TY - JOUR A1 - Beimler, Josef A1 - Leißl, Caroline A1 - Ebner, Lena A1 - Elsner, Michael A1 - Mühlbauer, Gerhard A1 - Kohlert, Dieter A1 - Schubert, Martin J. W. A1 - Weiß, Andreas P. A1 - Sterner, Michael A1 - Raith, Thomas A1 - Afranseder, Martin A1 - Krapf, Tobias A1 - Mottok, Jürgen A1 - Siemers, Christian A1 - Großmann, Benjamin A1 - Höcherl, Johannes A1 - Schlegl, Thomas A1 - Schneider, Ralph A1 - Milaev, Johannes A1 - Rampelt, Christina A1 - Roduner, Christian A1 - Glowa, Christoph A1 - Bachl, Christoph A1 - Schliekmann, Claus A1 - Gnan, Alfons A1 - Grill, Martin A1 - Ruhland, Karl A1 - Piehler, Thomas A1 - Friers, Daniel A1 - Wels, Harald A1 - Pflug, Kenny A1 - Kucera, Markus A1 - Waas, Thomas A1 - Schlachetzki, Felix A1 - Boy, Sandra A1 - Pemmerl, Josef A1 - Leis, Alexander A1 - Welsch, Andreas F.X. A1 - Graf, Franz A1 - Zenger, Gerhard A1 - Volbert, Klaus A1 - Waas, Thomas A1 - Scherzinger, Stefanie A1 - Klettke, Meike A1 - Störl, Uta A1 - Heyl, C. A1 - Boldenko, A. A1 - Monkman, Gareth J. A1 - Kujat, Richard A1 - Briem, Ulrich A1 - Hierl, Stefan A1 - Talbot, Sebastian A1 - Schmailzl, Anton A1 - Ławrowski, Robert Damian A1 - Prommesberger, Christian A1 - Langer, Christoph A1 - Dams, Florian A1 - Schreiner, Rupert A1 - Valentino, Piergiorgio A1 - Romano, Marco A1 - Ehrlich, Ingo A1 - Furgiuele, Franco A1 - Gebbeken, Norbert A1 - Eisenried, Michael A1 - Jungbauer, Bastian A1 - Hutterer, Albert A1 - Bauhuber, Michael A1 - Mikrievskij, Andreas A1 - Argauer, Monika A1 - Hummel, Helmut A1 - Lechner, Alfred A1 - Liebetruth, Thomas A1 - Schumm, Michael A1 - Joseph, Saskia A1 - Reschke, Michael A1 - Soska, Alexander A1 - Schroll-Decker, Irmgard A1 - Putzer, Michael A1 - Rasmussen, John A1 - Dendorfer, Sebastian A1 - Weber, Tim A1 - Al-Munajjed, Amir Andreas A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias A1 - Haug, Sonja A1 - Rudolph, Clarissa A1 - Zeitler, Annika A1 - Schaubeck, Simon A1 - Steffens, Oliver A1 - Rechenauer, Christian A1 - Schulz-Brize, Thekla A1 - Fleischmann, Florian A1 - Kusterle, Wolfgang A1 - Beer, Anne A1 - Wagner, Bernd A1 - Neidhart, Thomas ED - Baier, Wolfgang T1 - Forschungsbericht 2013 T3 - Forschungsberichte der OTH Regensburg - 2013 Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-7990 CY - Regensburg ER - TY - JOUR A1 - Renkawitz, Tobias A1 - Weber, Tim A. A1 - Dullien, Silvia A1 - Woerner, Michael A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Weber, Markus T1 - Leg length and offset differences above 5 mm after total hip arthroplasty are associated with altered gait kinematics JF - Gait & Posture N2 - We aimed to investigate the relationship between postoperative leg length/offset (LL/OS) reconstruction and gait performance after total hip arthroplasty (THA). In the course of a prospective randomized controlled trial, 60 patients with unilateral hip arthrosis received cementless THA through a minimally-invasive anterolateral surgical approach. One year post-operatively, LL and global OS restoration were analyzed and compared to the contralateral hip on AP pelvic radiographs. The combined postoperative limb length/OS reconstruction of the operated hip was categorized as restored (within 5 mm) or non-restored (more than 5 mm reduction or more than 5 mm increment). The acetabular component inclination, anteversion and femoral component anteversion were evaluated using CT scans of the pelvis and the femur. 3D gait analysis of the lower extremity and patient related outcome measures (HHS, HOOS, EQ-5D) were obtained pre-operatively, six months and twelve months post-operatively by an observer blinded to radiographic results. Component position of cup and stem was comparable between the restored and non-restored group. Combined LL and OS restoration within 5 mm resulted in higher Froude number (p < 0.001), normalized walking speed (p < 0.001) and hip range-of-motion (ROM) (p = 0.004) during gait twelve months postoperatively, whereas gait symmetry was comparable regardless of LL and OS reconstruction at both examinations. Clinical scores did not show any relevant association between the accuracy of LL or OS reconstruction and gait six/twelve months after THA. In summary, postoperative LL/OS discrepancies larger than 5 mm relate to unphysiological gait kinematics within the first year after THA. DRKS00000739, German Clinical Trials Register. KW - THA KW - Leg length KW - Offset KW - Gait analysis KW - Biomechanics Y1 - 2016 U6 - https://doi.org/10.1016/j.gaitpost.2016.07.011 VL - vol. 49 SP - 196 EP - 201 ER - TY - JOUR A1 - Renkawitz, Tobias A1 - Weber, Markus A1 - Springorum, H.-R. A1 - Sendtner, E. A1 - Woerner, Michael A1 - Ulm, K. A1 - Weber, Tim A1 - Grifka, Joachim T1 - Impingement-free range of motion, cup coverage and early clinical results between femur first navigation and conventional total hip arthroplasty: a randomised controlled trial JF - Journal of Bone & Joint Surgery N2 - We report the kinematic and early clinical results of a patient- and observer-blinded randomised controlled trial in which CT scans were used to compare potential impingement-free range of movement (ROM) and acetabular component cover between patients treated with either the navigated 'femur-first' total hip arthroplasty (THA) method (n = 66; male/female 29/37, mean age 62.5 years; 50 to 74) or conventional THA (n = 69; male/female 35/34, mean age 62.9 years; 50 to 75). The Hip Osteoarthritis Outcome Score, the Harris hip score, the Euro-Qol-5D and the Mancuso THA patient expectations score were assessed at six weeks, six months and one year after surgery. A total of 48 of the patients (84%) in the navigated 'femur-first' group and 43 (65%) in the conventional group reached all the desirable potential ROM boundaries without prosthetic impingement for activities of daily living (ADL) in flexion, extension, abduction, adduction and rotation (p = 0.016). Acetabular component cover and surface contact