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  <doc>
    <id>1386</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>periodicalpart</type>
    <publisherName/>
    <publisherPlace>Regensburg</publisherPlace>
    <creatingCorporation>Ostbayerische Technische Hochschule Regensburg</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Forschungsbericht 2015</title>
    <identifier type="isbn">978-3-00-048589-3</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-13867</identifier>
    <identifier type="doi">10.35096/othr/pub-1386</identifier>
    <author>Georg Scharfenberg</author>
    <author>Jürgen Mottok</author>
    <author>Christina Artmann</author>
    <author>Martin Hobelsberger</author>
    <author>Ivan Paric</author>
    <author>Benjamin Großmann</author>
    <author>Clemens Pohlt</author>
    <author>Alena Wackerbarth</author>
    <author>Uli Pausch</author>
    <author>Christiane Heidrich</author>
    <author>Martin Fadanelli</author>
    <author>Michael Elsner</author>
    <author>Daniel Pöcher</author>
    <author>Lenz Pittroff</author>
    <author>Stefan Beer</author>
    <author>Oliver Brückl</author>
    <author>Matthias Haslbeck</author>
    <author>Michael Sterner</author>
    <author>Martin Thema</author>
    <author>Nicole Muggenthaler</author>
    <author>Thorsten Lenck</author>
    <author>Philipp Götz</author>
    <author>Fabian Eckert</author>
    <author>Michael Deubzer</author>
    <author>Armin Stingl</author>
    <author>Erol Simsek</author>
    <author>Stefan Krämer</author>
    <author>Benjamin Großmann</author>
    <author>Thomas Schlegl</author>
    <author>Sascha Niedersteiner</author>
    <author>Thomas Berlehner</author>
    <author>Mitchell Joblin</author>
    <author>Wolfgang Mauerer</author>
    <author>Sven Apel</author>
    <author>Janet Siegmund</author>
    <author>Dirk Riehle</author>
    <author>Joachim Weber</author>
    <author>Christoph Palm</author>
    <author>Martin Zobel</author>
    <author>Ghassan Al-Falouji</author>
    <author>Dietmar Prestel</author>
    <author>Georg Scharfenberg</author>
    <author>Roland Mandl</author>
    <author>Arnulf Deinzer</author>
    <author>W. Halang</author>
    <author>Jutta Margraf-Stiksrud</author>
    <author>Bernhard Sick</author>
    <author>Renate Deinzer</author>
    <author>Stefanie Scherzinger</author>
    <author>Meike Klettke</author>
    <author>Uta Störl</author>
    <author>Katharina Wiech</author>
    <author>Christoph Kubata</author>
    <author>Dirk Sindersberger</author>
    <author>Gareth J. Monkman</author>
    <author>Markus Dollinger</author>
    <author>Sven Dembianny</author>
    <author>Andreas Kölbl</author>
    <author>Franz Welker</author>
    <author>Matthias Meier</author>
    <author>Philipp Thumann</author>
    <author>Krzysztof Swidergal</author>
    <author>Marcus Wagner</author>
    <author>Sonja Haug</author>
    <author>Matthias Vernim</author>
    <author>Barbara Seidenstücker</author>
    <author>Karsten Weber</author>
    <author>Christian Arsan</author>
    <author>Reinhold Schone</author>
    <author>Johannes Münder</author>
    <author>Irmgard Schroll-Decker</author>
    <author>Andrea Elisabeth Dillinger</author>
    <author>Rudolf Fuchshofer</author>
    <author>Gareth J. Monkman</author>
    <author>Mikhail Shamonin (Chamonine)</author>
    <author>Markus A. Geith</author>
    <author>Fabian Koch</author>
    <author>Christian Ühlin</author>
    <author>Thomas Schratzenstaller</author>
    <author>Sean Patrick Saßmannshausen</author>
    <author>Eberhard Auchter</author>
    <author>Willy Kriz</author>
    <author>Othmar Springer</author>
    <author>Maria Thumann</author>
    <author>Wolfgang Kusterle</author>
    <author>Andreas Obermeier</author>
    <author>Anton Udalzow</author>
    <author>Anton Schmailzl</author>
    <author>Stefan Hierl</author>
    <author>Christoph Langer</author>
    <author>Rupert Schreiner</author>
    <series>
      <title>Forschungsberichte der OTH Regensburg</title>
      <number>2015</number>
    </series>
    <collection role="institutes" number="HL">Hochschulleitung/Hochschulverwaltung</collection>
    <collection role="othpublikationsherkunft" number="">Von der OTH Regensburg herausgegeben</collection>
    <collection role="persons" number="weberlate">Weber, Karsten (Prof. Dr.) - Labor für Technikfolgenabschätzung und Angewandte Ethik</collection>
    <collection role="institutes" number="IAFW">Zentrum für Forschung und Transfer (ZFT ab 2024; vorher: IAFW)</collection>
    <collection role="persons" number="sternerfenes">Sterner, Michael (Prof. Dr.) - FENES / Forschungsgruppe Energiespeicher</collection>
    <collection role="persons" number="bruecklfenes">Brückl, Oliver (Prof. Dr.) - FENES / Forschungsgruppe Energienetze</collection>
    <collection role="persons" number="hauglasofo">Haug, Sonja (Prof. Dr.) - Labor Empirische Sozialforschung</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/1386/Forschungsbericht_2015.pdf</file>
  </doc>
  <doc>
    <id>1383</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>periodicalpart</type>
    <publisherName/>
    <publisherPlace>Regensburg</publisherPlace>
    <creatingCorporation>Ostbayerische Technische Hochschule Regensburg</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Forschungsbericht 2017</title>
    <identifier type="isbn">978-3-9818209-3-5</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-13835</identifier>
    <identifier type="doi">10.35096/othr/pub-1383</identifier>
    <author>Karsten Weber</author>
    <author>Sebastian Dendorfer</author>
    <author>Franz Süß</author>
    <author>Simone Kubowitsch</author>
    <author>Thomas Schratzenstaller</author>
    <author>Sonja Haug</author>
    <author>Christa Mohr</author>
    <author>Hans Kiesl</author>
    <author>Jörg Drechsler</author>
    <author>Markus Westner</author>
    <author>Jörn Kobus</author>
    <author>Martin J. W. Schubert</author>
    <author>Stefan Zenger</author>
    <author>Alexander Pietsch</author>
    <author>Josef Weiß</author>
    <author>Sebastian Hinterseer</author>
    <author>Roland Schieck</author>
    <author>Stefanie Scherzinger</author>
    <author>Meike Klettke</author>
    <author>Andreas Ringlstetter</author>
    <author>Uta Störl</author>
    <author>Tegawendé F. Bissyandé</author>
    <author>Achim Seeburger</author>
    <author>Timo Schindler</author>
    <author>Ralf Ramsauer</author>
    <author>Jan Kiszka</author>
    <author>Andreas Kölbl</author>
    <author>Daniel Lohmann</author>
    <author>Wolfgang Mauerer</author>
    <author>Johannes Maier</author>
    <author>Ulrike Scorna</author>
    <author>Christoph Palm</author>
    <author>Alexander Soska</author>
    <author>Jürgen Mottok</author>
    <author>Andreas Ellermeier</author>
    <author>Daniel Vögele</author>
    <author>Stefan Hierl</author>
    <author>Ulrich Briem</author>
    <author>Knut Buschmann</author>
    <author>Ingo Ehrlich</author>
    <author>Christian Pongratz</author>
    <author>Benjamin Pielmeier</author>
    <author>Quirin Tyroller</author>
    <author>Gareth J. Monkman</author>
    <author>Franz Gut</author>
    <author>Carina Roth</author>
    <author>Peter Hausler</author>
    <author>Rudolf Bierl</author>
    <author>Christian Prommesberger</author>
    <author>Robert Damian Ławrowski</author>
    <author>Christoph Langer</author>
    <author>Rupert Schreiner</author>
    <author>Yifeng Huang</author>
    <author>Juncong She</author>
    <author>Andreas Ottl</author>
    <author>Walter Rieger</author>
    <author>Agnes Kraml</author>
    <author>Thomas Poxleitner</author>
    <author>Simon Hofer</author>
    <author>Benjamin Heisterkamp</author>
    <author>Maximilian Lerch</author>
    <author>Nike Sammer</author>
    <author>Olivia Golde</author>
    <author>Felix Wellnitz</author>
    <author>Sandra Schmid</author>
    <author>Claudia Muntschick</author>
    <author>Wolfgang Kusterle</author>
    <author>Ivan Paric</author>
    <author>Oliver Brückl</author>
    <author>Matthias Haslbeck</author>
    <author>Ottfried Schmidt</author>
    <author>Peter Schwanzer</author>
    <author>Hans-Peter Rabl</author>
    <author>Michael Sterner</author>
    <author>Franz Bauer</author>
    <author>Sven Steinmann</author>
    <author>Fabian Eckert</author>
    <author>Andreas Hofrichter</author>
    <series>
      <title>Forschungsberichte der OTH Regensburg</title>
      <number>2017</number>
    </series>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Forschung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Forschungsbericht</value>
    </subject>
    <collection role="institutes" number="HL">Hochschulleitung/Hochschulverwaltung</collection>
    <collection role="othpublikationsherkunft" number="">Von der OTH Regensburg herausgegeben</collection>
    <collection role="persons" number="weberlate">Weber, Karsten (Prof. Dr.) - Labor für Technikfolgenabschätzung und Angewandte Ethik</collection>
    <collection role="institutes" number="IAFW">Zentrum für Forschung und Transfer (ZFT ab 2024; vorher: IAFW)</collection>
    <collection role="persons" number="sternerfenes">Sterner, Michael (Prof. Dr.) - FENES / Forschungsgruppe Energiespeicher</collection>
    <collection role="persons" number="bruecklfenes">Brückl, Oliver (Prof. Dr.) - FENES / Forschungsgruppe Energienetze</collection>
    <collection role="persons" number="hauglasofo">Haug, Sonja (Prof. Dr.) - Labor Empirische Sozialforschung</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/1383/Forschungsbericht_OTHR_2017.pdf</file>
  </doc>
  <doc>
    <id>2162</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>9</volume>
    <type>article</type>
    <publisherName>frontiers</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation>WICOVIR Study Group</contributingCorporation>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests</title>
    <abstract language="eng">Background: &#13;
