TY - PAT A1 - Muerrle, Ulrich A1 - Hornberger, Helga T1 - Method of making a ceramic restoration N2 - Production of a dental reconstruction comprises: (a) forming a mold (12) from a model (10); (b) using (12) to make an isotropically heat-expandable replica from a ceramic precursor (14); (c) oxidizing (14) to produce an enlarged ceramic replica; (d) forming a silicone mold from this replica; (e) using (d) to make a second ceramic replica; and (f) sintering the second replica with volume reduction to form a replica identical to (10). T2 - Verfahren zur Herstellung einer Zahnrestauration aus Keramik Y1 - 2003 UR - https://depatisnet.dpma.de/DepatisNet/depatisnet?action=bibdat&docid=EP000001346702A1 ER - TY - JOUR A1 - Weber, Karsten T1 - New Mobile Devices and Surveillance BT - Questions Concerning Epistemology and Some New Challenges for Privacy and Data Protection JF - Postmodern Openings Journal N2 - Mobile devices help people to stay connected across huge distances and to socially interact while in spatially separated environments. However, compared to faceto-face-interaction, communication and interaction via mobile phones currently are still restricted. Therefore, an idea of Mann, Fung, and Lo concerning cyborglogging with camera phones shall be taken a step further. A scenario is described in which a modified version of their design is used to support social interaction across the borders of spatially separated environments in a new manner. It shall be argued that this might create a new understanding of being present at a certain place while at the same time it raises questions concerning privacy, surveillance and authenticity of experience. Y1 - 2012 VL - 3 IS - 3 ER - TY - JOUR A1 - Manzeschke, Arne A1 - Weber, Karsten A1 - Fangerau, Heiner A1 - Rother, Elisabeth A1 - Dengler, Kathrin T1 - An ethical evaluation of telemedicine applications must consider four major aspects BT - A comment on Kidholm et al. JF - International Journal of Technology Assessment in Health Care Y1 - 2013 U6 - https://doi.org/10.1017/S0266462312000773 VL - 29 IS - 1 SP - 110 EP - 111 ER - TY - JOUR A1 - Weber, Karsten T1 - What is it like to encounter an autonomous artificial agent? JF - AI & Society N2 - Following up on Thomas Nagel’s paper “What is it like to be a bat?” and Alan Turing’s essay “Computing machinery and intelligence,” it shall be claimed that a successful interaction of human beings and autonomous artificial agents depends more on which characteristics human beings ascribe to the agent than on whether the agent really has those characteristics. It will be argued that Masahiro Mori’s concept of the “uncanny valley” as well as evidence from several empirical studies supports that assertion. Finally, some tentative conclusions concerning moral implications of the arguments presented here shall be drawn KW - Autonomous artificial agent KW - Turing test KW - Uncanny valley KW - Moral responsibility Y1 - 2013 U6 - https://doi.org/10.1007/s00146-013-0453-3 VL - 28 IS - 4 SP - 483 EP - 489 ER - TY - JOUR A1 - Weber, Karsten T1 - Internet = Demokratie? JF - Ethica Y1 - 2013 VL - 21 IS - 4 ER - TY - JOUR A1 - Weber, Karsten T1 - Vorausschau und Regulierung von Innovationsprozessen im Bereich der ubiquitären Informations- und Kommunikationstechnologie JF - Modern Management Review / Dawna Nazwa - Zardądzanie i Marketing N2 - On the one hand technological innovations can create new markets and can provide for solutions of current social problems; on the other hand the can raise questions concerning environmental and/or social adequacy on short-, middle-, and long-range time scales. In or-der to strengthen the positive outcomes of innovations and to reduce or even prevent nega-tive effects, the task of technology assessment is to predict the positive as well as the nega-tive effects and repercussions of innovations as early as possible. However, it must be pre-supposed that first, it must be possible to make to a certain extent reliable predications about the future development and second, that regulatory measurements in order to strengthen the positive outcomes of innovations and to reduce or even prevent negative effects will find their respective addressees. But if one takes, for instance, ubiquitous information and com-munication technology into account it can be demonstrated that those conditions rarely can be met. This is the result of the types of innovation which take place in case of ICT as well as of the so-called Collingridge dilemma. Both factors reduce the reliability of predictions. Furthermore, regulatory measurements often do not find their addressees since the borders of the societal subsystems in which innovation take place are blurring and therefore, these subsystems often cannot be reached with mainstream regulatory approaches like laws. KW - Technikfolgenabschätzung KW - Foresight KW - Innovationsforschung und –management KW - Informations-und Kommunikationstechnologie Y1 - 2013 U6 - https://doi.org/10.7862/rz.2013.mmr.39 VL - 20 IS - 3 ER - TY - JOUR A1 - Weber, Karsten T1 - Ökonomische Überlegungen zum Wissenschaftsbetrieb BT - Immaterialgüterrechte, Wissensallmende und Informationsnachhaltigkeit JF - Modern Management Review / Dawna Nazwa - Zardądzanie i Marketing N2 - Nachhaltigkeit und nachhaltiges Wirtschaften sind spätestens seit Mitte der 1980er Jahre wichtige Konzepte sowohl wissenschaftlicher als auch politischer Debatten. Sie werden ins-besondere thematisiert, wenn es um den Umgang mit knappen materiellen Ressourcen geht – fossile Energieträger sind hierfür sowohl als endliche Ressourcen als auch als Gefährdung anderer knapper Ressourcen wie eine saubere Umwelt ein paradigmatisches Beispiel. Da es jedoch nicht nur materielle Ressourcen, sondern auch Immaterialgüter gibt, soll untersucht werden, ob Konzepte der Nachhaltigkeit und des nachhaltigen Wirtschaftens auch in Bezug auf Immaterialgüter wie Informationen und Wissen angewendet werden können. Dazu wird es notwendig sein, zunächst die spezifischen ökonomischen Eigenschaften