5803 2020 eng 922 928 8 66 article Lippincott Williams & Wilkins 0 2023-02-13 -- -- Coagulative disorders, especially clotting during extracorporeal membrane oxygenation, are frequent complications. Direct visualization and analysis of deposits in membrane oxygenators using computed tomography (CT) may provide an insight into the underlying mechanisms causing thrombotic events. However, the already established multidetector CT1 (MDCT) method shows major limitations. Here, we demonstrate the feasibility of applying industrial micro-CT (μCT) to circumvent these restrictions. Three clinically used membrane oxygenators were investigated applying both MDCT and μCT. The scans were analyzed in terms of clot volume and local clot distribution. As validation, the clot volume was also determined from the fluid volume, which could be filled into the respective used oxygenator compared to a new device. In addition, cross-sectional CT images were compared with crosscut oxygenators. Based on the μCT findings, a morphological measure (sphericity) for assessing clot structures in membrane oxygenators is introduced. Furthermore, by comparing MDCT and μCT results, an augmentation of the MDCT method is proposed, which allows for improved clot volume determination in a clinical setting. ASAIO Journal / American Society for Artificial Internal Organs 10.1097/MAT.0000000000001089 1538-943X publish peer-reviewed Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG Clemens Birkenmaier Christian Dornia Karla Lehle Thomas Müller Michael Gruber Alois Philipp Lars Krenkel Fakultät Maschinenbau Research Center of Biomedical Engineering - RCBE Research Center of Health Sciences and Technology - RCHST Research Center for Artificial Intelligence - RCAI Labor Biofluidmechanik Krenkel, Lars (Prof. Dr.), Publikationen - Labor Biofluidmechanik Gesundheit und Soziales