Opening schools and keeping children safe from SARS-CoV-2 infections at the same time is urgently needed to protect children from direct and indirect consequences of the COVID-19 pandemic. To achieve this goal, a safe, efficient, and cost-effective SARS-CoV-2 testing system for schools in addition to standard hygiene measures is necessary.&#13;
&#13;
Methods: &#13;
We implemented the screening WICOVIR concept for schools in the southeast of Germany, which is based on gargling at home, pooling of samples in schools, and assessment of SARS-CoV-2 by pool rRT-PCR, performed decentralized in numerous participating laboratories. Depooling was performed if pools were positive, and results were transmitted with software specifically developed for the project within a day. Here, we report the results after the first 13 weeks in the project.&#13;
&#13;
Findings: &#13;
We developed and implemented the proof-of-concept test system within a pilot phase of 7 weeks based on almost 17,000 participants. After 6 weeks in the main phase of the project, we performed &gt;100,000 tests in total, analyzed in 7,896 pools, identifying 19 cases in &gt;100 participating schools. On average, positive children showed an individual CT value of 31 when identified in the pools. Up to 30 samples were pooled (mean 13) in general, based on school classes and attached school staff. All three participating laboratories detected positive samples reliably with their previously established rRT-PCR standard protocols. When self-administered antigen tests were performed concomitantly in positive cases, only one of these eight tests was positive, and when antigen tests performed after positive pool rRT-PCR results were already known were included, 3 out of 11 truly positive tests were also identified by antigen testing. After 3 weeks of repetitive WICOVIR testing twice weekly, the detection rate of positive children in that cohort decreased significantly from 0.042 to 0.012 (p = 0.008).&#13;
&#13;
Interpretation: &#13;
Repeated gargle pool rRT-PCR testing can be implemented quickly in schools. It is an effective, valid, and well-received test system for schools, superior to antigen tests in sensitivity, acceptance, and costs.</abstract>
    <parentTitle language="eng">Frontiers in Pediatrics</parentTitle>
    <identifier type="doi">10.3389/fped.2021.721518</identifier>
    <identifier type="issn">2296-2360</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Parastoo Kheiroddin</author>
    <author>Patricia Schöberl</author>
    <author>Michael Althammer</author>
    <author>Ezgi Cibali</author>
    <author>Thea Würfel</author>
    <author>Hannah Wein</author>
    <author>Birgit Kulawik</author>
    <author>Heike Buntrock-Döpke</author>
    <author>Eva Weigl</author>
    <author>Silvia Gran</author>
    <author>Magdalena Gründl</author>
    <author>Jana Langguth</author>
    <author>Benedikt Lampl</author>
    <author>Guido Judex</author>
    <author>Jakob Niggel</author>
    <author>Philipp Pagel</author>
    <author>Thomas Schratzenstaller</author>
    <author>Wulf Schneider-Brachert</author>
    <author>Susanne Gastiger</author>
    <author>Mona Bodenschatz</author>
    <author>Maike Konrad</author>
    <author>Artem Levchuk</author>
    <author>Cornelius Roth</author>
    <author>David Schöner</author>
    <author>Florian Schneebauer</author>
    <author>René Rohrmanstorfer</author>
    <author>Andreas Burkovski</author>
    <author>Andreas Ambrosch</author>
    <author>Thomas Wagner</author>
    <author>Michael Kabesch</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>children</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>COVID-19</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Germany</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PCR</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>pooling</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>gargle</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>schools</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>pandemic</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Covid-19</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Polymerase-Kettenreaktion</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Nachweis</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schulkind</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Deutschland</value>
    </subject>
    <collection role="ddc" number="610">Medizin und Gesundheit</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>6980</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>World Scientific</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Preliminary theoretical considerations on the stiffness characteristics of a tensegrity joint for the use in dynamic orthoses</title>
    <abstract language="eng">Early motion therapy plays an important role for effective long-term healing of joint injuries. In many cases, conventional dynamic orthoses fail to address the intricate movement possibilities of the underlying joints, limited by their simplistic joint representations, often represented by revolute joints, enabling rotations by only one axis. In this paper, a two-dimensional compliant tensegrity joint for use in biomedical applications is investigated. It consists of two compressed members and five compliant tensioned members. Relative movement possibilities are realized by the intrinsic compliance of the structure. In the development of these systems, the first step is the determination of the static stable equilibrium. This analysis is conducted in this paper by considering the potential energy approach or by using the geometric nonlinear finite element method. The mechanical behavior of the structure is assessed with a specific emphasis on its mechanical compliance. The primary objective of this study is the investigation of the influence of structural parameters on the overall stiffness and movability of the structure. The results underscore the significant effect of member parameters on the stiffness and movability of the compliant tensegrity joint, particularly under varying load magnitudes. These findings provide insights for optimizing the joint’s performance, contributing to its potential application in advanced orthotic and exoskeleton devices.</abstract>
    <parentTitle language="eng">Journal of Medical Robotics Research</parentTitle>
    <identifier type="doi">10.1142/S2424905X23400081</identifier>
    <enrichment key="opus.import.date">2024-01-05T16:36:33+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Leon Schaeffer</author>
    <author>David Herrmann</author>
    <author>Thomas Schratzenstaller</author>
    <author>Sebastian Dendorfer</author>
    <author>Valter Böhm</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>mechanical compliance</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>flexibility ellipsis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>form-finding</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>tensegrity joint</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="dendorferlbm">Dendorfer, Sebastian (Prof. Dr.), Zeitschriftenbeiträge - Labor Biomechanik</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Finite-Elemente-Methode (FEM)</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Biomechanik (LBM)</collection>
  </doc>
  <doc>
    <id>7293</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>5</issue>
    <volume>14</volume>
    <type>article</type>
    <publisherName>AIP Publishing</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrical properties of bisphenol-A-free magnetoactive borosilicate polymers</title>
    <abstract language="eng">The recent REACH regulations require the elimination of bisphenol-A and titanium dioxide from commercially available boron-based polymers. This has led to changes in some of the mechanical characteristics, which strongly influence the properties of magnetoactive borosilicate polymers. This work delivers results on the electrical properties and discusses some implications for future research using bisphenol-A and titanium-dioxide-free substitutes.</abstract>
    <parentTitle language="eng">AIP Advances</parentTitle>
    <identifier type="issn">2158-3226</identifier>
    <identifier type="doi">10.1063/5.0203017</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-72936</identifier>
    <note>Corresponding author der OTH Regensburg: Gareth J. Monkman</note>
    <enrichment key="CorrespondingAuthor">Gareth J. Monkman</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <enrichment key="Kostentraeger">DFG, No. MO 2196/11-1</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Xuyan Loo</author>
    <author>Bhavana Nagaraju</author>
    <author>Sai Pathivada</author>
    <author>Alexander Bartsch</author>
    <author>Thomas Schratzenstaller</author>
    <author>Robert Sattler</author>
    <author>Gareth J. Monkman</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrical components</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrical properties and parameters</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dielectric properties</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrical resistivity</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Viscoelasticity</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Non Newtonian fluids</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic fluids</value>
    </subject>
    <collection role="institutes" number="FakEI">Fakultät Elektro- und Informationstechnik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="oaweg" number="">Corresponding author der OTH Regensburg</collection>
    <collection role="funding" number="">Publikationsfonds der OTH Regensburg</collection>
    <collection role="institutes" number="">Mechatronics Research Unit (MRU)</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/7293/Monkman_AIP_2024.pdf</file>
  </doc>
