TY - CHAP A1 - Putzer, Michael A1 - Penzkofer, Rainer A1 - Ehrlich, Ingo A1 - Rasmussen, John A1 - Gebbeken, Norbert A1 - Dendorfer, Sebastian T1 - Musculoskeletal simulations to investigate the influence of vertebral geometrical parameters on lumbar spine loading T2 - 7th World Congress of Biomechanics, Boston, United States, 04/07/14 -11/07/14 Y1 - 2014 ER - TY - CHAP A1 - Galibarov, Pavel E. A1 - Al-Munajjed, Amir Andreas A1 - Dendorfer, Sebastian A1 - Christensen, Soeren Toerholm A1 - Rasmussen, John T1 - The effect of varying the stiffness of spinal fusion devices on the adjacent levels using multibody dynamics simulation T2 - Orthopaedic Proceedings N2 - INTRODUCTION Several clinical studies demonstrated long-term adjacent-level effects after implantation of spinal fusion devices[1]. These effects have been reported as adjacent joint degeneration and the development of new symptoms correlating with adjacent segment degeneration[2] and the trend has therefore gone to motion preservation devices; however, these effects have not been understood very well and have not been investigated thoroughly[3]. The aim of this study is to investigate the effect of varying the stiffness of spinal fusion devices on the adjacent vertebral levels. Disc forces, moments and facet joint forces were analyzed. METHODS The AnyBody Modeling System was used to compute the in-vivo muscle and joint reaction forces of a musculoskeletal model. The full body model used in this study consists of 188 muscle fascicles in the lumbar spine and more than 1000 individual muscle branches in total. The model has been proposed by de Zee et al.[3], validated by Rasmussen et al.[4] and by Galibarov et al.[5]. The new model[5] determines the individual motions between vertebrae based on the equilibrium between forces acting on the vertebrae from muscles and joints and the passive stiffness in disks and ligaments, figure 1a. An adult of 1.75 m and 75 kg with a spinal implant in L4L5 was modeled. This model was subjected to a flexion-extension motion using different elastic moduli to analyze and compare to a non-implanted scenario. The analyzed variables were vertebral motion, the disc reaction forces and moments, as well as facet joint forces in the treated and the adjacent levels: L2L3, L3L4, L4L5 and L5-Sacrum. RESULTS When introducing a spinal fusion device in the L4L5 joint the reaction forces and moments decreased in this joint with stiffer devices leading to lower joint loads. However, in the adjacent joints, L3L4 and L5Sacrum, an increase was observed when implanting stiffer devices. Similar trends could be found for the L2L3 joint. The loads in the facet joints showed the same trends. While introducing a spinal fusion device reduced the facet joint forces in the treated joint, the loads in the adjacent facet joints were increased according to the stiffness of the implanted device, figure 1b. DISCUSSION While the treated disc joint showed reduced motion and loads, the adjacent levels demonstrated a significant increase. In particular, the increased facet joint forces in the adjacent levels can lead to adjacent level facet pain or accelerated facet joint degeneration. Introducing a device resulted in preventing facet contact and therefore facet joint loads, even using the device with the lowest stiffness. CONCLUSION The presented model shows that clinical complications such as facet joint degeneration in adjacent levels after implantation of spinal fusion device are consistent with the change in the mechanical-stimulus distribution in the system. Y1 - 2011 VL - 94-B IS - SUPP_XL01 Sep 2012 SP - 2 ER - TY - CHAP A1 - Rasmussen, John A1 - Bichler, R. A1 - Christensen, Soeren