<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>155</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>793</pageFirst>
    <pageLast>797</pageLast>
    <pageNumber/>
    <edition/>
    <issue>8</issue>
    <volume>32</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Preferred stereoselective brain uptake of D-serine</title>
    <abstract language="eng">Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of l-serine in the brain. Stimulated by the observation of a preferred transport of the d-isomer of proline at the blood–brain barrier, we investigated the differential uptake of [3H]-d-serine and [3H]-l-serine in the rat brain 1 h after intravenous injection using quantitative autoradiography. Surprisingly, brain uptake of [3H]-d-serine was significantly higher than that of [3H]-l-serine, indicating a preferred transport of the d-enantiomer of serine at the blood–brain barrier. This finding indicates that exogenous d-serine may have a direct influence on glutamatergic neurotransmission and associated diseases.</abstract>
    <parentTitle language="eng">Nuclear Medicine and Biology</parentTitle>
    <subTitle language="eng">a modulator of glutamatergic neurotransmission</subTitle>
    <identifier type="doi">10.1016/j.nucmedbio.2005.07.004</identifier>
    <author>Dagmar Bauer</author>
    <author>Kurt Hamacher</author>
    <author>Stefan Bröer</author>
    <author>Dirk Pauleit</author>
    <author>Christoph Palm</author>
    <author>Karl Zilles</author>
    <author>Heinz H. Coenen</author>
    <author>Karl-Josef Langen</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Aminosäuren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirn</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Blut-Hirn-Schranke</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Aufnahme</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>d/l-serine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Amino acid transport</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Blood–brain barrier</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NMDA receptors</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>154</id>
    <completedYear/>
    <publishedYear>2006</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst>251</pageFirst>
    <pageLast>255</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Evaluierung von Registrierungsstrategien zur multimodalen 3D-Rekonstruktion von Rattenhirnschnitten</title>
    <abstract language="deu">In dieser Arbeit werden drei Strategien zur 3D Stapelung von multimodalen Schnittbildern vorgestellt. Die Strategien werden experimentell anhand von Dualtracer-Autoradiographien evaluiert. Dazu werden neue Maße zur Beschreibung der Konsistenz innerhalb einer Modalität und der Konsistenz der Modalitäten untereinander entwickelt, die auf bekannten Registrierungsmetriken basieren. Gerade bezüglich der Konsistenz der Modalitäten untereinander zeigen zwei Strategien die besten Resultate: (1) abwechselnde multimodale Registrierung (2) monomodale Rekonstruktion einer Modalität und multimodale 2D Registrierung der zweiten Modalität.</abstract>
    <parentTitle language="deu">Bildverarbeitung für die Medizin 2006</parentTitle>
    <identifier type="doi">10.1007/3-540-32137-3_51</identifier>
    <author>Christoph Palm</author>
    <author>Andrea Vieten</author>
    <author>Dagmar Bauer</author>
    <author>Uwe Pietrzyk</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Registrierung &lt;Bildverarbeitung&gt;</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Dreidimensionale Rekonstruktion</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirn</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schnittpräparat</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
</export-example>