von Informatio-nen und Wissen herauszuarbeiten. Dabei zeigt sich, dass Immaterialgüter durch Anwendung von Immaterialgüterrechten zu knappen Ressourcen gemacht werden können. Wenn aber auch Informationen und Wissen faktisch zu den knappen Ressourcen gezählt werden müs-sen, so macht es Sinn, Nachhaltigkeit auch für Immaterialgüter zu fordern – dies soll mit dem Ausdruck „Informationsnachhaltigkeit“ bezeichnet werden. Wird das Konzept der In-formationsnachhaltigkeit auf den Wissenschaftsbetrieb angewendet, so kann in Bezug auf den Wissensbestand der Wissenschaft von einer Wissensallmende gesprochen werden. Die schon länger stattfindenden Veränderungen des Wissenschaftsbetriebs und des wissenschaft-lichen Publikationswesens gefährden auf der einen Seite den Bestand der Wissensallmende; auf der anderen Seite finden sich jedoch auch Gegenreaktionen, die Versuche darstellen, bspw. durch den Open Access-Gedanken die Wissensallmende zu erhalten. Allerdings zeigt die Analyse, dass sowohl eine romantisierende Perspektive auf die Wissensallmende und Open Access als auch eine pauschale Kritik am existierenden privatwirtschaftlichen Publikationswesen falsch wären, da beide Teile des wissenschaftlichen Publikationswesens aufeinander angewiesen sind. Y1 - 2013 U6 - https://doi.org/10.7862/rz.2013.hss.55 VL - 20 IS - 4 ER - TY - JOUR A1 - Weber, Karsten T1 - Is there really a concept called "inherent ethical concern"? JF - American Journal of Bioethics Neuroscience Y1 - 2014 U6 - https://doi.org/10.1080/21507740.2013.868377 VL - 5 IS - 1 SP - 39 EP - 40 ER - TY - JOUR A1 - Weber, Karsten T1 - Normative Herausforderungen an Technik für die Pflege im Alter JF - Hauswirtschaft und Wissenschaft. Europäische Zeitschrift für Haushaltsökonomie, Haushaltstechnik und Sozialmanagement KW - Altengerechte Technik Y1 - 2014 VL - 62 IS - 3 SP - 1 EP - 8 ER - TY - JOUR A1 - Swigon, Marzena A1 - Weber, Karsten T1 - Managing Knowledge and Information by Students JF - Journal for Information & Knowledge Management N2 - The concept of Personal Knowledge and Information Management (PKIM) is based, among others, on two theories: Personal Information Management (PTM) and Personal Knowledge Management (PKM), which hitherto were both subjects of separate studies. Moreover, the concept of PKIM is related to IL, which is a concept of information skills and competences of individuals — a person who manages knowledge has to be information literate. Some of the empirical studies results in the field of PKIM, started in Poland and recently continued in Germany, are presented. As the research method an unstructured questionnaire with open questions was used. Given the results of the survey as well as taking into account the subject literature, the concepts of PIM, PKM, and Information Literacy (IL) seem to be compatible and connected with each other. Our respondents perceive Knowledge and Information as well as knowledge management (KM) and information management (IM) in the context of learning and studying as integrated areas of interests. Although they do see differences between them, interconnections and relations seem more important. Furthermore, KM and IM are recognized as tools of coping with information overload. All aspects that have repercussions on KM and IM are related to three categories: personal characteristics, environment (macro and micro environment), and knowledge and information sources. KW - personal knowledge and information KW - personal information management KW - personal knowledge management KW - Information literacy KW - students Y1 - 2014 U6 - https://doi.org/10.1142/S0219649214500300 VL - 13 IS - 4 ER - TY - JOUR A1 - Hornberger, Helga A1 - Marquis, Peter M. A1 - Franks, J. T1 - The impact of diamond-like coatings on the strength of dental ceramics JF - Journal of Dental Research Y1 - 1995 VL - 74 SP - 522 ER - TY - JOUR A1 - Hornberger, Helga A1 - Marquis, Peter M. A1 - Christiansen, Silke H. A1 - Albrecht, Manuel A1 - Strunk, Horst P. A1 - Franks, J. T1 - Microstructure of a high strength alumina-glass composite combined with a diamond like carbon coating JF - Electron Microscopy and Analysis N2 - We investigate the mechanical and microstructural properties of a diamond-like carbon coating (DLC) which is deposited by plasma enhanced chemical vapor deposition (PECVD) onto an alumina/aluminosilicate glass composite used for biomedical applications. Ball-on-ring tests yield a fracture strength that is essentially influenced by the surface topology/roughness. The surface topology of the coating is investigated by atomic force microscopy (AFM). Tribology tests and nanoindentation represent the wear resistance and hardness; these are properties that are mainly influenced by the microstructural properties of the DLC coating. This microstructure is investigated by transmission electron microscopy (TEM) and analyzed by parallel electron energy loss spectroscopy (PEELS). For the general applicability of the coated composite, the interfacial adhesion of the DLC coating on the comparably rough substrate (roughness amplitudes and wavelengths are in the micrometer range) is important. Therefore, we focus on TEM investigations that show the interface to be free of gaps and pores that we, together with a characteristic microstructure adjacent to the interface, relate to the excellent adhesion. The interlayer consists of a high density of SiC grains, part of them directly bound to the substrate, and part of them bound to other SiC grains. This interlayer is followed by an essentially different region of the coating as concerns the microstructure; this region consists of nanocrystalline diamond particles embedded in an amorphous carbon matrix. It is this heterogeneous microstructure to which we attribute (i) the good adhesion based upon the interface stabilizing SiC grains, and (ii) the high hardness and wear resistance based upon the diamond nanocrystals in the coating. Y1 - 1995 U6 - https://doi.org/10.1557/JMR.1996.0244 SP - 559 EP - 562 ER - TY - JOUR A1 - Hornberger, Helga