with the host bone were > 87% in both groups. There was a significant difference between the navigated and the conventional groups' Harris hip scores six weeks after surgery (p = 0.010). There were no significant differences with respect to any clinical outcome at six months and one year of follow-up. The navigated 'femur-first' technique improves the potential ROM for ADL without prosthetic impingement, although there was no observed clinical difference between the two treatment groups. KW - combined anteversion KW - computer-assisted orthopaedic surgery KW - THA KW - Hüftgelenkprothese KW - Operationstechnik KW - Computerunterstütztes Verfahren KW - Beweglichkeit Y1 - 2015 U6 - https://doi.org/10.1302/0301-620X.97B7.34729 VL - 97-B SP - 890 EP - 898 ER - TY - JOUR A1 - Weber, Markus A1 - Weber, Tim A. A1 - Woerner, Michael A1 - Craiovan, Benjamin A1 - Worlicek, Michael A1 - Winkler, Sebastian A1 - Grifka, Joachim A1 - Renkawitz, Tobias T1 - The impact of standard combined anteversion definitions on gait and clinical outcome within one year after total hip arthroplasty JF - International Orthopaedics N2 - Different target areas within the concept of combined cup and stem anteversion have been published for total hip arthroplasty (THA). We asked whether component positioning according to eight standard combined anteversion rules is associated with (1) more physiological gait patterns, (2) higher improvement of gait variables and (3) better clinical outcome after THA.In a prospective clinical study, 60 patients received cementless THA through an anterolateral MIS approach in a lateral decubitus position. Six weeks postoperatively, implant position was analysed using 3D-CT by an independent external institute. Preoperatively, six and 12 months postoperatively range of motion, normalized walking speed and hip flexion symmetry index were measured using 3D motion-capture gait analysis. Patient-related outcome measures (HHS, HOOS, EQ-5D) were obtained by an observer blinded to 3D-CT results. Eight combined anteversion definitions and Lewinnek's "safe zone" were evaluated regarding their impact on gait patterns and clinical outcome.Combined cup and stem anteversion according to standard combined anteversion definitions as well as cup placement within Lewinnek's "safe zone" did not influence range of motion, normalized walking speed and/or hip flexion symmetry index six and 12 months after THA. Similarly, increase of gait parameters within the first year after THA was comparable between all eight combined anteversion rules. Clinical outcome measures like HHS, HOOS and EQ-5D did not show any benefit for either of the combined anteversion definitions.Standard combined cup and stem anteversion rules do not improve postoperative outcome as measured by gait analysis and clinical scores within one year after THA. KW - Total hip athroplasty KW - Combined anteversion KW - Outcome KW - Gait analysis KW - Hüftgelenkprothese KW - Bewegungsanalyse KW - Gehen KW - Funktionelle Anatomie Y1 - 2015 U6 - https://doi.org/10.1007/s00264-015-2777-8 VL - 39 IS - 12 SP - 2323 EP - 2333 ER - TY - CHAP A1 - Weber, Tim A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Weber, Markus A1 - Wörner, Michael A1 - Dullien, Silvia A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias T1 - Verbessert die computerassistierte Femur First Operationstechnik für die Hüftendoprothetik den muskuloskelettalen Lastfall auf das Hüftgelenk? T2 - DKOU 2015, Deutscher Kongress für Orthopädie und Unfallchirurgie 2015 Y1 - 2015 UR - https://www.researchgate.net/publication/283259007_Verbessert_die_computerassistierte_Femur_First_Operationstechnik_fur_die_Huftendoprothetik_den_muskuloskelettalen_Lastfall_auf_das_Huftgelenk ER - TY - JOUR A1 - Völlner, Florian A1 - Weber, Tim A. A1 - Weber, Markus A1 - Renkawitz, Tobias A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Craiovan, Benjamin T1 - A simple method for determining ligament stiffness during total knee arthroplasty in vivo JF - Scientific Reports N2 - A key requirement in both native knee joints and total knee arthroplasty is a stable capsular ligament complex. However, knee stability is highly individual and ranges from clinically loose to tight. So far, hardly any in vivo data on the intrinsic mechanical of the knee are available. This study investigated if stiffness of the native ligament complex may be determined in vivo using a standard knee balancer. Measurements were obtained with a commercially available knee balancer, which was initially calibrated in vitro. 5 patients underwent reconstruction of the force-displacement curves of the ligament complex. Stiffness of the medial and lateral compartments were calculated to measure the stability of the capsular ligament complex. All force-displacement curves consisted of a non-linear section at the beginning and of a linear section from about 80 N onwards. The medial compartment showed values of 28.4 ± 1.2 N/mm for minimum stiffness and of 39.9 ± 1.1 N/mm for maximum stiffness; the respective values for the lateral compartment were 19.9 ± 0.9 N/mm and 46.6 ± 0.8 N/mm. A commercially available knee balancer may be calibrated for measuring stiffness of knee ligament complex in vivo, which may contribute to a better understanding of the intrinsic mechanical behaviour of knee joints. KW - Biomechanische Analyse KW - Kniegelenkband KW - Steifigkeit Y1 - 2019 U6 - https://doi.org/10.1038/s41598-019-41732-x VL - 9 SP - 1 EP - 8 PB - Nature ER - TY - JOUR A1 - Mauerer, Wolfgang A1 - Rexhepaj, Tanja A1 - Monkman, Gareth J. A1 - Sindersberger, Dirk A1 - Diermeier, Andreas A1 - Neidhart, Thomas A1 - Wolfrum, Dominik A1 - Sterner, Michael A1 - Heberl, Michael A1 - Nusko, Robert A1 - Maier, Georg A1 - Nagl, Klaus A1 - Reuter, Monika A1 - Hofrichter, Andreas A1 - Lex, Thomas A1 - Lesch, Florian A1 - Kieninger, Bärbel A1 - Szalo, Alexander Eduard A1 - Zehner, Alexander A1 - Palm, Christoph