  <doc>
    <id>5010</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>13</pageNumber>
    <edition/>
    <issue>16</issue>
    <volume>11</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The Effects of Shear Force-Based Processing of Lipoaspirates on White Adipose Tissue and the Differentiation Potential of Adipose Derived Stem Cells</title>
    <abstract language="eng">Autologous lipotransfer is a promising method for tissue regeneration, because white adipose tissue contains a heterogeneous cell population, including mesenchymal stem cells, endothelial cells, immune cells, and adipocytes. In order to improve the outcome, adipose tissue can be processed before application. In this study, we investigated changes caused by mechanical processing.&#13;
Lipoaspirates were processed using sedimentation, first-time centrifugation, shear-force homogenization, and second-time centrifugation. The average adipocyte size, stromal vascular cell count, and adipocyte depot size were examined histologically at every processing step. In addition, the adipose derived stem cells (ADSCs) were isolated and differentiated osteogenically and adipogenically. While homogenization causes a disruption of adipocyte depots, the shape of the remaining adipocytes is not changed. On average, these adipocytes are smaller than the depot adipocytes, they are surrounded by the ECM, and therefore mechanically more stable. The volume loss of adipocyte depots leads to a significant enrichment of stromal vascular cells such as ADSCs. However, the mechanical processing does not change the potential of the ADSCs to differentiate adipogenically or steogenically. It thus appears that mechanically  processed lipoaspirates are promising for the reparation of even mechanically stressed tissue as that found in nasolabial folds. The changes resulting from the processing correspond more to a filtration of mechanically less stable components than to a manipulation of the tissue.</abstract>
    <parentTitle language="deu">cells</parentTitle>
    <identifier type="doi">10.3390/cells11162543</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Andreas Eigenberger</author>
    <author>Oliver Felthaus</author>
    <author>Thomas Schratzenstaller</author>
    <author>Silke Haerteis</author>
    <author>Kirsten Utpatel</author>
    <author>Lukas Prantl</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>white adipose tissue</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>lipograft</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>stem cells</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fat grafting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>surgery</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>cell-enriched lipotransfer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CELT</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>lipoaspirate</value>
    </subject>
    <collection role="ddc" number="610">Medizin und Gesundheit</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="institutes" number="RCHST">Regensburg Center of Health Sciences and Technology - RCHST</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>5585</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>285</pageFirst>
    <pageLast>293</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>63</volume>
    <type>article</type>
    <publisherName>Karger</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Introduction of a new ex vivo porcine coronary artery model: Evaluation of the direct vascular injury after stent implantation with and without dogbone effect</title>
    <abstract language="eng">Introduction: &#13;
Neointimal hyperplasia after percutaneous coronary intervention remains a major determinant of in-stent restenosis (ISR). The extent of mechanical vessel injury correlates with ISR. A new ex vivo porcine stent model was introduced and evaluated comparing different stent designs. &#13;
&#13;
Methods: &#13;
Coronary arteries were prepared from pig hearts from the slaughterhouse and used for ex vivo implantations of coronary stents. One basic stent design in two configurations (dogbone, DB; non-dogbone, NDB) was used. Vascular injury was determined according to a modified injury score (IS). &#13;
&#13;
Results: &#13;
Standardized experimental conditions ensured comparable vessel dimensions and overstretch data. DB stents caused more severe IS compared to NDB stents. The mean IS and the IS at the distal end of all stents were significantly reduced for NDB stents (ISMean, DB, 1.16 ±0.12; NDB, 1.02 ±0.12; p=0.018; ISDist, DB, 1.39 ±0.28; NDB, 1.13 ±0.24; p=0.03). &#13;
&#13;
Discussion/Conclusion: &#13;
The introduced ex-vivo model allowed the evaluation of different stent designs exclude unfavorable stent designs.</abstract>
    <parentTitle language="eng">European Surgical Research</parentTitle>
    <identifier type="doi">10.1159/000527883</identifier>
    <identifier type="pmid">36380648</identifier>
    <identifier type="issn">1421-9921</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Lisa Obermaier</author>
    <author>Karla Lehle</author>
    <author>Stefanie Schmid</author>
    <author>Christof Schmid</author>
    <author>Thomas Schratzenstaller</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stent screening</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stent design</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Injury score</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ex vivo porcine stent model</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>2167</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>285</pageFirst>
    <pageLast>301</pageLast>
    <pageNumber/>
    <edition/>
    <issue>October</issue>
    <volume>116</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Quantifying stent-induced damage in coronary arteries by investigating mechanical and structural alterations</title>
    <abstract language="eng">Vascular damage develops with diverging severity during and after percutaneous coronary intervention with stent placement and is the prevailing stimulus for in-stent restenosis. Previous work has failed to link mechanical data obtained in a realistic in vivo or in vitro environment with data collected during imaging processes. We investigated whether specimens of porcine right coronary arteries soften when indented with a stent strut shaped structure, and if the softening results from damage mechanisms inside the fibrillar collagen structure. To simulate the multiaxial loading scenario of a stented coronary artery, we developed the testing device ‘LAESIO’ that can measure differences in the stress-stretch behavior of the arterial wall before and after the indentation of a strut-like stamp. The testing protocol was optimized according to preliminary experiments, more specifically equilibrium and relaxation tests. After chemical fixation of the specimens and subsequent tissue clearing, we performed three-dimensional surface and second-harmonic generation scans on the deformed specimens. We analyzed and correlated the mechanical response with structural parameters of high-affected tissue located next to the stamp indentation and low-affected tissue beyond the injured area. The results reveal that damage mechanisms, like tissue compression as well as softening, fiber dispersion, and the lesion extent, are direction-dependent, and the severity of them is linked to the strut orientation, indentation pressure, and position. The findings highlight the need for further investigations by applying the proposed methods to human coronary arteries. Additional data and insights might help to incorporate the observed damage mechanisms into material models for finite element analyses to perform more accurate simulations of stent-implantations.</abstract>
    <parentTitle language="deu">Acta Biomaterialia</parentTitle>
    <identifier type="doi">10.1016/j.actbio.2020.08.016</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Markus A. Geith</author>
    <author>Laurenz Nothdurfter</author>
    <author>Manuel Heiml</author>
    <author>Emmanouil Agrafiotis</author>
    <author>Markus Gruber</author>
    <author>Gerhard Sommer</author>
    <author>Thomas Schratzenstaller</author>
    <author>Gerhard A. Holzapfel</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Percutaneous coronary intervention</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stent</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mechanical properties</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Damage mechanism</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Vascular injury</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Coronary artery</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Indentation test</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Softening</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Second-harmonic generation imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Micro-structure</value>
    </subject>
    <collection role="ddc" number="610">Medizin und Gesundheit</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>332</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>25</pageLast>
    <pageNumber/>
    <edition/>
    <issue>10</issue>
    <volume>14</volume>
    <type>article</type>
    <publisherName>PLOS</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning</title>