A1 - Marquis, Peter M. T1 - Mechanical properties and microstructure of In-Ceram BT - a ceramic-glass composite for dental crowns JF - Glastechnische Berichte - Glass Science and Technology Y1 - 1995 VL - 68 IS - 6 SP - 188 EP - 194 ER - TY - JOUR A1 - Hornberger, Helga A1 - Weissmann, R. A1 - Lutz, N. T1 - Machining of silica glasses using excimer laser radiation JF - Glastechnische Berichte - Glass Science and Technology Y1 - 1996 VL - 69 IS - 2 SP - 44 EP - 49 ER - TY - JOUR A1 - Hornberger, Helga A1 - Marquis, Peter M. A1 - Christiansen, Silke H. A1 - Strunk, Horst P. T1 - Microstructure of a high strength alumina glass composite JF - Journal of Materials Research N2 - The morphology and microstructure of an Al2O3 glass composite (trade name In-Ceram, Vita Zahnfabrik) were studied using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The composite was produced by infiltration of a lanthanum-based glass throughout a porous Al2O3 body. This alumina body was formed by three classes of particles differing in size and shape: faceted particles typically ≤4 μm in diameter, platelets of average diameter 8 μm, 1.5 μm thickness, and small spheres 0.4 μm in diameter. The outstanding strength properties of the composite (600 MPa, ball-on-ring test) are a result of the high wetting capability of the glass phase on the Al2O3 surface. In addition, plastic strain relaxation in the faceted particles by dislocation formation compensates partially for residual stresses and impedes crack formation at the glass/Al2O3 interface. Y1 - 1996 U6 - https://doi.org/10.1557/JMR.1996.0104 VL - 11 IS - 4 SP - 855 EP - 858 ER - TY - JOUR A1 - Christiansen, Silke H. A1 - Albrecht, Manuel A1 - Strunk, Horst P. A1 - Hornberger, Helga A1 - Marquis, Peter M. A1 - Franks, J. T1 - Mechanical properties and microstructural analysis of a diamond-like carbon coating on an alumina/glass composite JF - Journal of Materials Research N2 - We investigate the mechanical and microstructural properties of a diamond-like carbon coating (DLC) which is deposited by plasma enhanced chemical vapor deposition (PECVD) onto an alumina/aluminosilicate glass composite used for biomedical applications. Ball-on-ring tests yield a fracture strength that is essentially influenced by the surface topology/roughness. The surface topology of the coating is investigated by atomic force microscopy (AFM). Tribology tests and nanoindentation represent the wear resistance and hardness; these are properties that are mainly influenced by the microstructural properties of the DLC coating. This microstructure is investigated by transmission electron microscopy (TEM) and analyzed by parallel electron energy loss spectroscopy (PEELS). For the general applicability of the coated composite, the interfacial adhesion of the DLC coating on the comparably rough substrate (roughness amplitudes and wavelengths are in the micrometer range) is important. Therefore, we focus on TEM investigations that show the interface to be free of gaps and pores that we, together with a characteristic microstructure adjacent to the interface, relate to the excellent adhesion. The interlayer consists of a high density of SiC grains, part of them directly bound to the substrate, and part of them bound to other SiC grains. This interlayer is followed by an essentially different region of the coating as concerns the microstructure; this region consists of nanocrystalline diamond particles embedded in an amorphous carbon matrix. It is this heterogeneous microstructure to which we attribute (i) the good adhesion based upon the interface stabilizing SiC grains, and (ii) the high hardness and wear resistance based upon the diamond nanocrystals in the coating. Y1 - 1996 U6 - https://doi.org/10.1557/JMR.1996.0244 VL - 11 IS - 8 SP - 1934 EP - 1942 ER - TY - JOUR A1 - Reich, Sven A1 - Hornberger, Helga T1 - The effect of multicolored machinable ceramics on the esthetics of all-ceramic crowns JF - Journal of Prosthetic Dentistry N2 - Statement of problems: Computer-aided design/computer-assisted machining systems offer the possibility of fabricating restorations from one machinable ceramic block. Whether multishaded blocks improve esthetic results and are a viable alternative to individually stained ceramics has not been fully determined. Purpose: The aim of this investigation was to examine the effect of multishaded blocks on the esthetic appearance of all-ceramic CEREC crowns and compare these crowns with single-shade and stained restorations. Material and methods: Ten subjects were included in this study. For each subject, 6 different crowns were milled with the use of a CEREC machine. One crown was milled from each of the following machinable ceramic materials: CEREC Vitablocs Mark II in classic colors; Vitablocs Mark II in 3D-Master colors; Vitablocs Mark II in either classic or 3D-Master colors, with additional staining; Megadenta Bloxx multishaded; Mark II experimental multilayer; and an experimental multilayer leucite ceramic. Three independent examiners assessed the esthetic appearance of crowns fabricated to match each subject's anterior tooth shade. A scale of 1 to 6 was used to score the shade match and esthetic adaptation of each crown, with 1 representing excellent characteristics and 3.5 serving as the threshold for clinical acceptability. The examiners' scores were averaged, and the mean values were analyzed with the Wilcoxon signed rank test (P 4 cm (i.e. bulky disease). KW - Gebärmutterhalskrebs KW - Chirurgie KW - Tumorwachstum Y1 - 2007 U6 - https://doi.org/10.1016/j.ygyno.2007.06.026 VL - 107 IS - 2 SP - 310 EP - 315 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Fischer, Uta A1 - Raptis, Georgios A1 - Bilek, Karin A1 - Hentschel, Bettina A1 - Richter, Christine E. A1 - Braumann, Ulf Dietrich A1 - Einenkel, Jens T1 - Pattern of invasion is of prognostic value in surgically treated cervical cancer patients JF - Gynecologic Oncology N2 - Objectives: Different patterns of invasion (representing different grades of