A1 - Joblin, Mitchell A1 - Apel, Sven A1 - Ramsauer, Ralf A1 - Lohmann, Daniel A1 - Westner, Markus A1 - Strasser, Artur A1 - Munndi, Maximilian A1 - Ebner, Lena A1 - Elsner, Michael A1 - Weiß, Nils A1 - Segerer, Matthias A1 - Hackenberg, Rudolf A1 - Steger, Sebastian A1 - Schmailzl, Anton A1 - Dostalek, Michael A1 - Armbruster, Dominik A1 - Koch, Fabian A1 - Hierl, Stefan A1 - Thumann, Philipp A1 - Swidergal, Krzysztof A1 - Wagner, Marcus A1 - Briem, Ulrich A1 - Diermeier, Andreas A1 - Spreitzer, Stefan A1 - Beiderbeck, Sabrina A1 - Hook, Christian A1 - Zobel, Martin A1 - Weber, Tim A1 - Groß, Simon A1 - Penzkofer, Rainer A1 - Dendorfer, Sebastian A1 - Schillitz, Ingo A1 - Bauer, Thomas A1 - Rudolph, Clarissa A1 - Schmidt, Katja A1 - Liebetruth, Thomas A1 - Hamer, Markus A1 - Haug, Sonja A1 - Vernim, Matthias A1 - Weber, Karsten A1 - Saßmannshausen, Sean Patrick A1 - Books, Sebastian A1 - Neuleitner, Nikolaus A1 - Rechenauer, Christian A1 - Steffens, Oliver A1 - Kusterle, Wolfgang A1 - Gömmel, Roland A1 - Wellnitz, Felix A1 - Stierstorfer, Johannes A1 - Stadler, Dominik A1 - Hofmann, Matthias J. A1 - Motschmann, Hubert A1 - Shamonin (Chamonine), Mikhail A1 - Bleicher, Veronika A1 - Fischer, Sebastian A1 - Hackenberg, Rudolf A1 - Horn, Anton A1 - Kawasch, Raphael A1 - Petzenhauser, Michael A1 - Probst, Tobias A1 - Udalzow, Anton A1 - Dams, Florian A1 - Schreiner, Rupert A1 - Langer, Christoph A1 - Prommesberger, Christian A1 - Ławrowski, Robert Damian ED - Baier, Wolfgang T1 - Forschungsbericht 2016 T3 - Forschungsberichte der OTH Regensburg - 2016 Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-13840 CY - Regensburg ER - TY - JOUR A1 - Weber, Tim A. A1 - Dendorfer, Sebastian A1 - Bulstra, Sjoerd K. A1 - Grifka, Joachim A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias T1 - Gait six month and one-year after computer assisted Femur First THR vs. conventional THR. Results of a patient- and observer- blinded randomized controlled trial JF - Gait & Posture N2 - A prospective randomized controlled trial is presented that is used to compare gait performance between the computer assisted Femur First (CAS FF) operation method and conventional THR (CON). 60 patients underwent a 3D gait analysis of the lower extremity at pre-operative, 6 months post-operative and twelve months post-operative. Detailed verification experiments were facilitated to ensure the quality of data as well as to avoid over-interpreting of the data. The results confirm a similar data-quality as reported in the literature. Walking speed, range of motion and symmetry thereof improved over the follow-up period, without significant differences between the groups. While all parameters do significantly increase over the follow-up period for both groups, there were no significant differences between them at any given time-point. Patients undergoing CAS FF showed a trend to improved hip flexion angle indicating a possible long-term benefit. KW - Biomechanics KW - Combined anteversion KW - Computer-assisted surgery KW - Femur first KW - Gait analysis Y1 - 2016 U6 - https://doi.org/10.1016/j.gaitpost.2016.06.035 VL - vol. 49 SP - 418 EP - 425 ER - TY - VIDEO A1 - Auer, Simon A1 - Reinker, Lukas A1 - Süß, Franz A1 - Kubowitsch, Simone A1 - Krutsch, Werner A1 - Weber, Markus A1 - Renkawitz, Tobias A1 - Dendorfer, Sebastian T1 - Webcast: Effect of mental demand on leg loading in highly dynamic motion N2 - Football players have a high risk of leg muscle injuries, especially when exposed to mental stress. Injuries to muscles of the thigh are common in amateur and professional football, representing almost a third of all injuries. These injuries occur primarily in non-contact situations and from overuse. They can lead to a range of costs, including financial costs associated with treatment as well as those associated with long-term recovery, and absence from training and/or competition. Further, there is a high risk of injury recurrence and subsequent injury. KW - Webcast KW - AnyBody KW - Stress KW - Football KW - Speedcourt Y1 - 2020 UR - https://www.youtube.com/watch?v=uSc_9XlnkaA ER - TY - JOUR A1 - Weber, Markus A1 - Merle, Christian A1 - Nawabi, Danyal H. A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Renkawitz, Tobias T1 - Inaccurate offset restoration in total hip arthroplasty results in reduced range of motion JF - Scientific Reports N2 - Offset restoration in total hip arthroplasty (THA) is associated with postoperative range of motion (ROM) and gait kinematics. We aimed to research into the impact of high offset (HO) and standard stems on postoperative ROM. 121 patients received cementless THA through a minimally-invasive anterolateral approach. A 360° hip ROM analysis software calculated impingement-free hip movement based on postoperative 3D-CTs compared to ROM values necessary for activities of daily living (ADL). The same model was then run a second time after changing the stem geometry between standard and HO configuration with the implants in the same position. HO stems showed higher ROM for all directions between 4.6 and 8.9° (p < 0.001) compared with standard stems but with high interindividual variability. In the subgroup with HO stems for intraoperative offset restoration, the increase in ROM was even higher for all ROM directions with values between 6.1 and 14.4° (p < 0.001) compared to offset underrestoration with standard stems. Avoiding offset underrestoration resulted in a higher amount of patients of over 20% for each ROM direction that fulfilled the criteria for ADL (p < 0.001). In contrast, in patients with standard stems for offset restoration ROM did increase but not clinically relevant by offset overcorrection for all directions between 3.1 and 6.1° (p < 0.001). Offset overcorrection by replacing standard with HO stems improved ROM for ADL in a low number of patients below 10% (p > 0.03). Patient-individual restoration of offset