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    <completedYear/>
    <publishedYear>2026</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>xxix, 496</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencevolume</type>
    <publisherName>Springer Vieweg</publisherName>
    <publisherPlace>Wiesbaden</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation>Gesellschaft für Informatik e.V.</contributingCorporation>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2026-03-29</completedDate>
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    <title language="deu">Bildverarbeitung für die Medizin 2026 : Proceedings, German Conference on Medical Image Computing, Lübeck March 15–17, 2026</title>
    <abstract language="deu">Die Konferenz "BVM – Bildverarbeitung für die Medizin" ist seit vielen Jahren als die nationale Plattform für den Austausch von Ideen und die Diskussion der neuesten Forschungsergebnisse im Bereich der Medizinischen Bildverarbeitung und der Künstlichen Intelligenz (KI) etabliert. Auch 2026 haben (junge) Wissenschaftler*innen, Industrie und Anwender*innen diesen Austausch vertieft. Die Beiträge dieses Bandes – die meisten davon in englischer Sprache – umfassen alle Bereiche der medizinischen Bildverarbeitung, insbesondere die Bildgebung und -akquisition, Segmentierung und Analyse, Registrierung, Visualisierung und Animation, computerunterstützte Diagnose sowie bildgestützte Therapieplanung und Therapie. Hierbei kommen Methoden des maschinellen Lernens, der biomechanischen Modellierung sowie der Validierung und Qualitätssicherung zum Einsatz.</abstract>
    <identifier type="isbn">978-3-658-51099-2</identifier>
    <identifier type="issn">1431-472X</identifier>
    <identifier type="doi">10.1007/978-3-658-51100-5</identifier>
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    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Deep Learning</value>
    </subject>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
    <collection role="DFGFachsystematik" number="1">Ingenieurwissenschaften</collection>
    <collection role="othforschungsschwerpunkt" number="">Gesundheit und Soziales</collection>
  </doc>
  <doc>
    <id>7967</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>XXIII, 354</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencevolume</type>
    <publisherName>Springer Fachmedien Wiesbaden</publisherName>
    <publisherPlace>Wiesbaden</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
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    <title language="deu">Bildverarbeitung für die Medizin 2025</title>
    <abstract language="deu">Die Konferenz "BVM - Bildverarbeitung für die Medizin" ist seit vielen Jahren als die nationale Plattform für den Austausch von Ideen und die Diskussion der neuesten Forschungsergebnisse im Bereich der Medizinischen Bildverarbeitung und der Künstlichen Intelligenz (KI) etabliert. Auch 2025 werden wir aktuelle Forschungsergebnisse vorstellen und Gespräche zwischen (jungen) Wissenschaftler*innen, Industrie und Anwender*innen vertiefen. Die Beiträge dieses Bandes – die meisten davon in englischer Sprache - umfassen alle Bereiche der medizinischen Bildverarbeitung, insbesondere die Bildgebung und -akquisition, Segmentierung und Analyse, Registrierung, Visualisierung und Animation, computerunterstützte Diagnose sowie bildgestützte Therapieplanung und Therapie. Hierbei kommen Methoden des maschinellen Lernens, der biomechanischen Modellierung sowie der Validierung und Qualitätssicherung zum Einsatz. Das Kapitel "Leveraging multiple total body segmentators and anatomy-informed post-processing for segmenting bones in Lung CTs" ist unter einer Creative Commons Attribution 4.0 International License über link.springer.com frei verfügbar (Open Access). Die Herausgebenden Prof. Palm forscht im Bereich KI für die Medizin mit einem Schwerpunkt in der Analyse endoskopischer Bilddaten zur computerunterstützten Diagnose und Therapie. Prof. Breininger entwickelt robuste Ansätze des maschinellen Lernens in verschiedenen interdisziplinären Bereichen, mit einem Schwerpunkt auf medizinischen Bilddaten. Prof. Deserno forscht in Biosignal- und Bilderzeugung und -verarbeitung, insbesondere in der videobasierten Vitaldatenmessung. Prof. Handels entwickelt problemoptimierte, lernfähige Bildverarbeitungsmethoden und integriert diese in hybride Bildverarbeitungssysteme zur Unterstützung der medizinischen Diagnostik und Therapie. Prof. Maier entwickelt Anwendungen in der medizinischen Bildverarbeitung zur Diagnoseunterstützung bis hin zur Schichtbildberechnung durch künstliche Intelligenz. Prof. Maier-Hein forscht im Bereich maschinelles Lernen und entwickelt Open-Source-Lösungen wie das Medical Imaging Interaction Toolkit (MITK), Kaapana oder das nnU-Net. Prof. em. Tolxdorff ist Experte für maschinelles Lernen, biomedizinisches Datenmanagement, Datenvisualisierung und -analyse sowie Medizinproduktentwicklung in klinischen Workflows.</abstract>
    <subTitle language="deu">Proceedings, German Conference on Medical Image Computing, Regensburg March 09-11, 2025</subTitle>
    <identifier type="isbn">978-3-658-47421-8</identifier>
    <identifier type="doi">10.1007/978-3-658-47422-5</identifier>
    <identifier type="issn">1431-472X</identifier>
    <enrichment key="opus.import.date">2025-03-17T20:19:32+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">importuser</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Deep Learning</value>
    </subject>
    <collection role="institutes" number="FakEI">Fakultät Elektro- und Informationstechnik</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="institutes" number="RCHST">Regensburg Center of Health Sciences and Technology - RCHST</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
    <collection role="DFGFachsystematik" number="1">Ingenieurwissenschaften</collection>
  </doc>
  <doc>
    <id>7115</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>370</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencevolume</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Wiesbaden</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-03-10</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Bildverarbeitung für die Medizin 2024</title>
    <abstract language="deu">Seit mehr als 25 Jahren ist der Workshop "Bildverarbeitung für die Medizin" als erfolgreiche Veranstaltung etabliert. Ziel ist auch 2024 wieder die Darstellung aktueller Forschungsergebnisse und die Vertiefung der Gespräche zwischen Wissenschaftlern, Industrie und Anwendern. Die Beiträge dieses Bandes - viele davon in englischer Sprache - umfassen alle Bereiche der medizinischen Bildverarbeitung, insbesondere die Bildgebung und -akquisition, Segmentierung und Analyse, Visualisierung und Animation, computerunterstützte Diagnose sowie bildgestützte Therapieplanung und Therapie. Hierbei kommen Methoden des maschinelles Lernens, der biomechanischen Modellierung sowie der Validierung und Qualitätssicherung zum Einsatz.</abstract>
    <subTitle language="deu">Proceedings, German Workshop on Medical Image Computing, Erlangen, March 10-12, 2024</subTitle>
    <identifier type="isbn">978-3-658-44037-4</identifier>
    <identifier type="doi">10.1007/978-3-658-44037-4</identifier>
    <identifier type="issn">1431-472X</identifier>
    <enrichment key="opus.source">publish</enrichment>
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    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Deep Learning</value>
    </subject>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="institutes" number="RCHST">Regensburg Center of Health Sciences and Technology - RCHST</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>6079</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>317</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencevolume</type>
    <publisherName>Springer Vieweg</publisherName>