tumor cell dissociation) are associated with prognostic outcome in cancer. We evaluated the prognostic value of different patterns of invasion (PI) in cervical carcinomas (CX). Methods: Six hundred eleven surgically treated CX (FIGO IB to IIB) were re-evaluated histologically regarding the PI, using a three-level scoring system. Closed PI was defined as cohesive growth with well-delineated (pushing) borders. In finger-like PI the tumor grows in solid cords/trabecles. Highly dissociative growth in small groups or single cells was defined as spray-like PI. Types of PI were correlated to tumor stage, histo-morphologic factors and prognostic outcome. Results: Sixty percent of the tumors showed a spray-like PI, 30% a finger-like PI and only 7.4% were of the closed type. Spray-like PI showed a significant correlation with advanced stage disease, lymphovascular space involvement, poorly differentiated tumors and pelvic lymph node metastases. Spray-like PI was accompanied by a reduced 5-year overall survival when compared to the finger-like and closed PI (68.7% vs. 80.9% vs. 88.5%; P=0.0004). The prognostic impact of the PI disappeared in node-positive patients (P=0.06) but persisted in patients without pelvic lymph node disease (P=0.03). In multivariate analysis, using COX regression model, the PI represented as independent prognostic factor. Conclusions: Spray-like PI (i.e., highest degree of tumor cell dissociation) is associated with advanced tumor stages, increased rate of recurrency and a reduced overall survival. In separate analysis of patients with and without lymph node metastases, the impact of PI persisted only in node-negative cases as a prognostic factor. KW - Gebärmutterhalskrebs KW - Chirurgie KW - Metastase Y1 - 2006 U6 - https://doi.org/10.1016/j.ygyno.2006.05.046 VL - 103 IS - 3 SP - 906 EP - 911 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Hentschel, Bettina A1 - Köhler, U. A1 - Richter, Christine E. A1 - Martin, Rosemarie T1 - CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance JF - Archives of Gynecology and Obstetrics N2 - Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information. KW - Gebärmutterhalskrebs KW - Antigen CD44 Y1 - 2005 U6 - https://doi.org/10.1007/s00404-005-0039-5 VL - 273 IS - 2 SP - 104 EP - 106 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Nenning, Hans T1 - DNA cytometric analysis of surgically treated squamous cell cancer of the uterine cervix, stage pT1b1-pT2b JF - Analytical and quantitative cytology and histology N2 - Objective: To determine the utility of DNA content and DNA-related variables of proliferative activity regarding prognosis in cervical cancer. Study design: DNA image (ICM) andflow cytometry (FCM) were performed to determine the DNA index (DI), 5c-exceeding rate (5c-ER), S-phase fraction (SPF) and proliferation index (PI) in 163 patients with surgically staged pT1b1-pT2b squamous cell cancer of the uterine cervix and treated with primary radical hysterectomy. ICM was performed on imprint cytology, obtained from fresh tumor tissue, which was also used for FCM. Results were analyzed using the chi2 test and Cox regression analysis for risk of pelvic lymph node involvement, tumor recurrence and recurrence-free survival (RFS). Results: ICM was performed on all 163 and FCM on 133 samples. One-third of the tumors showed DNA aneuploidy. Analysis demonstrated prognostic significance of a DI > or = 1.70, with a (70:30) 2.3-fold risk of recurrence (P=.024) and reduced RFS of 10 months (P=.003) in cases of DI > or = 1.70. A high 5c-ER > 11% was associated with pelvic lymph node involvement and decreased RFS (P < or = .04). Significantly more relapses were found in tumors with SPF > 12% (70.8% vs. 29.2%, P=.007). RFS was markedly reduced in tumors with high SPF (52.3 vs. 61.1 months, P=.011). Low proliferative tumors (PI<25%) were associated with lower stage (P=.036) and increased RFS (61.2 vs. 47.1 months, P=.028). In multivariate analysis of clinicopathologic variables (pT category, nodal status, lymphovascular space involvement) and DNA related variables, pelvic lymph node involvement was the only significant predictor of RFS. In patients with nodal involvement, tumors with DI >1.70 were associated with lessfavorable outcomes. Conclusion: DNA-related variables of cell cycle analysis were valuablefor predicting prognosis in cervical cancer patients. Tumors with DI>1.70, 5c-ER >11% and high proliferative activity (SPF>12%, PI>25%) represent a subgroup with a poor prognosis. KW - Gebärmutterhals KW - squamöser Krebs KW - Cytometrie KW - Chirurgie Y1 - 2002 VL - 24 IS - 1 SP - 23 EP - 29 ER - TY - CHAP A1 - Horn, Lars-Christian A1 - Pippig, S. A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Köhler, U. A1 - Hentschel, Bettina A1 - Martin, Rosemarie T1 - Tumorassoziierte Proteolyse beim Zervixkarzinom BT - Vortrag T2 - 87. Tagung der Deutschen Gesellschaft für Pathologie, 14. Juni 2003 KW - Gebärmutterhalskrebs KW - Chirurgie KW - Tumorassoziierte Proteolyse KW - Immuncytochemie KW - Zelladhäsion Y1 - 2003 ER - TY - CHAP A1 - Höh, H. A1 - Raptis, Georgios T1 - Applications of the Erbium: YAG Laser in Ophthalmology - Cataracta-, Glaukoma-, Eyelid-Surgery and pars plana Vitrectomy BT - Symposium on Cataract, IOL, and Refractive Surgery. Boston, 20.05.2000 und 22.05.2000 N2 - Recent developments in lasers have provided us the possibility of laser ocular surgery. The xenon, argon, neodymium:YAG and dye lasers have been successfully used in out-patient clinics. The excimer laser has been attracting researchers' interest in the new application of laser to cornea and lens. The erbium:YAG laser emits a 2.94-microns beam that can ablate the transparent ocular tissues such as lenses and corneas. The author has applied this laser to the cornea, lens, vitreous and other ocular tissues. The erbium:YAG laser beam was directed through a 1.5-meter-long, 200-microns-diameter fiberoptic guide. The radiant energy measured about 50 mJ at the end of the probe. The laser was emitted as a 