is crucial for free ROM in THA. Both over and underrestoration of offset should be avoided. KW - Adaptive clinical trial KW - Bone imaging Y1 - 2020 U6 - https://doi.org/10.1038/s41598-020-70059-1 VL - 10 IS - 13208 SP - 9 PB - Nature ER - TY - JOUR A1 - Erb, Wolfgang A1 - Weinmann, Andreas A1 - Ahlborg, Mandy A1 - Brandt, Christina A1 - Bringout, Gael A1 - Buzug, Thorsten M. A1 - Frikel, Jürgen A1 - Kaethner, C. A1 - Knopp, Tobias A1 - März, T. A1 - Moddel, Martin A1 - Storath, Martin A1 - Weber, A. T1 - Mathematical analysis of the 1D model and reconstruction schemes for magnetic particle imaging JF - Inverse Problems N2 - Magnetic particle imaging (MPI) is a promising new in vivo medical imaging modality in which distributions of super-paramagnetic nanoparticles are tracked based on their response in an applied magnetic field. In this paper we provide a mathematical analysis of the modeled MPI operator in the univariate situation. We provide a Hilbert space setup, in which the MPI operator is decomposed into simple building blocks and in which these building blocks are analyzed with respect to their mathematical properties. In turn, we obtain an analysis of the MPI forward operator and, in particular, of its ill-posedness properties. We further get that the singular values of the MPI core operator decrease exponentially. We complement our analytic results by some numerical studies which, in particular, suggest a rapid decay of the singular values of the MPI operator. KW - FORMULATION KW - ill-posedness KW - INTERPOLATION KW - inverse problems KW - magnetic particle imaging KW - model-based reconstruction KW - MPI KW - NODES KW - reconstruction operator KW - RELAXATION KW - RESOLUTION Y1 - 2018 U6 - https://doi.org/10.1088/1361-6420/aab8d1 VL - 34 IS - 5 PB - IOP Publishing ER - TY - CHAP A1 - Weber, Tim A. A1 - Dendorfer, Sebastian A1 - Dullien, Silvia A1 - Grifka, Joachim A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias T1 - Measuring functional outcome after total hip replacement with subject-specific hip joint loading T2 - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine N2 - Total hip replacement is an often-performed orthopedic surgical procedure; the amount of procedures undertaken will increase since our life expectancy is growing. In order to optimize function, hip biomechanics should be restored to as near normal as possible. The goal of this pilot study was to determine whether or not it is feasible to compute the vectorial hip reaction force pathways on the head of the prosthesis and the force angles relative to the cup of the prosthesis that occur during gait in total hip replacement patients, serving as an objective measurement of the functional outcome following hip replacement. A three-dimensional gait analysis, measuring ground reaction forces and kinematics, was performed. The data retrieved from the gait analysis was used as the input for the musculoskeletal model to compute vectorial joint reaction forces for data processing. To evaluate the position and orientation of the joint reaction forces, the force path, as well as the force angles for the operated and non-operated joint, has been calculated during the stance phase of the specific leg. The force path for subject 2 on the non-operated side is only located in the posterior-lateral quarter, as is the force path for subject 1. In contrast to this subject, the force path for subject 2 at the operated hip joint can be found only within the anterior quarter of the head of the implant, where it is nearly equally distributed in the medio-lateral half of the prosthesis head. The force-inclination angles on the cup of subject 1, with respect to the plane of the socket face, indicates that the force vector is mainly positioned in the same quadrant when compared with subject 2 (in a cup-fixed coordinate system). The force-anteversion angle behaves similarly to the force-inclination angle, even when the effects are not as pronounced. The proposed methods in this article are aiming to define two functional outcomes of total hip replacement that are related to wear and rim loading. It is accepted that wear is not only a function of time, but a function of use. Owing to the methods listed in this article, we are able to determine a) the applied force and b) the sliding distance (force pathway) in a subject-specific manner. The computed hip-reaction force angles and the distance to the rim cup are a measurement for cup or rim loading, and occurs in the so-called safe-zones. This method may well give us insight into the biomechanical situation during gait, after receiving total hip replacement, that we need to fully understand the mechanisms acting on a hip joint and to prove a possible increase of functional outcome after receiving total hip replacement. KW - total hip replacement KW - subject-specific musculoskeletal modeling KW - functional outcome KW - force pathways KW - force angles KW - critical hip joint loading KW - rim loading KW - cup loading KW - Hüftgelenkprothese KW - Biomechanik KW - Lastverteilung KW - Ganganalyse KW - Simulation Y1 - 2012 U6 - https://doi.org/10.1177/0954411912447728 VL - 226 IS - 12 SP - 939 EP - 946 ER - TY - JOUR A1 - Weber, Tim A1 - Al-Munajjed, Amir Andreas A1 - Verkerke, Gijsbertus Jacob A1 - Dendorfer, Sebastian A1 - Renkawitz, Tobias T1 - Influence of minimally invasive total hip replacement on hip reaction forces and their orientations JF - Journal of Orthopaedic Research N2 - Minimally invasive surgery (MIS) is becoming increasingly popular. Supporters claim that the main advantages of MIS total hip replacement (THR) are less pain and a faster rehabilitation and recovery. Critics claim that safety and efficacy of MIS are yet to be determined. We focused on a biomechanical comparison between surgical standard and MIS approaches for THR during the early recovery of patients. A validated, parameterized musculoskeletal