    <publisherPlace>Wiesbaden</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-06-24</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Bildverarbeitung für die Medizin 2023</title>
    <abstract language="deu">Seit mehr als 25 Jahren ist der Workshop "Bildverarbeitung für die Medizin" als erfolgreiche Veranstaltung etabliert. Ziel ist auch 2023 wieder die Darstellung aktueller Forschungsergebnisse und die Vertiefung der Gespräche zwischen Wissenschaftlern, Industrie und Anwendern. Die Beiträge dieses Bandes - viele davon in englischer Sprache - umfassen alle Bereiche der medizinischen Bildverarbeitung, insbesondere die Bildgebung und -akquisition, Segmentierung und Analyse, Visualisierung und Animation, computerunterstützte Diagnose sowie bildgestützte Therapieplanung und Therapie. Hierbei kommen Methoden des maschinelles Lernens, der biomechanischen Modellierung sowie der Validierung und Qualitätssicherung zum Einsatz.</abstract>
    <subTitle language="eng">Proceedings, German Workshop on Medical Image Computing, Braunschweig, July 2-4, 2023</subTitle>
    <identifier type="isbn">978-3-658-41656-0</identifier>
    <identifier type="doi">10.1007/978-3-658-41657-7</identifier>
    <identifier type="issn">1431-472X</identifier>
    <enrichment key="ConferenceStatement">Bildverarbeitung für die Medizin (BVM), 2023, Braunschweig</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="OtherSeries">Informatik aktuell</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Machine Learning</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Medical Image Computing</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Visualisierung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Deep Learning</value>
    </subject>
    <collection role="ddc" number="000">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="ddc" number="610">Medizin und Gesundheit</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="institutes" number="RCHST">Regensburg Center of Health Sciences and Technology - RCHST</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>5436</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>08</issue>
    <volume>60</volume>
    <type>conferencepresentation</type>
    <publisherName>Georg Thieme Verlag</publisherName>
    <publisherPlace>Stuttgart</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-09-16</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Artificial Intelligence (AI) – assisted vessel and tissue recognition during third space endoscopy (Smart ESD)</title>
    <abstract language="eng">Clinical setting &#13;
Third space procedures such as endoscopic submucosal dissection (ESD) and peroral endoscopic myotomy (POEM) are complex minimally invasive techniques with an elevated risk for operator-dependent adverse events such as bleeding and perforation. This risk arises from accidental dissection into the muscle layer or through submucosal blood vessels as the submucosal cutting plane within the expanding resection site is not always apparent. Deep learning algorithms have shown considerable potential for the detection and characterization of gastrointestinal lesions. So-called AI – clinical decision support solutions (AI-CDSS) are commercially available for polyp detection during colonoscopy. Until now, these computer programs have concentrated on diagnostics whereas an AI-CDSS for interventional endoscopy has not yet been introduced. We aimed to develop an AI-CDSS („Smart ESD“) for real-time intra-procedural detection and delineation of blood vessels, tissue structures and endoscopic instruments during third-space endoscopic procedures.&#13;
&#13;
Characteristics of Smart ESD &#13;
An AI-CDSS was invented that delineates blood vessels, tissue structures and endoscopic instruments during third-space endoscopy in real-time. The output can be displayed by an overlay over the endoscopic image with different modes of visualization, such as a color-coded semitransparent area overlay, or border tracing (demonstration video). Hereby the optimal layer for dissection can be visualized, which is close above or directly at the muscle layer, depending on the applied technique (ESD or POEM). Furthermore, relevant blood vessels (thickness&gt; 1mm) are delineated. Spatial proximity between the electrosurgical knife and a blood vessel triggers a warning signal. By this guidance system, inadvertent dissection through blood vessels could be averted.&#13;
&#13;
Technical specifications &#13;
A DeepLabv3+ neural network architecture with KSAC and a 101-layer ResNeSt backbone was used for the development of Smart ESD. It was trained and validated with 2565 annotated still images from 27 full length third-space endoscopic videos. The annotation classes were blood vessel, submucosal layer, muscle layer, electrosurgical knife and endoscopic instrument shaft. A test on a separate data set yielded an intersection over union (IoU) of 68%, a Dice Score of 80% and a pixel accuracy of 87%, demonstrating a high overlap between expert and AI segmentation. Further experiments on standardized video clips showed a mean vessel detection rate (VDR) of 85% with values of 92%, 70% and 95% for POEM, rectal ESD and esophageal ESD respectively. False positive measurements occurred 0.75 times per minute. 7 out of 9 vessels which caused intraprocedural bleeding were caught by the algorithm, as well as both vessels which required hemostasis via hemostatic forceps.&#13;
&#13;
Future perspectives &#13;
Smart ESD performed well for vessel and tissue detection and delineation on still images, as well as on video clips. During a live demonstration in the endoscopy suite, clinical applicability of the innovation was examined. The lag time for processing of the live endoscopic image was too short to be visually detectable for the interventionist. Even though the algorithm could not be applied during actual dissection by the interventionist, Smart ESD appeared readily deployable during visual assessment by ESD experts. Therefore, we plan to conduct a clinical trial in order to obtain CE-certification of the algorithm. This new technology may improve procedural safety and speed, as well as training of modern minimally invasive endoscopic resection techniques.</abstract>
    <parentTitle language="deu">Zeitschrift für Gastroenterologie</parentTitle>
    <identifier type="doi">10.1055/s-0042-1755110</identifier>
    <enrichment key="ConferenceStatement">Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie, 76, 2022, Hamburg</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Markus W. Scheppach</author>
    <author>Robert Mendel</author>
    <author>Andreas Probst</author>
    <author>Michael Meinikheim</author>
    <author>Christoph Palm</author>
    <author>Helmut Messmann</author>
    <author>Alanna Ebigbo</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Artificial Intelligence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Medical Image Computing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Endoscopy</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Künstliche Intelligenz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Endoskopie</value>
    </subject>
    <collection role="ddc" number="004">Datenverarbeitung; Informatik</collection>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="institutes" number="RCHST">Regensburg Center of Health Sciences and Technology - RCHST</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>3512</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencepresentation</type>
    <publisherName/>
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    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-04-12</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Blutdruck, Hämodynamik und Gefäßzustand: Innovative Erfassung und Bewertung – Schwerpunkt bildbasierte Verfahren</title>
    <abstract language="deu">Einleitung: &#13;
