<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>325</id>
    <completedYear/>
    <publishedYear>2007</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>408</pageFirst>
    <pageLast>413</pageLast>
    <pageNumber/>
    <edition/>
    <issue>5</issue>
    <volume>110</volume>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-02-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Conductive bone substitute material with variable antibiotic delivery</title>
    <abstract language="eng">A new bone substitute, consisting of hydroxylapatite and calcium sulphate, was prepared in two formulations and analysed for its mechanical strength and antibiotic elution.The bone substitute PerOssal has osteoconductive and degradable properties. The material has a built-in capillary structure, which results in an immediate fluid uptake. Antibiotics absorbed to the bone substitute resulted in a prolonged release rate. Mechanical strength was investigated by an unconfined compression test up to failure under both wet and dry conditions for both formulations of the bone substitute. Antibiotic release was analysed microbiologically for two antibiotics, vancomycin and gentamicin, over an elution period of 10 days using the agar diffusion method.The drug release analysis resulted in a prolonged release rate of both antibiotics over 10 days. In vitro the amount of gentamicin and vancomycin eluted at day 10. From one pellet still exceeded the minimal inhibitory concentration of most aetiologically important pathogens. Formulation two of the present bone substitute is significantly harder in both wet and dry conditions when compared to formulation one. Both formulations lose strength in the wet condition relative to their performance in the dry condition. However, formulation two is as hard under wet conditions as formulation one is when dry.PerOssal is a suitable new degradable osteoconductive bone substitute that can be loaded with antibiotic solutions, which are released in effective doses over 10 days. The mechanical strength of PerOssal is sufficient to support cancellous bone defects in non-weight-bearing areas or in combination with osteosynthesis.</abstract>
    <parentTitle language="deu">Der Unfallchirurg</parentTitle>
    <identifier type="doi">10.1007/s00113-007-1229-3</identifier>
    <author>Carsten Englert</author>
    <author>Peter Angele</author>
    <author>J. Fierlbeck</author>
    <author>Sebastian Dendorfer</author>
    <author>T. Schubert</author>
    <author>R. Müller</author>
    <author>S. Lienhard</author>
    <author>Johannes Zellner</author>
    <author>Michael Nerlich</author>
    <author>Carsten Neumann</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Knochenersatz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Leitfähgkeit</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Antibiotika</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Biomechanik</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone substitute materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Osteoconductive</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Osteomyelitis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Multiresistant</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biomechanics</value>
    </subject>
    <collection role="ddc" number="617">Chirurgie und verwandte medizinische Fachrichtungen</collection>
    <collection role="institutes" number="FAKMB">Fakultät Maschinenbau</collection>
    <collection role="othpublikationsherkunft" number="">Externe Publikationen</collection>
    <collection role="persons" number="dendorferlbm">Dendorfer, Sebastian (Prof. Dr.), Zeitschriftenbeiträge - Labor Biomechanik</collection>
    <collection role="othforschungsschwerpunkt" number="16314">Lebenswissenschaften und Ethik</collection>
    <collection role="institutes" number="">Labor Biomechanik (LBM)</collection>
  </doc>
</export-example>