Toerholm A1 - Wirix-Speetjens, Roel A1 - Dendorfer, Sebastian A1 - Renkawitz, Tobias T1 - Subject-specific Musculoskeletal Simulation of Hip Dislocation Risk in Activities of Daily Living T2 - Proceedings of the 2011 ORS Annual Meeting, Long Beach, CA. Y1 - 2011 UR - http://www.ors.org/Transactions/57/0306.pdf IS - Paper No. 306 ER - TY - CHAP A1 - Robie, Bruce A1 - Dendorfer, Sebastian A1 - Rasmussen, John A1 - Christensen, Soeren Toerholm T1 - Axial Rotation Requires Greatest Load in Multifidus Muscle – Potential Association with Low Back Pain? T2 - Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, 2011, Phoenix, Arizona Y1 - 2011 UR - https://paperpile.com/shared/o0LQEG ER - TY - CHAP A1 - Galibarov, Pavel E. A1 - Dendorfer, Sebastian A1 - Rasmussen, John T1 - Two Computational Models of the Lumbar Spine: BT - Comparison and Validation T2 - Proceedings of the 2011 ORS Annual Meeting, Long Beach, CA, vol. Marie Curie Initial Training Network "SpineFX" Y1 - 2011 UR - http://www.ors.org/Transactions/57/0786.pdf ER - TY - CHAP A1 - Al-Munajjed, Amir Andreas A1 - Nolte, Daniel A1 - Rasmussen, John A1 - Dendorfer, Sebastian T1 - Force distribution in the foot during braking – a musculoskeletal approach T2 - Human Modeling Symposium 2014, Munich, Germany N2 - High loads can appear in the individual joints of the human foot while the driver uses the pedals, in particular, during breaking. Measuring these internal forces is very difficult or almost impossible; therefore, advanced models are necessary to perform musculoskeletal simulations. The objective of this investigation was to see what loads are acting in the individual foot joints from the phalanges to calcaneus and talus during different brake scenarios. The Glasgow-Maastricht AnyBody Foot Model with 26 separate segments, connected by joints, ligaments and muscles was used inside the AnyBody Modeling System to compute individual mid foot joint loads. The amount, the direction of the force and additionally also the load insertion point was varied for several simulations. Figure 1: Seated musculoskeletal body model with applied brake force and forces for the lateral, intermediate and medial cuneiform-navicular joint for two different brake forces. The simulation showed that for the different brake scenarios, different muscles will be activated in the human and therefore different loads are apply in the fore-and mid-foot, respectively. The torso of the subject was assumed to be fixed in the seat. Further studies are ongoing to simulate the seat as an elastic element that allows different H-point locations according to the different loadings in the foot from the brake pedal using a new inverse dynamics analysis method called force-dependent kinematics. Y1 - 2014 UR - https://www.researchgate.net/publication/281229902_Force_distribution_in_the_foot_during_braking_-a_musculoskeletal_approach ER - TY - JOUR A1 - Putzer, Michael A1 - Ehrlich, Ingo A1 - Rasmussen, John A1 - Gebbeken, Norbert A1 - Dendorfer, Sebastian T1 - Sensitivity of lumbar spine loading to anatomical parameters JF - Journal of Biomechanics N2 - Musculoskeletal simulations of lumbar spine loading rely on a geometrical representation of the anatomy. However, this data has an inherent inaccuracy. This study evaluates the influence of defined geometrical parameters on lumbar spine loading utilising five parametrised musculoskeletal lumbar spine models for four different postures. The influence of the dimensions of vertebral body, disc, posterior parts of the vertebrae as well as the curvature of the lumbar spine was studied. Additionally, simulations with combinations of selected parameters were conducted. Changes in L4/L5 