400-microsecond pulse. Freshly enucleated rabbit eyes were used in this study. Laser burns were applied to the tissue surface at various energy settings. At minimal power, the tissues were coagulated by the erbium:YAG laser application. At a power of more than 636-954 mJ/mm2, tissue began to evaporate; the tissue loss was observed under a surgical light microscope. Corneal photoablation, lens ablation, iridotomy, trabeculotomy, cutting of the vitreous and retinal ablation were easily performed. Like the excimer laser, the erbium:YAG laser is a potential tool for ocular surgery. KW - Augenchirurgie KW - YAG-Laser KW - Erbium-Laser Y1 - 2000 ER - TY - JOUR A1 - Chaloupka, I. A1 - Raptis, Georgios A1 - Zach, A. A1 - Brändlin, K. A1 - Meier-Ewert, H. T1 - Rolle der quantitativen CMV-DNA-Bestimmungen in der Diagnostik und Therapie der Cytomegalovirusinfektion bei immunsupprimierten Patienten BT - Vortrag JF - Jahrestagung der Gesellschaft für Virologie in Wien, April 2000 KW - Cytomegalie-Virus KW - Diagnose KW - Immunsuppresion Y1 - 2000 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Pippig, S. A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Köhler, U. A1 - Hentschel, Bettina A1 - Martin, Rosemarie T1 - Clinical relevance of urokinase-type plasminogen activator and its inhibitor type-1 (PAI-1) in squamous cell carcinoma of the uterine cervix JF - Australian and New Zealand Journal of Obstetrics and Gynaecology N2 - Objective The expression of uPA and PAI‐1 as parameters of tumour‐associated proteolysis has been implicated in the process of tumour cell invasion and the metastatic process. However, there is limited information on the impact of these parameters in cervical carcinoma. Methods Quantitative levels for uPA (n = 114) and PAI‐1 (n = 103) were researched in operatively treated, surgically staged squamous cell cancer of the uterine cervix, using an ELISA‐technique. Results were assessed regarding their impact in predicting pelvic lymph nodes metastases, tumour recurrence rate and recurrence free survival (RFS) using uni‐ and multivariate analysis. Results Median levels of both parameters were significantly higher in tumour tissue than in normal cervical tissue (p < 0.001). Detection of uPA gave no useful prognostic information. PAI‐1 concentration showed a positive correlation with advanced tumour stage (p = 0.008), but no significant correlation with nodal status (pN0: 2.6 vs. pN1: 4.0 ng/mg protein; p = 0.092). Using a cut‐off level of 2.4 ng/mg protein, patients with elevated PAI‐1 levels demonstrated reduced RFS (45.9 versus 52.9 months; p = 0.1). Multivariate analysis, including nodal status, tumour stage, lymphovascular space involvement and grading failed to demonstrate any prognostic impact of uPA and PAI‐1. Conclusions The results indicate, that PAI‐1 expression is of some prognostic impact in cervical cancer, indicating an association of elevated PAI levels with local tumour progression and reduced recurrence‐free survival. KW - Plasminogen human-Aktivator KW - Urokinase KW - squamöser Krebs KW - Gebärmutterhals Y1 - 2004 U6 - https://doi.org/10.1111/j.0004-8666.2002.00385.x VL - 42 IS - 4 SP - 385 EP - 388 ER - TY - JOUR A1 - Fischer, Uta A1 - Raptis, Georgios A1 - Geßner, W. A1 - Roschlau, U. A1 - Dressel, K. A1 - Bilek, Karin A1 - Horn, Lars-Christian T1 - Epidemiologie und formale Pathogenese des Zervixkarzinoms JF - Zentralblatt für Gynäkologie T2 - Epidemiology and pathogenesis of cervical cancer KW - Gebärmutterhalskrebs KW - Epidemiologie KW - Pathogenese Y1 - 2001 VL - 123 IS - 4 SP - 198 EP - 205 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Fischer, Uta A1 - Hanel, C. A1 - Kuhn, H. A1 - Raptis, Georgios A1 - Bilek, Karin T1 - p53 in surgically treated and pathologically staged cervical cancer BT - correlation with local tumor progression, but not with lymphatic spread JF - Pathology - Research and Practice KW - Gebärmutterhalskrebs KW - Tumorsuppressor-Gen KW - Chirurgie KW - Histopathologie Y1 - 2001 VL - 197 IS - 9 SP - 605 EP - 609 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Bilek, Karin T1 - Impact of tumorload in surgically treated, histologically staged early cervical cancer: Multivariate analysis of 568 patients JF - International Journal of Gynecology & Obstetrics KW - Gebärmutterhalskrebs KW - Chirurgie KW - Tumorklasifikation Y1 - 2000 VL - 70 IS - Suppl. 1 SP - 20 EP - 21 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Bilek, Karin T1 - p53-tumorsuppressor gene in surgically treated histologically staged early cervical cancer JF - International Journal of Gynecology & Obstetrics KW - Tumorsuppressor-Gen KW - Chirurgie KW - Histopathologie KW - Gebärmutterhalskrebs Y1 - 2000 VL - 70 IS - Suppl. 1 SP - 112 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Martin, Rosemarie T1 - Tumorassoziierte Proteolyse, p53-Immunhistochemie und Zelladhäsion bei primär operierten Zervixkarzinomen JF - Geburtshilfe und Frauenheilkunde KW - Tumorassoziierte Proteolyse KW - Immuncytochemie KW - Zelladhäsion KW - Gebärmutterhalskrebs Y1 - 2000 VL - 60 IS - Suppl. 1 SP - 200 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Fischer, Uta A1 - Bilek, Karin T1 - Standardised handling of hysterectomy specimen in cervical cancer – report of over 900 stage pT1b1- to pT2b-tumors JF - Pathology - Research and Practice KW - Gebärmutterhalskrebs KW - Chirurgie KW - Gewebe KW - Gebärmutterentfernung Y1 - 2000 VL - 196 SP - 450 ER - TY - JOUR A1 - Kopper, Andreas A1 - Klotz, Stefan A1 - Westner, Markus A1 - Strahringer, Susanne T1 - Shadow IT and Business-managed IT BT - Practitioner Perceptions and Their Comparison to Literature JF - Journal of Information Technology Management (JITM) N2 - Two concepts describe the autonomous deployment of IT by business entities: Shadow IT and Business-managed IT. Shadow IT is deployed covertly, that is, software, hardware, or IT services created/procured or managed by business entities without alignment with the IT organization. In contrast, Business-managed IT describes the