TY - GEN A1 - Friedrich, Janet A1 - Rivoire, Julien A1 - Scholz, Alexander A1 - Wiegbert, A1 - Terekov, Maxim A1 - Kbrich, Rainer A1 - Krenkel, Lars A1 - Wagner, Claus A1 - Schreiber, Laura Maria T1 - Exploration of Gas Flow During High Frequency Oscillated Ventilation by 19F-Gas-MRI T2 - Proceedings of the International Society for Magnetic Resonance in Medicine N2 - To detect convective gas flow inside the large airways during high frequency oscillated ventilation (HFOV) the fluorinated contrast gas Heptafluoropropane was used for 19F-MRI. In a first study the comparison between constant flow measurements and Computational Fluid Dynamics (CFD) simulations provided a good agreement. In a following experiment oscillated flow was applied to a lung phantom consisting of ventilation bag and long pipe. The pressure wave inside the pipe was explored point-by-point and corresponding velocities were determined. With these experiments it could be shown for the first time that flow measurement during HFOV using fluorinated contrast gas is feasible. Y1 - 2010 UR - https://archive.ismrm.org/2010/2527.html VL - 18 ER - TY - CHAP A1 - Scholz, Alexander-Wigbert K. A1 - Krenkel, Lars A1 - Terekhov, Maxim A1 - Friedrich, Janet A1 - Rivoire, Julien A1 - Köbrich, Rainer A1 - Wolf, Ursula A1 - Kalthoff, Daniel A1 - David, Matthias A1 - Wagner, Claus A1 - Schreiber, Laura Maria ED - Hirschel, Ernst Heinrich ED - Schröder, Wolfgang ED - Fujii, Kozo ED - Haase, Werner ED - Leer, Bram ED - Leschziner, Michael A. ED - Pandolfi, Maurizio ED - Periaux, Jacques ED - Rizzi, Arthur ED - Roux, Bernard ED - Shokin, Yurii I. ED - Klaas, Michael ED - Koch, Edmund ED - Schröder, Wolfgang T1 - Magnetic Resonance Imaging and Computational Fluid Dynamics of High Frequency Oscillatory Ventilation (HFOV) T2 - Fundamental Medical and Engineering Investigations on Protective Artificial Respiration N2 - In order to better understand the mechanisms of gas transport during High Frequency Oscillatory Ventilation (HFOV) Magnetic Resonance Imaging (MRI) with contrast gases and numerical flow simulations based on Computational Fluid Dynamics(CFD) methods are performed. Validation of these new techniques is conducted by comparing the results obtained with simplified models of the trachea and a first lung bifurcation as well as in a cast model of the upper central airways with results achieved from conventional fluid mechanical measurement techniques like e.g. Laser Doppler Anemometry (LDA). Further it is demonstrated that MRI of experimental HFOV is feasible and that Hyperpolarized 3He allows for imaging the gas re-distribution inside the lung. Finally, numerical results of oscillatory flow in a 3rd generation model of the lung as well as the impact of endotracheal tubes on the flow regime development in a trachea model are presented. KW - Central Airway KW - computational fluid dynamics KW - Computational Fluid Dynamics Simulation KW - Laser Doppler Anemometry KW - Magnetic Resonance Imaging Measurement Y1 - 2011 SN - 978-3-642-20325-1 U6 - https://doi.org/10.1007/978-3-642-20326-8_7 VL - 116 SP - 107 EP - 128 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Rück, Thomas A1 - Bierl, Rudolf A1 - Lechner, Alfred A1 - Graf, Antonia A1 - Dams, Florian A1 - Schreiner, Rupert A1 - Auchter, Eberhard A1 - Kriz, Willy A1 - Deubzer, MIchael A1 - Schiller, Frank A1 - Mottok, Jürgen A1 - Niemetz, Michael A1 - Margull, Ulrich A1 - Hagel, Georg A1 - Utesch, Matthias A1 - Waldherr, Franz A1 - Böhm, Matthias A1 - Fraunhoffer, Judith A1 - Gardeia, Armin A1 - Schneider, Ralph A1 - Streubel, Janet A1 - Landes, Dieter A1 - Studt, Reimer A1 - Peuker, Dominik A1 - Scharfenberg, Georg A1 - Hook, Christian A1 - Schuster, Dietwald A1 - Ehrlich, Ingo A1 - Dinnebier, Heinrich A1 - Briem, Ulrich A1 - Lämmlein, Stephan A1 - Koder, Alexander A1 - Bialek, Adam A1 - Genewsky, Axel A1 - Neumeier, Michael A1 - Schlosser, Philipp A1 - Rabl, Hans-Peter A1 - Paule, Matthias A1 - Galster, Christoph A1 - Schiedermeier, Michael A1 - Zwickel, Andreas A1 - Hobmeier, Christoph A1 - Bischoff, Tobias A1 - Rill, Georg A1 - Schaeffer, Thomas A1 - Arbesmeier, Martin A1 - Groß, Andreas A1 - Schlegl, Thomas A1 - Becker, Mark A1 - Senn, Konrad A1 - Schliekmann, Claus A1 - Scholz, Peter A1 - Sippl, Christian A1 - Grill, Martin ED - Eckstein, Josef T1 - Forschungsbericht 2011 / Hochschule für Angewandte Wissenschaften - Fachhochschule Regensburg T3 - Forschungsberichte der OTH Regensburg - 2011 Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-7321 SN - 1868-3533 CY - Regensburg ER -