidney like cross section geometry. The influence of molecular species of different densities onto the formation of secondary flows and the convectional transport within the trachea is investigated. In order to clarify the physical mechanisms behind flow simulations have been conducted by using state of the art CFD techniques. KW - CFD KW - Generic-Trachea Flows Y1 - 2012 UR - https://elib.dlr.de/75733/ ER - TY - CHAP A1 - Friedrich, Janet A1 - Feldmann, Daniel A1 - Krenkel, Lars A1 - Wagner, Claus A1 - Schreiber, Laura Maria T1 - 19F Gas Flow Measurement of C3F7H During Constant Flow and High Frequency Oscillatory Ventilation T2 - Discovery, innovation & application - advancing mr for improved health : ISMRM 21st Annual Meeting & Exhibition ; SMRT 22nd Annual Meeting Salt Lake City, Utah, USA 20-26 April 2013 N2 - The aim of the current study is the development of MRI methods that enable the investigation of gas flow mechanisms during high frequency oscillatory ventilation. This work includes flow measurements during three constant flows (19.9, 30.6 and 41.4 L min-1) and the comparison to direct numerical simulations (DNS) using a second-order-acurate finite-volume method and to data measured with a volume flow meter. 19F-MRI, DNS and flow meter data are in good agreement. Flow measurements during HFOV of 4 Hz were successfully performed and velocity profiles could be recorded at different phases of the ventilation cycle. Y1 - 2013 UR - https://archive.ismrm.org/2013/1482.html VL - 21 ER - TY - CHAP A1 - Raptis, Georgios T1 - Notfalldaten und Datenerhalt mit der elektronischen Gesundheitskarte. T2 - Tagungsband 22. Smartcard-Workshop 2012 KW - Elektronische Gesundheitskarte KW - Notfallmedizin KW - Datensicherung Y1 - 2012 SP - 166 PB - Fraunhofer-Verlag ER - TY - CHAP A1 - Meyer-Sickendiek, Burkhard A1 - Hussein, Hussein A1 - Baumann, Timo ED - Berton, André ED - Haiber, Udo ED - Minker, Wolfgang T1 - Recognizing Modern Sound Poetry with LSTM Networks T2 - Proceedings of Elektronische Sprachsignalverarbeitung (ESSV) N2 - Our paper focuses on the computational analysis of “readout poetry” (german: Hördichtung) – recordings of poets reading their own work – with regards to the most important type of this genre, the modern “sound poetry” (german: Lautdichtung). Whereas “readout poetry” often uses normal words and sentences, the “sound poetry”, developed by dadaistic poets like Hugo Ball and Kurt Schwitters or concrete poets like Ernst Jandl, Oskar Pastior, or Bob Cobbing, combines the “microparticles of the human voice” like the segments in Ernst Jandls sound poem “schtzngrmm” (“schtzngrmm / schtzngrmm / tttt / tttt / grrrmmmmm / tttt / sch / tzngrmm”). Within the genre of sound poetry, there are two main forms: The lettristic and the syllabic decomposition. A short anecdote will explain this difference: The dadaist Raoul Hausmann developed the lettristic sound poetry in his early dadaistic poem “fmsbw” from 1918. This is said to have inspired his successor Schwitters, whose famous “Ursonate” [The Sonata in Primal Speech] begins with the words “Fümms bö wö tää zää Uu”. With the “Ursonate”, Schwitters developed a syllabic variation of the lettristic poems of Hausmann. The paper shows how to train a bidirectional LSTM network in order to differ between these “dadaistic” sound poems and the “normal” read out poems. In a further step, we will also show how to distinguish between the lettristic and the syllabic decomposition. Based on a bidirectional LSTM network that reads encodings of the character sequence in the poem and uses the output of each directional layer, we identify poems of the sound poetry genre and differentiate between its two types of compositions. The classification results of sound poetry vs. other poetry as well as lettristic vs. syllabic decomposition are with a high performance, yielding a f-scores of 0.86 and 0.84, respectively. KW - Sprachverarbeitung Y1 - 2018 UR - http://www.essv.de/paper.php?id=407 SN - 978-3-959081-28-3 SP - 192 EP - 199 PB - TUDpress CY - Ulm, Germany ER - TY - CHAP A1 - Laumer, Tobias A1 - Schmidt, Michael A1 - Stichel, Thomas T1 - Correlation Analysis of Different Building Parameters on the Part Properties of Parts Built by Simultaneous Laser Beam Melting of Polymers T2 - Fraunhofer Direct Digital Manufacturing Conference DDMC 2016 : Conference