TY - JOUR A1 - Lautenschläger, Toni A1 - Leis, Alexander A1 - Dendorfer, Sebastian A1 - Palm, Christoph A1 - Schreiner, Rupert A1 - Langer, Christoph A1 - Prommesberger, Christian A1 - Ławrowski, Robert Damian A1 - Dams, Florian A1 - Bornmann, Benjamin A1 - Navitski, Aliaksandr A1 - Serbun, Pavel A1 - Müller, Günter A1 - Liebetruth, Thomas A1 - Kohlert, Dieter A1 - Pernsteiner, Jochen A1 - Schreier, Franz A1 - Heerklotz, Sabrina A1 - Heerklotz, Allwin A1 - Boos, Alexander A1 - Herwald, Dominik A1 - Monkman, Gareth J. A1 - Treiber, Daniel A1 - Mayer, Matthias A1 - Hörner, Eva A1 - Bentz, Alexander A1 - Shamonin (Chamonine), Mikhail A1 - Johansen, Søren Peter A1 - Reichel, Marco A1 - Stoll, Andrea A1 - Briem, Ulrich A1 - Dullien, Silvia A1 - Renkawitz, Tobias A1 - Weber, Tim A1 - Dendorfer, Sebastian A1 - Grifka, Joachim A1 - Penzkofer, Rainer A1 - Barnsteiner, K. A1 - Jovanovik, M. A1 - Wernecke, P. A1 - Vögele, A. A1 - Bachmann, T. A1 - Plötz, Martin A1 - Schliekmann, Claus A1 - Wels, Harald A1 - Helmberger, Paul A1 - Kaspar, Marcel A1 - Hönicka, M. A1 - Schrammel, Siegfried A1 - Enser, Markus A1 - Schmidmeier, Monika A1 - Schroll-Decker, Irmgard A1 - Haug, Sonja A1 - Gelfert, Verena A1 - Vernim, Matthias ED - Baier, Wolfgang T1 - Forschungsbericht 2012 T3 - Forschungsberichte der OTH Regensburg - 2012 Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-7834 CY - Regensburg ER - TY - JOUR A1 - Mayer, Matthias A1 - Rabindranath, Raman A1 - Börner, Juliane A1 - Hörner, Eva A1 - Bentz, Alexander A1 - Salgado, Josefina A1 - Han, Hong A1 - Böse, Holger A1 - Probst, Jörn A1 - Shamonin (Chamonine), Mikhail A1 - Monkman, Gareth J. A1 - Schlunck, Günther T1 - Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata JF - PLoS ONE N2 - Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young’s modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0076196 VL - 8 IS - 10 PB - PLOS ER - TY - CHAP A1 - Forster, Eva A1 - Mayer, Matthias A1 - Rabindranath, Raman A1 - Bentz, Alexander A1 - Böse, Holger A1 - Shamonin (Chamonine), Mikhail A1 - Monkman, Gareth J. T1 - Surface Control Magneto-Active Polymers (MAP) T2 - EuroEAP 2011, First international conference on Electromechanically Active Polymer (EAP) transducers & artificial muscles, Pisa, 8-9 June N2 - Smart materials change their properties with external energy supply. Besides the known ferro-fluids and Magneto Rheological Fluid (MRF) also the Electro Active Polymer (EAP) and Magneto Rheological Elastomer (MRE) belong to these intelligent materials. The latest generation of magnetic elastomers represents a new class of composite materials. This consists of small magnetized particles which are sized in the micron or even nanometer range that in turn is bounded in a highly elastic rubber matrix. These materials are very often called MRE. Only recently, it has managed to develop these materials even further, so that very soft composite materials with a young?s modulus up to 10 kPa are possible. These soft polymers could be named magneto-active polymers. The combination of polymers with magnetic materials show novel and often enhanced properties. A precisely controllable young?s modulus and hardness, giant and non-homogeneous deformation behavior and rapid response to the magnetic field opens up new possibilities for various applications. Since MAP represent a very new technology, the behavior of these materials as a function of their composition and external conditions so far are not yet sufficiently understood. Therefore, some fundamental studies are necessary. In this paper, the mechanical surface properties are studied using a micro hardness meter. This work shows the possibility to control mechanical properties at the surface of MAP with new developed magnetic systems. Y1 - 2011 ER - TY - CHAP A1 - Mayer, Matthias A1 - Forster, Eva A1 - Rabindranath, Raman A1 - Bentz, Alexander A1 - Böse, Holger A1 - Shamonin (Chamonine), Mikhail A1 - Monkman, Gareth J. T1 - Highly compliant Magneto-Active Polymers (MAPs) T2 - Actuator'11, Bremen, May 2011 Y1 - 2011 ER - TY - CHAP A1 - Forster, Eva A1 - Rabindranath, Raman A1 - Mayer, Matthias A1 - Bentz, Alexander A1 - Böse, Holger A1 - Shamonin (Chamonine), Mikhail A1 - Monkman, Gareth J. T1 - Characterization of ultra soft Magneto-Active Polymers (MAPs) T2 - Conference proceedings / INDUCTICA 2011, Berlin, Germany, 24 - 26 May Y1 - 2011 ER - TY - RPRT A1 - Rabindranath, Raman A1 - Böse, Holger A1 - Probst, Jörn A1 - Schlunck, Günther A1 - Mayer, Matthias A1 - Forster, Eva A1 - Bentz, Alexander A1 - Shamonin (Chamonine), Mikhail A1 - Monkman, Gareth J. T1 - EAP mit magnetisch steuerbarer Elastizität zur Interaktion mit Bindegewebszellen MagElan BT - Teilvorhaben (HS-Regensburg) "Etablierung eines mechatronischen Systems zur (Magneto) Elastophorese von Bindegewebszellen" ; Schlussbericht ; Verbundprojekt "MagElan" ; Laufzeit des Vorhabens: 01.07.2009 - 30.10.2011 Y1 - 2012 N1 - Förderkennzeichen BMBF 13N10574 CY - Regensburg ER -