model was set to perform a squat of a 50th percentile healthy European male. A bilateral motion was chosen to investigate effects on the contralateral side. Surgical approaches were simulated by excluding the incised muscles from the computations. Resulting hip reaction forces and their symmetry and orientation were analyzed. MIS THR seemed less influential on the symmetry index of hip reaction forces between the operated and nonoperated leg when compared to the standard lateral approach. Hip reaction forces at peak loads of the standard transgluteal approach were 24% higher on the contralateral side when compared to MIS approaches. Our results suggest that MIS THR contributes to a greater symmetry of hip reaction forces in absolute value as well as force-orientation following THR. KW - THA KW - THR KW - Biomechanics KW - Conventional surgery KW - Early recovery KW - Hüftgelenkprothese KW - Minimal-invasive Chirurgie KW - Biomechanik Y1 - 2014 U6 - https://doi.org/10.1002/jor.22710 VL - 32 IS - 12 SP - 1680 EP - 1687 ER - TY - CHAP A1 - Weber, Tim A1 - Dendorfer, Sebastian A1 - Renkawitz, Tobias A1 - Dullien, Silvia A1 - Grifka, Joachim T1 - Clinical gait analysis combined with musculoskeletal modelling – coding a new generation of evaluation instruments T2 - Deutsche Gesellschaft für Biomechanik, Murnau, 2011 Y1 - 2011 ER - TY - CHAP A1 - Weber, Tim A1 - Renkawitz, Tobias A1 - Grifka, Joachim A1 - Bulstra, Sjoerd K. A1 - Verkerke, Gijsbertus Jacob A1 - Dendorfer, Sebastian T1 - The musculoskeletal load scenario of computer-assisted Femur-First THR up to one year after surgery T2 - VI International Conference on Computational Bioengineering, Barcelona, Sept. 2015 Y1 - 2015 UR - https://www.researchgate.net/publication/281745827_The_musculoskeletal_load_scenario_of_computer-assisted_Femur-First_THR_up_to_one_year_after_surgery ER - TY - CHAP A1 - Weber, Tim A1 - Dendorfer, Sebastian A1 - Bulstra, Sjoerd K. A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias T1 - Biomechanical Outcome after computer-assisted vs. Conventional THR T2 - ANSYS Conference & 32th CADFEM Users' Meeting 2014, 04.-06. Juni, Nürnberg Y1 - 2014 UR - https://www.researchgate.net/publication/264547774_Biomechanical_outcome_after_computer-assisted_vs_conventional_THR ER - TY - JOUR A1 - Weber, Tim A1 - Dullien, Silvia A1 - Grifka, Joachim A1 - Renkawitz, Tobias A1 - Dendorfer, Sebastian T1 - Validation of a Motion Capture Laboratory and a new marker-placement protcol for clinical applications JF - Gait & Posture Y1 - 2013 U6 - https://doi.org/10.1016/j.gaitpost.2013.07.229 VL - 38 IS - Suppl. 1 SP - 113 EP - 114 ER - TY - CHAP A1 - Weber, Tim A1 - Dullien, Silvia A1 - Putzer, Michael A1 - Dendorfer, Sebastian A1 - Renkawitz, Tobias T1 - Biomechanical outcome after computer-assisted vs. conventional THR – study concept and preliminary gait analysis results T2 - GAMMA Workshop, Hannover, 2012 Y1 - 2012 ER - TY - CHAP A1 - Weber, Tim A1 - Renkawitz, Tobias A1 - Bulstra, Sjoerd K. A1 - Grifka, Joachim A1 - Verkerke, Gijsbertus Jacob A1 - Dendorfer, Sebastian T1 - Biomechanics of computer-assisted vs. conventional THR after one year follow up T2 - XXV Congress of the International Society of Biomechanics, Glasgow, UK, 12th-16th July 2015 Y1 - 2015 ER - TY - CHAP A1 - Weber, Tim A1 - Dendorfer, Sebastian A1 - Bulstra, Sjoerd K. A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias T1 - Musculoskeletal modeling for orthopedic surgery – Applications and chances T2 - Orthopedics meets Engineering, Regensburg, 2015 Y1 - 2015 ER - TY - JOUR A1 - Käsbauer, Johannes A1 - Schmailzl, Anton A1 - Weber, Ulrich A1 - Hierl, Stefan A1 - Jaus, Tobias A1 - Schwalme, Michael T1 - Simulationsgestützte Evaluierung von Strahloszillationsmustern beim quasi-simultanen Laser-Durchstrahlschweißen JF - JOINING PLASTICS - Fügen von Kunststoffen Y1 - 2019 VL - 13 IS - 2 SP - 102 EP - 109 ER - TY - CHAP A1 - Haug, Sonja A1 - Schiele, Agnes A1 - Weber, Karsten A1 - Riederer, Michael A1 - Saller, Tobias T1 - Nachhaltig Leben und Wirtschaften am Beispiel des Sanierungsgebiets Margaretenau Regensburg T2 - XX. Tagung für Angewandte Sozialwissenschaften. Nachhaltig Leben und Wirtschaften. Management Sozialer Innovationen als Gestaltung gesellschaftlicher Transformation, 24.-26.05.2019, Hochschule München Y1 - 2019 ER - TY - JOUR A1 - Weber, Karsten A1 - Haug, Sonja A1 - Altenbuchner, Amelie A1 - Zachmayer, Tobias T1 - Impfbereitschaft, Impfskepsis und Impfung in der COVID-19-Pandemie JF - GWP - Gesellschaft. Wirtschaft. Politik N2 - Der Beitrag fasst sozialwissenschaftliche Erkenntnisse zur Impfbereitschaft und Impfung mit einem COVID-19 Vakzin zusammen. Diskutiert werden Impfskepsis und Einflussfaktoren wie Sozialstruktur, Verschwörungsüberzeugungen, kollektive Verantwortung, Einstellungen zu alternativen Heilverfahren und zur Impfpflicht. KW - Impfung KW - Verschwörungsüberzeugung KW - Verantwortung KW - Corona-Pandemie Y1 - 2022 U6 - https://doi.org/10.3224/gwp.v71i2.08 IS - 2 SP - 192 EP - 204 PB - Budrich ER - TY - JOUR A1 - Weber, Tim A. A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias ED - Takagi, Michiaki T1 - Does Computer-Assisted Femur First THR Improve Musculoskeletal Loading Conditions? JF - BioMed Research International N2 - We have developed a novel, computer-assisted operation method for minimal-invasive total hip replacement (THR) following the concept of “femur first/combined anteversion,” which incorporates various aspects of performing a functional optimization of the prosthetic stem and cup position (CAS FF). The purpose of this study is to assess whether the hip joint reaction forces and patient’s gait parameters are being improved by CAS FF in relation to conventional THR (CON). We enrolled 60 patients (28 CAS FF/32 CON) and invited them for gait analysis at three time points (preoperatively, postop six months, and postop 12 months). Data retrieved from gait