<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>1361</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>140</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>doctoralthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation>Universität der Bundeswehr München</contributingCorporation>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2019-01-21</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Development of subject-specific musculoskeletal models for studies of lumbar loading</title>
    <abstract language="eng">Anatomical differences between individuals are often neglected in musculoskeletal models, but they are necessary in case of subject-specific questions regarding the lumbar spine. A modification of models to each subject is complex and the effects on lumbar loading are difficult to assess. The objective of this thesis is to create a validated musculoskeletal model of the human body, which facilitates a subject-specific modification of the geometry of the lumbar spine. Furthermore, important parameters are identified in sensitivity studies and a case study regarding multifidus muscle atrophy after a disc herniation is conducted. Therefore, a generic model is heavily modified and a semi-automatic process is implemented. This procedure remodels the geometry of the lumbar spine to a subject-specific one on basis of segmented medical images. The resulting five models are validated with regard to the lumbar loading at the L4/L5 level. The influence of lumbar ligament stiffness is determined by changing the stiffness values of all lumbar ligaments in eleven steps during a flexion motion. Sensitivities of lumbar loading to an altered geometry of the lumbar spine are identified by varying ten lumbar parameters in simulations with each model in four postures. The case study includes an analysis of the loading of the multifidus muscle and of the lumbar discs throughout various stages of disc herniation. This time each model performs four motions with two different motion rhythms. The results indicate that lumbar motion and loading is dependent on lumbar ligament stiffness. Furthermore, subject-specific modelling of the lumbar spine should include at least the vertebral height, disc height and lumbar lordosis. The results of the case study suggest that an overloading of the multifidus muscle could follow disc herniation. Additionally, a subsequent atrophy of the muscles could expose adjacent levels to an increased loading, but these findings are highly dependent on the individual.</abstract>
    <identifier type="urn">urn:nbn:de:bvb:706-5924</identifier>
    <note>Kooperative Promotion an der Fakultät Maschinenbau der Ostbayerischen Technischen Hochschule Regensburg (OTH.R) im Labor für Biomechanik (LBM) bei Prof. Dr.-Ing. Sebastian Dendorfer und Labor für Faserverbundtechnik (LFT) bei Prof. Dr.-Ing. Ingo Ehrlich</note>
    <enrichment key="opus.source">publish</enrichment>
    <author>Michael Putzer</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Lendenwirbelsäule</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Geometrie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Lendenwirbelsäulenkrankheit</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computertomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Modell</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Hochschulschrift</value>
    </subject>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="institutes" number="TCNeustadt">Technologie-Campus Neustadt an der Donau</collection>
    <collection role="persons" number="ehrlichlft">Ehrlich, Ingo (Prof. Dr.) - Labor Faserverbundtechnik</collection>
    <collection role="persons" number="tcnehno">Technologie-Campus Neustadt a. d. Donau (Prof. Ehrlich+ Prof. Nonn)</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Faserverbundtechnik (LFT)</collection>
    <collection role="othpublikationsherkunft" number="">Dissertation in Kooperation</collection>
  </doc>
  <doc>
    <id>319</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2384</pageFirst>
    <pageLast>2386</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>22</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Controlled central advancement of the midface after Le Fort III osteotomy by a 3-point skeletal anchorage</title>
    <abstract language="eng">A 3-point skeletal anchorage with taping screws for distraction osteogenesis after a Le Fort III osteotomy was applied for the first time in a severely mentally impaired patient where intraoral devices had to be avoided. All 3-force application points included the center of resistance, which allowed an optimal control on the resulting moment. A novel device for skeletal long-term retention into the nasal dorsum prevented a relapse, whereas adjustment of the midface position was observed. Fusioned three-dimensional computed tomography analysis revealed real movements not accessible by a conventional cephalometry.</abstract>
    <parentTitle language="eng">The Journal of craniofacial surgery</parentTitle>
    <identifier type="doi">10.1097/SCS.0b013e318231fc8d</identifier>
    <author>J.C. Roldán</author>
    <author>A. Moralis</author>
    <author>Sebastian Dendorfer</author>
    <author>J. Witte</author>
    <author>C. Reicheneder</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Mund-Kiefer-Gesichts-Chirurgie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Le Fort III</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>distraction</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>vector</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>anchorage</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>three-dimensional computed tomography analysis</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Distraktion</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Knochenbildung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Osteotomie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Dreidimensionale Bildverarbeitung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computertomografie</value>
    </subject>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="persons" number="dendorferlbm">Dendorfer, Sebastian (Prof. Dr.), Zeitschriftenbeiträge - Labor Biomechanik</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Biofluidmechanik</collection>
  </doc>
  <doc>
    <id>141</id>
    <completedYear/>