    <abstract language="eng">In-stent restenosis remains a major problem of arteriosclerosis treatment by stenting. Expansion-optimized stents could reduce this problem. With numerical simulations, stent designs/ expansion behaviours can be effectively analyzed. For reasons of efficiency, simplified models of balloon-expandable stents are often used, but their accuracy must be challenged due to insufficient experimental validation. In this work, a realistic stent life-cycle simulation has been performed including balloon folding, stent crimping and free expansion of the balloon-stent-system. The successful simulation and validation of two stent designs with homogenous and heterogeneous stent stiffness and an asymmetrically positioned stent on the balloon catheter confirm the universal applicability of the simulation approach. Dogboning ratio, as well as the final dimensions of the folded balloon, the crimped and expanded stent, correspond well to the experimental dimensions with only slight deviations. In contrast to the detailed stent life-cycle simulation, a displacement-controlled simulation can not predict the transient stent expansion, but is suitable to reproduce the final expanded stent shape and the associated stress states. The detailed stent life-cycle simulation is thus essential for stent expansion analysis/optimization, whereas for reasons of computational efficiency, the displacement-controlled approach can be considered in the context of pure stress analysis.</abstract>
    <parentTitle language="eng">PlOS One</parentTitle>
    <identifier type="doi">10.1371/journal.pone.0224026</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Lisa Wiesent</author>
    <author>Ulrich Schultheiss</author>
    <author>Christof Schmid</author>
    <author>Thomas Schratzenstaller</author>
    <author>Aida Nonn</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Catheters</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Coronary stenting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Deformation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stent implantation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stiffness</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Stent</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Ballondilatation</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Numerische Strömungssimulation</value>
    </subject>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="persons" number="nonncmm">Nonn, Aida (Prof. Dr.) - Computational Mechanics and Materials Lab</collection>
    <collection role="persons" number="tcnehno">Technologie-Campus Neustadt a. d. Donau (Prof. Ehrlich+ Prof. Nonn)</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Computational Mechanics and Materials Lab (CMM)</collection>
  </doc>
  <doc>
    <id>331</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>11</issue>
    <volume>35</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">On the importance of modeling balloon folding, pleating, and stent crimping: An FE study comparing experimental inflation tests</title>
    <abstract language="eng">Finite element (FE)–based studies of preoperative processes such as folding,pleating, and stent crimping with a comparison with experimental inflation tests are not yet available. Therefore, a novel workflow is presented in which residual stresses of balloon folding and pleating, as well as stent crimping, and the geometries of all contact partners were ultimately implemented in an FE code to simulate stent expansion by using an implicit solver. The numerical results demonstrate that the incorporation of residual stresses and strains experienced during the production step significantly increased the accuracy of the subsequent simulations, especially of the stent expansion model. During the preoperative processes, stresses inside the membrane and the stent material also reached a rather high level. Hence, there can be no presumption that balloon catheters or stents are undamaged before the actual surgery. The implementation of the realistic geometry, in particular the balloon tapers, and the blades of the process devices improved the simulation of the expansion mech-anisms, such as dogboning, concave bending, or overexpansion of stent cells. This study shows that implicit solvers are able to precisely simulate the mentioned preoperative processes and the stent expansion procedure without a preceding manipulation of the simulation time or physical mass.</abstract>
    <parentTitle language="eng">International Journal for Numerical Methods in Biomedical Engineering</parentTitle>
    <identifier type="doi">10.1002/cnm.3249</identifier>
    <note>This study was funded by the Bavarian Research Foundation within the project “PIZ‐225‐18”</note>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Markus A. Geith</author>
    <author>Krzysztof Swidergal</author>
    <author>Bernd Hochholdinger</author>
    <author>Thomas Schratzenstaller</author>
    <author>Marcus Wagner</author>
    <author>Gerhard A. Holzapfel</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Catheter</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Coronary</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Crimping</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Finite element</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stent</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Stent</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Implantation</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Simulation</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Finite-Elemente-Methode</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Finite-Elemente-Methode (FEM)</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Maschinendynamik und Strukturanalyse (LMS)</collection>
  </doc>
  <doc>
    <id>337</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>s1</issue>
    <volume>63</volume>
    <type>conferencepresentation</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Optimization of the cardiovascular stent design towards improved expansion behaviour and radial stiffness properties</title>
    <abstract language="eng">- Development of a FEA Tool for a realistic stent simulation - investigation on minor modification on the stent design on the expansion behaviour - analysis of three stent designs: classical stent design with pronounced dogbone effect, two modified stent design (non-dogbone-design)</abstract>
    <parentTitle language="deu">Biomedizinische Technik</parentTitle>
    <identifier type="doi">10.1515/bmt-2018-6031</identifier>
    <enrichment key="ConferenceStatement">BMT 2018 - Biomedical Technology Conference, 2018, Aachen</enrichment>
    <author>Lisa Wiesent</author>
    <author>Constantin Hupke</author>
    <author>Christian Balk</author>
    <author>Ulrich Schultheiss</author>
    <author>Thomas Schratzenstaller</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Kardiovaskuläres System</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Stent</value>
    </subject>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>336</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencepresentation</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Numerical analysis of stent delivery systems during pre- and intraoperative processes</title>
    <parentTitle language="deu">15. Deutsches LS-DYNA Forum, 15.-17.10.2018, Bamberg</parentTitle>
    <identifier type="url">https://www.researchgate.net/publication/335260823_Numerical_analysis_of_stent_delivery_systems_during_pre-_and_intraoperative_processes</identifier>
    <author>Markus A. Geith</author>
    <author>Krzysztof Swidergal</author>
    <author>Thomas Schratzenstaller</author>
    <author>Gerhard A. Holzapfel</author>
    <author>Marcus Wagner</author>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Finite-Elemente-Methode (FEM)</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Maschinendynamik und Strukturanalyse (LMS)</collection>
  </doc>
  <doc>
    <id>333</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>50</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>Issue C</issue>
    <volume>20</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Biomechanical and structural quantification of vascular damage: A unique investigation of stent implantation</title>
    <parentTitle language="eng">Artery Research</parentTitle>
    <identifier type="doi">10.1016/j.artres.2017.10.025</identifier>
    <licence>Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International</licence>
    <author>Markus A. Geith</author>
    <author>Gerhard Sommer</author>
    <author>Thomas Schratzenstaller</author>
    <author>Gerhard A. Holzapfel</author>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>7395</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>16</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-08-20</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Surface Treatment of Additively Manufactured Polyetheretherketone (PEEK) by Centrifugal Disc Finishing Process: Identification of the Key Parameters</title>
    <abstract language="eng">Polyetheretherketone is a promising material for implants due to its good mechanical properties and excellent biocompatibility. Its accessibility to a wide range of applications is facilitated by the ability to process it with an easy-to-use manufacturing process such as fused filament fabrication. The elimination of disadvantages associated with the manufacturing process, such as a poor surface quality, is a main challenge to deal with. As part of the mass finishing process, centrifugal disc finishing has demonstrated good results in surface optimization, making it a promising candidate for the post-processing of additively manufactured parts. The objective of this study is to identify the key parameters of the centrifugal disc finishing process on the waviness of additively manufactured PEEK specimens, which has not been investigated previously. The waviness of the specimen was investigated by means of confocal laser scanning microscopy (CLSM), while weight loss was additionally tracked. Six parameters were investigated: type, amount and speed of media, use of compound, amount of water and time. Type of media, time and speed were found to significantly influence waviness reduction and weight loss. Surface electron microscopy images demonstrated the additional effects of deburring and corner rounding. Results on previous studies with specimens made of metal showed similar results. Further investigation is required to optimize waviness reduction and polish parts in a second post-processing step.</abstract>