Proceedings, March 2016, Berlin N2 - Simultaneous Laser Beam Melting of polymers (SLBM) allows the generation of multi-material components,consisting of different thermoplastic polymers, within one additive building process. Besides the common advantagesof conventional Laser Beam Melting (LBM), multi-material components built by SLBM can fulfill different productrequirements like different chemical resistances or haptic material properties within a single part. To achieve suchparts, different powder materials are deposited next to each other and preheated a few degrees below their meltingtemperatures by infrared emitters and laser radiation (λ = 10.60 μm), before in the last step the preheated powdersare molten simultaneously by an additional laser source (λ = 1.94 μm). In this paper, different polymer powders likepolypropylene (PP) and polyamide 12 (PA12) are used for the generation of multi-material specimens. By varyingdifferent building parameters according to a specified design of experiments, their influence on the part properties isanalyzed. Important building parameters are the intensity and the irradiation time of the laser beam used for meltingthe preheated powders. Besides using tensile tests to determine the tensile strength and the elongation at break, theaverage part height in dependence of the energy input is analyzed. The overall aim is to specify the correlationbetween different building parameters regarding the energy deposition on the resulting part properties. Y1 - 2016 UR - https://www.researchgate.net/publication/298791419_Correlation_Analysis_of_Different_Building_Parameters_on_the_Part_Properties_of_Parts_Built_by_Simultaneous_Laser_Beam_Melting_of_Polymers PB - Fraunhofer Verlag ER - TY - CHAP A1 - Laumer, Tobias A1 - Stichel, Thomas A1 - Bock, Thomas A1 - Amend, Philipp A1 - Schmidt, Michael T1 - Characterization of temperature-dependent optical material properties of polymer powders T2 - AIP Conference Proceedings N2 - In former works, the optical material properties of different polymer powders used for Laser Beam Melting (LBM) at room temperature have been analyzed. With a measurement setup using two integration spheres, it was shown that the optical material properties of polymer powders differ significantly due to multiple reflections within the powder compared to solid bodies of the same material. Additionally, the absorption behavior of the single particles shows an important influence on the overall optical material properties, especially the reflectance of the powder bed. Now the setup is modified to allow measurements at higher temperatures. Because crystalline areas of semi-crystalline thermoplastics are mainly responsible for the absorption of the laser radiation, the influence of the temperature increase on the overall optical material properties is analyzed. As material, conventional polyamide 12 and polypropylene as new polymer powder material, is used. By comparing results at room temperature and at higher temperatures towards the melting point, the temperature-dependent optical material properties and their influence on the beam-matter interaction during the process are discussed. It is shown that the phase transition during melting leads to significant changes of the optical material properties of the analyzed powders. KW - laser beam melting KW - material qualification KW - Optical Material Properties KW - Polymers Y1 - 2014 U6 - https://doi.org/10.1063/1.4918508 IS - 1 PB - AIP Publishing ER - TY - CHAP A1 - Rill, Daniel A1 - Butz, Christiane A1 - Rill, Georg ED - Kecskeméthy, Andrés ED - Geu Flores, Francisco T1 - Dynamic Interaction of Heavy Duty Vehicles and Expansion Joints T2 - Multibody Dynamics 2019, Proceedings of the 9th ECCOMAS Thematic Conference on Multibody Dynamics N2 - The “Smart Bridge (Intelligente Brücke)” project cluster, initiated by the German Federal Highway Research Institute (Bundesanstalt für Straßenwesen, BASt) and the Federal Ministry of Transport and Digital Infrastructure (BMVI), focuses on “smart” monitoring devices that allow an efficient and economic maintenance management of bridge infrastructures. Among the participating projects, the one presented herein focuses on the development of a smart expansion joint, to assess the traffic parameters on site. This is achieved by measuring velocity and weight of crossing