resultant joint force were used as outcome variable. Variations of the vertebral body height, disc height, transverse process width and the curvature of the lumbar spine were the most influential. These parameters can be easily acquired from X-rays and should be used to morph a musculoskeletal lumbar spine model for subject-specific approaches with respect to bone geometry. Furthermore, the model was very sensitive to uncommon configurations and therefore, it is advised that stiffness properties of discs and ligaments should be individualised. KW - Musculoskeletal simulation KW - Lumbar spine KW - Parameter study KW - Vertebra KW - Wirbelsäule KW - Belastung KW - Simulation Y1 - 2015 U6 - https://doi.org/10.1016/j.jbiomech.2015.11.003 VL - 49 IS - 6 SP - 953 EP - 958 PB - Elsevier Science ER - TY - CHAP A1 - Süß, Franz A1 - Kubowitsch, Simone A1 - Rasmussen, John A1 - Verkerke, Gijsbertus Jacob A1 - Dendorfer, Sebastian T1 - The influence of cognitive stress on muscle activation and spinal disc load T2 - European Society of Biomechanics meeting 2019, Vienna, Austria Y1 - 2019 UR - https://owncloud.tuwien.ac.at/index.php/s/dovqqcj02VeZHze ER - TY - CHAP A1 - Andersen, Michael Skipper A1 - de Zee, Mark A1 - Dendorfer, Sebastian A1 - MacWilliams, Bruce A1 - Rasmussen, John T1 - Validation of a detailed lower extremity model based on the Klein Horsman data set T2 - Proceedings of the 12th International Symposium on Computer Simulation in Biomechanics (ISB 2009), July 2nd - 4th 2009, Cape Town, South Africa Y1 - 2009 SP - 27 EP - 28 ER - TY - CHAP A1 - Dendorfer, Sebastian A1 - Rasmussen, John A1 - Christensen, Soeren Toerholm A1 - Robie, Bruce T1 - The Effect of Spinal Disc Herniation on Multifidus Muscles T2 - 56th Orthopaedic Research Society Meeting, New Orleans, USA, 2010 Y1 - 2010 UR - https://www.ors.org/Transactions/56/1487.pdf ER - TY - CHAP A1 - Robie, Bruce A1 - Rasmussen, John A1 - Christensen, Soeren Toerholm A1 - Dendorfer, Sebastian T1 - Herniation Induces 55% Increase in Load of Key Stabilizing Muscle – Impact on Herniation Treatment Devices? T2 - Spine Arthoplasty Society Meeting, New Orleans, 2010 Y1 - 2010 ER - TY - CHAP A1 - Dendorfer, Sebastian A1 - Carbes, S. A1 - Rasmussen, John T1 - The influence of muscle forces on biomechanical fracture fixation simulations – from in-vivo forces to tissue strains T2 - World Congress on Medical Physics and Biomedical Engineering, 7 - 12, 2009, Munich Y1 - 2009 ER - TY - CHAP A1 - Dendorfer, Sebastian A1 - Rasmussen, John T1 - The influence of in-vivo muscle forces on the stress distribution in a vertebral body during activities of daily living T2 - Eurospine Warsaw, Poland 2009 Y1 - 2009 ER - TY - RPRT A1 - Putzer, Michael A1 - Rasmussen, John A1 - Ehrlich, Ingo A1 - Gebbeken, Norbert A1 - Dendorfer, Sebastian ED - Baier, Wolfgang T1 - Muskuloskelettale Simulation zur Untersuchung des Einflusses geometrischer Parameter der Wirbelkörper auf die Belastung der Lendenwirbelsäule T2 - Forschungsbericht 2013 / Ostbayerische Technische Hochschule Regensburg Y1 - 2013 UR - https://doi.org/10.35096/othr/pub-799 SP - 60 EP - 61 CY - Regensburg ER - TY - JOUR A1 - Wong, Christian A1 - Rasmussen, John A1 - Simonsen, Erik B. A1 - Hansen, Lone A1 - de Zee, Mark A1 - Dendorfer, Sebastian T1 - The Influence of Muscle Forces on the Stress Distribution in the Lumbar Spine JF - The Open Spine Journal N2 - Introduction: Previous studies of bone stresses in the human lumbar spine have relied on simplified models when modeling the spinal musculature, even though muscle forces are likely major contributors to the stresses in the vertebral bones. Detailed musculoskeletal spine models have recently become