    <parentTitle language="eng">Polymers</parentTitle>
    <identifier type="doi">10.3390/polym16162348</identifier>
    <identifier type="issn">2073-4360</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-73959</identifier>
    <note>Corresponding author der OTH Regensburg: Jan Zentgraf</note>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <enrichment key="CorrespondingAuthor">Jan Zentgraf</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Jan Zentgraf</author>
    <author>Florian Nützel</author>
    <author>Nico Mühlbauer</author>
    <author>Ulrich Schultheiss</author>
    <author>Marius Grad</author>
    <author>Thomas Schratzenstaller</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PEEK</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fused deposition modeling</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fused filament fabrication</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>centrifugal disc finishing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>mass finishing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3D printing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>post-processing of 3D printed parts</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>surface treatment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>high-performance polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>additive manufacturing</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="funding" number="">Publikationsfonds der OTH Regensburg</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/7395/Zentgraf_polymers-2024.pdf</file>
  </doc>
  <doc>
    <id>2161</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>30</pageLast>
    <pageNumber/>
    <edition/>
    <issue>12</issue>
    <volume>15</volume>
    <type>article</type>
    <publisherName>PLOS</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Computational analysis of the effects of geometric irregularities and post-processing steps on the mechanical behavior of additively manufactured 316L stainless steel stents</title>
    <abstract language="eng">Advances in additive manufacturing enable the production of tailored lattice structures and thus, in principle, coronary stents. This study investigates the effects of process-related irregularities, heat and surface treatment on the morphology, mechanical response, and expansion behavior of 316L stainless steel stents produced by laser powder bed fusion and provides a methodological approach for their numerical evaluation. A combined experimental and computational framework is used, based on both actual and computationally reconstructed laser powder bed fused stents. Process-related morphological deviations between the as-designed and actual laser powder bed fused stents were observed, resulting in a diameter increase by a factor of 2-2.6 for the stents without surface treatment and 1.3-2 for the electropolished stent compared to the as-designed stent. Thus, due to the increased geometrically induced stiffness, the laser powder bed fused stents in the as-built (7.11 ± 0.63 N) or the heat treated condition (5.87 ± 0.49 N) showed increased radial forces when compressed between two plates. After electropolishing, the heat treated stents exhibited radial forces (2.38 ± 0.23 N) comparable to conventional metallic stents. The laser powder bed fused stents were further affected by the size effect, resulting in a reduced yield strength by 41% in the as-built and by 59% in the heat treated condition compared to the bulk material obtained from tensile tests. The presented numerical approach was successful in predicting the macroscopic mechanical response of the stents under compression. During deformation, increased stiffness and local stress concentration were observed within the laser powder bed fused stents. Subsequent numerical expansion analysis of the derived stent models within a previously verified numerical model of stent expansion showed that electropolished and heat treated laser powder bed fused stents can exhibit comparable expansion behavior to conventional stents. The findings from this work motivate future experimental/numerical studies to quantify threshold values of critical geometric irregularities, which could be used to establish design guidelines for laser powder bed fused stents/lattice structures.</abstract>
    <parentTitle language="eng">PLoS ONE</parentTitle>
    <identifier type="doi">10.1371/journal.pone.0244463</identifier>
    <note>Corresponding author: Lisa Wiesent</note>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Lisa Wiesent</author>
    <author>Ulrich Schultheiß</author>
    <author>Philipp Lulla</author>
    <author>Ulf Noster</author>
    <author>Thomas Schratzenstaller</author>
    <author>Christof Schmid</author>
    <author>Aida Nonn</author>
    <author>Ashley Spear</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Heat treatment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lasers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Surface treatments</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Specimen preparation and treatment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Material properties</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stiffness</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Deformation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Powders</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Koronarendoprothese</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Rapid prototyping</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Numerische Methode</value>
    </subject>
    <collection role="ddc" number="610">Medizin und Gesundheit</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="institutes" number="TCNeustadt">Technologie-Campus Neustadt an der Donau</collection>
    <collection role="persons" number="nonncmm">Nonn, Aida (Prof. Dr.) - Computational Mechanics and Materials Lab</collection>
    <collection role="persons" number="tcnehno">Technologie-Campus Neustadt a. d. Donau (Prof. Ehrlich+ Prof. Nonn)</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="oaweg" number="">Corresponding author der OTH Regensburg</collection>
    <collection role="institutes" number="TCParsberg">Technologie-Campus Parsberg-Lupburg</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Computational Mechanics and Materials Lab (CMM)</collection>
    <collection role="institutes" number="">Labor Werkstoffrandschichtanalytik</collection>
  </doc>
  <doc>
    <id>2171</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>748</pageFirst>
    <pageLast>753</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>25</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Inhibition of neointima formation by a novel drug-eluting stent system that allows for dose-adjustable, multiple, and on-site stent coating</title>
    <abstract language="eng">Objective&#13;
The risk of in-stent restenosis can be considerably reduced by stents eluting cytostatic compounds. We created a novel drug-eluting stent system that includes several new features in the rapidly evolving field of stent-based drug delivery.&#13;
&#13;
Methods and Results&#13;
The aim of the present study was the preclinical evaluation of a stent-coating system permitting individual, on-site coating of stents with a unique microporous surface allowing for individualizable, dose-adjustable, and multiple coatings with identical or various compounds, designated ISAR (individualizable drug-eluting stent system to abrogate restenosis). Stents were coated with 0.75% rapamycin solution, and high-performance liquid chromatography (HPLC)-based determination of drug release profile indicated drug release for &gt;21 days. Rapamycin-eluting microporous (REMP) stents implanted in porcine coronary arteries were safe. To determine the efficacy of REMP stents, this novel drug-eluting stent platform was compared with the standard sirolimus-eluting stent. At 30 days, in-stent neointima formation in porcine coronary arteries was similar in both groups, yielding a significant decrease of neointimal area and injury-dependent neointimal thickness compared with bare-metal stents.&#13;
&#13;
Conclusion&#13;
The ISAR drug-eluting stent platform as a novel concept for stent coating allows for a safe, effective, on-site stent coating process, thus justifying further clinical evaluation to decrease in-stent restenosis in humans.&#13;
In-stent neointima formation can be successfully attenuated by drug-eluting stents. We introduce a novel conceptual approach for stent-coating that allows for dose-adjustable, on-site stent coating process if desired with multiple compounds. Microporous stents coated with rapamycin proved safe and effective for the limitation of neointima formation in a porcine coronary stent model.</abstract>
    <parentTitle language="eng">Arteriosclerosis, Thrombosis, and Vascular Biology</parentTitle>
    <identifier type="doi">10.1161/01.ATV.0000157579.52566.ee</identifier>
    <identifier type="issn">1524-4636</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Rainer Wessely</author>
    <author>Jörg Hausleiter</author>
    <author>Cornelia Michaelis</author>
    <author>Birgit Jaschke</author>
    <author>Michael Vogeser</author>
    <author>Stefan Milz</author>
    <author>Boris Behnisch</author>
    <author>Thomas Schratzenstaller</author>
    <author>Magdalena Renke-Gluszko</author>
    <author>Michael Stöver</author>
    <author>Erich Wintermantel</author>
    <author>Adnan Kastrati</author>
