TY - JOUR A1 - Zellner, Johannes A1 - Hierl, Katja A1 - Mueller, Michael A1 - Pfeifer, Christian A1 - Berner, Arne A1 - Dienstknecht, Thomas A1 - Krutsch, Werner A1 - Geis, Sebastian A1 - Gehmert, Sebastian A1 - Kujat, Richard A1 - Dendorfer, Sebastian A1 - Prantl, Lukas A1 - Nerlich, Michael A1 - Angele, Peter ED - Gilbert, Jeremy T1 - Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone JF - Journal of Biomedical Materials Research Part B Applied Biomaterials N2 - Meniscal tears in the avascular zone have a poor self-healing potential, however partial meniscectomy predisposes the knee for early osteoarthritis. Tissue engineering with mesenchymal stem cells and a hyaluronan collagen based scaffold is a promising approach to repair meniscal tears in the avascular zone. 4 mm longitudinal meniscal tears in the avascular zone of lateral menisci of New Zealand White Rabbits were performed. The defect was left empty, sutured with a 5-0 suture or filled with a hyaluronan/collagen composite matrix without cells, with platelet rich plasma or with autologous mesenchymal stem cells. Matrices with stem cells were in part precultured in chondrogenic medium for 14 days prior to the implantation. Menisci were harvested at 6 and 12 weeks. The developed repair tissue was analyzed macroscopically, histologically and biomechanically. Untreated defects, defects treated with suture alone, with cell-free or with platelet rich plasma seeded implants showed a muted fibrous healing response. The implantation of stem cell-matrix constructs initiated fibrocartilage-like repair tissue, with better integration and biomechanical properties in the precultured stem cell-matrix group. A hyaluronan-collagen based composite scaffold seeded with mesenchymal stem cells is more effective in the repair avascular meniscal tear with stable meniscus-like tissue and to restore the native meniscus. KW - biomechanics KW - meniscus KW - scaffolds KW - stem cells KW - tissue engineering KW - Meniskusschaden KW - Tissue Engineering KW - Mesenchymzelle KW - Hyaluronsäure Y1 - 2013 U6 - https://doi.org/10.1002/jbm.b.32922 VL - 101 IS - 7 SP - 1133 EP - 1142 ER - TY - GEN A1 - Dendorfer, Sebastian T1 - Biomechanische Aspekte bei Sportverletzungen T2 - OT World Leipzig, Internationale Fachmesse und Weltkongress für Orthopädie und Rehatechnik, 10.-13. Mai 2022 Y1 - 2022 ER - TY - GEN A1 - Auer, Simon A1 - Reinker, Lukas A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Comparing calculated and measured muscle activity of thigh muscles in dynamic motion. T2 - 27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal Y1 - 2022 UR - https://drive.google.com/uc?id=1RBguxyHZE-Wr2y6ktOWK06_3lQg2M9Rb&export=download&confirm=t SP - 640 ER - TY - GEN A1 - Melzner, Maximilian A1 - Pfeifer, Christian A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Muskuloskeletal analysis of elbow stability for common injury patterns T2 - 27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal Y1 - 2022 UR - https://drive.google.com/uc?id=1RBguxyHZE-Wr2y6ktOWK06_3lQg2M9Rb&export=download&confirm=t SP - 654 ER - TY - GEN A1 - Melzner, Maximilian A1 - Dendorfer, Sebastian T1 - Biomechanik und muskuloskeletale Simulation T2 - Jahreskongress des ISPO Deutschland e.V., 2./3. Juni 2022, Hedelberg Y1 - 2022 ER - TY - GEN A1 - Eger, Maximilian A1 - Bergstraesser, Marcel A1 - Dendorfer, Sebastian A1 - Lenich, Andreas A1 - Pfeifer, Christian T1 - Influence of radial head prosthetic design on humeroradial stability: Validation of a test rig therefore T2 - DOKU2022, Deutscher Kongress für Orthopädie und Unfallchirurgie, 25.-28. 10.2022, Berlin KW - radial head prostheses KW - humeroradial stability KW - radial head arthroplasty KW - subluxation Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0183-22dkou6115 PB - German Medical Science GMS Publishing House CY - Düsseldorf ER - TY - GEN A1 - Dendorfer, Sebastian T1 - KI-basierte mechanische Modelle für Prävention, Diagnostik und Rehabilitation T2 - Serien-Webmeeting zu AI - KI-basierte Bildanalyse zur computer-unterstützten Frakturerkennung, 09.11.22 Y1 - 2022 ER - TY - GEN A1 - Kögler, Michael A1 - Ismail, Khaled M. A1 - Rusavy, Zdenek A1 - Kalis, Vladimir A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Influence of bed height and stance on accoucheurs lower back and glenohumeral load during simulated childbirth T2 - 31st meeting of Czech Urogynaecological Society, Prague, 2022 Y1 - 2022 ER - TY - GEN A1 - Dendorfer, Sebastian T1 - Muskuloskelettale Simulation - Implikationen für die Hüftendoprothetik T2 - Primär- und Revisionsendoprothetik des Hüftgelenks Trends und zukünftige Herausforderungen, 11.-12.11.2022, OTH Ostbayerische Technische Hochschule, Regensburg Y1 - 2022 ER - TY - GEN A1 - Dendorfer, Sebastian T1 - Patientenindividuelle biomechanisch optimierte Rehabilitation T2 - Primär- und Revisionsendoprothetik des Kniegelenks. Trends und zukünftige Herausforderungen. Regensburg 2023 Y1 - 2023 ER - TY - GEN A1 - Melzner, Maximilian A1 - Engelhardt, Leonard A1 - Süß, Friedrich A1 - Dendorfer, Sebastian T1 - Sensitivity evaluation of a musculoskeletal hand model using Latin hypercube sampling T2 - ESMAC 2020 Abstracts Y1 - 2020 U6 - https://doi.org/10.1016/j.gaitpost.2020.08.008 VL - 81 IS - Suppl. 1 PB - Elsevier ER - TY - GEN A1 - Dendorfer, Sebastian T1 - Diagnostische Genauigkeit und klinische Anwendungen tragbarer Bewegungssensoren für die Kniegelenksrehabilitation Y1 - 2024 CY - Nürnberg ER -