TY - CHAP A1 - Wiesmaier, Alexander A1 - Lippert, Markus A1 - Karatsiolis, Vangelis A1 - Raptis, Georgios A1 - Buchmann, Johannes T1 - An Evaluated Certification Services System for the German National Root CA - Legally Binding and Trustworthy Transactions in E-Business and E-Government T2 - Proceedings of The 2005 International Conference on E-Business, Enterprise Information Systems, E-Government, and Outsourcing, EEE 2005, Las Vegas, Nevada, USA, June 20-23, 2005 Y1 - 2005 SN - 1-932415-76-9 SP - 103 EP - 108 PB - CSREA Press ER - TY - JOUR A1 - Busch, Ch. A1 - Daum, H. A1 - Raptis, Georgios T1 - Merkmal Iris. Können diese Augen lügen? JF - Spektrum der Wissenschaft KW - Biometrie KW - Mustererkennung KW - Iris KW - Regenbogenhaut Y1 - 2003 UR - https://www.spektrum.de/magazin/koennen-diese-augen-luegen/829906 IS - 7 SP - 81 EP - 82 ER - TY - GEN A1 - Raptis, Georgios T1 - Mögliche Auswirkungen der eIDAS-Verordnung auf die Telematikinfrastruktur und die eArztausweise BT - Vortrag T2 - CAST-Workshop PKI, Darmstadt, 29.01.2015 KW - Europäische Union KW - Telemedizin KW - eArztausweis KW - Elektronischer Arztausweis Y1 - 2015 ER - TY - BOOK A1 - Sauer, S. A1 - Wolf, Th. A1 - Buch, M. A1 - Raptis, Georgios T1 - Sichere Client-Server-Architekturen für E-Government BT - E-Government-Handbuch KW - Client-Server-Konzept KW - Datensicherheit KW - E-Government Y1 - 2004 ER - TY - GEN A1 - Raptis, Georgios T1 - HPCs als Basis für den elektronischen Arztausweis BT - Vortrag T2 - Smartcard-Workshops, Fraunhofer SIT, 07.02.2006 KW - Arzt KW - Ausweis KW - Hochleistungsrechnen Y1 - 2006 ER - TY - THES A1 - Raptis, Georgios T1 - Klassifikation, Anwendungen und Sicherheitskonzept von Trustcentern KW - Trust Center Y1 - 2004 ER - TY - GEN A1 - Raptis, Georgios T1 - Datenschutzfragen zur Telemedizin BT - Vortrag T2 - Fachtagung Datenschutz in der Medizin - Update 2015 I, Hamburg 03.02.2015 KW - Telemedizin KW - Datenschutz Y1 - 2015 ER - TY - JOUR A1 - Raptis, Georgios T1 - Kryptographischer Langzeitschutz JF - KES - The Information Security Journal KW - Kryptologie KW - Datensicherung Y1 - 2008 VL - 1 SP - 55 EP - 62 ER - TY - JOUR A1 - Raptis, Georgios T1 - Computer können Ärzte nicht ersetzen BT - Interview JF - Technology Review Y1 - 2014 VL - 11 SP - 82 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Fischer, Uta A1 - Raptis, Georgios A1 - Bilek, Karin A1 - Hentschel, Bettina A1 - Richter, Christine E. A1 - Braumann, Ulf Dietrich A1 - Einenkel, Jens T1 - Pattern of invasion is of prognostic value in surgically treated cervical cancer patients JF - Gynecologic Oncology N2 - Objectives: Different patterns of invasion (representing different grades of tumor cell dissociation) are associated with prognostic outcome in cancer. We evaluated the prognostic value of different patterns of invasion (PI) in cervical carcinomas (CX). Methods: Six hundred eleven surgically treated CX (FIGO IB to IIB) were re-evaluated histologically regarding the PI, using a three-level scoring system. Closed PI was defined as cohesive growth with well-delineated (pushing) borders. In finger-like PI the tumor grows in solid cords/trabecles. Highly dissociative growth in small groups or single cells was defined as spray-like PI. Types of PI were correlated to tumor stage, histo-morphologic factors and prognostic outcome. Results: Sixty percent of the tumors showed a spray-like PI, 30% a finger-like PI and only 7.4% were of the closed type. Spray-like PI showed a significant correlation with advanced stage disease, lymphovascular space involvement, poorly differentiated tumors and pelvic lymph node metastases. Spray-like PI was accompanied by a reduced 5-year overall survival when compared to the finger-like and closed PI (68.7% vs. 80.9% vs. 88.5%; P=0.0004). The prognostic impact of the PI disappeared in node-positive patients (P=0.06) but persisted in patients without pelvic lymph node disease (P=0.03). In multivariate analysis, using COX regression model, the PI represented as independent prognostic factor. Conclusions: Spray-like PI (i.e., highest degree of tumor cell dissociation) is associated with advanced tumor stages, increased rate of recurrency and a reduced overall survival. In separate analysis of patients with and without lymph node metastases, the impact of PI persisted only in node-negative cases as a prognostic factor. KW - Gebärmutterhalskrebs KW - Chirurgie KW - Metastase Y1 - 2006 U6 - https://doi.org/10.1016/j.ygyno.2006.05.046 VL - 103 IS - 3 SP - 906 EP - 911 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Fischer, Uta A1 - Raptis, Georgios A1 - Bilek, Karin A1 - Hentschel, Bettina T1 - Tumor size is of prognostic value in surgically treated FIGO stage II cervical cancer JF - Gynecologic Oncology N2 - Objectives Tumor size is a well recognized prognostic factor in early stage cervical carcinoma (CX). However, limited knowledge exists about the value of tumor size in surgically treated CX with extrauterine extension. Methods 245 cases of local advanced CX (FIGO stage IIA and IIB) who received upfront surgery were evaluated regarding tumor size, regarding the prediction of pelvic lymph node involvement and recurrence free and overall survival during a median follow-up time of 54 months (95% CI 45.4–62.6 months). Tumors larger than 4 cm were defined as bulky stage disease. Results Bulky disease was seen in 46.1% (113/245). 60.2% of these patients showed pelvic lymph node involvement, compared to 42.4% (56/132) in non-bulky tumors (p = 0.006; odds ratio: 2.2 [95% CI: 1.3–3.6]). Patients with bulky tumors showed an increase of recurrent disease (40.2% vs. 28.0%; p = 0.045). The relative risk for recurrent disease was 1.97 (95% CI: 1.3–3.0). The 5-year overall survival rate was significantly lower (67.7% [95% CI: 58.2–74.8] vs. 49.5% [95% CI: 36.8–59.1]; p = 0.0015). In multivariate analysis, tumor stage, pelvic lymph node involvement and maximal tumor size were independent prognostic factors. Conclusions The results suggest that tumor size, defining bulky disease as tumors larger than 4 cm, is of prognostic impact also in FIGO stage II cervical carcinomas. A revised FIGO/TNM classification system similar to the subgrouping of stage IB CX is recommended for stage II using a cut-off value of 4 cm as discriminator: stage IIA1 and stage IIB1 for tumors with ≤ 4 cm and IIA2 and IIB2 for tumors > 4 cm (i.e. bulky disease). KW - Gebärmutterhalskrebs KW - Chirurgie KW - Tumorwachstum Y1 - 2007 U6 - https://doi.org/10.1016/j.ygyno.2007.06.026 VL - 107 IS - 2 SP - 310 EP - 315 ER -