    <author>Albert Schömig</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>drug-eluting stent</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>stent platform</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>sirolimus</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>rapamycin</value>
    </subject>
    <collection role="ddc" number="610">Medizin und Gesundheit</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>2170</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1475</pageFirst>
    <pageLast>1481</pageLast>
    <pageNumber/>
    <edition/>
    <issue>15</issue>
    <volume>26</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Prevention of restenosis by a novel drug-eluting stent system with a dose-adjustable, polymer-free, on-site stent coating</title>
    <abstract language="eng">Aims &#13;
Drug-eluting stents (DES) represent a major advance in interventional cardiology. Along with the success shown, current DES also present limitations related to the presence of polymer-coating, fixed drug, and dose used. With the ISAR (Individualized Drug-Eluting Stent System to Abrogate Restenosis) project, a DES system has been developed that permits individualized choice of the drug and dose to use for the given patient. The objective of this prospective dose finding study was to assess the feasibility, safety, and efficacy of a polymer-free on-site stent coating with increasing rapamycin doses.&#13;
&#13;
Methods and results &#13;
In this dose finding study, 602 patients were sequentially enrolled in four groups: microporous bare metal stent (BMS), DES stents coated with a 0.5, 1.0, and 2.0% rapamycin solution. The angiographic in-segment restenosis rate at follow-up angiography was the primary study endpoint. In-segment restenosis was significantly reduced from 25.9% with BMS to 18.9, 17.2, and 14.7% with 0.5, 1.0, and 2.0% rapamycin-eluting stents, respectively (P=0.024). Similarly, the need for target lesion revascularization at 1 year follow-up was reduced from 21.5% with BMS to 16.4, 12.6, and 8.8% with 0.5, 1.0, and 2.0% rapamycin-eluting stents, respectively (P=0.006).&#13;
&#13;
Conclusion &#13;
The placement of polymer-free stents coated on-site with rapamycin is feasible and safe. Furthermore, a dose-dependent efficacy in restenosis prevention is achievable with this new DES concept.</abstract>
    <parentTitle language="eng">European Heart Journal - Clinical research</parentTitle>
    <identifier type="doi">10.1093/eurheartj/ehi405</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Jörg Hausleiter</author>
    <author>Adnan Kastrati</author>
    <author>Rainer Wessely</author>
    <author>Alban Dibra</author>
    <author>Julinda Mehilli</author>
    <author>Thomas Schratzenstaller</author>
    <author>Isolde Graf</author>
    <author>Magdalena Renke-Gluszko</author>
    <author>Boris Behnisch</author>
    <author>Josef Dirschinger</author>
    <author>Erich Wintermantel</author>
    <author>Albert Schömig</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Restenosis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stents</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Randomized</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rapamycin</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polymer</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>2169</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>749e</pageFirst>
    <pageLast>758e</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>146</volume>
    <type>article</type>
    <publisherName>American Society of Plastic Surgeons</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Shear Force Processing of Lipoaspirates for Stem Cell Enrichment Does Not Affect Secretome of Human Cells Detected by Mass Spectrometry In Vitro</title>
    <abstract language="eng">Background: &#13;
Lipofilling is one of the most often performed surgical procedures in plastic and reconstructive surgery. Lipoaspirates provide a ready source of stem cells and secreted factors that contribute to neoangiogenesis and fat graft survival. However, the regulations about the enrichment of these beneficial cells and factors are ambiguous. In this study, the authors tested whether a combination of centrifugation and homogenization allowed the enrichment of viable stem cells in lipoaspirates through the selective removal of tumescent solution, blood, and released lipids without significantly affecting the cell secretome.&#13;
&#13;
Methods: &#13;
Human lipoaspirate was harvested from six different patients using water jet–assisted liposuction. Lipoaspirate was homogenized by first centrifugation (3584 rpm for 2 minutes), shear strain (10 times intersyringe processing), and second centrifugation (3584 rpm for 2 minutes). Stem cell enrichment was shown by cell counting after stem cell isolation. Lipoaspirate from different processing steps (unprocessed, after first centrifugation, after homogenization, after second centrifugation) was incubated in serum-free cell culture medium for mass spectrometric analysis of secreted proteins.&#13;
&#13;
Results: &#13;
Lipoaspirate homogenization leads to a significant 2.6 ± 1.75-fold enrichment attributable to volume reduction without reducing the viability of the stem cells. Protein composition of the secretome did not change significantly after tissue homogenization. Considering the enrichment effects, there were no significant differences in the protein concentration of the 83 proteins found in all processing steps.&#13;
&#13;
Conclusions: &#13;
Stem cells can be enriched mechanically without significantly affecting the composition of secreted proteins. Shear-assisted enrichment of lipoaspirate constitutes no substantial manipulation of the cells’ secretome.</abstract>
    <parentTitle language="eng">Plastic and Reconstructive Surgery</parentTitle>
    <identifier type="doi">10.1097/PRS.0000000000007343</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Lukas Prantl</author>
    <author>Andreas Eigenberger</author>
    <author>Silvan Klein</author>
    <author>Katharina Limm</author>
    <author>Peter J. Oefner</author>
    <author>Thomas Schratzenstaller</author>
    <author>Oliver Felthaus</author>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>2168</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>22</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>15</volume>
    <type>article</type>
    <publisherName>PLOS</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Experimental and mathematical characterization of coronary polyamide-12 balloon catheter membranes</title>
    <abstract language="eng">The experimental quantification and modeling of the multiaxial mechanical response of polymer membranes of coronary balloon catheters have not yet been carried out. Due to the lack of insights, it is not shown whether isotropic material models can describe the material response of balloon catheter membranes expanded with nominal or higher, supra-nominal pressures. Therefore, for the first time, specimens of commercial polyamide-12 balloon catheters membranes were investigated during uniaxial and biaxial loading scenarios. Furthermore, the influence of kinematic effects on the material response was observed by comparing results from quasi-static and dynamic biaxial extension tests. Novel clamping techniques are described, which allow to test even tiny specimens taken from the balloon membranes. The results of this study reveal the semi-compliant, nonlinear, and viscoelastic character of polyamide-12 balloon catheter membranes. Above nominal pressure, the membranes show a pronounced anisotropic mechanical behavior with a stiffer response in the circumferential direction. The anisotropic feature intensifies with an increasing strain-rate. A modified polynomial model was applied to represent the realistic mechanical response of the balloon catheter membranes during dynamic biaxial extension tests. This study also includes a compact set of constitutive model parameters for the use of the proposed model in future finite element analyses to perform more accurate simulations of expanding balloon catheters.</abstract>
    <parentTitle language="eng">PLoS One</parentTitle>
    <identifier type="doi">10.1371/journal.pone.0234340</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Markus A. Geith</author>
    <author>Jakob D. Eckmann</author>
    <author>Daniel Ch. Haspinger</author>
    <author>Emmanouil Agrafiotis</author>
    <author>Dominik Maier</author>
    <author>Patrick Szabo</author>
    <author>Gerhard Sommer</author>
    <author>Thomas Schratzenstaller</author>
    <author>Gerhard A. Holzapfel</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Catheters</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Anisotropy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Viscoelasticity</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Coronary stenting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Finite element analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Deformation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Adhesives</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>334</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">First Approaches in Quantifying Acute Vascular Damage due to Stenting</title>
    <parentTitle language="eng">23rd Congress of the European Society of Biomechanics, July 2-5,2017, Seville, Spain</parentTitle>
    <author>Markus A. Geith</author>
    <author>Gerhard Sommer</author>
    <author>Thomas Schratzenstaller</author>
    <author>Gerhard A. Holzapfel</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Stent</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Implantation</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gefäßverletzung</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
  </doc>
  <doc>
    <id>6742</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>14</volume>
    <type>article</type>
