TY - CHAP A1 - Maier, Johannes A1 - Haug, Sonja A1 - Huber, Michaela A1 - Katzky, Uwe A1 - Neumann, Sabine A1 - Perret, Jérôme A1 - Prinzen, Martin A1 - Weber, Karsten A1 - Wittenberg, Thomas A1 - Wöhl, Rebecca A1 - Scorna, Ulrike A1 - Palm, Christoph T1 - Development of a haptic and visual assisted training simulation concept for complex bone drilling in minimally invasive hand surgery T2 - CARS Conference, 5.10.-7.10.2017 Y1 - 2017 ER - TY - CHAP A1 - Kranz, Michael A1 - Pointner, Daniel A1 - Wagner, Maria Stella A1 - Lubnow, Matthias A1 - Lehle, Karla A1 - Krenkel, Lars ED - Dillmann, Andreas ED - Heller, Gerd ED - Krämer, Ewald ED - Breitsamter, Christian ED - Wagner, Claus ED - Krenkel, Lars T1 - High-Resolution Flow Investigations in Membrane-Lungs for Understanding Shear-Induced Blood Clot Formation T2 - New Results in Numerical and Experimental Fluid Mechanics XV : Contributions to the 24th STAB/DGLR Symposium, Regensburg, Germany, 2024 N2 - Complex blood flow phenomena in membrane lungs (MLs) play a crucial role in intra-device clot formation and the occurrence of thromboembolic events. At present, however, the local flow conditions within an ML are not yet sufficiently known. The aim was to gain a deeper understanding of local flow regimes inside MLs by performing highly resolved computational fluid dynamics (CFD) of generic and native fiber mat bundles. Straight cylinders with a diameter of 380 μm in parallel arrangement were the foundation of the generic model. For validation, a method for reconstructing a native geometry from a microcomputed tomography (μCT) scan was established, with both models used for CFD. While the generic model showed a symmetrical flow regime without indicating any pathological flow, the native model did show an irregular fiber arrangement and no symmetrical flow regime. In conclusion, the fiber arrangement significantly affects the local flow regimes inside MLs. KW - CFD KW - ECMO KW - membrane lung KW - ML KW - µCT Y1 - 2026 U6 - https://doi.org/10.1007/978-3-032-11115-9_12 SP - 125 EP - 134 PB - Springer CY - Cham ER - TY - CHAP A1 - Michel, Johanna A1 - Krenkel, Lars ED - Dillmann, Andreas ED - Heller, Gerd ED - Krämer, Ewald ED - Breitsamter, Christian ED - Wagner, Claus ED - Krenkel, Lars T1 - Towards Experimental Validation of Models of Shear-Induced Aerosol Generation in the Human Respiratory System T2 - New Results in Numerical and Experimental Fluid Mechanics XV : Contributions to the 24th STAB/DGLR Symposium, Regensburg, Germany, 2024 N2 - Numerical modeling is a valuable tool to research shear-induced aerosol generation inside the human respiratory system. While the volume of fluid method and Eulerian wall film models have been used to predict the stripping of particles from the mucus film, sufficient validation data is lacking. Here, we present an experimental method to create such validation data. A film of mucus mimetic hydrogel with an initial thickness of 1 mm covering the floor of a rectangular channel (75.5 mm 25.5 mm 3 mm) was exposed to an airflow with a flow rate of 9.5 and 21.6 L/min. The number of created particles and the emergence of waves on the mucus surface were measured. Shear-induced aerosol generation was triggered successfully and caused an increase of mean particle flow. Different wave profiles were observed at varying film depths. Y1 - 2026 SN - 978-3-032-11114-2 U6 - https://doi.org/10.1007/978-3-032-11115-9_13 SP - 135 EP - 144 PB - Springer Nature CY - Cham ER -