available and show good correlation with experimental findings. A combined inverse dynamics and finite element analysis study was conducted in the lumbar spine to investigate the effects of muscle forces on a detailed musculoskeletal finite element model of the 4th lumbar vertebral body. Materials and Methodology: The muscle forces were computed with a detailed and validated inverse dynamics musculoskeletal spine model in a lifting situation, and were then applied to an orthotropic finite element model of the 4th lumbar vertebra. The results were compared with those from a simplified load case without muscles. Results: In general the von Mises stress was larger by 30%, and even higher when looking at the von Mises stress distribution in the superio-anterior and central part of the vertebral body and in the pedicles. Conclusion: The application of spine muscles to a finite element model showed markedly larger von Mises stress responses in the central and anterior part of the vertebral body, which can be tolerated in the young and healthy spine, but it would increase the risk of compression fractures in the elderly, osteoporotic spine. KW - Lumbar spine KW - Muscle influence KW - Inverse dynamics KW - Finite element analysis KW - Lendenwirbelsäule KW - Muskelkraft KW - Belastung KW - Finite-Elemente-Methode Y1 - 2011 U6 - https://doi.org/10.2174/1876532701103010021 VL - 3 IS - 1 SP - 21 EP - 26 ER - TY - JOUR A1 - Beimler, Josef A1 - Leißl, Caroline A1 - Ebner, Lena A1 - Elsner, Michael A1 - Mühlbauer, Gerhard A1 - Kohlert, Dieter A1 - Schubert, Martin J. W. A1 - Weiß, Andreas P. A1 - Sterner, Michael A1 - Raith, Thomas A1 - Afranseder, Martin A1 - Krapf, Tobias A1 - Mottok, Jürgen A1 - Siemers, Christian A1 - Großmann, Benjamin A1 - Höcherl, Johannes A1 - Schlegl, Thomas A1 - Schneider, Ralph A1 - Milaev, Johannes A1 - Rampelt, Christina A1 - Roduner, Christian A1 - Glowa, Christoph A1 - Bachl, Christoph A1 - Schliekmann, Claus A1 - Gnan, Alfons A1 - Grill, Martin A1 - Ruhland, Karl A1 - Piehler, Thomas A1 - Friers, Daniel A1 - Wels, Harald A1 - Pflug, Kenny A1 - Kucera, Markus A1 - Waas, Thomas A1 - Schlachetzki, Felix A1 - Boy, Sandra A1 - Pemmerl, Josef A1 - Leis, Alexander A1 - Welsch, Andreas F.X. A1 - Graf, Franz A1 - Zenger, Gerhard A1 - Volbert, Klaus A1 - Waas, Thomas A1 - Scherzinger, Stefanie A1 - Klettke, Meike A1 - Störl, Uta A1 - Heyl, C. A1 - Boldenko, A. A1 - Monkman, Gareth J. A1 - Kujat, Richard A1 - Briem, Ulrich A1 - Hierl, Stefan A1 - Talbot, Sebastian A1 - Schmailzl, Anton A1 - Ławrowski, Robert Damian A1 - Prommesberger, Christian A1 - Langer, Christoph A1 - Dams, Florian A1 - Schreiner, Rupert A1 - Valentino, Piergiorgio A1 - Romano, Marco A1 - Ehrlich, Ingo A1 - Furgiuele, Franco A1 - Gebbeken, Norbert A1 - Eisenried, Michael A1 - Jungbauer, Bastian A1 - Hutterer, Albert A1 - Bauhuber, Michael A1 - Mikrievskij, Andreas A1 - Argauer, Monika A1 - Hummel, Helmut A1 - Lechner, Alfred A1 - Liebetruth, Thomas A1 - Schumm, Michael A1 - Joseph, Saskia A1 - Reschke, Michael A1 - Soska, Alexander A1 - Schroll-Decker, Irmgard A1 - Putzer, Michael A1 - Rasmussen, John A1 - Dendorfer, Sebastian A1 - Weber, Tim A1 - Al-Munajjed, Amir Andreas A1 - Verkerke, Gijsbertus Jacob A1 - Renkawitz, Tobias A1 - Haug, Sonja A1 - Rudolph, Clarissa A1 - Zeitler, Annika A1 - Schaubeck, Simon A1 - Steffens, Oliver A1 - Rechenauer, Christian A1 - Schulz-Brize, Thekla A1 - Fleischmann, Florian A1 - Kusterle, Wolfgang A1 - Beer, Anne A1 - Wagner, Bernd A1 - Neidhart, Thomas ED - Baier, Wolfgang T1 - Forschungsbericht 2013 T3 - Forschungsberichte der OTH Regensburg - 2013 Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-7990 CY - Regensburg ER -