<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>155</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>793</pageFirst>
    <pageLast>797</pageLast>
    <pageNumber/>
    <edition/>
    <issue>8</issue>
    <volume>32</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Preferred stereoselective brain uptake of D-serine</title>
    <abstract language="eng">Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of l-serine in the brain. Stimulated by the observation of a preferred transport of the d-isomer of proline at the blood–brain barrier, we investigated the differential uptake of [3H]-d-serine and [3H]-l-serine in the rat brain 1 h after intravenous injection using quantitative autoradiography. Surprisingly, brain uptake of [3H]-d-serine was significantly higher than that of [3H]-l-serine, indicating a preferred transport of the d-enantiomer of serine at the blood–brain barrier. This finding indicates that exogenous d-serine may have a direct influence on glutamatergic neurotransmission and associated diseases.</abstract>
    <parentTitle language="eng">Nuclear Medicine and Biology</parentTitle>
    <subTitle language="eng">a modulator of glutamatergic neurotransmission</subTitle>
    <identifier type="doi">10.1016/j.nucmedbio.2005.07.004</identifier>
    <author>Dagmar Bauer</author>
    <author>Kurt Hamacher</author>
    <author>Stefan Bröer</author>
    <author>Dirk Pauleit</author>
    <author>Christoph Palm</author>
    <author>Karl Zilles</author>
    <author>Heinz H. Coenen</author>
    <author>Karl-Josef Langen</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Aminosäuren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirn</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Blut-Hirn-Schranke</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Aufnahme</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>d/l-serine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Amino acid transport</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Blood–brain barrier</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NMDA receptors</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
</export-example>