Blutdruck gilt als sogenannter Vitalparameter als einer der grundlegenden Indikatoren für den Gesundheitszustand einer Person. Sowohl zu niedriger als auch zu hoher Blutdruck kann lebensbedrohend sein, letzerer ist darüber hinaus ein Risikofaktor insbesondere für Herz-Kreislauferkrankungen, die trotz wichtiger Fortschritte in der Behandlung immer noch die häufigste Todesursache in Deutschland darstellen. Die Hämodynamik, also die raumzeitliche Dynamik des Blutflusses, und der Gefäßzustand sind eng verbunden mit dem Blutdruck und ebenfalls von hoher klinischer Relevanz, u.a. zur Identifikation von Durchblutungsstörungen und ungünstigen Druckverteilungen der Gefäßwand. Innovationen in der Messtechnik als auch in der Datenanalyse bieten heute neue Möglichkeiten der Erfassung und Bewertung von Blutdruck, Hämodynamik und Gefäßzustand [1], [2], [3], [4].&#13;
&#13;
Methodik:&#13;
In einer gemeinsamen Workshopserie der AG Medizinische Bild- und Signalverarbeitung der GMDS und des Fachausschusses Biosignale der DGBMT werden wir neue Ansätze und Lösungen für Mess- und Analyseverfahren zu Blutdruck und -fluss sowie zum Gefäßzustand vorstellen und diskutieren. Dabei stehen im ersten Workshop auf der GMDS Jahrestagung Bildbasierte Verfahren im Zentrum, während der zweite Workshop auf der DGBMT Jahrestagung den Fokus auf Biosignalbasierten Verfahren legt. Es werden aktuelle Forschungsergebnisse vorgestellt und diskutiert. Es sind jeweils mehrere Vorträge geplant mit ausreichend Zeit zur Diskussion. Folgende Vorträge sind geplant (Arbeitstitel):&#13;
&#13;
Sebastian Zaunseder: Videobasierte Erfassung des Blutdrucks&#13;
Anja Hennemuth: A Visualization Toolkit for the Analysis of Aortic Anatomy and Pressure Distribution&#13;
Lars Krenkel: Numerische Analyse der Rupturwahrscheinlichkeit zerebraler Aneurysmata&#13;
Susanne Schnell: Messung des Blutflusses und hämodynamischer Parameter mit 4D flow MRI: Möglichkeiten und Herausforderungen&#13;
&#13;
Ergebnisse: &#13;
Ziel des Workshops ist die Identifikation von innovativen Ansätzen und neuen Methoden zur qualitativen und quantitativen Bestimmung von hämodynamischen Parametern sowie deren kritische Bewertung durch die Community für die Eignung in der klinischen Entscheidungsunterstützung.&#13;
&#13;
Diskussion:&#13;
Der Workshop leistet inhaltlich einen Beitrag zu zentralen Aspekten für die Herz-Kreislauf-Medizin. Er bringt dabei Expertise aus verschiedenen Bereichen zusammen und schlägt die Brücke zwischen Kardiologie, Medizininformatik und Medizintechnik.&#13;
&#13;
Schlussfolgerung:&#13;
Innovative Technologien aus Medizintechnik und Informatik ermöglichen zunehmend einfache und raumzeitlich aufgelöste Erfassung und Bewertung wichtiger Informationen zur Unterstützung von Diagnose und Therapieverfolgung.&#13;
&#13;
[1] Zaunseder S, Trumpp A, Wedekind D, Malberg H. Cardiovascular assessment by imaging photoplethysmography - a review. Biomed Tech (Berl). 2018 Oct 25;63(5):617–34.&#13;
[2] Huellebrand M, Messroghli D, Tautz L, Kuehne T, Hennemuth A. An extensible software platform for interdisciplinary cardiovascular imaging research. Comput Methods Programs Biomed. 2020 Feb;184:105277.&#13;
[3] Schmitter S, Adriany G, Waks M, Moeller S, Aristova M, Vali A, et al. Bilateral Multiband 4D Flow MRI of the Carotid Arteries at 7T. Magn Reson Med. 2020 Oct;84(4):1947–60.&#13;
[4] Birkenmaier C, and Krenkel, L.  Flow in Artificial Lungs. In: New Results in Numerical and Experimental Fluid Mechanics XIII. Contributions to the 22nd STAB/DGLR Symposium. Springer; 2021.</abstract>
    <parentTitle language="deu">66. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS), 12. Jahreskongress der Technologie- und Methodenplattform für die vernetzte medizinische Forschung e. V. (TMF), 26. - 30.09.2021, online</parentTitle>
    <identifier type="doi">10.3205/21gmds016</identifier>
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    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Dagmar Krefting</author>
    <author>Sebastian Zaunseder</author>
    <author>Dennis Säring</author>
    <author>Thomas Wittenberg</author>
    <author>Christoph Palm</author>
    <author>Karin Schiecke</author>
    <author>Lars Krenkel</author>
    <author>Anja Hennemuth</author>
    <author>Susanne Schnell</author>
    <author>Nicolai Spicher</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Bildbasierte Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Blutdruck</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Hämodynamik</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Blutgefäß</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
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    <title language="eng">IJCARS: BVM 2021 special issue</title>
    <abstract language="eng">The German workshop on medical image computing (BVM) has been held in different locations in Germany for more than 20 years. In terms of content, BVM focused on the computer-aided analysis of medical image data with a wide range of applications, e.g. in the area of imaging, diagnostics, operation planning, computer-aided intervention and visualization.&#13;
&#13;
During this time, there have been remarkable methodological developments and upheavals, on which the BVM community has worked intensively. The area of machine learning should be emphasized, which has led to significant improvements, especially for tasks of classification and segmentation, but increasingly also in image formation and registration. As a result, work in connection with deep learning now dominates the BVM. These developments have also contributed to the establishment of medical image processing at the interface between computer science and medicine as one of the key technologies for the digitization of the health system.&#13;
&#13;
In addition to the presentation of current research results, a central aspect of the BVM is primarily the promotion of young scientists from the diverse BVM community, covering not only Germany but also Austria, Switzerland, The Netherland and other European neighbors. The conference serves primarily doctoral students and postdocs, but also students with excellent bachelor and master theses as a platform to present their work, to enter into professional discourse with the community, and to establish networks with specialist colleagues. Despite the many conferences and congresses that are also relevant for medical image processing, the BVM has therefore lost none of its importance and attractiveness and has retained its permanent place in the annual conference rhythm.&#13;
&#13;
Building on this foundation, there are some innovations and changes this year. The BVM 2021 was organized for the first time at the Ostbayerische Technische Hochschule Regensburg (OTH Regensburg, a technical university of applied sciences). After Aachen, Berlin, Erlangen, Freiburg, Hamburg, Heidelberg, Leipzig, Lübeck, and Munich, Regensburg is not just a new venue. OTH Regensburg is the first representative of the universities of applied sciences (HAW) to organize the conference, which differs to universities, university hospitals, or research centers like Fraunhofer or Helmholtz. This also considers the further development of the research landscape in Germany, where HAWs increasingly contribute to applied research in addition to their focus on teaching. This development is also reflected in the contributions submitted to the BVM in recent years.&#13;
&#13;
At BVM 2021, which was held in a virtual format for the first time due to the Corona pandemic, an attractive and high-quality program was offered. Fortunately, the number of submissions increased significantly. Out of 97 submissions, 26 presentations, 51 posters and 5 software demonstrations were accepted via an anonymized reviewing process with three reviews each. The three best works have been awarded BVM prizes, selected by a separate committee.&#13;
&#13;
Based on these high-quality submissions, we are able to present another special issue in the International Journal of Computer Assisted Radiology and Surgery (IJCARS). Out of the 97 submissions, the ones with the highest scores have been invited to submit an extended version of their paper to be presented in IJCARS. As a result, we are now able to present this special issue with seven excellent articles. Many submissions focus on machine learning in a medical context.</abstract>
