<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>404</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>104</pageFirst>
    <pageLast>106</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>273</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance</title>
    <abstract language="deu">Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.</abstract>
    <parentTitle language="eng">Archives of Gynecology and Obstetrics</parentTitle>
    <identifier type="doi">10.1007/s00404-005-0039-5</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Lars-Christian Horn</author>
    <author>Georgios Raptis</author>
    <author>Uta Fischer</author>
    <author>Bettina Hentschel</author>
    <author>U. Köhler</author>
    <author>Christine E. Richter</author>
    <author>Rosemarie Martin</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gebärmutterhalskrebs</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Antigen CD44</value>
    </subject>
    <collection role="ddc" number="618">Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="raptisehealth">Raptis, Georgios (Prof. Dr.) - eHealth Lab</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor eHealth (eH)</collection>
  </doc>
  <doc>
    <id>407</id>
    <completedYear/>
    <publishedYear>2003</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Tumorassoziierte Proteolyse beim Zervixkarzinom</title>
    <parentTitle language="deu">87. Tagung der Deutschen Gesellschaft für Pathologie, 14. Juni 2003</parentTitle>
    <subTitle language="deu">Vortrag</subTitle>
    <author>Lars-Christian Horn</author>
    <author>S. Pippig</author>
    <author>Georgios Raptis</author>
    <author>Uta Fischer</author>
    <author>U. Köhler</author>
    <author>Bettina Hentschel</author>
    <author>Rosemarie Martin</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gebärmutterhalskrebs</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Chirurgie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Tumorassoziierte Proteolyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Immuncytochemie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Zelladhäsion</value>
    </subject>
    <collection role="ddc" number="618">Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="raptisehealth">Raptis, Georgios (Prof. Dr.) - eHealth Lab</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor eHealth (eH)</collection>
  </doc>
  <doc>
    <id>403</id>
    <completedYear/>
    <publishedYear>2004</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>385</pageFirst>
    <pageLast>388</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>42</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Clinical relevance of urokinase-type plasminogen activator and its inhibitor type-1 (PAI-1) in squamous cell carcinoma of the uterine cervix</title>
    <abstract language="eng">Objective&#13;
&#13;
The expression of uPA and PAI‐1 as parameters of tumour‐associated proteolysis has been implicated in the process of tumour cell invasion and the metastatic process. However, there is limited information on the impact of these parameters in cervical carcinoma.&#13;
Methods&#13;
&#13;
Quantitative levels for uPA (n = 114) and PAI‐1 (n = 103) were researched in operatively treated, surgically staged squamous cell cancer of the uterine cervix, using an ELISA‐technique. Results were assessed regarding their impact in predicting pelvic lymph nodes metastases, tumour recurrence rate and recurrence free survival (RFS) using uni‐ and multivariate analysis.&#13;
Results&#13;
&#13;
Median levels of both parameters were significantly higher in tumour tissue than in normal cervical tissue (p &lt; 0.001). Detection of uPA gave no useful prognostic information. PAI‐1 concentration showed a positive correlation with advanced tumour stage (p = 0.008), but no significant correlation with nodal status (pN0: 2.6 vs. pN1: 4.0 ng/mg protein; p = 0.092). Using a cut‐off level of 2.4 ng/mg protein, patients with elevated PAI‐1 levels demonstrated reduced RFS (45.9 versus 52.9 months; p = 0.1). Multivariate analysis, including nodal status, tumour stage, lymphovascular space involvement and grading failed to demonstrate any prognostic impact of uPA and PAI‐1.&#13;
Conclusions&#13;
&#13;
The results indicate, that PAI‐1 expression is of some prognostic impact in cervical cancer, indicating an association of elevated PAI levels with local tumour progression and reduced recurrence‐free survival.</abstract>
    <parentTitle language="eng">Australian and New Zealand Journal of Obstetrics and Gynaecology</parentTitle>
    <identifier type="doi">10.1111/j.0004-8666.2002.00385.x</identifier>
    <author>Lars-Christian Horn</author>
    <author>S. Pippig</author>
    <author>Georgios Raptis</author>
    <author>Uta Fischer</author>
    <author>U. Köhler</author>
    <author>Bettina Hentschel</author>
    <author>Rosemarie Martin</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Plasminogen human-Aktivator</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Urokinase</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>squamöser Krebs</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gebärmutterhals</value>
    </subject>
    <collection role="ddc" number="618">Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="raptisehealth">Raptis, Georgios (Prof. Dr.) - eHealth Lab</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor eHealth (eH)</collection>
  </doc>
  <doc>
    <id>7329</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast>74</pageLast>
    <pageNumber/>
    <edition/>
    <issue>Suppl 2</issue>
    <volume>15</volume>
    <type>conferencesummary</type>
    <publisherName>BMJ</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">00083 PAI-1 AND UFA AS PARAMETERS OF TUMORASSOCIATED PROTEOLYSIS IN CERVICAL CARCINOMA</title>
    <parentTitle language="eng">International Journal of Gynecologic Cancer</parentTitle>
    <identifier type="issn">1048-891X</identifier>
    <identifier type="doi">10.1136/ijgc-00009577-200509001-00083</identifier>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>L. C Horn</author>
    <author>S. Pippig</author>
    <author>Georgios Raptis</author>
    <author>Uta Fischer</author>
    <author>U. Kohler</author>
    <author>Bettina Hentschel</author>
    <author>Rosemarie Martin</author>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="raptisehealth">Raptis, Georgios (Prof. Dr.) - eHealth Lab</collection>
    <collection role="othforschungsschwerpunkt" number="16311">Digitalisierung</collection>
    <collection role="institutes" number="">Labor eHealth (eH)</collection>
  </doc>
</export-example>