vehicles. In reference measurements, performed with a three-axle truck and a typical tractor semi-trailer combination with five axles in total, it was shown that the interaction between the vehicle and the expansion joint is highly dynamic and depends on several factors. To get more insight into this dynamic problem, a virtual test rig was set up. Although nearly all vehicle parameters had to be estimated, the simulation results conform very well with the measurements and are robust to vehicle parameter variations. In addition, they indicate a significant influence of the expansion joint dynamic to the peak values of the measured wheel loads, in particular on higher driving velocities. By compensating the relevant dynamic effects in the measurements, a “smart” data processing algorithm makes it possible to determine the actual vehicle weights in random traffic with reliability and appropriate accuracy. Y1 - 2020 SN - 978-3-030-23131-6 U6 - https://doi.org/10.1007/978-3-030-23132-3_56 VL - 53 SP - 471 EP - 478 PB - Springer International Publishing CY - Cham ER - TY - CHAP A1 - Baumann, Timo A1 - Siegert, Ingo ED - Alt, Florian ED - Schneegass, Stefan ED - Hornecker, Eva T1 - Prosodic addressee-detection : ensuring privacy in always-on spoken dialog systems T2 - Tagungsband Mensch und Computer (MuC'20): 06.09.2020 - 09.09.2020, Magdeburg N2 - We analyze the addressee detection task for complexity-identical dialog for both human conversation and device-directed speech. Our recurrent neural model performs at least as good as humans, who have problems with this task, even native speakers, who profit from the relevant linguistic skills. We perform ablation experiments on the features used by our model and show that fundamental frequency variation is the single most relevant feature class. Therefore, we conclude that future systems can detect whether they are addressed based only on speech prosody which does not (or only to a very limited extent) reveal the content of conversations not intended for the system. KW - addressee detection KW - complexity-identical human-computer interaction KW - computational paralinguistics KW - fundamental frequency variation KW - recurrent neural network Y1 - 2020 SN - 9781450375405 U6 - https://doi.org/10.1145/3404983.3410021 SP - 195 EP - 198 PB - Association for Computing Machinery CY - New York, NY, United States ER - TY - CHAP A1 - Bittner, Peter A1 - Hornecker, Eva A1 - Twisselmann, Ute A1 - Weber, Karsten ED - Dittrich, Klaus T1 - Die berufliche Situation informatisch Handelnder in der ethischen Reflexion T2 - Informatik 2003 - Innovative Informatikanwendungen, Band 2 der Beiträge der 33. Jahrestagung der Gesellschaft für Informatik e.V. (GI), 29. September - 2. Oktober 2003 in Frankfurt am Main N2 - Ausgehend von einer Betrachtung des Einflusses von InformatikerInnen und ihren Handlungsmustern auf Arbeitsprozesse und vor dem Hintergrund einer kritischen Auseinandersetzung mit bisherigen berufsethischen Leitlinien wollen wir einen neuen Ansatz wagen, über Informatik und Verantwortung nachzudenken. Eine Rekonstruktion des Begriffs Verantwortung bietet uns ein reichhaltiges begriffliches Instrumentarium zur Reflexion des Verhältnisses von Verantwortung und informatischer Praxis. Wir plädieren dafür, dass informatisch Handelnde lernen müssen, ethische Probleme zu erkennen, implizite Annahmen von Arbeitskulturen zu durchschauen und ein Bewusstsein für die Veränderbarkeit dieser Arbeitskulturen entwickeln sollten. Zusätzlich bedarf es kollektiver und rechtlicher Veränderungen der Rahmenbedingungen für verantwortliches Handeln. Y1 - 2003 UR - https://dl.gi.de/handle/20.500.12116/29680 SP - 176 EP - 181 ER - TY - CHAP A1 - Deubzer, Michael A1 - Hobelsberger, Martin A1 - Mottok, Jürgen A1 - Schiller, Frank A1 - Dumke, Reiner A1 - Siegle, Markus A1 - Margull, Ulrich A1 - Niemetz, Michael A1 - Wirrer, Gerhard T1 - Modeling and Simulation of Embedded Real-Time Multi-Core Systems T2 - Proceedings of the 3rd Embedded Software Engineering Congress, 7. bis 9. Dezember 2010, Sindelfingen KW - Real-Time Systems KW - Multicore KW - Model-Driven Development KW - Architecture Description Language KW - Simulation Y1 - 2010 UR - https://www.unibw.de/technische-informatik/mitarbeiter/professoren/siegle/publikationen/ese2010_muco_modsim.pdf ER - TY - CHAP A1 - Westner, Markus T1 - Antecedents