    <parentTitle language="eng">International Journal of Computer Assisted Radiology and Surgery</parentTitle>
    <identifier type="doi">10.1007/s11548-021-02534-7</identifier>
    <identifier type="urn">urn:nbn:de:bvb:898-opus4-21666</identifier>
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    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Andreas Maier</author>
    <author>Thomas M. Deserno</author>
    <author>Heinz Handels</author>
    <author>Klaus H. Maier-Hein</author>
    <author>Christoph Palm</author>
    <author>Thomas Tolxdorff</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Medical Image Computing</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Medizin</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="ddc" number="6">Technik, Medizin, angewandte Wissenschaften</collection>
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    <collection role="oaweg" number="">Hybrid Open Access - OA-Veröffentlichung in einer Subskriptionszeitschrift/-medium</collection>
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    <thesisPublisher>Ostbayerische Technische Hochschule Regensburg</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-oth-regensburg/files/2166/Maier2021_Article_IJCARSBVM2021SpecialIssue.pdf</file>
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    <title language="eng">Fusion strategies in multi-modality imaging</title>
    <parentTitle language="eng">Medical Physics, Vol 2. Proceedings of the jointly held Congresses: ICMP 2005, 14th International Conference of Medical Physics of the International Organization for Medical Physics (IOMP), the European Federation of Organizations in Medical Physics (EFOMP) and the German Society of Medical Physics (DGMP) ; BMT 2005, 39th Annual Congress of the German Society for Biomedical Engineering (DGBMT) within VDE ; 14th - 17th September 2005, Nuremberg, Germany</parentTitle>
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    <enrichment key="OtherSeries">Biomedizinische Technik ; 50, Suppl. 1</enrichment>
    <author>Uwe Pietrzyk</author>
    <author>Christoph Palm</author>
    <author>Thomas Beyer</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Registrierung &lt;Bildverarbeitung&gt;</value>
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    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-04-22</completedDate>
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    <title language="eng">Retrospective Color Shading Correction for Endoscopic Images</title>
    <abstract language="eng">In this paper, we address the problem of retrospective color shading correction. An extension of the established gray-level shading correction algorithm based on signal envelope (SE) estimation to color images is developed using principal color components. Compared to the probably most general shading correction algorithm based on entropy minimization, SE estimation does not need any computationally expensive optimization and thus can be implemented more effciently. We tested our new shading correction scheme on artificial as well as real endoscopic images and observed promising results. Additionally, an indepth analysis of the stop criterion used in the SE estimation algorithm is provided leading to the conclusion that a fixed, user-defined threshold is generally not feasible. Thus, we present new ideas how to develop a non-parametric version of the SE estimation algorithm using entropy.</abstract>
    <parentTitle language="deu">Bildverarbeitung für die Medizin 2020. Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 15. bis 17. März 2020 in Berlin</parentTitle>
    <identifier type="isbn">978-3-658-29266-9</identifier>
    <identifier type="doi">10.1007/978-3-658-29267-6</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Maximilian Weiherer</author>
    <author>Martin Zorn</author>
    <author>Thomas Wittenberg</author>
    <author>Christoph Palm</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Endoskopie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Farbenraum</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Graustufe</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="ddc" number="6">Technik, Medizin, angewandte Wissenschaften</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>153</id>
    <completedYear/>
    <publishedYear>2006</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>384P</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>Suppl. 1</issue>
    <volume>47</volume>
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    <publisherPlace/>
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    <title language="eng">Towards MR-based attenuation correction for whole-body PET/MR imaging</title>
    <parentTitle language="eng">The Journal of Nuclear Medicine</parentTitle>
    <identifier type="url">http://jnm.snmjournals.org/content/47/suppl_1/384P.1.abstract</identifier>
    <author>Thomas Beyer</author>
    <author>Markus Weigert</author>
    <author>Christoph Palm</author>
    <author>Harald H. Quick</author>
    <author>Stefan P. Müller</author>
    <author>Uwe Pietrzyk</author>
    <author>Florian Vogt</author>
    <author>M.J. Martinez</author>
    <author>Andreas Bockisch</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Kernspintomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Positronen-Emissions-Tomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schwächung</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>144</id>
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    <publishedYear>2007</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>A115</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>46</volume>
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    <creatingCorporation/>
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    <completedDate>--</completedDate>
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    <title language="eng">Template for MR-based attenuation correction for whole-body PET/MR imaging</title>
    <parentTitle language="deu">Nuklearmedizin</parentTitle>
    <author>Markus Weigert</author>
    <author>Christoph Palm</author>
    <author>Harald H. Quick</author>
    <author>Stefan P. Müller</author>
    <author>Uwe Pietrzyk</author>
    <author>Thomas Beyer</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Kernspintomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Positronen-Emissions-Tomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schwächung</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
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  </doc>
  <doc>
    <id>141</id>
    <completedYear/>
    <publishedYear>2008</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>59</pageFirst>
    <pageLast>66</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>18</volume>
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    <title language="eng">Whole-body PET/CT imaging</title>
    <abstract language="eng">Aim&#13;
Combined whole-body (WB) PET/CT imaging provides better overall co-registration compared to separate CT and PET. However, in clinical routine local PET-CT mis-registration cannot be avoided. Thus, the reconstructed PET tracer distribution may be biased when using the misaligned CT transmission data for CT-based attenuation correction (CT-AC). We investigate the feasibility of retrospective co-registration techniques to align CT and PET images prior to CT-AC, thus improving potentially the quality of combined PET/CT imaging in clinical routine.&#13;
Methods&#13;
