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  <doc>
    <id>4728</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>10</issue>
    <volume>8</volume>
    <type>article</type>
    <publisherName>PLOS</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata</title>
    <abstract language="eng">Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young’s modulus &lt;100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (&lt;18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.</abstract>
    <parentTitle language="eng">PLoS ONE</parentTitle>
    <identifier type="doi">10.1371/journal.pone.0076196</identifier>
    <enrichment key="opus.import.date">2022-07-04T20:29:15+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Matthias Mayer</author>
    <author>Raman Rabindranath</author>
    <author>Juliane Börner</author>
    <author>Eva Hörner</author>
    <author>Alexander Bentz</author>
    <author>Josefina Salgado</author>
    <author>Hong Han</author>
    <author>Holger Böse</author>
    <author>Jörn Probst</author>
    <author>Mikhail Shamonin (Chamonine)</author>
    <author>Gareth J. Monkman</author>
    <author>Günther Schlunck</author>
    <collection role="institutes" number="FakEI">Fakultät Elektro- und Informationstechnik</collection>
    <collection role="oaweg" number="">Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="institutes" number="">Labor Intelligente Materialien und Strukturen</collection>
    <collection role="institutes" number="">Mechatronics Research Unit (MRU)</collection>
  </doc>
  <doc>
    <id>5149</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>37</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>report</type>
    <publisherName/>
    <publisherPlace>Regensburg</publisherPlace>
    <creatingCorporation>Hochschule für Angewandte Wissenschaften Regensburg / Fachbereich Elektro- und Informationstechnik</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">EAP mit magnetisch steuerbarer Elastizität zur Interaktion mit Bindegewebszellen MagElan</title>
    <subTitle language="deu">Teilvorhaben (HS-Regensburg) "Etablierung eines mechatronischen Systems zur (Magneto) Elastophorese von Bindegewebszellen" ; Schlussbericht ; Verbundprojekt "MagElan" ; Laufzeit des Vorhabens: 01.07.2009 - 30.10.2011</subTitle>
    <note>Förderkennzeichen BMBF 13N10574</note>
    <enrichment key="opus.import.date">2022-08-10T13:23:02+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <enrichment key="ConferenceStatement">presented at the 5. WING-Konferenz des Bundesministeriums für Bildung und Forschung (BMBF), Berlin, 2012</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Raman Rabindranath</author>
    <author>Holger Böse</author>
    <author>Jörn Probst</author>
    <author>Günther Schlunck</author>
    <author>Matthias Mayer</author>
    <author>Eva Forster</author>
    <author>Alexander Bentz</author>
    <author>Mikhail Shamonin (Chamonine)</author>
    <author>Gareth J. Monkman</author>
    <collection role="institutes" number="FakEI">Fakultät Elektro- und Informationstechnik</collection>
    <collection role="othforschungsschwerpunkt" number="16316">Produktion und Systeme</collection>
    <collection role="institutes" number="">Labor Intelligente Materialien und Strukturen</collection>
    <collection role="institutes" number="">Mechatronics Research Unit (MRU)</collection>
  </doc>
</export-example>