analysis was processed using patient-specific musculoskeletal models. The target parameters were hip reaction force magnitude (hrf), symmetries, and orientation with respect to the cup. Hrf in the CAS FF group were closer to a young healthy normal. Phase-shift symmetry showed an increase in the CAS FF group. Hrf orientation in the CAS FF group was closer to optimum, though no edge or rim-loading occurred in the CON group as well. The CAS FF group showed an improved hrf orientation in an early stage and a trend to an improved long-term outcome. KW - Hüftgelenkprothese KW - Operationstechnik KW - Computerunterstütztes Verfahren KW - Bewegungsapparat KW - Mechanische Belastung Y1 - 2015 U6 - https://doi.org/10.1155/2015/625317 VL - 2015 SP - ID 625317 ER - TY - JOUR A1 - Weber, Markus A1 - Suess, Franz A1 - Jerabek, Seth A1 - Meyer, Matthias A1 - Grifka, Joachim A1 - Renkawitz, Tobias A1 - Dendorfer, Sebastian T1 - Kinematic pelvic tilt during gait alters functional cup position in total hip arthroplasty JF - Journal of Orthopaedic Research N2 - Static pelvic tilt impacts functional cup position in total hip arthroplasty (THA). In the current study we investigated the effect of kinematic pelvic changes on cup position. In the course of a prospective controlled trial postoperative 3D-computed tomography (CT) and gait analysis before and 6 and 12 months after THA were obtained in 60 patients. Kinematic pelvic motion during gait was measured using Anybody Modeling System. By fusion with 3D-CT, the impact of kinematic pelvic tilt alterations on cup anteversion and inclination was calculated. Furthermore, risk factors correlating with high pelvic mobility were evaluated. During gait a high pelvic range of motion up to 15.6° exceeding 5° in 61.7% (37/60) of patients before THA was found. After surgery, the pelvis tilted posteriorly by a mean of 4.0 ± 6.6° (p < .001). The pelvic anteflexion led to a mean decrease of −1.9 ± 2.2° (p < .001) for cup inclination and −15.1 ± 6.1° (p < .001) for anteversion in relation to the anterior pelvic plane (APP). Kinematic pelvic changes resulted in a further change up to 2.3° for inclination and up to 12.3° for anteversion. In relation to the preoperative situation differences in postoperative cup position ranged from −4.4 to 4.6° for inclination and from −7.8 to 17.9° for anteversion, respectively. Female sex (p < .001) and normal body weight (p < .001) correlated with high alterations in pelvic tilt. Kinematic pelvic changes highly impact cup anteversion in THA. Surgeons using the APP as reference should aim for a higher anteversion of about 15° due to the functional anteflexion of the pelvis during gait. KW - component position KW - gait analysis KW - kinematics KW - pelvic tilt KW - total hip arthroplasty KW - Hüftgelenkprothese KW - Haltungsfehler KW - Hüftgelenkpfanne Y1 - 2021 U6 - https://doi.org/10.1002/jor.25106 SN - 1554-527X VL - 40 IS - 4 SP - 846 EP - 853 PB - Wiley ER - TY - JOUR A1 - Lautenschläger, Toni A1 - Leis, Alexander A1 - Dendorfer, Sebastian A1 - Palm, Christoph A1 - Schreiner, Rupert A1 - Langer, Christoph A1 - Prommesberger, Christian A1 - Ławrowski, Robert Damian A1 - Dams, Florian A1 - Bornmann, Benjamin A1 - Navitski, Aliaksandr A1 - Serbun, Pavel A1 - Müller, Günter A1 - Liebetruth, Thomas A1 - Kohlert, Dieter A1 - Pernsteiner, Jochen A1 - Schreier, Franz A1 - Heerklotz, Sabrina A1 - Heerklotz, Allwin A1 - Boos, Alexander A1 - Herwald, Dominik A1 - Monkman, Gareth J. A1 - Treiber, Daniel A1 - Mayer, Matthias A1 - Hörner, Eva A1 - Bentz, Alexander A1 - Shamonin (Chamonine), Mikhail A1 - Johansen, Søren Peter A1 - Reichel, Marco A1 - Stoll, Andrea A1 - Briem, Ulrich A1 - Dullien, Silvia A1 - Renkawitz, Tobias A1 - Weber, Tim A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Penzkofer, Rainer A1 - Barnsteiner, K. A1 - Jovanovik, M. A1 - Wernecke, P. A1 - Vögele, A. A1 - Bachmann, T. A1 - Plötz, Martin A1 - Schliekmann, Claus A1 - Wels, Harald A1 - Helmberger, Paul A1 - Kaspar, M. A1 - Hönicka, M. A1 - Schrammel, Siegfried A1 - Enser, Markus A1 - Schmidmeier, Monika A1 - Schroll-Decker, Irmgard A1 - Haug, Sonja A1 - Gelfert, Verena A1 - Vernim, Matthias ED - Baier, Wolfgang T1 - Forschungsbericht 2012 T3 - Forschungsberichte der OTH Regensburg - 2012 Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-7834 CY - Regensburg ER - TY - GEN A1 - Zellmer, Stephan A1 - Rauber, David A1 - Probst, Andreas A1 - Weber, Tobias A1 - Nagl, Sandra A1 - Römmele, Christoph A1 - Schnoy, Elisabeth A1 - Palm, Christoph A1 - Messmann, Helmut A1 - Ebigbo, Alanna T1 - Verwendung künstlicher Intelligenz bei der Detektion der Papilla duodeni major T2 - Zeitschrift für Gastroenterologie N2 - Einleitung Die Endoskopische Retrograde Cholangiopankreatikographie (ERCP) ist der Goldstandard in der Diagnostik und Therapie von Erkrankungen des pankreatobiliären Trakts. Jedoch ist sie technisch sehr anspruchsvoll und weist eine vergleichsweise hohe Komplikationsrate auf. Ziele  In der vorliegenden Machbarkeitsstudie soll geprüft werden, ob mithilfe eines Deep-learning-Algorithmus die Papille und das Ostium zuverlässig detektiert werden können und somit für Endoskopiker mit geringer Erfahrung ein geeignetes Hilfsmittel, insbesondere für die Ausbildungssituation, darstellen könnten. Methodik Wir betrachteten insgesamt 606 Bilddatensätze von 65 Patienten. In diesen wurde sowohl die Papilla duodeni major als auch das Ostium segmentiert. Anschließend wurde eine neuronales Netz mittels eines Deep-learning-Algorithmus trainiert. Außerdem erfolgte eine 5-fache Kreuzvaldierung. Ergebnisse Bei einer 5-fachen Kreuzvaldierung auf den 606 gelabelten Daten konnte für die Klasse Papille eine F1-Wert von 0,7908, eine Sensitivität von 0,7943 und eine Spezifität von 0,9785 erreicht werden, für die Klasse Ostium eine F1-Wert von 0,5538, eine Sensitivität von 0,5094 und eine Spezifität von 0,9970 (vgl. [Tab. 1]). Unabhängig von