First, using a commercial software registration package CT images were aligned to the uncorrected PET data by rigid and non-rigid registration methods. Co-registration accuracy of both alignment approaches was assessed by reviewing the PET tracer uptake patterns (visual, linked cursor display) following attenuation correction based on the original and co-registered CT. Second, we investigated non-rigid registration based on a prototype ITK implementation of the B-spline algorithm on a similar targeted MR-CT registration task, there showing promising results.&#13;
Results&#13;
Manual rigid, landmark-based co-registration introduced unacceptable misalignment, in particular in peripheral areas of the whole-body images. Manual, non-rigid landmark-based co-registration prior to CT-AC was successful with minor loco-regional distortions. Nevertheless, neither rigid nor non-rigid automatic co-registration based on the Mutual Information image to image metric succeeded in co-registering the CT and noAC-PET images. In contrast to widely available commercial software registration our implementation of an alternative automated, non-rigid B-spline co-registration technique yielded promising results in this setting with MR-CT data.&#13;
Conclusion&#13;
In clinical PET/CT imaging, retrospective registration of CT and uncorrected PET images may improve the quality of the AC-PET images. As of today no validated and clinically viable commercial registration software is in routine use. This has triggered our efforts in pursuing new approaches to a validated, non-rigid co-registration algorithm applicable to whole-body PET/CT imaging of which first results are presented here. This approach appears suitable for applications in retrospective WB-PET/CT alignment.&#13;
&#13;
Ziel&#13;
Kombinierte PET/CT-Bildgebung ermöglicht verbesserte Koregistrierung von PET- und CT-Daten gegenüber separat akquirierten Bildern. Trotzdem entstehen in der klinischen Anwendung lokale Fehlregistrierungen, die zu Fehlern in der rekonstruierten PET- Tracerverteilung führen können, falls die unregistrierten CT-Daten zur Schwächungskorrektur (AC) der Emissionsdaten verwendet werden. Wir untersuchen daher die Anwendung von Bildregistrierungsalgorithmen vor der CT-basierten AC zur Verbesserung der PET-Aufnahmen.&#13;
Methoden&#13;
Mittels einer kommerziellen Registrierungssoftware wurden die CT-Daten eines PET/CT- Tomographen durch landmarken- und intensitätsbasierte rigide (starre) und nicht-rigide Registrierungsverfahren räumlich an die unkorrigierten PET-Emissionsdaten angepasst und zur AC verwendet. Zur Bewertung wurden die Tracerverteilungen in den PET-Bildern (vor AC, CT-AC, CT-AC nach Koregistrierung) visuell und mit Hilfe korrelierter Fadenkreuze verglichen. Zusätzlich untersuchten wir die ITK-Implementierung der bekannten B-spline basierten, nicht-rigiden Registrierungsansätze im Hinblick auf ihre Verwendbarkeit für die multimodale PET/CT-Ganzkörperregistrierung.&#13;
Ergebnisse&#13;
Mittels landmarkenbasierter, nicht-rigider Registrierung konnte die Tracerverteilung in den PET-Daten lokal verbessert werden. Landmarkenbasierte rigide Registrierung führte zu starker Fehlregistrierung in entfernten Körperregionen. Automatische rigide und nicht-rigide Registrierung unter Verwendung der Mutual-Information-Ähnlichkeitsmetrik versagte auf allen verwendeten Datensätzen. Die automatische Registrierung mit B-spline-Funktionen zeigte vielversprechende Resultate in der Anwendung auf einem ähnlich gelagerten CT–MR-Registrierungsproblem.&#13;
Fazit&#13;
Retrospektive, nicht-rigide Registrierung unkorrigierter PET- und CT-Aufnahmen aus kombinierten Aufnahmensystemen vor der AC kann die Qualität von PET-Aufnahmen im klinischen Einsatz verbessern. Trotzdem steht bis heute im klinischen Alltag keine validierte, automatische Registrierungssoftware zur Verfügung. Wir verfolgen dazu Ansätze für validierte, nicht-rigide Bildregistrierung für den klinischen Einsatz und präsentieren erste Ergebnisse.</abstract>
    <parentTitle language="deu">Zeitschrift für Medizinische Physik</parentTitle>
    <subTitle language="eng">Combining software- and hardware-based co-registration</subTitle>
    <identifier type="doi">10.1016/j.zemedi.2007.07.004</identifier>
    <author>Markus Weigert</author>
    <author>Uwe Pietrzyk</author>
    <author>Stefan P. Müller</author>
    <author>Christoph Palm</author>
    <author>Thomas Beyer</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PET/CT</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>combined imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>image co-registration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>attenuation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>correction</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Positronen-Emissions-Tomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computertomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Registrierung &lt;Bildverarbeitung&gt;</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schwächung</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>135</id>
    <completedYear/>
    <publishedYear>2009</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>142</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>Suppl. 1</issue>
    <volume>47</volume>
    <type>conferencepresentation</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Visualization of Fiber Tracts in the Postmortem Human Brain by Means of Polarized Light</title>
    <parentTitle language="eng">NeuroImage</parentTitle>
    <identifier type="doi">10.1016/S1053-8119(09)71415-6</identifier>
    <enrichment key="ConferenceStatement">Organization for Human Brain Mapping 2009 Annual Meeting - OHBM 2009</enrichment>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>David Gräßel</author>
    <author>Markus Axer</author>
    <author>Christoph Palm</author>
    <author>Jürgen Dammers</author>
    <author>Katrin Amunts</author>
    <author>Uwe Pietrzyk</author>
    <author>Karl Zilles</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirn</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Polarisiertes Licht</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Pathologische Anatomie</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>132</id>
    <completedYear/>
    <publishedYear>2009</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>3269</pageFirst>
    <pageLast>3289</pageLast>
    <pageNumber/>
    <edition/>
    <issue>10</issue>
    <volume>54</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Evaluation of Registration Strategies for Multi-modality Images of Rat Brain Slices</title>
    <abstract language="eng">In neuroscience, small-animal studies frequently involve dealing with series of images from multiple modalities such as histology and autoradiography. The consistent and bias-free restacking of multi-modality image series is obligatory as a starting point for subsequent non-rigid registration procedures and for quantitative comparisons with positron emission tomography (PET) and other in vivo data. Up to now, consistency between 2D slices without cross validation using an inherent 3D modality is frequently presumed to be close to the true morphology due to the smooth appearance of the contours of anatomical structures. However, in multi-modality stacks consistency is difficult to assess. In this work, consistency is defined in terms of smoothness of neighboring slices within a single modality and between different modalities. Registration bias denotes the distortion of the registered stack in comparison to the true 3D morphology and shape. Based on these metrics, different restacking strategies of multi-modality rat brain slices are experimentally evaluated. Experiments based on MRI-simulated and real dual-tracer autoradiograms reveal a clear bias of the restacked volume despite quantitatively high consistency and qualitatively smooth brain structures. However, different registration strategies yield different inter-consistency metrics. If no genuine 3D modality is available, the use of the so-called SOP (slice-order preferred) or MOSOP (modality-and-slice-order preferred) strategy is recommended.</abstract>