of success in IS offshoring projects BT - Proposal for an empirical research study T2 - Proceedings of the 17th European Conference on Information Systems (ECIS 2009), Verona N2 - The paper presents a research model and a measurement instrument for a research-in-progress study on the antecedents of success in IS offshoring projects. In this empirical-confirmatory study, we intend to analyse the impact of the constructs “offshoring expertise”, “trust in offshore service provider”, “project suitability”, “knowledge transfer”, and “liaison quality” on offshore project success. Constructs and indicators are derived from an extensive literature review. We plan to formulate a structural equation model and to test it using partial least squares (PLS) as an analysis technique. Our research model addresses the paucity of research that quantitatively examines offshoring success. KW - Informationstechnik KW - Offshoring KW - Methode der partiellen kleinsten Quadrate KW - Offshoring KW - Outsourcing KW - Project success KW - Partial least squares Y1 - 2009 UR - https://aisel.aisnet.org/cgi/viewcontent.cgi?article=1272&context=ecis2009 SP - 3104 EP - 3116 ER - TY - CHAP A1 - Westner, Markus A1 - Strahringer, Susanne T1 - Current state of IS offshoring research BT - A descriptive meta-analysis T2 - Mäkiö, Juho; Betz, Stefanie; Stephan, Rolf (Eds.): Offshoring of software development. Methods and tools for risk management. Karlsruhe: Universitätsverlag Karlsruhe N2 - This paper empirically examines the current state of the IS offshoring phenomenon in Germany regarding project characteristics and success patterns. Relying on a sample of 304 projects conducted at various industry sectors and companies, results show that IS offshoring primarily occurs in sectors Telecommunications and IT at large corporations. Cost reduction is the main reason for going offshore and offshore projects are executed as part of a larger program at companies. Noticeably, most projects are delivered from India. Additionally, neither captive offshoring nor offshore outsourcing dominates as a de-livery option. Comparing different project subgroups regarding project success, the results reveal that projects delivered by an internal or partially owned service provider are more successful. Other project characteristics such as a project’s embedded-ness in a larger offshoring program, a project’s size, or a project’s offshoring degree in terms of relatively offshored labor hours show few significant differences. The paper addresses the paucity of empirical research on the current state of the IS offshoring phenomenon in Germany. KW - Informationsmanagement KW - Offshoring KW - Erfolgsfaktor KW - Offshoring KW - Nearshoring KW - Informations systems sourcing KW - Outcome KW - Project success KW - Success factors Y1 - 2007 UR - http://jitm.ubalt.edu/XXI-1/article4.pdf SP - 7 EP - 22 ER - TY - CHAP A1 - Weber, Karsten ED - Dittrich, Klaus T1 - Ethische Leitlinien: inhaltlich oder prozedural? T2 - Informatik 2003 - Innovative Informatikanwendungen, Band 2 der Beiträge der 33. Jahrestagung der Gesellschaft für Informatik e.V. (GI), 29. September - 2. Oktober 2003 in Frankfurt am Main N2 - Der neue Entwurf der ethischen Leitlinien nimmt in der Präambel Bezug auf die Allgemeine Erklärung der Menschenrechte der Vereinten Nationen; außerdem wird mit Artikel 11 die soziale Verantwortung von Informatikerinnen und Informatikern inhaltlich ausformuliert. Infrage steht nun, ob die Explizierung solcher moralischer Forderungen in den ethischen Leitlinien akzeptabel ist oder ob damit nicht deren Möglichkeiten überdehnt werden. Anders ausgedrückt: Sollen die ethischen Leitlinien rein prozedural ausgerichtet sein oder stattdessen konkrete Zielvorgaben formuliert werden? Um diese Frage zu beantworten, werden zunächst die genannten Alternativen der Formulierung dargestellt. Dem folgt eine kritische Auseinandersetzung mit dem neuen Artikel 11 und dem Bezug auf die Allgemeine Erklärung der Menschenrechte. Zuletzt werden Gründe und Bedingungen für die Akzeptabilität dieser und gegen eine Aufnahme weitergehender moralischer Forderungen genannt. Y1 - 2003 UR - https://dl.gi.de/handle/20.500.12116/29682 SP - 188 EP - 193 PB - Gesellschaft für Informatik e.V. CY - Bonn ER - TY - CHAP A1 - Galibarov, Pavel E. A1 - Al-Munajjed, Amir Andreas A1 - Dendorfer, Sebastian