der Klasse zeigte sich gemittelt (Klasse Papille und Klasse Ostium) ein F1-Wert von 0,6673, eine Sensitivität von 0,6519 und eine Spezifität von 0,9877 (vgl. [Tab. 2]). Schlussfolgerung  In vorliegende Machbarkeitsstudie konnte das neuronale Netz die Papilla duodeni major mit einer hohen Sensitivität und sehr hohen Spezifität identifizieren. Bei der Detektion des Ostiums war die Sensitivität deutlich geringer. Zukünftig soll das das neuronale Netz mit mehr Daten trainiert werden. Außerdem ist geplant, den Algorithmus auch auf Videos anzuwenden. Somit könnte langfristig ein geeignetes Hilfsmittel für die ERCP etabliert werden. KW - Künstliche Intelligenz Y1 - 2023 UR - https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1772000 U6 - https://doi.org/10.1055/s-0043-1772000 VL - 61 IS - 08 PB - Thieme CY - Stuttgart ER - TY - RPRT A1 - Andratschke, Christin A1 - Ceullo, Laura A1 - Dawoud, Belal A1 - Draeger, Susan A1 - Gerdes, Thorsten A1 - Giebisch, Matthias A1 - Grießhammer, Peter A1 - Haas, Katharina A1 - Haug, Sonja A1 - Helling, Dominik A1 - Kominis, Lena A1 - Lang, Christian A1 - Malz, Sebastian A1 - Melzl, Johannes A1 - Michlbauer, David A1 - Mühlberger, Thomas A1 - Nagl, Klaus A1 - Preis, Michael A1 - Rechenauer, Christian A1 - Riederer, Michael A1 - Rückerl, Alexander A1 - Saller, Tobias A1 - Schnabl, Andreas A1 - Stadler, Michael A1 - Steffens, Oliver A1 - Steininger, Peter A1 - Stelzl, André A1 - Toutouly, Lovis A1 - Trauner, Matthias A1 - Vetter, Miriam A1 - Walbrunn, Johannes A1 - Weber, Karsten A1 - Zielbauer, Lukas ED - Steffens, Oliver T1 - MAGGIE: Energetische Modernisierung des genossenschaftlichen Wohnquartiers Margaretenau in Regensburg BT - Musterlösungen für solaroptimiertes Wohnen mit innovativen solaraktiven Baustoffen und einem KI-gestützten Energiemanagement für eine netzdienliche, emissionsarme Strom- und Wärmelogistik; Ergebnisbericht N2 - Im Projekt MAGGIE wurden für das genossenschaftliche historische Stadtquartier „Margaretenau“ in Regensburg Musterlösungen für energieoptimiertes Wohnen mit innovativen Wandaufbauten aus solaraktiven Baukonstruktionen und einer vorhersagebasierten Versorgungstechnologie erforscht. Dazu wurde ein bestehendes Wohngebäude als Demonstrations- und Versuchsobjekt mit einem neuartigen, besonders effizienten Hybridsystem aus Wärmepumpentechnologie und Kraft- Wärme-Kopplung ausgestattet und untersucht, ergänzt durch eine dynamische Wärmelogistik zur Verringerung von Verteilungsverlusten. Das System wurde durch ein neu entwickeltes, allgemein einsetzbares Planungs-, Optimierungs- und Steuerungstool ausgelegt und im Betrieb geregelt. Die in Echtzeit laufende Nachoptimierung des Systems während des Betriebs greift dabei auf reale Monitoringdaten zu. Die Einbindung von Nutzerbedarfsprofilen, Strombörse und Wetterdaten in die Steuerung gestattet einen dynamischen und perspektivischen Anlagenbetrieb zur Maximierung der Solar- und Umweltwärme-Anteile der Energieversorgung und leistet damit einen wirksamen Beitrag zu einem emissionsarmen, klimafreundlichen Gebäudebetrieb. Für die denkmalgerechte Modernisierung der historischen Fassaden wurde ein solaraktives und solaradaptives Außenputzsystem entwickelt und in der Realität getestet. Am Bestandsgebäude kam anstelle eines Wärmedämmverbundsystems ein innovativer Dämmputz mit Mikrohohlglaskugeln zum Einsatz. Die Skalierbarkeit erlaubt eine abschnittsweise Modernisierung des gesamten Ensembles über mehrere Jahre. Durch die hohe Energieeffizienz wird die Warmmiete für die Bewohner der genossenschaftlichen Siedlung durch die Modernisierungsmaßnahmen nicht erhöht, so dass auch nach der Modernisierung ein bezahlbares Wohnen sichergestellt wird. KW - Altbaumodernisierung KW - Energieeinsparung KW - Energiebewusstes Bauen KW - Haus Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-59011 SN - 978-3-96256-100-0 N1 - Gefördert durch einen Beschluss des Bundestages durch das Bundesministerium für Wirtschaft und Klimaschutz (BMWK); Projektlaufzeit Oktober 2017 bis Juni 2022; Förderkennzeichen 03SBE0007A–E CY - Regensburg ER - TY - RPRT A1 - Andratschke, Christin A1 - Ceullo, Laura A1 - Dawoud, Belal A1 - Draeger, Susan A1 - Gerdes, Thorsten A1 - Giebisch, Matthias A1 - Grießhammer, Peter A1 - Haas, Katharina A1 - Haug, Sonja A1 - Helling, Dominik A1 - Kominis, Lena A1 - Lang, Christian A1 - Malz, Sebastian A1 - Melzl, Johannes A1 - Michlbauer, David A1 - Mühlberger, Thomas A1 - Nagl, Klaus A1 - Preis, Michael A1 - Rechenauer, Christian A1 - Riederer, Michael A1 - Rückerl, Alexander A1 - Saller, Tobias A1 - Schnabl, Andreas A1 - Stadler, Michael A1 - Steffens, Oliver A1 - Steininger, Peter A1 - Stelzl, André A1 - Toutouly, Lovis A1 - Trauner, Matthias A1 - Vetter, Miriam A1 - Walbrunn, Johannes A1 - Weber, Karsten A1 - Zielbauer, Lukas ED - Steffens, Oliver T1 - MAGGIE: Energetische Modernisierung des genossenschaftlichen Wohnquartiers Margaretenau in Regensburg BT - Musterlösungen für solaroptimiertes Wohnen mit innovativen solaraktiven Baustoffen und einem KI-gestützten Energiemanagement für eine netzdienliche, emissionsarme Strom- und Wärmelogistik; Ergebnisbericht N2 - Im Projekt MAGGIE wurden für das genossenschaftliche historische Stadtquartier „Margaretenau“ in Regensburg Musterlösungen für energieoptimiertes Wohnen mit innovativen Wandaufbauten aus solaraktiven Baukonstruktionen und einer vorhersagebasierten Versorgungstechnologie erforscht. Dazu wurde ein bestehendes Wohngebäude als Demonstrations- und Versuchsobjekt mit einem neuartigen, besonders effizienten Hybridsystem aus Wärmepumpentechnologie und Kraft- Wärme-Kopplung ausgestattet und untersucht, ergänzt durch eine dynamische Wärmelogistik zur Verringerung von Verteilungsverlusten. Das System wurde durch ein neu entwickeltes, allgemein einsetzbares Planungs-, Optimierungs- und Steuerungstool ausgelegt und im Betrieb geregelt. Die in Echtzeit laufende Nachoptimierung des Systems