    <parentTitle language="eng">Physics in Medicine and Biology</parentTitle>
    <identifier type="doi">10.1088/0031-9155/54/10/021</identifier>
    <author>Christoph Palm</author>
    <author>Andrea Vieten</author>
    <author>Dagmar Salber</author>
    <author>Uwe Pietrzyk</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Histologie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schnittdarstellung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Multimodales Verfahren</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>131</id>
    <completedYear/>
    <publishedYear>2010</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>301</pageFirst>
    <pageLast>305</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Error Correction using Registration for Blockface Volume Reconstruction of Serial Histological Sections of the Human Brain</title>
    <abstract language="eng">For accurate registration of histological sections blockface images are frequently used as three dimensional reference. However, due to the use of endocentric lenses the images suﬀer from perspective errors such as scaling and seemingly relative movement of planes which are located in diﬀerent distances parallel to the imaging sensor. The suggested correction of those errors is based on the estimation of scaling factors derived from image registration of regions characterized by diﬀering distances to the point of view in neighboring sections. The correction allows the generation of a consistent three dimensional blockface volume.</abstract>
    <parentTitle language="deu">Bildverarbeitung für die Medizin 2010; Algorithmen - Systeme - Anwendungen ; Proceedings des Workshops vom 22. bis 25. März 2009 in Heidelberg</parentTitle>
    <identifier type="url">http://ceur-ws.org/Vol-574/bvm2010_61.pdf</identifier>
    <author>Björn Eiben</author>
    <author>Christoph Palm</author>
    <author>Uwe Pietrzyk</author>
    <author>Christos Davatzikos</author>
    <author>Katrin Amunts</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Histologie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Diagnostik</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schnittdarstellung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Fehlerbehandlung</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>129</id>
    <completedYear/>
    <publishedYear>2010</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>156</pageFirst>
    <pageLast>175</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>29</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Bioimaging of Metals by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS)</title>
    <abstract language="eng">The distribution analysis of (essential, beneficial, or toxic) metals (e.g., Cu, Fe, Zn, Pb, and others), metalloids, and non‐metals in biological tissues is of key interest in life science. Over the past few years, the development and application of several imaging mass spectrometric techniques has been rapidly growing in biology and medicine. Especially, in brain research metalloproteins are in the focus of targeted therapy approaches of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, or stroke, or tumor growth. Laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS) using double‐focusing sector field (LA‐ICP‐SFMS) or quadrupole‐based mass spectrometers (LA‐ICP‐QMS) has been successfully applied as a powerful imaging (mapping) technique to produce quantitative images of detailed regionally specific element distributions in thin tissue sections of human or rodent brain. Imaging LA‐ICP‐QMS was also applied to investigate metal distributions in plant and animal sections to study, for example, the uptake and transport of nutrient and toxic elements or environmental contamination. The combination of imaging LA‐ICP‐MS of metals with proteomic studies using biomolecular mass spectrometry identifies metal‐containing proteins and also phosphoproteins. Metal‐containing proteins were imaged in a two‐dimensional gel after electrophoretic separation of proteins (SDS or Blue Native PAGE). Recent progress in LA‐ICP‐MS imaging as a stand‐alone technique and in combination with MALDI/ESI‐MS for selected life science applications is summarized.</abstract>
    <parentTitle language="eng">Mass Spectrometry Reviews</parentTitle>
    <identifier type="doi">10.1002/mas.20239</identifier>
    <author>Johanna Sabine Becker</author>
    <author>Miroslav Zoriy</author>
    <author>Andreas Matusch</author>
    <author>Bei Wu</author>
    <author>Dagmar Salber</author>
    <author>Christoph Palm</author>
    <author>Julia Susanne Becker</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>ICP-Massenspektrometrie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Metalle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Metallproteide</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Elektrophorese</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirnkarte</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioimaging of metals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laser ablation inductively coupled plasma mass spectrometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>metal distribution</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>metallomics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>neurodegenerative diseases</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>127</id>
    <completedYear/>
    <publishedYear>2010</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1241</pageFirst>
    <pageLast>1248</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>49</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Signal enhancement in polarized light imaging by means of independent component analysis</title>
    <abstract language="eng">Polarized light imaging (PLI) enables the evaluation of fiber orientations in histological sections of human postmortem brains, with ultra-high spatial resolution. PLI is based on the birefringent properties of the myelin sheath of nerve fibers. As a result, the polarization state of light propagating through a rotating polarimeter is changed in such a way that the detected signal at each measurement unit of a charged-coupled device (CCD) camera describes a sinusoidal signal. Vectors of the fiber orientation defined by inclination and direction angles can then directly be derived from the optical signals employing PLI analysis. However, noise, light scatter and filter inhomogeneities interfere with the original sinusoidal PLI signals. We here introduce a novel method using independent component analysis (ICA) to decompose the PLI images into statistically independent component maps. After decomposition, gray and white matter structures can clearly be distinguished from noise and other artifacts. The signal enhancement after artifact rejection is quantitatively evaluated in 134 histological whole brain sections. Thus, the primary sinusoidal signals from polarized light imaging can be effectively restored after noise and artifact rejection utilizing ICA. Our method therefore contributes to the analysis of nerve fiber orientation in the human brain within a micrometer scale.</abstract>
    <parentTitle language="eng">NeuroImage</parentTitle>
    <identifier type="doi">10.1016/j.neuroimage.2009.08.059</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Jürgen Dammers</author>
    <author>Markus Axer</author>
    <author>David Gräßel</author>
    <author>Christoph Palm</author>
    <author>Karl Zilles</author>
    <author>Katrin Amunts</author>
    <author>Uwe Pietrzyk</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Polarisiertes Licht</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Signalverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Signaltrennung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Komponentenanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirn</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>126</id>
    <completedYear/>