overt deployment of IT, that is, in alignment with the IT organization or in a split responsibility model. The purpose of this paper is to extend the conceptual understanding of Shadow IT and Business-managed IT, comparing the perceptions of 29 CIOs and senior IT managers with the results of a systematic literature review. By doing so, this paper presents a structured and comprehensive view of causing factors, outcomes, and governance of Shadow IT and Business-managed IT in practice. A comparison of academic literature and practitioner perceptions reveals the limitations and gaps of the current research and highlights avenues for future research. The authors find three category-spanning themes occurring as causing factors, outcomes, and—as part of governance measures—factors to improve the IT organization: (1) (Poor) business-IT alignment (2) (lack of) agility, and (3) (lack of) policies. This study is innovative with its comprehensive qualitative interview data that the authors compare to the existing literature. Therefore, the paper brings together theoretical and practical insights into Shadow IT and Businessmanaged IT, which should aid practitioners and scholars in decision making and future research. KW - Corporate Governance KW - Strategisches Management KW - Shadow IT KW - Business-managed IT KW - IT governance KW - Agility KW - Business-IT alignment KW - Informationsmanagement Y1 - 2019 UR - http://home.thejitm.org/XXX-4/contents.html SN - 1042-1319 VL - 30 IS - 4 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Fischer, Uta T1 - Familial cancer history in patients with carcinoma of the cervix uteri JF - European Journal of Obstetrics & Gynecology and Reproductive Biology KW - Gebärmutterhalskrebs KW - Familienanamnese Y1 - 2002 U6 - https://doi.org/10.1016/s0301-2115(01)00520-6 VL - 101 IS - 1 SP - 54 EP - 57 ER - TY - JOUR A1 - Horn, Lars-Christian A1 - Fischer, Uta A1 - Tannapfel, A. A1 - Kuhn, H. A1 - Hänel, C. A1 - Raptis, Georgios T1 - The role of p53 tumorsuppressorgene in tumor progression in cervical cancer JF - Pathology - Research and Practice KW - Tumorsuppressor-Gen KW - Tumorwachstum KW - Gebärmutterhalskrebs Y1 - 1999 VL - 195 SP - 328 ER - TY - CHAP A1 - Raptis, Georgios T1 - Die Konzepte und Mechanismen der elektronischen Gesundheitskarte und des Heilberufsausweises aus der Sicht der Datensicherheit / des Datenschutzes BT - Vortrag T2 - Forschungsseminar med. Informatik an der Universität Heidelberg, 22.06.2006 KW - Elektronische Gesundheitskarte KW - Heilberuf KW - Ausweis KW - Datenschutz KW - Datensicherheit Y1 - 2005 ER - TY - CHAP A1 - Raptis, Georgios T1 - Empfehlungen der BÄK zum Datenschutz im Praxisalltag, Darstellung unter technischen Aspekten BT - Vortrag im Rahmen der conhIT 2009, Berlin, 22.04.2009, zertifiziert von der Ärztekammer Berlin T2 - conhIT 2009, Berlin, 22.04.2009 KW - Arztpraxis KW - Datenschutz Y1 - 2009 ER - TY - CHAP A1 - Raptis, Georgios T1 - Health Professional eIDs vis-á-vis a Single Market Perspective BT - Vortrag T2 - European Health Telematics Association, Berlin, 25.10.2011 KW - eArztausweis KW - Elektronischer Arztausweis Y1 - 2011 ER - TY - JOUR A1 - De Pieri, Enrico A1 - Atzori, Federica A1 - Ferguson, Stephen J. A1 - Dendorfer, Sebastian A1 - Leunig, Michael A1 - Aepli, Martin T1 - Contact force path in total hip arthroplasty: effect of cup medialisation in a whole-body simulation JF - HIP International N2 - Background: Cup medialisation down to the true acetabular floor in total hip arthroplasty with a compensatory femoral offset increase seems to be mechanically advantageous for the abductor muscles due to the relocation of the lever arms (body weight lever arm decreased, abductor lever arm increased). However, limited information is currently available about the effects of this reconstruction type at the head cup interface, compared to an anatomical reconstruction that maintains the natural lever arms. Through a whole-body simulation analysis, we compared medialised versus anatomical reconstruction in THA to analyse the effects on: (1) contact force magnitude at the head cup interface; (2) contact force path in the cup; and (3) abductor activity. Methods: Musculoskeletal simulations were performed to calculate the above-mentioned parameters using inverse dynamics analysis. The differences between the virtually implanted THAs were calculated to compare the medialised versus anatomical reconstruction. Results: Cup medialisation with compensatory femoral offset increase led to: (1) a reduction in contact force magnitude at the head cup interface up to 6.6%; (2) a similar contact force path in the cup in terms of sliding distance and aspect ratio; and (3) a reduction in abductor activity up to 17.2% (gluteus medius). Conclusions: In our opinion, these potential biomechanical gains do not generally justify a fully medialised reconstruction, especially in younger patients that are more likely to undergo revision surgery in their lifetime. Cup medialisation should be performed until sufficient press fit and bony coverage of a properly sized and oriented cup can be achieved. KW - Cup medialisation KW - femoral offset KW - hip contact force KW - total hip anthroplasty KW - total hip replacement KW - Hüftgelenkprothese KW - Kontaktkraft KW - Biomechanische Analyse KW - Simulation Y1 - 2020 U6 - https://doi.org/10.1177/1120700020917321 VL - 31 IS - 5 SP - 624 EP - 631 PB - Sage ER - TY - INPR A1 - Bock, Sebastian A1 - Weiß, Martin Georg T1 - Rotation Detection of Components with Convolutional Neural Networks N2 - The main issues in many image processing applications are object recognition and detection of objects, which answers the questions whether an object is present and if it is present, where it is located. Popular object detection algorithms like YOLO use a regression formulation for the whole problem, especially for the bounding box parameters. In production industry the setting usually is different: One usually knows the object type and rather wants to know with high precision where the object is. We study a prototype application in this area where we identify the rotation of an object in a plane. To solve this problem use a regression approach with a CNN architecture as a function approximator. We compare our results to standard image processing algorithms, which do not use neural networks, and present quantitative results on the accuracy. CNNs seem at least competitive to classical image processing. KW - Neural networks KW - Network Architecture KW - CNN KW - Functionapproximation KW - Image orientation Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:898-opus4-4120 ER - TY - JOUR A1 - Höh, H. A1 - Gamael, A. A1 - Raptis, Georgios T1 - Energie und Phakozeit bei Ultraschall und Laserphakoemulsifikation JF - Klinische Monatsblätter für Augenheilkunde KW - Phakoemulsifikation KW - Ultraschall Y1 - 2000 VL - 217 IS - Suppl. 