während des Betriebs greift dabei auf reale Monitoringdaten zu. Die Einbindung von Nutzerbedarfsprofilen, Strombörse und Wetterdaten in die Steuerung gestattet einen dynamischen und perspektivischen Anlagenbetrieb zur Maximierung der Solar- und Umweltwärme-Anteile der Energieversorgung und leistet damit einen wirksamen Beitrag zu einem emissionsarmen, klimafreundlichen Gebäudebetrieb. Für die denkmalgerechte Modernisierung der historischen Fassaden wurde ein solaraktives und solaradaptives Außenputzsystem entwickelt und in der Realität getestet. Am Bestandsgebäude kam anstelle eines Wärmedämmverbundsystems ein innovativer Dämmputz mit Mikrohohlglaskugeln zum Einsatz. Die Skalierbarkeit erlaubt eine abschnittsweise Modernisierung des gesamten Ensembles über mehrere Jahre. Durch die hohe Energieeffizienz wird die Warmmiete für die Bewohner der genossenschaftlichen Siedlung durch die Modernisierungsmaßnahmen nicht erhöht, so dass auch nach der Modernisierung ein bezahlbares Wohnen sichergestellt wird. KW - Altbaumodernisierung KW - Energieeinsparung KW - Energiebewusstes Bauen KW - Haus Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-53354 SN - 978-3-96256-100-0 N1 - Gefördert durch einen Beschluss des Bundestages durch das Bundesministerium für Wirtschaft und Klimaschutz (BMWK); Projektlaufzeit Oktober 2017 bis Juni 2022; Förderkennzeichen 03SBE0007A–E N1 - korrigierte Version unter: https://doi.org/10.35096/othr/pub-5901 CY - Regensburg ER - TY - JOUR A1 - Broser, Christian A1 - Falter, Thomas A1 - Ławrowski, Robert Damian A1 - Altenbuchner, Amelie A1 - Vögele, Daniel A1 - Koss, Claus A1 - Schlampp, Matthias A1 - Dunnweber, Jan A1 - Steffens, Oliver A1 - Heckner, Markus A1 - Jaritz, Sabine A1 - Schiegl, Thomas A1 - Corsten, Sabine A1 - Lauer, Norina A1 - Guertler, Katherine A1 - Koenig, Eric A1 - Haug, Sonja A1 - Huber, Dominik A1 - Birkenmaier, Clemens A1 - Krenkel, Lars A1 - Wagner, Thomas A1 - Justus, Xenia A1 - Saßmannshausen, Sean Patrick A1 - Kleine, Nadine A1 - Weber, Karsten A1 - Braun, Carina N. A1 - Giacoppo, Giuliano A1 - Heinrich, Michael A1 - Just, Tobias A1 - Schreck, Thomas A1 - Schnabl, Andreas A1 - Gilmore, Amador Téran A1 - Roeslin, Samuel A1 - Schmid, Sandra A1 - Wellnitz, Felix A1 - Malz, Sebastian A1 - Maurial, Andreas A1 - Hauser, Florian A1 - Mottok, Jürgen A1 - Klettke, Meike A1 - Scherzinger, Stefanie A1 - Störl, Uta A1 - Heckner, Markus A1 - Bazo, Alexander A1 - Wolff, Christian A1 - Kopper, Andreas A1 - Westner, Markus A1 - Pongratz, Christian A1 - Ehrlich, Ingo A1 - Briem, Ulrich A1 - Hederer, Sebastian A1 - Wagner, Marcus A1 - Schillinger, Moritz A1 - Görlach, Julien A1 - Hierl, Stefan A1 - Siegl, Marco A1 - Langer, Christoph A1 - Hausladen, Matthias A1 - Schreiner, Rupert A1 - Haslbeck, Matthias A1 - Kreuzer, Reinhard A1 - Brückl, Oliver A1 - Dawoud, Belal A1 - Rabl, Hans-Peter A1 - Gamisch, Bernd A1 - Schmidt, Ottfried A1 - Heberl, Michael A1 - Gänsbauer, Bianca A1 - Bick, Werner A1 - Ellermeier, Andreas A1 - Monkman, Gareth J. A1 - Prem, Nina A1 - Sindersberger, Dirk A1 - Tschurtschenthaler, Karl A1 - Aurbach, Maximilian A1 - Dendorfer, Sebastian A1 - Betz, Michael A. A1 - Szecsey, Tamara A1 - Mauerer, Wolfgang A1 - Murr, Florian ED - Baier, Wolfgang T1 - Forschung 2018 T3 - Forschungsberichte der OTH Regensburg - 2018 KW - Forschung KW - Forschungsbericht Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-13826 SN - 978-3-9818209-5-9 CY - Regensburg ER - TY - GEN A1 - Zellmer, Stephan A1 - Rauber, David A1 - Probst, Andreas A1 - Weber, Tobias A1 - Braun, Georg A1 - Römmele, Christoph A1 - Nagl, Sandra A1 - Schnoy, Elisabeth A1 - Messmann, Helmut A1 - Ebigbo, Alanna A1 - Palm, Christoph T1 - Artificial intelligence as a tool in the detection of the papillary ostium during ERCP T2 - Endoscopy N2 - Aims Endoscopic retrograde cholangiopancreaticography (ERCP) is the gold standard in the diagnosis as well as treatment of diseases of the pancreatobiliary tract. However, it is technically complex and has a relatively high complication rate. In particular, cannulation of the papillary ostium remains challenging. The aim of this study is to examine whether a deep-learning algorithm can be used to detect the major duodenal papilla and in particular the papillary ostium reliably and could therefore be a valuable tool for inexperienced endoscopists, particularly in training situation. Methods We analyzed a total of 654 retrospectively collected images of 85 patients. Both the major duodenal papilla and the ostium were then segmented. Afterwards, a neural network was trained using a deep-learning algorithm. A 5-fold cross-validation was performed. Subsequently, we ran the algorithm on 5 prospectively collected videos of ERCPs. Results 5-fold cross-validation on the 654 labeled data resulted in an F1 value of 0.8007, a sensitivity of 0.8409 and a specificity of 0.9757 for the class papilla, and an F1 value of 0.5724, a sensitivity of 0.5456 and a specificity of 0.9966 for the class ostium. Regardless of the class, the average F1 value (class papilla and class ostium) was 0.6866, the sensitivity 0.6933 and the specificity 0.9861. In 100% of cases the AI-detected localization of the papillary ostium in the prospectively collected videos corresponded to the localization of the cannulation performed by the endoscopist. Conclusions In the present study, the neural network was able to identify the major duodenal papilla with a high sensitivity and high specificity. In detecting the papillary ostium, the sensitivity was notably lower. However, when used on videos, the AI was able to identify the location of the subsequent cannulation with 100% accuracy. In the future, the neural network will be trained with more data. Thus, a suitable tool for ERCP could be established, especially in the training situation. Y1 - 2024 U6 - https://doi.org/10.1055/s-0044-1783138 VL - 56 IS - S 02 SP - S198 PB - Thieme CY - Stuttgart ER -