TY - JOUR A1 - Pourshahidi, Ali Mohammad A1 - Jean, Neha A1 - Kaulen, Corinna A1 - Jakobi, Simon A1 - Krause, Hans-Joachim T1 - Impact of Particle Size on the Nonlinear Magnetic Response of Iron Oxide Nanoparticles during Frequency Mixing Magnetic Detection JF - Sensors N2 - Magnetic nanoparticles (MNPs), particularly iron oxide nanoparticles (IONPs), play a pivotal role in biomedical applications ranging from magnetic resonance imaging (MRI) enhancement and cancer hyperthermia treatments to biosensing. This study focuses on the synthesis, characterization, and application of IONPs with two different size distributions for frequency mixing magnetic detection (FMMD), a technique that leverages the nonlinear magnetization properties of MNPs for sensitive biosensing. IONPs are synthesized through thermal decomposition and subsequent growth steps. Our findings highlight the critical influence of IONP size on the FMMD signal, demonstrating that larger particles contribute dominantly to the FMMD signal. This research advances our understanding of IONP behavior, underscoring the importance of size in their application in advanced diagnostic tools. KW - frequency mixing magnetic detection KW - magnetic nanoparticles KW - magnetic particle spectroscopy KW - magnetic biosensing KW - thermal decomposition KW - iron oxide nanoparticles KW - MNP characterization Y1 - 2024 U6 - https://doi.org/10.3390/s24134223 SN - 1424-8220 VL - 24 IS - 13 PB - MDPI CY - Basel ER -