    <publisherName>Walsh Medical Media</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-10-23</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Mechanical Properties of NdPrFeB Based Magnetoactive Bisphenol-Free Boron-Silicate Polymers</title>
    <abstract language="eng">Following a ban on many materials containing bisphenol-A, new bisphenol-free Boron silicates have been found as substitutes. The purpose of this study is to describe the mechanical properties of these bisphenol-free magnetoactive borosilicate polymers containing hard magnetic particles. Samples of 0%, 33% and 66% by wt. were loaded for compression using a universal testing machine. The maximum forces occurring for different travel speeds were compared before and after post-magnetization treatments. The post-magnetization included 2 stages. In addition, the change in mechanical properties within 24 hours after the post-magnetization process was investigated. Furthermore, the influence of speed and particle content were investigated. In general, there is a correlation between the required compressive force and, the level of post-magnetization stress, the increase in travel speed and particle content in the boron silicate. Comparison of the non-post-magnetized and post-magnetized samples using two-tailed t-tests shows that the p-values for all weight fraction changes in NdPrFeB particles and travel speeds are less than 0.001. Also, a comparison between tests in which the traverse speed was varied also showed significant changes in the resulting compression forces. The same is valid for changes in the weight ratio of the NdPrFeB particles in the samples. For post-magnetized samples, no significant difference can be observed in the first 24 hours following magnetization. In summary, the material presents viscoelastic, plastic force-displacement behavior, which can be well recognized by its bi-linear curve shape.&#13;
The investigation shows that borosilicate polymers based on NdPrFeB can have their mechanical behavior modified and controlled by post-magnetization processes. This opens new possibilities for many future applications.</abstract>
    <parentTitle language="eng">Journal of Nanomedicine and Nanotechnology</parentTitle>
    <identifier type="doi">10.35248/2157-7439.23.14.705</identifier>
    <identifier type="issn">2157-7439</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-67425</identifier>
    <identifier type="url">https://www.walshmedicalmedia.com/open-access/mechanical-properties-of-ndprfeb-based-magnetoactive-bisphenolfree-boronsilicate-polymers-124385.html</identifier>
    <note>Corresponding author: Alexander Bartsch</note>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <enrichment key="CorrespondingAuthor">Bartsch, Alexander</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Alexander Bartsch</author>
    <author>Daniela Beham</author>
    <author>Jakob Gebhardt</author>
    <author>Ingo Ehrlich</author>
    <author>Thomas Schratzenstaller</author>
    <author>Gareth J. Monkman</author>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="oaweg" number="">Corresponding author der OTH Regensburg</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/6742/Bartsch_Mechanical_properties.pdf</file>
  </doc>
  <doc>
    <id>6564</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>9</pageNumber>
    <edition/>
    <issue>10</issue>
    <volume/>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Enhancement of laser cut edge quality of ultra-thin titanium grade 2 sheets by applying an in-process approach using modulated Yb:YAG continuous wave fiber laser</title>
    <abstract language="eng">Titanium is used in many areas due to its excellent mechanical, biological and corrosion-resistant properties. Implants often have thin and filigree structures, providing an ideal application for fine cutting with laser. In the literature, the main focus is primarily on investigating and optimizing the parameters for titanium sheets with thicknesses greater than 1 mm. Hence, in this study, the basic manufacturing parameters of laser power, cutting speed and laser pulse of a 200 W modulated fiber laser are investigated for 0.15 mm thick grade 2 titanium sheets. A reproducible, continuous cut could be achieved using 90 W laser-power and 2 mm/s cutting-speed. Pulse pause variations between 85 and 335 μs in 50 μs steps and a fixed pulse width of 50 μs show that a minimum kerf width of 23.4 μm, as well as a minimum cut edge roughness Rz of 3.59 μm, is achieved at the lowest pulse pause duration. An increase in roughness towards the laser exit side, independent of the laser pulse pause duration, was found and discussed. The results provide initial process parameters for cutting thin titanium sheets and thus provide the basis for further investigations, such as the influence of cutting gas pressure and composition on the cut edge.</abstract>
    <parentTitle language="eng">Discover Mechanical Engineering</parentTitle>
    <identifier type="doi">10.1007/s44245-023-00018-3</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-65647</identifier>
    <note>Corresponding author: Alexander Bartsch</note>
    <enrichment key="CorrespondingAuthor">Alexander Bartsch</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Alexander Bartsch</author>
    <author>Moritz Burger</author>
    <author>Marius Grad</author>
    <author>Lukas Esper</author>
    <author>Ulrich Schultheiß</author>
    <author>Ulf Noster</author>
    <author>Thomas Schratzenstaller</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laser cutting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Titanium sheet</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Kerf</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="oaweg" number="">Corresponding author der OTH Regensburg</collection>
    <collection role="institutes" number="TCParsberg">Technologie-Campus Parsberg-Lupburg</collection>
    <collection role="funding" number="">Publikationsfonds der OTH Regensburg</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Werkstoffrandschichtanalytik</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/6564/Burger_Bartsch_Disc_Medical_Eng.pdf</file>
  </doc>
  <doc>
    <id>5784</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>preprint</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-02-10</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Enhancement of laser cut edge quality of ultra-thin titanium grade 2 sheets by applying in-process approach using modulated Yb:YAG continuous wave fibre laser</title>
    <abstract language="eng">Titanium is used in many areas due to its excellent mechanical, biological and corrosion-resistant properties. Implants often have thin and filigree structures, providing an ideal application for laser fine cutting. In literature, the main focus is primarily on investigating and optimizing the parameters for titanium sheet thicknesses greater than 1 mm. Hence, in this study, the basic manufacturing parameters of laser power, cutting speed and laser pulsing of a 200 W modulated fibre laser are investigated for 0.15 mm thick titanium grade 2 sheets. A reproducible, continuous cut could be achieved using 90 W laserpower and 2 cutting-speed. Pulse pause variations between 85–335 μs in 50 μs steps and fixed&#13;
pulse duration of 50 μs show that a minimum kerf width of 23.4 μm, as well as a minimum cut edge roughness Rz of 3.59 μm, is achieved at the lowest pulse pause. An increase in roughness towards the laser exit side, independent of the laser pulse pause, was found and discussed. The results provide initial process parameters for cutting thin titanium sheets and thus provide the basis for further investigations, such as the influence of cutting gas pressure and composition on the cut edge.</abstract>
    <identifier type="doi">10.21203/rs.3.rs-2520041/v1</identifier>
    <note>Erschienen in der Zeitschrift: Discover Mechanical Engineering, https://opus4.kobv.de/opus4-oth-regensburg/frontdoor/index/index/docId/6564</note>
    <enrichment key="opus.source">publish</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Moritz Burger</author>
    <author>Alexander Bartsch</author>
    <author>Marius Grad</author>
    <author>Lukas Esper</author>
    <author>Ulrich Schultheiß</author>
    <author>Ulf Noster</author>
    <author>Thomas Schratzenstaller</author>
    <collection role="ddc" number="6">Technik, Medizin, angewandte Wissenschaften</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="institutes" number="TCParsberg">Technologie-Campus Parsberg-Lupburg</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Werkstoffrandschichtanalytik</collection>
  </doc>
  <doc>
    <id>7943</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>World Scientific</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Theoretical considerations on stiffness characteristics of a 3-dimensional tensegrity joint model for the use in dynamic hand orthoses</title>
    <parentTitle language="eng">Journal of Medical Robotics Research</parentTitle>
    <identifier type="doi">10.1142/S2424905X25400069</identifier>
    <enrichment key="opus.import.date">2025-01-27T16:00:19+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Leon Schaeffer</author>
    <author>David Herrmann</author>
    <author>Thomas Schratzenstaller</author>
    <author>Sebastian Dendorfer</author>
    <author>Valter Böhm</author>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="dendorferlbm">Dendorfer, Sebastian (Prof. Dr.), Zeitschriftenbeiträge - Labor Biomechanik</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Biomechanik (LBM)</collection>
    <collection role="DFGFachsystematik" number="1">Ingenieurwissenschaften</collection>
  </doc>
  <doc>
    <id>8149</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>12</pageNumber>
    <edition/>
    <issue/>
