TY - JOUR A1 - Lehle, Karla A1 - Philipp, Alois A1 - Krenkel, Lars A1 - Gruber, Michael A1 - Hiller, Karl-Anton A1 - Müller, Thomas A1 - Lubnow, Matthias T1 - Thrombocytopenia During Venovenous Extracorporeal Membrane Oxygenation in Adult Patients With Bacterial, Viral, and COVID-19 Pneumonia JF - ASAIO Journal N2 - Contact of blood with artificial surfaces triggers platelet activation. The aim was to compare platelet kinetics after venovenous extracorporeal membrane oxygenation (V-V ECMO) start and after system exchange in different etiologies of acute lung failure. Platelet counts and coagulation parameters were analyzed from adult patients with long and exchange-free (≥8 days) ECMO runs (n = 330) caused by bacterial (n = 142), viral (n = 76), or coronavirus disease 2019 (COVID-19) (n = 112) pneumonia. A subpopulation requiring a system exchange and with long, exchange-free runs of the second oxygenator (≥7 days) (n = 110) was analyzed analogously. Patients with COVID-19 showed the highest platelet levels before ECMO implantation. Independent of the underlying disease and ECMO type, platelet counts decreased significantly within 24 hours and reached a steady state after 5 days. In the subpopulation, at the day of a system exchange, platelet counts were lower compared with ECMO start, but without differences between underlying diseases. Subsequently, platelets remained unchanged in the bacterial pneumonia group, but increased in the COVID-19 and viral pneumonia groups within 2–4 days, whereas D-dimers decreased and fibrinogen levels increased. Thus, overall platelet counts on V-V ECMO show disease-specific initial dynamics followed by an ongoing consumption by the ECMO device, which is not boosted by new artificial surfaces after a system exchange. Y1 - 2025 U6 - https://doi.org/10.1097/MAT.0000000000002383 SN - 1058-2916 SN - 1538-943X PB - Wolters Kluwer ER - TY - GEN A1 - Kranz, Michael A1 - Wagner, Maria Stella A1 - Pointner, Daniel A1 - Waldbauer, Selina A1 - Müller, Thomas A1 - Lubnow, Matthias A1 - Foltan, Maik A1 - Krenkel, Lars A1 - Lehle, Karla T1 - Polymeric Embedding of Membrane Lungs: A Novel Method for Histological Investigations of Intra-Device Clot Formation T2 - 12th EuroELSO Congress, 24-27. April 2024, Krakow Y1 - 2024 ER - TY - GEN A1 - Kranz, Michael A1 - Wagner, Maria Stella A1 - Krenkel, Lars A1 - Müller, Thomas A1 - Lubnow, Matthias A1 - Philipp, Alois A1 - Lehle, Karla T1 - Clot Localization within Membrane Lungs using different Imaging Methods and Histological Clot Characterization as a way to prevent Thrombosis in Extracorporeal Membrane Oxygenation Y1 - 2023 VL - 2023 ER - TY - GEN A1 - Köster, Leonie A1 - Kranz, Michael A1 - Wagner, Maria Stella A1 - Foltan, Maik A1 - Müller, Thomas A1 - Lubnow, Matthias A1 - Krenkel, Lars A1 - Lehle, Karla T1 - Histological Investigations of Intra-Device Clot Formation in ECMO Pumps T2 - 12th EuroELSO Congress, 24-27. April 2024, Krakow Y1 - 2024 ER -