A1 - Christensen, Soeren Toerholm A1 - Rasmussen, John T1 - The effect of varying the stiffness of spinal fusion devices on the adjacent levels using multibody dynamics simulation T2 - Orthopaedic Proceedings N2 - INTRODUCTION Several clinical studies demonstrated long-term adjacent-level effects after implantation of spinal fusion devices[1]. These effects have been reported as adjacent joint degeneration and the development of new symptoms correlating with adjacent segment degeneration[2] and the trend has therefore gone to motion preservation devices; however, these effects have not been understood very well and have not been investigated thoroughly[3]. The aim of this study is to investigate the effect of varying the stiffness of spinal fusion devices on the adjacent vertebral levels. Disc forces, moments and facet joint forces were analyzed. METHODS The AnyBody Modeling System was used to compute the in-vivo muscle and joint reaction forces of a musculoskeletal model. The full body model used in this study consists of 188 muscle fascicles in the lumbar spine and more than 1000 individual muscle branches in total. The model has been proposed by de Zee et al.[3], validated by Rasmussen et al.[4] and by Galibarov et al.[5]. The new model[5] determines the individual motions between vertebrae based on the equilibrium between forces acting on the vertebrae from muscles and joints and the passive stiffness in disks and ligaments, figure 1a. An adult of 1.75 m and 75 kg with a spinal implant in L4L5 was modeled. This model was subjected to a flexion-extension motion using different elastic moduli to analyze and compare to a non-implanted scenario. The analyzed variables were vertebral motion, the disc reaction forces and moments, as well as facet joint forces in the treated and the adjacent levels: L2L3, L3L4, L4L5 and L5-Sacrum. RESULTS When introducing a spinal fusion device in the L4L5 joint the reaction forces and moments decreased in this joint with stiffer devices leading to lower joint loads. However, in the adjacent joints, L3L4 and L5Sacrum, an increase was observed when implanting stiffer devices. Similar trends could be found for the L2L3 joint. The loads in the facet joints showed the same trends. While introducing a spinal fusion device reduced the facet joint forces in the treated joint, the loads in the adjacent facet joints were increased according to the stiffness of the implanted device, figure 1b. DISCUSSION While the treated disc joint showed reduced motion and loads, the adjacent levels demonstrated a significant increase. In particular, the increased facet joint forces in the adjacent levels can lead to adjacent level facet pain or accelerated facet joint degeneration. Introducing a device resulted in preventing facet contact and therefore facet joint loads, even using the device with the lowest stiffness. CONCLUSION The presented model shows that clinical complications such as facet joint degeneration in adjacent levels after implantation of spinal fusion device are consistent with the change in the mechanical-stimulus distribution in the system. Y1 - 2011 VL - 94-B IS - SUPP_XL01 Sep 2012 SP - 2 ER - TY - CHAP A1 - Galibarov, Pavel E. A1 - Dendorfer, Sebastian A1 - Christensen, Soeren Toerholm T1 - On modelling spine curvature dependent on muscular and external forces in multibody dynamics system T2 - International Society of Biomechanics (ISB), 13th congress, 2011, Brussels, Belgium N2 - This paper presents a computational approach for investigating effect of muscular and external forces on curvature of the lumbar spine. Multibody dynamics system is used to compute the lumbar spine curvature using a force-dependent kinematics facility, e.g. this method allows releasing some degrees of freedom in order to be computed based on the current load configuration. Y1 - 2011 UR - https://paperpile.com/shared/63VCBY/download/2608c6d1-adef-0330-86f8-7996e623c627 SP - 2 ER - TY - CHAP A1 - Rasmussen, John A1 - Bichler, R. A1 - Christensen, Soeren Toerholm A1 - Wirix-Speetjens, Roel A1 - Dendorfer, Sebastian A1 - Renkawitz, Tobias T1 - Subject-specific Musculoskeletal Simulation of Hip Dislocation Risk in Activities of Daily Living T2 - Proceedings of the 2011 ORS Annual Meeting, Long Beach, CA. Y1 - 2011 UR - http://www.ors.org/Transactions/57/0306.pdf IS - Paper No. 306 ER -