TY - CHAP A1 - Scholz, Alexander-Wigbert K. A1 - Krenkel, Lars A1 - Terekhov, Maxim A1 - Friedrich, Janet A1 - Rivoire, Julien A1 - Köbrich, Rainer A1 - Wolf, Ursula A1 - Kalthoff, Daniel A1 - David, Matthias A1 - Wagner, Claus A1 - Schreiber, Laura Maria ED - Hirschel, Ernst Heinrich ED - Schröder, Wolfgang ED - Fujii, Kozo ED - Haase, Werner ED - Leer, Bram ED - Leschziner, Michael A. ED - Pandolfi, Maurizio ED - Periaux, Jacques ED - Rizzi, Arthur ED - Roux, Bernard ED - Shokin, Yurii I. ED - Klaas, Michael ED - Koch, Edmund ED - Schröder, Wolfgang T1 - Magnetic Resonance Imaging and Computational Fluid Dynamics of High Frequency Oscillatory Ventilation (HFOV) T2 - Fundamental Medical and Engineering Investigations on Protective Artificial Respiration N2 - In order to better understand the mechanisms of gas transport during High Frequency Oscillatory Ventilation (HFOV) Magnetic Resonance Imaging (MRI) with contrast gases and numerical flow simulations based on Computational Fluid Dynamics(CFD) methods are performed. Validation of these new techniques is conducted by comparing the results obtained with simplified models of the trachea and a first lung bifurcation as well as in a cast model of the upper central airways with results achieved from conventional fluid mechanical measurement techniques like e.g. Laser Doppler Anemometry (LDA). Further it is demonstrated that MRI of experimental HFOV is feasible and that Hyperpolarized 3He allows for imaging the gas re-distribution inside the lung. Finally, numerical results of oscillatory flow in a 3rd generation model of the lung as well as the impact of endotracheal tubes on the flow regime development in a trachea model are presented. KW - Central Airway KW - computational fluid dynamics KW - Computational Fluid Dynamics Simulation KW - Laser Doppler Anemometry KW - Magnetic Resonance Imaging Measurement Y1 - 2011 SN - 978-3-642-20325-1 U6 - https://doi.org/10.1007/978-3-642-20326-8_7 VL - 116 SP - 107 EP - 128 PB - Springer CY - Berlin, Heidelberg ER -