    <publishedYear>2010</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>9</pageNumber>
    <edition/>
    <issue/>
    <volume>4</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Towards ultra-high resolution fibre tract mapping of the human brain</title>
    <abstract language="eng">Polarised light imaging (PLI) utilises the birefringence of the myelin sheaths in order to visualise the orientation of nerve fibres in microtome sections of adult human post-mortem brains at ultra-high spatial resolution. The preparation of post-mortem brains for PLI involves fixation, freezing and cutting into 100-μm-thick sections. Hence, geometrical distortions of histological sections are inevitable and have to be removed for 3D reconstruction and subsequent fibre tracking. We here present a processing pipeline for 3D reconstruction of these sections using PLI derived multimodal images of post-mortem brains. Blockface images of the brains were obtained during cutting; they serve as reference data for alignment and elimination of distortion artefacts. In addition to the spatial image transformation, fibre orientation vectors were reoriented using the transformation fields, which consider both affine and subsequent non-linear registration. The application of this registration and reorientation approach results in a smooth fibre vector field, which reflects brain morphology. PLI combined with 3D reconstruction and fibre tracking is a powerful tool for human brain mapping. It can also serve as an independent method for evaluating in vivo fibre tractography.</abstract>
    <parentTitle language="eng">Frontiers in Human Neuroscience</parentTitle>
    <subTitle language="eng">registration of polarised light images and reorientation of fibre vectors</subTitle>
    <identifier type="doi">10.3389/neuro.09.009.2010</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Christoph Palm</author>
    <author>Markus Axer</author>
    <author>David Gräßel</author>
    <author>Jürgen Dammers</author>
    <author>Johannes Lindemeyer</author>
    <author>Karl Zilles</author>
    <author>Uwe Pietrzyk</author>
    <author>Katrin Amunts</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Dreidimensionale Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Polarisiertes Licht</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirnkarte</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>125</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1091</pageFirst>
    <pageLast>1101</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>54</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Novel Approach to the Human Connectome</title>
    <abstract language="eng">Signal transmission between different brain regions requires connecting fiber tracts, the structural basis of the human connectome. In contrast to animal brains, where a multitude of tract tracing methods can be used, magnetic resonance (MR)-based diffusion imaging is presently the only promising approach to study fiber tracts between specific human brain regions. However, this procedure has various inherent restrictions caused by its relatively low spatial resolution. Here, we introduce 3D-polarized light imaging (3D-PLI) to map the three-dimensional course of fiber tracts in the human brain with a resolution at a submillimeter scale based on a voxel size of 100 μm isotropic or less. 3D-PLI demonstrates nerve fibers by utilizing their intrinsic birefringence of myelin sheaths surrounding axons. This optical method enables the demonstration of 3D fiber orientations in serial microtome sections of entire human brains. Examples for the feasibility of this novel approach are given here. 3D-PLI enables the study of brain regions of intense fiber crossing in unprecedented detail, and provides an independent evaluation of fiber tracts derived from diffusion imaging data.</abstract>
    <parentTitle language="eng">NeuroImage</parentTitle>
    <subTitle language="eng">Ultra-High Resolution Mapping of Fiber Tracts in the Brain</subTitle>
    <identifier type="doi">10.1016/j.neuroimage.2010.08.075</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Markus Axer</author>
    <author>Katrin Amunts</author>
    <author>David Gräßel</author>
    <author>Christoph Palm</author>
    <author>Jürgen Dammers</author>
    <author>Hubertus Axer</author>
    <author>Uwe Pietrzyk</author>
    <author>Karl Zilles</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Connectome</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Human brain</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Method</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polarized light imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Tractography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Systems biology</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Dreidimensionale Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Polarisiertes Licht</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirnkarte</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>124</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>3</pageFirst>
    <pageLast>15</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1-3</issue>
    <volume>307</volume>
    <type>article</type>
    <publisherName>eLSEVIER</publisherName>
    <publisherPlace>Elsevier</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Mass spectrometric imaging (MSI) of metals using advanced BrainMet techniques for biomedical research</title>
    <abstract language="eng">Mass spectrometric imaging (MSI) is a young innovative analytical technique and combines different fields of advanced mass spectrometry and biomedical research with the aim to provide maps of elements and molecules, complexes or fragments. Especially essential metals such as zinc, copper, iron and manganese play a functional role in signaling, metabolism and homeostasis of the cell. Due to the high degree of spatial organization of metals in biological systems their distribution analysis is of key interest in life sciences. We have developed analytical techniques termed BrainMet using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging to measure the distribution of trace metals in biological tissues for biomedical research and feasibility studies—including bioaccumulation and bioavailability studies, ecological risk assessment and toxicity studies in humans and other organisms. The analytical BrainMet techniques provide quantitative images of metal distributions in brain tissue slices which can be combined with other imaging modalities such as photomicrography of native or processed tissue (histochemistry, immunostaining) and autoradiography or with in vivo techniques such as positron emission tomography or magnetic resonance tomography.&#13;
&#13;
Prospective and instrumental developments will be discussed concerning the development of the metalloprotein microscopy using a laser microdissection (LMD) apparatus for specific sample introduction into an inductively coupled plasma mass spectrometer (LMD-ICP-MS) or an application of the near field effect in LA-ICP-MS (NF-LA-ICP-MS). These nano-scale mass spectrometric techniques provide improved spatial resolution down to the single cell level.</abstract>
    <parentTitle language="eng">International Journal of Mass Spectrometry</parentTitle>
    <identifier type="doi">10.1016/j.ijms.2011.01.015</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Johanna Sabine Becker</author>
    <author>Andreas Matusch</author>
    <author>Julia Susanne Becker</author>
    <author>Bei Wu</author>
    <author>Christoph Palm</author>
    <author>Albert Johann Becker</author>
