TY - GEN A1 - Eger, Maximilian A1 - Bergstraesser, Marcel A1 - Dendorfer, Sebastian A1 - Lenich, Andreas A1 - Pfeifer, Christian T1 - Influence of radial head prosthetic design on humeroradial stability: Validation of a test rig therefore T2 - DOKU2022, Deutscher Kongress für Orthopädie und Unfallchirurgie, 25.-28. 10.2022, Berlin KW - radial head prostheses KW - humeroradial stability KW - radial head arthroplasty KW - subluxation Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0183-22dkou6115 PB - German Medical Science GMS Publishing House CY - Düsseldorf ER - TY - GEN A1 - Melzner, Maximilian A1 - Pfeifer, Christian A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Muskuloskeletal analysis of elbow stability for common injury patterns T2 - 27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal Y1 - 2022 UR - https://drive.google.com/uc?id=1RBguxyHZE-Wr2y6ktOWK06_3lQg2M9Rb&export=download&confirm=t SP - 654 ER - TY - JOUR A1 - Zellner, Johannes A1 - Hierl, Katja A1 - Mueller, Michael A1 - Pfeifer, Christian A1 - Berner, Arne A1 - Dienstknecht, Thomas A1 - Krutsch, Werner A1 - Geis, Sebastian A1 - Gehmert, Sebastian A1 - Kujat, Richard A1 - Dendorfer, Sebastian A1 - Prantl, Lukas A1 - Nerlich, Michael A1 - Angele, Peter ED - Gilbert, Jeremy T1 - Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone JF - Journal of Biomedical Materials Research Part B Applied Biomaterials N2 - Meniscal tears in the avascular zone have a poor self-healing potential, however partial meniscectomy predisposes the knee for early osteoarthritis. Tissue engineering with mesenchymal stem cells and a hyaluronan collagen based scaffold is a promising approach to repair meniscal tears in the avascular zone. 4 mm longitudinal meniscal tears in the avascular zone of lateral menisci of New Zealand White Rabbits were performed. The defect was left empty, sutured with a 5-0 suture or filled with a hyaluronan/collagen composite matrix without cells, with platelet rich plasma or with autologous mesenchymal stem cells. Matrices with stem cells were in part precultured in chondrogenic medium for 14 days prior to the implantation. Menisci were harvested at 6 and 12 weeks. The developed repair tissue was analyzed macroscopically, histologically and biomechanically. Untreated defects, defects treated with suture alone, with cell-free or with platelet rich plasma seeded implants showed a muted fibrous healing response. The implantation of stem cell-matrix constructs initiated fibrocartilage-like repair tissue, with better integration and biomechanical properties in the precultured stem cell-matrix group. A hyaluronan-collagen based composite scaffold seeded with mesenchymal stem cells is more effective in the repair avascular meniscal tear with stable meniscus-like tissue and to restore the native meniscus. KW - biomechanics KW - meniscus KW - scaffolds KW - stem cells KW - tissue engineering KW - Meniskusschaden KW - Tissue Engineering KW - Mesenchymzelle KW - Hyaluronsäure Y1 - 2013 U6 - https://doi.org/10.1002/jbm.b.32922 VL - 101 IS - 7 SP - 1133 EP - 1142 ER - TY - GEN A1 - Melzner, Maximilian A1 - Pfeifer, Christian A1 - Alt, V. A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Änderung der Gelenkreaktionskraft bei Schädigung des medialen Bandapparates im Ellenbogen T2 - Zeitschrift fur Orthopadie und Unfallchirurgie KW - Muskuloskelettale Simulation KW - Ellenbogenstabilität Y1 - 2020 U6 - https://doi.org/10.1055/s-0040-1717270 N1 - Poster VL - 158 IS - S01 PB - Thieme ER - TY - JOUR A1 - Pfeifer, Christian A1 - Müller, Michael A1 - Prantl, Lukas A1 - Berner, Arne A1 - Dendorfer, Sebastian A1 - Englert, Carsten T1 - Cartilage labelling for mechanical testing in T-peel configuration JF - International Orthopaedics N2 - PURPOSE: The purpose of this study was to find a suitable method of labelling cartilage samples for the measurement of distraction distances in biomechanical testing. METHODS: Samples of bovine cartilage were labelled using five different methods: hydroquinone and silver nitrate (AgNO3), potassium permanganate (KMnO4) with sodium thiosulphate (Na2S2O3), India ink, heat, and laser energy. After the labelling, we analysed the cartilage samples with regard to cytotoxity by histochemical staining with ethidiumbromide homodimer (EthD-1) and calcein AM. Furthermore, we tested cartilages labelled with India ink and heat in a T-peel test configuration to analyse possible changes in the mechanical behaviour between marked and unlabelled samples. RESULTS: Only the labelling methods with Indian ink or a heated needle showed acceptable results in the cytotoxity test with regard to labelling persistence, accuracy, and the influence on consistency and viability of the chondrocytes. In the biomechanical T-peel configuration, heat-labelled samples collapsed significantly earlier than unlabelled samples. CONCLUSION: Labelling bovine cartilage samples with Indian ink in biomechanical testing is a reliable, accurate, inexpensive, and easy-to-perform method. This labelling method influenced neither the biomechanical behaviour nor the viability of the tissue compared to untreated bovine cartilage. KW - Bovine cartilage KW - Cartilage samples KW - Indian ink KW - T-peel configuration KW - Method labeling KW - Knorpel KW - Rind KW - Kennzeichnung KW - Tinte KW - Biomechanik KW - Prüfung Y1 - 2012 U6 - https://doi.org/10.1007/s00264-011-1468-3 VL - 36 IS - 7 SP - 1493 EP - 1499 PB - Springer ER -