    <publishedYear>2008</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>59</pageFirst>
    <pageLast>66</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>18</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Whole-body PET/CT imaging</title>
    <abstract language="eng">Aim&#13;
Combined whole-body (WB) PET/CT imaging provides better overall co-registration compared to separate CT and PET. However, in clinical routine local PET-CT mis-registration cannot be avoided. Thus, the reconstructed PET tracer distribution may be biased when using the misaligned CT transmission data for CT-based attenuation correction (CT-AC). We investigate the feasibility of retrospective co-registration techniques to align CT and PET images prior to CT-AC, thus improving potentially the quality of combined PET/CT imaging in clinical routine.&#13;
Methods&#13;
First, using a commercial software registration package CT images were aligned to the uncorrected PET data by rigid and non-rigid registration methods. Co-registration accuracy of both alignment approaches was assessed by reviewing the PET tracer uptake patterns (visual, linked cursor display) following attenuation correction based on the original and co-registered CT. Second, we investigated non-rigid registration based on a prototype ITK implementation of the B-spline algorithm on a similar targeted MR-CT registration task, there showing promising results.&#13;
Results&#13;
Manual rigid, landmark-based co-registration introduced unacceptable misalignment, in particular in peripheral areas of the whole-body images. Manual, non-rigid landmark-based co-registration prior to CT-AC was successful with minor loco-regional distortions. Nevertheless, neither rigid nor non-rigid automatic co-registration based on the Mutual Information image to image metric succeeded in co-registering the CT and noAC-PET images. In contrast to widely available commercial software registration our implementation of an alternative automated, non-rigid B-spline co-registration technique yielded promising results in this setting with MR-CT data.&#13;
Conclusion&#13;
In clinical PET/CT imaging, retrospective registration of CT and uncorrected PET images may improve the quality of the AC-PET images. As of today no validated and clinically viable commercial registration software is in routine use. This has triggered our efforts in pursuing new approaches to a validated, non-rigid co-registration algorithm applicable to whole-body PET/CT imaging of which first results are presented here. This approach appears suitable for applications in retrospective WB-PET/CT alignment.&#13;
&#13;
Ziel&#13;
Kombinierte PET/CT-Bildgebung ermöglicht verbesserte Koregistrierung von PET- und CT-Daten gegenüber separat akquirierten Bildern. Trotzdem entstehen in der klinischen Anwendung lokale Fehlregistrierungen, die zu Fehlern in der rekonstruierten PET- Tracerverteilung führen können, falls die unregistrierten CT-Daten zur Schwächungskorrektur (AC) der Emissionsdaten verwendet werden. Wir untersuchen daher die Anwendung von Bildregistrierungsalgorithmen vor der CT-basierten AC zur Verbesserung der PET-Aufnahmen.&#13;
Methoden&#13;
Mittels einer kommerziellen Registrierungssoftware wurden die CT-Daten eines PET/CT- Tomographen durch landmarken- und intensitätsbasierte rigide (starre) und nicht-rigide Registrierungsverfahren räumlich an die unkorrigierten PET-Emissionsdaten angepasst und zur AC verwendet. Zur Bewertung wurden die Tracerverteilungen in den PET-Bildern (vor AC, CT-AC, CT-AC nach Koregistrierung) visuell und mit Hilfe korrelierter Fadenkreuze verglichen. Zusätzlich untersuchten wir die ITK-Implementierung der bekannten B-spline basierten, nicht-rigiden Registrierungsansätze im Hinblick auf ihre Verwendbarkeit für die multimodale PET/CT-Ganzkörperregistrierung.&#13;
Ergebnisse&#13;
Mittels landmarkenbasierter, nicht-rigider Registrierung konnte die Tracerverteilung in den PET-Daten lokal verbessert werden. Landmarkenbasierte rigide Registrierung führte zu starker Fehlregistrierung in entfernten Körperregionen. Automatische rigide und nicht-rigide Registrierung unter Verwendung der Mutual-Information-Ähnlichkeitsmetrik versagte auf allen verwendeten Datensätzen. Die automatische Registrierung mit B-spline-Funktionen zeigte vielversprechende Resultate in der Anwendung auf einem ähnlich gelagerten CT–MR-Registrierungsproblem.&#13;
Fazit&#13;
Retrospektive, nicht-rigide Registrierung unkorrigierter PET- und CT-Aufnahmen aus kombinierten Aufnahmensystemen vor der AC kann die Qualität von PET-Aufnahmen im klinischen Einsatz verbessern. Trotzdem steht bis heute im klinischen Alltag keine validierte, automatische Registrierungssoftware zur Verfügung. Wir verfolgen dazu Ansätze für validierte, nicht-rigide Bildregistrierung für den klinischen Einsatz und präsentieren erste Ergebnisse.</abstract>
    <parentTitle language="deu">Zeitschrift für Medizinische Physik</parentTitle>
    <subTitle language="eng">Combining software- and hardware-based co-registration</subTitle>
    <identifier type="doi">10.1016/j.zemedi.2007.07.004</identifier>
    <author>Markus Weigert</author>
    <author>Uwe Pietrzyk</author>
    <author>Stefan P. Müller</author>
    <author>Christoph Palm</author>
    <author>Thomas Beyer</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PET/CT</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>combined imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>image co-registration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>attenuation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>correction</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Positronen-Emissions-Tomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Computertomografie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Bildgebendes Verfahren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Registrierung &lt;Bildverarbeitung&gt;</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schwächung</value>
    </subject>
    <collection role="ddc" number="0">Informatik, Informationswissenschaft, allgemeine Werke</collection>
    <collection role="institutes" number="FakIM">Fakultät Informatik und Mathematik</collection>
    <collection role="persons" number="palmremic">Palm, Christoph (Prof. Dr.) - ReMIC</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Regensburg Medical Image Computing (ReMIC)</collection>
  </doc>
</export-example>