    <volume>2025</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>2025-04-10</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A re-usable 3D-printed training model for the endodontic management of dental trauma in immature teeth</title>
    <abstract language="eng">AIM: &#13;
To develop a 3D-printed model enabling treatment simulation of trauma-related endodontic and restorative procedures like revitalization or placement of an apical plug on teeth with incomplete root formation.&#13;
METHODOLOGY: &#13;
To generate a realistic training model suitable for trauma-related simulations, CT-Data sets were segmented, combined, adjusted and optimized using computer-aided design features. Specific focus was on optimally reflecting characteristics of immature teeth like open apical foramina and thin root walls. For reflection of the revitalization process, a set-up including a tube filled with red liquid under pressure was developed to be perforated during the procedure by the trainee, simulating bleeding from the apical papilla into the root canal system. Design was based on a combination of cost-effective simple parts combined with 3D-printed components to achieve maximal accessibility, exchangeability and re-usability. Model assembly and preparation were described in step-by-step instructions.&#13;
RESULTS: &#13;
As a result of the developmental process, the presented model qualifies for the training of the endodontic management of complications on immature teeth after dental trauma. Step-by-step descriptions aligned with the clinical procedures are performable for a revitalization procedure, for pulpotomy followed by fragment re-attachment and splint application and for placement of an apical plug using hydraulic calcium silicate cements.&#13;
CONCLUSIONS: &#13;
The model successfully achieved its intended objectives, so that it may be used in the future in various dental trauma treatment simulations for undergraduate and postgraduate education on the endodontic management of trauma-related therapies in immature teeth. Its common manufacturing process, affordability and re-usability support accessibility and sustainability.</abstract>
    <parentTitle language="eng">International endodontic journal</parentTitle>
    <identifier type="doi">10.1111/iej.14235</identifier>
    <identifier type="pmid">40205914</identifier>
    <identifier type="issn">1365-2591</identifier>
    <enrichment key="opus.import.date">2025-06-03T21:32:12+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Eva Maier</author>
    <author>Jan Zentgraf</author>
    <author>Eveline Angele</author>
    <author>José Zorzin</author>
    <author>Michael Taschner</author>
    <author>Matthias Widbiller</author>
    <author>Kerstin Galler</author>
    <author>Thomas Schratzenstaller</author>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="oaweg" number="">Hybrid Open Access - OA-Veröffentlichung in einer Subskriptionszeitschrift/-medium</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="DFGFachsystematik" number="1">Ingenieurwissenschaften</collection>
  </doc>
  <doc>
    <id>8656</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>American Society of Plastic Surgeons</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation>Ovid Technologies (Wolters Kluwer Health)</contributingCorporation>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Quantification of Cannula Influence on Negative Pressure in Syringe Assisted Liposuction</title>
    <abstract language="eng">To make the results of the autologous fat transfer more satisfactory, all parameters of suction, preparation, and reapplication must be well understood. Since syringe-assisted liposuction is frequently used for small-volume procedures, we quantified the influence of the cannula on negative pressure.&#13;
 For these experiments, we used a digital manometer to which a syringe and one of seven different cannulas were connected. Data was collected and analyzed using LabVIEW and Matlab. The volume of our measurement setup was calculated using Boyle-Mariotte's law to ease interpretation, which revealed a volume of 2.82 ± 0.03 mL.&#13;
 We demonstrate that the volume of the measurement setup significantly affects the measurement results. Consequently, we accounted for this factor and calculated the theoretical values accordingly. Statistical analysis shows a significant influence on negative pressure across different cannulas, except for two pairs, which had minimal volume differences. Exemplary, for cannulas with volumes under 1.75 mL, a 2 mL syringe plunger pull was sufficient to create a - 0.5 bar (- 14.8 inHg) negative pressure.&#13;
 The present data indicate that the size of the suction cannula must be considered in syringe-assisted suction to ensure a specific negative pressure is not exceeded. Other research groups have demonstrated that adipocyte vitality and the amount of stromal vascular fraction are reduced by excessively strong negative pressure.</abstract>
    <parentTitle language="eng">Plastic &amp; Reconstructive Surgery</parentTitle>
    <identifier type="issn">0032-1052</identifier>
    <identifier type="doi">10.1097/PRS.0000000000012477</identifier>
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Data was collected and analyzed using LabVIEW and Matlab. The volume of our measurement setup was calculated using Boyle-Mariotte's law to ease interpretation, which revealed a volume of 2.82 \u00b1 0.03 mL.&lt;\/jats:p&gt;\n            &lt;jats:p&gt;We demonstrate that the volume of the measurement setup significantly affects the measurement results. Consequently, we accounted for this factor and calculated the theoretical values accordingly. Statistical analysis shows a significant influence on negative pressure across different cannulas, except for two pairs, which had minimal volume differences. Exemplary, for cannulas with volumes under 1.75 mL, a 2 mL syringe plunger pull was sufficient to create a - 0.5 bar (- 14.8 inHg) negative pressure.&lt;\/jats:p&gt;\n            &lt;jats:p&gt;The present data indicate that the size of the suction cannula must be considered in syringe-assisted suction to ensure a specific negative pressure is not exceeded. Other research groups have demonstrated that adipocyte vitality and the amount of stromal vascular fraction are reduced by excessively strong negative pressure.&lt;\/jats:p&gt;\n          &lt;\/jats:sec&gt;","DOI":"10.1097\/prs.0000000000012477","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:00:28Z","timestamp":1758733228000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Quantification of Cannula Influence on Negative Pressure in Syringe Assisted Liposuction"],"prefix":"10.1097","author":[{"given":"Alexander","family":"Bartsch","sequence":"first","affiliation":[{"name":"Medical Device Lab, Regensburg Center of Biomedical Engineering (RCBE), Technical University of Applied Sciences (OTH) Regensburg, Seybothstra\u00dfe 2, 93053 Regensburg, Germany"}]},{"given":"Andreas","family":"Eigenberger","sequence":"additional","affiliation":[{"name":"Medical Device Lab, Regensburg Center of Biomedical Engineering (RCBE), Technical University of Applied Sciences (OTH) Regensburg, Seybothstra\u00dfe 2, 93053 Regensburg, Germany"},{"name":"Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, University Hospital Regensburg and Caritas Hospital St. Josef Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany"}]},{"given":"Oliver","family":"Felthaus","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, University Hospital Regensburg and Caritas Hospital St. Josef Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany"}]},{"given":"Brian W.","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, College of Engineering, Computing and Applied Sciences, Clemson University, 401-1 Rhodes Engineering Research Center, Clemson, South Carolina 29634 USA"}]},{"given":"Lars","family":"Krenkel","sequence":"additional","affiliation":[{"name":"Department of Biofluid Mechanics, Faculty of Mechanical Engineering, Technical University of Applied Sciences (OTH) Regensburg, Seybothstra\u00dfe 2, 93053 Regensburg, Germany"}]},{"given":"Thomas","family":"Schratzenstaller","sequence":"additional","affiliation":[{"name":"Medical Device Lab, Regensburg Center of Biomedical Engineering (RCBE), Technical University of Applied Sciences (OTH) Regensburg, Seybothstra\u00dfe 2, 93053 Regensburg, Germany"}]},{"given":"Lukas","family":"Prantl","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, University Hospital Regensburg and Caritas Hospital St. Josef Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany"}]}],"member":"276","published-online":{"date-parts":[[2025,9,23]]},"container-title":["Plastic &amp;amp; Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PRS.0000000000012477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:00:28Z","timestamp":1758733228000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PRS.0000000000012477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1097\/prs.0000000000012477","relation":{},"ISSN":["0032-1052","1529-4242"],"issn-type":[{"value":"0032-1052","type":"print"},{"value":"1529-4242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]}}}</enrichment>
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    <author>Alexander Bartsch</author>
    <author>Andreas Eigenberger</author>
    <author>Oliver Felthaus</author>
    <author>Brian W. Booth</author>
    <author>Lars Krenkel</author>
    <author>Thomas Schratzenstaller</author>
    <author>Lukas Prantl</author>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="persons" number="schratzenstallermd">Schratzenstaller, Thomas (Prof. Dr.) -Labor Medizinprodukte</collection>
    <collection role="institutes" number="">Labor Medizinprodukte</collection>
    <collection role="DFGFachsystematik" number="1">Ingenieurwissenschaften</collection>
    <collection role="othforschungsschwerpunkt" number="">Gesundheit und Soziales</collection>
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