    <author>Dagmar Salber</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioimaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Brain tissue</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laser ablation inductively coupled plasma mass spectrometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laser microdissection inductively coupled plasma mass spectrometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Metals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Metallomics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nano-LA-ICP-MS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Tumour</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Massenspektrometrie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Metalle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Metallproteide</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gehirn</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>117</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>784</pageFirst>
    <pageLast>800</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>17</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Current standards and new concepts in MRI and PET response assessment of antiangiogenic therapies in high-grade glioma patients</title>
    <abstract language="eng">Despite multimodal treatment, the prognosis of high-grade gliomas is grim. As tumor growth is critically dependent on new blood vessel formation, antiangiogenic treatment approaches offer an innovative treatment strategy. Bevacizumab, a humanized monoclonal antibody, has been in the spotlight of antiangiogenic approaches for several years. Currently, MRI including contrast-enhanced T1-weighted and T2/fluid-attenuated inversion recovery (FLAIR) images is routinely used to evaluate antiangiogenic treatment response (Response Assessment in Neuro-Oncology criteria). However, by restoring the blood–brain barrier, bevacizumab may reduce T1 contrast enhancement and T2/FLAIR hyperintensity, thereby obscuring the imaging-based detection of progression. The aim of this review is to highlight the recent role of imaging biomarkers from MR and PET imaging on measurement of disease progression and treatment effectiveness in antiangiogenic therapies. Based on the reviewed studies, multimodal imaging combining standard MRI with new physiological MRI techniques and metabolic PET imaging, in particular amino acid tracers, may have the ability to detect antiangiogenic drug susceptibility or resistance prior to morphological changes. As advances occur in the development of therapies that target specific biochemical or molecular pathways and alter tumor physiology in potentially predictable ways, the validation of physiological and metabolic imaging biomarkers will become increasingly important in the near future.</abstract>
    <parentTitle language="eng">Neuro-Oncology</parentTitle>
    <identifier type="doi">10.1093/neuonc/nou322</identifier>
    <licence>Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG</licence>
    <author>Markus Hutterer</author>
    <author>Elke Hattingen</author>
    <author>Christoph Palm</author>
    <author>Martin Andreas Proescholdt</author>
    <author>Peter Hau</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>High-grade glioma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Antiangiogenic treatment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MRI</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PET</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Multimodal response assessment</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Gliom</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Antiangiogenese</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Biomarker</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="RCBE">Regensburg Center of Biomedical Engineering - RCBE</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>121</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>79</pageFirst>
    <pageLast>88</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>9</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Viewpoints on Medical Image Processing</title>
    <abstract language="eng">Medical image processing provides core innovation for medical imaging. This paper is focused on recent developments from science to applications analyzing the past fifteen years of history of the proceedings of the German annual meeting on medical image processing (BVM). Furthermore, some members of the program committee present their personal points of views: (i) multi-modality for imaging and diagnosis, (ii) analysis of diffusion-weighted imaging, (iii) model-based image analysis, (iv) registration of section images, (v) from images to information in digital endoscopy, and (vi) virtual reality and robotics. Medical imaging and medical image computing is seen as field of rapid development with clear trends to integrated applications in diagnostics, treatment planning and treatment.</abstract>
    <parentTitle language="eng">Current Medical Imaging Reviews</parentTitle>
    <subTitle language="eng">From Science to Application</subTitle>
    <identifier type="doi">10.2174/1573405611309020002</identifier>
    <enrichment key="BegutachtungStatus">peer-reviewed</enrichment>
    <author>Thomas M. Deserno</author>
    <author>Heinz Handels</author>
    <author>Klaus H. Maier-Hein</author>
    <author>Sven Mersmann</author>
    <author>Christoph Palm</author>
    <author>Thomas Tolxdorff</author>
    <author>Gudrun Wagenknecht</author>
    <author>Thomas Wittenberg</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Medical imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Image processing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Image analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Vizualization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Multi-modal imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diffusion-weighted imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Model-based imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Digital endoscopy</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Medizin</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>106</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencevolume</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Bildverarbeitung für die Medizin 2018</title>
    <subTitle language="deu">Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 11. bis 13. März 2018 in Erlangen</subTitle>
    <identifier type="doi">10.1007/978-3-662-56537-7</identifier>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
  <doc>
    <id>100</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferencevolume</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2019-12-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Bildverarbeitung für die Medizin 2019</title>
    <abstract language="deu">In den letzten Jahren hat sich der Workshop "Bildverarbeitung für die Medizin" durch erfolgreiche Veranstaltungen etabliert. Ziel ist auch 2019 wieder die Darstellung aktueller Forschungsergebnisse und die Vertiefung der Gespräche zwischen Wissenschaftlern, Industrie und Anwendern. Die Beiträge dieses Bandes - einige davon in englischer Sprache - umfassen alle Bereiche der medizinischen Bildverarbeitung, insbesondere Bildgebung und -akquisition, Maschinelles Lernen, Bildsegmentierung und Bildanalyse, Visualisierung und Animation, Zeitreihenanalyse, Computerunterstützte Diagnose, Biomechanische Modellierung, Validierung und Qualitätssicherung, Bildverarbeitung in der Telemedizin u.v.m.</abstract>
    <subTitle language="deu">Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 17. bis 19. März 2019 in Lübeck</subTitle>
    <identifier type="isbn">978-3-658-25325-7</identifier>
    <identifier type="issn">1431-472X</identifier>
    <identifier type="doi">10.1007/978-3-658-25326-4</identifier>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Bilderkennung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Computerunterstützte Medizin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Computerunterstützte Diagnose</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Medizininformatik</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
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