8 SP - 5 ER - TY - JOUR A1 - Lekakis, J. A1 - Nanas, J. A1 - Prassopoulos, V. A1 - Raptis, Georgios T1 - Cardiac I-123 metaiodobenzylguanidine uptake in predicting early and late mortality in patients with congestive heart failure JF - Circulation (Suppl.) KW - Stauungssuffizienz KW - Radiologische Diagnostik KW - Prognose Y1 - 1997 VL - 96 IS - 8 SP - 2104 ER - TY - GEN A1 - Raptis, Georgios T1 - Biometrie - Anwendungen und Datenschutz. Welche Zusatzinformationen liefert der IRIS-Pförtner? Nebennutzen in einem biometrischen Zugangskontrollsystem. Medizinische Hintergründe. Symposium des Bundesamtes für Sicherheit in der Informationstechnik, Vortrag, Darmstadt 23. Mai 2002 BT - Vortrag, Darmstadt 23. Mai 2002 T2 - Symposium des Bundesamtes für Sicherheit in der Informationstechnik Y1 - 2002 ER - TY - CHAP A1 - Wiesmaier, Alexander A1 - Lippert, Markus A1 - Karatsiolis, Vangelis A1 - Raptis, Georgios A1 - Buchmann, Johannes T1 - An Evaluated Certification Services System for the German National Root CA - Legally Binding and Trustworthy Transactions in E-Business and E-Government T2 - Proceedings of The 2005 International Conference on E-Business, Enterprise Information Systems, E-Government, and Outsourcing, EEE 2005, Las Vegas, Nevada, USA, June 20-23, 2005 Y1 - 2005 SN - 1-932415-76-9 SP - 103 EP - 108 PB - CSREA Press ER - TY - GEN A1 - Raptis, Georgios T1 - Übersicht über die neuen Technischen Richtlinien des BSI zum ersetzenden Scannen und zur Langzeitarchivierung BT - Vortrag T2 - Telemed 2014, Berlin, 14.10.2014 Y1 - 2014 ER - TY - GEN A1 - Raptis, Georgios T1 - Mögliche Auswirkungen der eIDAS-Verordnung auf die Telematikinfrastruktur und die eArztausweise BT - Vortrag T2 - CAST-Workshop PKI, Darmstadt, 29.01.2015 KW - Europäische Union KW - Telemedizin KW - eArztausweis KW - Elektronischer Arztausweis Y1 - 2015 ER - TY - GEN A1 - Raptis, Georgios T1 - HPCs als Basis für den elektronischen Arztausweis BT - Vortrag T2 - Smartcard-Workshops, Fraunhofer SIT, 07.02.2006 KW - Arzt KW - Ausweis KW - Hochleistungsrechnen Y1 - 2006 ER - TY - GEN A1 - Raptis, Georgios T1 - Ist die Sicherheit der medizinischen Daten in der Telematik-Infrastruktur zu gewährleisten? BT - Vortrag an der Universität Heidelberg, Kolloquium Wissenschaftlichkeit in der Medizin, 10.05.2007 T2 - Kolloquium Wissenschaftlichkeit in der Medizin, Universität Heidelberg, 10.05.2007 KW - Telemedizin KW - Datensicherheit Y1 - 2007 ER - TY - GEN A1 - Raptis, Georgios T1 - Datenschutz und IT-Sicherheit: Empfehlungen von BÄK und KBV für Ärzte BT - Vortrag T2 - AK-Sicherheit des eco-Verband der deutschen Internetwirtschaft e.V., Köln, 06.05.2009 KW - Arztpraxis KW - Datenschutz KW - Datensicherheit Y1 - 2009 ER - TY - THES A1 - Raptis, Georgios T1 - Klassifikation, Anwendungen und Sicherheitskonzept von Trustcentern KW - Trust Center Y1 - 2004 ER - TY - GEN A1 - Raptis, Georgios T1 - Mechanismen und Einsatzkonzepte von Heilberufsausweis und elektronischer Gesundheitskarte BT - Vortrag T2 - Oberseminar im Fachbereich Informatik, Kryptographie und Computeralgebra der TU-Darmstadt, 28.11.2006 KW - Elektronische Gesundheitskarte KW - Heilberuf KW - Ausweis Y1 - 2006 ER - TY - JOUR A1 - Schenkel, Johannes A1 - Albert, Jürgen A1 - Raptis, Georgios A1 - Butz, Norbert ED - Duesberg, Felix T1 - Notfalldatenmanagement auf der elektronischen Gesundheitskarte JF - e-Health KW - Elektronische Gesundheitskarte KW - Notfallmedizin Y1 - 2012 SP - 64 EP - 67 PB - medical future verlag CY - Solingen ER - TY - JOUR A1 - Aurbach, Maximilian A1 - Spicka, Jan A1 - Süß, Franz A1 - Dendorfer, Sebastian T1 - Evaluation of musculoskeletal modelling parameters of the shoulder complex during humeral abduction above 90° JF - Journal of Biomechanics N2 - Based on electromyographic data and force measurements within the shoulder joint, there is an indication that muscle and resulting joint reaction forces keep increasing over an abduction angle of 90°. In inverse dynamics models, no single parameter could be attributed to simulate this force behaviour accordingly. The aim of this work is to implement kinematic, kinetic and muscle model modifications to an existing model of the shoulder (AnyBody™) and assess their single and combined effects during abduction up to 140° humeral elevation. The kinematics and the EMG activity of 10 test subjects were measured during humeral abduction. Six modifications were implemented in the model: alternative wrapping of the virtual deltoid muscle elements, utilization of a three element Hill model, strength scaling, motion capture driven clavicle elevation/protraction, translation of the GH joint in dependency of the acting forces and an alteration of the scapula/clavicle rhythm. From the six modifications, 16 different combinations were considered. Parameter combinations with the Hill model changed the resultant GH joint reaction force and led to an increase in force during abduction of the humerus above 90°. Under the premise of muscle activities and forces within the GH joint rising after 90° of humeral abduction, we propose that the Hill type muscle model is a crucial parameter for accurately modelling the shoulder. Furthermore, the