<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>6123</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>21</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>10</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes</title>
    <abstract language="eng">Osteoarthritis (OA) is a degenerative joint disease causing loss of articular cartilage and structural damage in all joint tissues. Given the limited regenerative capacity of articular cartilage, methods to support the native structural properties of articular cartilage are highly anticipated. The aim of this study was to infiltrate zwitterionic monomer solutions into human OA-cartilage explants to replace lost proteoglycans. The study included polymerization and deposition of methacryloyloxyethyl-phosphorylcholine- and a novel sulfobetaine-methacrylate-based monomer solution within ex vivo human OA-cartilage explants and the encapsulation of isolated chondrocytes within hydrogels and the corresponding effects on chondrocyte viability. The results demonstrated that zwitterionic cartilage–hydrogel networks are formed by infiltration. In general, cytotoxic effects of the monomer solutions were observed, as was a time-dependent infiltration behavior into the tissue accompanied by increasing cell death and penetration depth. The successful deposition of zwitterionic hydrogels within OA cartilage identifies the infiltration method as a potential future therapeutic option for the repair/replacement of OA-cartilage extracellular suprastructure. Due to the toxic effects of the monomer solutions, the focus should be on sealing the OA-cartilage surface, instead of complete infiltration. An alternative treatment option for focal cartilage defects could be the usage of monomer solutions, especially the novel generated sulfobetaine-methacrylate-based monomer solution, as bionic for cell-based 3D bioprintable hydrogels.</abstract>
    <parentTitle language="eng">Bioengineering</parentTitle>
    <identifier type="doi">10.3390/bioengineering10070767</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-61235</identifier>
    <note>Corresponding author: Helga Hornberger</note>
    <enrichment key="opus.import.data">@articlearticle, author = Köck, Hannah and Striegl, Birgit and Kraus, Annalena and Zborilova, Magdalena and Christiansen, Silke and Schäfer, Nicole and Grässel, Susanne and Hornberger, H., year = 2023, month = 06, pages = 767, title = In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes, volume = 10, journal = Bioengineering, doi = 10.3390/bioengineering10070767</enrichment>
    <enrichment key="opus.import.dataHash">md5:259fefd1488ba80f897befdbf68256b4</enrichment>
    <enrichment key="opus.import.date">2023-06-30T15:13:21+00:00</enrichment>
    <enrichment key="opus.import.file">/tmp/phpviUmRr</enrichment>
    <enrichment key="opus.import.format">bibtex</enrichment>
    <enrichment key="opus.import.id">649ef1117e8476.40764068</enrichment>
    <enrichment key="CorrespondingAuthor">Helga Hornberger</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Hannah Köck</author>
    <author>Birgit Striegl</author>
    <author>Annalena Kraus</author>
    <author>Magdalena Zborilova</author>
    <author>Silke H. Christiansen</author>
    <author>Nicole Schäfer</author>
    <author>Susanne Grässel</author>
    <author>Helga Hornberger</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>osteoarthritis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>human articular cartilage</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>chondrocytes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>hydrogels</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>zwitterionic monomers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>infiltration</value>
    </subject>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="hornbergerbma">Hornberger, Helga (Prof. Dr.) - Labor Biomaterialien</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="oaweg" number="">Corresponding author der OTH Regensburg</collection>
    <collection role="funding" number="">Publikationsfonds der OTH Regensburg</collection>
    <collection role="institutes" number="">Labor Biomaterialien</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/6123/Hornberger_bioengineering-10-00767.pdf</file>
  </doc>
  <doc>
    <id>2449</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>8</pageFirst>
    <pageLast>19</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>73</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Bioactivity and corrosion behavior of magnesium barrier membranes</title>
    <abstract language="eng">In the current research, magnesium and its alloys have been intensively studied as resorbable implant materials. Magnesium materials combine their good mechanical properties with bioactivity, which make them interesting for guided bone regeneration and for the application as barrier membranes. In this study, the in vitro degradation behavior of thin magnesium films was investigated in cell medium and simulated body fluid. Three methods were applied to evaluate corrosion rates: measurements of (i) the gaseous volume evolved during immersion, (ii) volume change after immersion, and (iii) polarization curves. In this comparison, measurements of H2 development in Dulbecco's modified Eagle's medium showed to be the most appropriate method, exhibiting a corrosion rate of 0.5 mm·year−1. Observed oxide and carbon contamination have a high impact on controlled degradation, suggesting that surface treatment of thin foils is necessary. The bioactivity test showed positive results; more detailed tests in this area are of interest.</abstract>
    <parentTitle language="deu">Materials and Corrosion</parentTitle>
    <identifier type="doi">10.1002/maco.202112385</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-24499</identifier>
    <note>Corresponding author: Helga Hornberger</note>
    <enrichment key="opus.import.date">2022-01-21T08:21:02+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <enrichment key="CorrespondingAuthor">Helga Hornberger</enrichment>
    <licence>Creative Commons - CC BY-NC-SA - Namensnennung - Nicht kommerziell -  Weitergabe unter gleichen Bedingungen 4.0 International</licence>
    <author>Helga Hornberger</author>
    <author>Hannah Kissel</author>
    <author>Birgit Striegl</author>
    <author>Matthias Kronseder</author>
    <author>Florian Vollnhals</author>
    <author>Silke H. Christiansen</author>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="persons" number="hornbergerbma">Hornberger, Helga (Prof. Dr.) - Labor Biomaterialien</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="oaweg" number="">Hybrid Open Access - OA-Veröffentlichung in einer Subskriptionszeitschrift/-medium</collection>
    <collection role="oaweg" number="">Corresponding author der OTH Regensburg</collection>
    <collection role="funding" number="">DEAL Wiley</collection>
    <collection role="institutes" number="">Labor Biomaterialien</collection>
    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/2449/Hornberger_Materials_Corrosion_2021.pdf</file>
  </doc>
  <doc>
    <id>530</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>5</pageLast>
    <pageNumber/>
    <edition/>
    <issue>June</issue>
    <volume>2</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Degradation and bioactivity studies of Mg membranes for dental surgery</title>
    <abstract language="eng">Bioresorbable materials are under investigation due to their promising properties for applications as implant material. This study is about the degradation and bioactivity behaviour of magnesium foils, which allegorize dental membranes. The degradation behaviour including pitting corrosion during immersion tests can be precisely observed using micro-computed tomography. Using the bioactivity test according to Kokubo, it is shown that magnesium has strong Ca-phosphate layer formation correlated with high degradation. Therefore, magnesium foils appear to hold a great potential for bone implant application.</abstract>
    <parentTitle language="deu">Materials Letter X</parentTitle>
    <identifier type="doi">10.1016/j.mlblux.2019.100007</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Creative Commons - CC BY-ND - Namensnennung - Keine Bearbeitungen 4.0 International</licence>
    <author>Helga Hornberger</author>
    <author>Birgit Striegl</author>
    <author>M. Trahanofsky</author>
    <author>F. Kneissl</author>
    <author>Matthias Kronseder</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnesium</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dental membrane</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioactivity</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Corrosion rate</value>
    </subject>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="persons" number="hornbergerbma">Hornberger, Helga (Prof. Dr.) - Labor Biomaterialien</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Biomaterialien</collection>
  </doc>
</export-example>
