TY - JOUR A1 - Scharfenberg, Georg A1 - Mottok, Jürgen A1 - Artmann, Christina A1 - Hobelsberger, Martin A1 - Paric, Ivan A1 - Großmann, Benjamin A1 - Pohlt, Clemens A1 - Wackerbarth, Alena A1 - Pausch, Uli A1 - Heidrich, Christiane A1 - Fadanelli, Martin A1 - Elsner, Michael A1 - Pöcher, Daniel A1 - Pittroff, Lenz A1 - Beer, Stefan A1 - Brückl, Oliver A1 - Haslbeck, Matthias A1 - Sterner, Michael A1 - Thema, Martin A1 - Muggenthaler, Nicole A1 - Lenck, Thorsten A1 - Götz, Philipp A1 - Eckert, Fabian A1 - Deubzer, Michael A1 - Stingl, Armin A1 - Simsek, Erol A1 - Krämer, Stefan A1 - Großmann, Benjamin A1 - Schlegl, Thomas A1 - Niedersteiner, Sascha A1 - Berlehner, Thomas A1 - Joblin, Mitchell A1 - Mauerer, Wolfgang A1 - Apel, Sven A1 - Siegmund, Janet A1 - Riehle, Dirk A1 - Weber, Joachim A1 - Palm, Christoph A1 - Zobel, Martin A1 - Al-Falouji, Ghassan A1 - Prestel, Dietmar A1 - Scharfenberg, Georg A1 - Mandl, Roland A1 - Deinzer, Arnulf A1 - Halang, W. A1 - Margraf-Stiksrud, Jutta A1 - Sick, Bernhard A1 - Deinzer, Renate A1 - Scherzinger, Stefanie A1 - Klettke, Meike A1 - Störl, Uta A1 - Wiech, Katharina A1 - Kubata, Christoph A1 - Sindersberger, Dirk A1 - Monkman, Gareth J. A1 - Dollinger, Markus A1 - Dembianny, Sven A1 - Kölbl, Andreas A1 - Welker, Franz A1 - Meier, Matthias A1 - Thumann, Philipp A1 - Swidergal, Krzysztof A1 - Wagner, Marcus A1 - Haug, Sonja A1 - Vernim, Matthias A1 - Seidenstücker, Barbara A1 - Weber, Karsten A1 - Arsan, Christian A1 - Schone, Reinhold A1 - Münder, Johannes A1 - Schroll-Decker, Irmgard A1 - Dillinger, Andrea Elisabeth A1 - Fuchshofer, Rudolf A1 - Monkman, Gareth J. A1 - Shamonin (Chamonine), Mikhail A1 - Geith, Markus A. A1 - Koch, Fabian A1 - Ühlin, Christian A1 - Schratzenstaller, Thomas A1 - Saßmannshausen, Sean Patrick A1 - Auchter, Eberhard A1 - Kriz, Willy A1 - Springer, Othmar A1 - Thumann, Maria A1 - Kusterle, Wolfgang A1 - Obermeier, Andreas A1 - Udalzow, Anton A1 - Schmailzl, Anton A1 - Hierl, Stefan A1 - Langer, Christoph A1 - Schreiner, Rupert ED - Baier, Wolfgang T1 - Forschungsbericht / Ostbayerische Technische Hochschule Regensburg T3 - Forschungsberichte der OTH Regensburg - 2015 Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-13867 SN - 978-3-00-048589-3 CY - Regensburg ER - TY - GEN A1 - Krämer, Stefan T1 - Effects of Arbitrary Hardware Faults on Multicore Scheduling in Safety-critical Applications – Evaluation by enhanced Markov models and discrete event simulation T2 - 2014 PESW - The 2nd Prague Embedded Systems Workshop, June 2014 Y1 - 2014 UR - https://pesw.fit.cvut.cz/2014/presentations/pesw2014_Kramer.pdf ER - TY - JOUR A1 - Sellmer, Andreas A1 - Stangl, Hubert A1 - Beyer, Mandy A1 - Grünstein, Elisabeth A1 - Leonhardt, Michel A1 - Pongratz, Herwig A1 - Eichhorn, Emerich A1 - Elz, Sigurd A1 - Striegl, Birgit A1 - Jenei-Lanzl, Zsuzsa A1 - Dove, Stefan A1 - Straub, Rainer H. A1 - Krämer, Oliver H. A1 - Mahboobi, Siavosh T1 - Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors JF - Journal of medicinal chemistry N2 - Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising new drugs for the therapy of these diseases. Whereas pan-HDACi inhibit all 11 Zn2+-dependent histone deacetylases (HDACs) and cause a broad spectrum of side effects, specific inhibitors of histone deacetylase 6 (HDAC6i) are supposed to have less side effects. We present the synthesis and biological evaluation of Marbostats, novel HDAC6i that contain the hydroxamic acid moiety linked to tetrahydro-β-carboline derivatives. Our lead compound Marbostat-100 is a more potent and more selective HDAC6i than previously established well-characterized compounds in vitro as well as in cells. Moreover, Marbostat-100 is well tolerated by mice and effective against collagen type II induced arthritis. Thus, Marbostat-100 represents a most selective known HDAC6i and the possibility for clinical evaluation of a HDAC isoform-specific drug. KW - Animals KW - anti-Inflammatory agent KW - chemical synthesis KW - pharmacology KW - therapeutic use KW - toxicity Y1 - 2018 U6 - https://doi.org/10.1021/acs.jmedchem.7b01593 VL - 61 IS - 8 SP - 3454 EP - 3477 PB - ACS Publications ER - TY - CHAP A1 - Herbold, Florian A1 - Reindl, Andrea A1 - Meier, Hans A1 - Niemetz, Michael A1 - Krämer, Stefan ED - Kubátová, Hana ED - Fišer, Petr ED - Borecký, Jaroslav T1 - Secure Software Updates: Challenges and Solutions for Embedded IoT Systems T2 - Proceedings of the 9th Embedded Systems Workshop: July 1-3, 2021 Horomerice, Czech Republic N2 - The invention of the internet made the development of intelligent networking of millions of embedded systems possible. This enabled smart buildings, power grids and cities as well as applications in the fields of health, agriculture and industry. These systems frequently perform safety-critical applications and operations. This makes it urgent to protect these sensible systems as effectively as possible. Especially firmware updates are often the weak point in the systems. If unauthorised persons gain access to the system during the update, malware can be injected or sensitive data can be read and stolen. This paper describes the challenges of secure firmware updates. To protect an embedded system from potential attackers, the concepts integrity, authenticity and confidentiality have to be adhered during the update process. Otherwise, there is an increased risk of modifying or reverse engineering the firmware image. Likewise, inadequately protected software can enable the installation of third-party firmware as well as the installation of firmware on a third-party system. Threat prevention is presented with solutions derived from functional safety and IT security. Aspects of protection against errors in the transmission of updates and against attacks aiming to compromise the system are explained. Finally, a possible sequence of a secure update process is examined in detail for a real embedded system implementation. For this purpose, the preparation, transmission and installation of a firmware update in the bootloader are discussed KW - Bootloader KW - Cryptograph KW - Embedded systems KW - Firmware Update KW - IoT KW - Safety, Security KW - Software Protection Y1 - 2021 UR - https://www.researchgate.net/publication/354995594_Secure_Software_Updates_Challenges_and_Solutions_for_Embedded_IoT_Systems SN - 978-80-01-06858-8 SP - 5 EP - 13 ER - TY - CHAP A1 - Raab, Peter A1 - Krämer, Stefan A1 - Mottok, Jürgen A1 - Meier, Hans A1 - Racek, Stanislav T1 - Safe software processing by concurrent execution in a real-time operating system T2 - 16th International Conference on Applied Electronics (AE 2011), 2011, Pilsen, Czech Republic N2 - The requirements for safety-related software systems increases rapidly. To detect arbitrary hardware faults, there are applicable coding mechanism, that add redundancy to the software. In this way it is possible to replace conventional multi-channel hardware and so reduce costs. Arithmetic codes are one possibility of coded processing and are used in this approach. A further approach to increase fault tolerance is the multiple execution of certain critical parts of software. This kind of time redundancy is easily realized by the parallel processing in an operating system. Faults in the program flow can be monitored. No special compilers, that insert additional generated code into the existing program, are required. The usage of multi-core processors would further increase the performance of such multi-channel software systems. In this paper we present the approach of program flow monitoring combined with coded processing, which is encapsulated in a library of coded data types. The program flow monitoring is indirectly realized by means of an operating system. Y1 - 2011 SP - 315 EP - 319 ER - TY - CHAP A1 - Mucha, Matthias A1 - Mottok, Jürgen A1 - Krämer, Stefan T1 - Estimation of Worst Case Response Time Boundaries in Multi-Core Real-Time Systems T2 - 2017 International Conference on Applied Electronics (AE), 5-6 Sept. 2017, Pilsen N2 - We address a novel probabilistic approach to estimate the Worst Case Response Time boundaries of