outcome of this study indicates that the Hill model induces the co-contraction of the muscles of the shoulder without the need of an additional stability criterion for an inverse dynamics approach. KW - Shoulder joint KW - Musculoskeletal modelling KW - EMG KW - Glenohumeral joint reaction force KW - Muscle model KW - Schultergelenk KW - Bewegungsapparat KW - Biomechanik KW - Simulation Y1 - 2020 U6 - https://doi.org/10.1016/j.jbiomech.2020.109817 VL - 106 IS - June PB - Elsevier ER - TY - GEN A1 - Raptis, Georgios T1 - Einsatzmöglichkeiten des elektronischen Heilberufsausweises BT - Vortrag im Rahmen des CAST-Forums, Fraunhofer IGD, 14.09.2006 T2 - CAST-Forums, Fraunhofer IGD, 14.09.2006 KW - Heilberuf KW - Ausweis Y1 - 2006 ER - TY - JOUR A1 - Raptis, Georgios T1 - App statt Arzt ist kein gutes Motto BT - Interview JF - medizin & technik Y1 - 2013 UR - https://medizin-und-technik.industrie.de/medizin/mediziner-ueber-technik/app-statt-arzt-ist-kein-gutes-motto/ IS - 2 ER - TY - CHAP A1 - Raptis, Georgios T1 - Notfalldaten und Datenerhalt mit der elektronischen Gesundheitskarte. T2 - Tagungsband 22. Smartcard-Workshop 2012 KW - Elektronische Gesundheitskarte KW - Notfallmedizin KW - Datensicherung Y1 - 2012 SP - 166 PB - Fraunhofer-Verlag ER - TY - JOUR A1 - Fischer, Uta A1 - Raptis, Georgios A1 - Horn, Lars-Christian T1 - Bedeutung der Familienanamnese bei Zervixkarzinom JF - Zentralblatt für Gynäkologie N2 - Fragestellung: Molekulare Analysen haben deutlich gemacht, dass maligne Tumoren durch Veränderungen des Genoms hervorgerufen werden. Im Gegensatz zu den erblich bedingten Tumorerkrankungen sind die Kenntnisse zur Bedeutung familiärer Faktoren bei den sog. sporadischen Tumoren, insbesondere beim Zervixkarzinom (CX) begrenzt. Material und Methode: Patientinnen des CX-Registers der Universitäts-Frauenklinik wurden retrospektiv bezüglich der Familienanamnese (FA) analysiert. Als positive FA wurde eine maligne Tumorerkrankung bei einem oder mehreren Verwandten ersten Grades definiert. Es wurde unterschieden, ob es sich um Zervixkarzinome, andere gynäkologische Malignome (außer Mammakarzinom) oder eine extragenitale Lokalisation handelte. Diese Daten wurden zum Erkrankungsalter und zum Nachweis pelviner Lymphknotenmetastasen in Beziehung gesetzt. Ergebnisse: 159/737 Frauen (21,6 %) wiesen eine positive FA auf. In 10,7 % der Fälle war mehr als ein Verwandter ersten Grades erkrankt; bei 6,9 % Angehörige ersten und zweiten Grades. Weibliche Verwandte ersten Grades von 42 Frauen wiesen Malignome des weiblichen Genitaltraktes (außer CX) auf. In 6,9 % waren die Mutter und/oder die Schwester an einem Zervixkarzinom erkrankt. Das Durchschnittsalter der Patientinnen mit positiver Familienanamnese (FA) unterschied sich nicht von dem derjenigen mit leerer FA, wohl aber bei getrennter Betrachtung nach der Tumorlokalisation. Bezüglich des Tumorstadiums (pTNM) und der Zahl der Patientinnen mit histologisch nachgewiesenen pelvinen Lymphknotenmetastasen bestand kein Unterschied. Schlussfolgerungen: Die bisherigen Ergebnisse deuten auch beim Zervixkarzinom auf eine familiäre Belastung hin. Dabei existieren offenbar Familien, in denen mit HPV-assoziierte Präkanzerosen bzw. Tumoren vermehrt auftreten. Besonders gefährdet sind Patientinnen, deren weibliche Anverwandte ersten Grades bereits an einer zervikalen Präkanzerose (besonders CIN III) oder einem invasiven CX erkrankt sind. Diese Frauen sollten einem engmaschigen Screening unterzogen werden. T2 - Impact of familiar history in cervical cancer patients KW - Gebärmutterhalskrebs KW - Familienanamnese KW - Zervixkarzinom KW - hereditär KW - familiär KW - Anamnese KW - Karzinom KW - Prognose Y1 - 2001 U6 - https://doi.org/10.1055/s-2001-14791 VL - 123 SP - 302 EP - 307 ER - TY - GEN A1 - Horn, Lars-Christian A1 - Raptis, Georgios A1 - Fischer, Uta T1 - Familiäres Zervixkarzinom – Erste Ergebnisse BT - Poster T2 - 54. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe KW - Gebärmutterhalskrebs KW - Familienanamnese Y1 - 2002 ER - TY - CHAP A1 - Raptis, Georgios T1 - Ein Verfahren zur Lösung des Problems der kryptographischen Langzeitsicherheit medizinischer Daten, die in einer Infrastruktur gespeichert werden T2 - BIOSIG-Konferenz 2007, Darmstadt N2 - Medizinische Daten, die - wie derzeit für die Telematik-Infrastruktur nach §291a SGB V spe-zifiziert - auch außerhalb der physischen Kontrolle der Eigentümer oder Ersteller (also z.B. außerhalb von Arztpraxen oder Klinken) auf Servern kryptographisch verschlüsselt gespeichert werden, müssen sehr lange vertraulich bleiben. Insbesondere darf der technische Betreiber des Servers, der die Daten speichert, keinen Zugriff erlangen. Es kann jedoch keine verlässliche Aussage dahingehend getroffen werden, ob die heute eingesetzten kryp-tographischen Algorithmen in 30 oder 40 Jahren die Vertraulichkeit der medizinischen Daten weiterhin gewährleisten. Es wird ein Verfahren vorgestellt, welches das Problem der langfristigen Sicherheit von verschlüsselt gespeicherten medizinischen Daten aus kryptographischer Sicht löst. Die Anwendung des Verfahrens wird am Beispiel einer nach den derzeit bekannten gematik-Spezifikationen definierten Infrastruktur veranschaulicht. Es wird von einer getrennten Speicherung von verschlüsselten medizinischen Daten und Schlüsselmaterial ausgegangen. Die Daten werden an der Datenquelle (Konnektor, z.B. eines Arztes) mit einem Einmalblock (One Time Pad, OTP) verschlüsselt. Sie sind damit beweisbar sicher verschlüsselt, weil das One-Time-Pad-Verschlüsselungsverfahren beweisbar „perfekt geheim“ ist. Der OTP-Schlüssel wird mit einem symmetrischen Schlüssel verschlüsselt, der wiederum mit den asymmetrischen Schlüsseln aller Zugriffsberechtigten verschlüsselt wird. Die kryptographische, technische und organisatorische Sicherheit des Verfahrens sowie seine Voraussetzungen und Kosten werden analysiert. KW - Gesundheitsinformationssystem KW - Datensicherhung KW - Kryptologie Y1 - 2007 UR - http://www.baek.de/downloads/Raptis_Verfahren-2.pdf ER -