tasks. Multi-core real-time systems process tasks in parallel on two or more cores. Tasks in our contribution may preempt other tasks, block tasks with semaphores to access global shared resources, or migrate to another core. The depicted task behavior is random. The shape of collected response times of a task within a processing time is multimodal. Extreme Value approaches need unimodal response time distributions to estimate the Worst Case Response Time of tasks. The new proposed method derives a set of three task set shapes from the source task set. It is used to minimize the uncertainty of random task behavior by maximizing the coverage of possible Worst Case Response Times. The case study evaluates the new proposed estimation method by the use of dynamically generated random tasks with varying task properties. Y1 - 2017 SN - 978-80-261-0641-8 U6 - https://doi.org/10.23919/ae.2017.8053598 SN - 1803-7232 SP - 1 EP - 6 PB - IEEE ER - TY - CHAP A1 - Krämer, Stefan A1 - Mottok, Jürgen A1 - Meier, Hans T1 - Modifikation des Taskzustandsmodells des LLREF-Schedulers auf einem Dual-Core-Prozess T2 - Proceedings of the 2nd Embedded Software Engineering Congress, 8. bis 10. Dezember 2009, Sindelfingen Y1 - 2009 SP - 628 EP - 636 ER - TY - CHAP A1 - Krämer, Stefan A1 - Raab, Peter A1 - Mottok, Jürgen A1 - Racek, Stanislav T1 - Comparison of Enhanced Markov Models and Discrete Event Simulation T2 - 17th Euromicro Conference on Digital System Design (DSD), 27-29 August 2014, Verona, Italy N2 - In this paper we present simulation and model based approaches for evaluating and validating the temporal and safety relevant properties of software intensive safety-critical real-time embedded systems. A high level reliability model of a safe task execution is described by a continuous-time Markov process, enhanced by the modeling of execution times. It is shown that the behavior - regarding real-time and safety metrics - of this theoretical model can be transferred into an abstract system timing model, which then can be analyzed by a discrete event simulation approach. The verification of the discrete event simulation by Markov models offers the possibility of a holistic approach for reliability analysis combined with schedulability analysis of complex safety-critical multicore real-time systems by the discrete event simulation. Y1 - 2014 U6 - https://doi.org/10.1109/DSD.2014.42 SP - 591 EP - 598 ER - TY - CHAP A1 - Mottok, Jürgen A1 - Krämer, Stefan A1 - Deubzer, Michael A1 - Hobelsberger, Martin A1 - Martin, Felix T1 - Hardware Based Tracing of Embedded Multi-Core Systems T2 - 4th Applied Research Conference, 5th July 2014, Ingolstadt Y1 - 2014 SN - 978-3-8440-2875-1 ER - TY - CHAP A1 - Raab, Peter A1 - Krämer, Stefan A1 - Mottok, Jürgen T1 - Error Model and the Reliability of Arithmetic Operations T2 - 2013 IEEE EUROCON - International Conference on Computer as a Tool, Zagreb, Croatia, July 1-4, 2013 N2 - Error detecting and correcting codes are widely used in data transmission, storage systems and also for data processing. In logical circuits like arithmetic operations, arbitrary faults can cause errors in the result. However in safety critical applications, it is important to avoid those errors which would lead to system failures. Several approaches are known to protect the result of operations during software processing. In the same way like transmission systems, coded processing uses codes for fault detection. But in contrast to transmission systems, there is no adequate channel model available which makes it possible to evaluate the residue error probability of an arithmetic operation in an analytical way. This paper tries to close the gap of arithmetic error models by the development of a model for an ordinary addition in a computer system. Thus, the reliability of an addition's result can be analytically evaluated. KW - addition KW - channel model KW - coded processing KW - fault simulation KW - Markov model KW - residue error probability Y1 - 2013 U6 - https://doi.org/10.1109/EUROCON.2013.6625047 SP - 630 EP - 637 ER -