@article{SuezeroğluMelchiors, author = {S{\"u}zeroğlu-Melchiors, Sevim}, title = {The supply side of IP management: Understanding firms' choices regarding IP intermediaries}, series = {World Patent Information}, volume = {50}, journal = {World Patent Information}, publisher = {Elsevier}, issn = {0172-2190}, doi = {10.1016/j.wpi.2017.08.002}, pages = {55 -- 63}, abstract = {Studies focusing on the supply side of IP management, particularly on the outsourcing of patent related work, are relatively rare. This paper aims to contribute to the IP literature in two ways. First, a definition of the IP service provider is proposed. Second, I consider three main hypotheses that determine a firm's preference for outsourced IP work. Using data on the outsourcing of patent renewal payments, I found evidence that the choice of IP supplier is affected by: (1) the firm's own IP maintenance capabilities, (2) the firm's IP knowledge utilization, and (3) the IP complexity.}, language = {en} } @incollection{SuezeroğluMelchiors, author = {S{\"u}zeroğlu-Melchiors, Sevim}, title = {Blind As a Mole? How Patent Data can Help Start-ups to Compete}, series = {Intellectual Property Management for Start-ups: Enhancing Value and Leveraging the Potential}, booktitle = {Intellectual Property Management for Start-ups: Enhancing Value and Leveraging the Potential}, editor = {Bader, Martin A. and S{\"u}zeroğlu-Melchiors, Sevim}, publisher = {Springer}, isbn = {978-3-031-16993-9}, doi = {10.1007/978-3-031-16993-9_24}, pages = {463 -- 490}, abstract = {This chapter provides an overview of common types of patent search and analyses such as novelty search, freedom-to-operate search (FTO), patent landscape, patent-based market and competitor analysis, technology scouting, and infringement assessment. Two special sections highlight the step-by-step approach for conducting a patent technology landscape and a technology scouting. The chapter concludes with practical tips for applying patent search results in a strategic and operative view.}, language = {en} } @incollection{SuezeroğluMelchiorsBader, author = {S{\"u}zeroğlu-Melchiors, Sevim and Bader, Martin A.}, title = {How to Increase the Success of Innovative Start-Ups with Intellectual Property: An Introductory Overview}, series = {Intellectual Property Management for Start-ups}, booktitle = {Intellectual Property Management for Start-ups}, publisher = {Springer}, doi = {10.1007/978-3-031-16993-9_1}, pages = {1 -- 25}, abstract = {This introductory chapter builds on the topic of intellectual property management and its relevance to the success of innovative start-ups. Existing literature, trends, and developments in the start-up market are presented. The edited volume features six parts corresponding to categorical views of the main stakeholder groups within the start-up ecosystem: the start-up's view, the investor's view, the corporation's view, the university's view, the global intellectual property office's view, and the advisor's view. All chapters are introduced in a condensed form and an overview is given of the topics covered, case studies, regions, and industry sectors, as well as learnings and takeaways from all contributions in this compact compilation.}, language = {en} } @phdthesis{Suess, author = {S{\"u}ß, Franz}, title = {The influence of mental stress on the musculoskeletal human back during static posture and trunk motion}, doi = {10.5283/epub.46055}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:355-epub-460554}, pages = {106}, abstract = {The investigation of the influence of mental stress on muscle recruitment of the back and its effect on the intervertebral discs was the main focus of this work. Furthermore, the goal was to develop algorithms to use mental stress as an input parameter in musculoskeletal simulation models. In the first step, a study was designed to investigate the influence of emotional and cognitive stress without kinetic influencing factors during sitting. At the muscular level, emotional stress was found to affect the upper back, while cognitive stress elicited higher muscle activity in the upper and lower back. Using a newly developed algorithm to apply back muscle recruitment changes to static inverse kinematic simulation models, load increases at the discs of up to 189 N on average and up to 907 N at peak were found.Based on the results of the first study, a second dynamic study was designed and conducted. In this case, the focus was on the cognitive stressor and the lower back. Using a dynamometer, subject-specific loads were applied during extension and flexion of the upper back. In contrast to the first study, in the upper back, only the right m. trapezius pars descendens showed a load-induced difference in muscle activity, but the lower back did. To investigate the effects of muscle tone increase in detail, the algorithm developed in the first study was extended to the dynamic case. The use of simulation models allowed the inference of the effects of the purely stress-induced tone increase. For this purpose, the kinetic and muscular effects were isolated and simulated. The study revealed a stress increase of 47\% of the body weight in the L4L5 disc. The final numerical study focused on the general application of muscle activities to inverse kinematic simulation models. This was based on the novel simulation algorithm used in study two and the measured muscle activities. The simulation of the measured muscle activities formed the link between reality and simulation. To simulate the activities, neural networks and gradient boosting regression algorithms were investigated. The latter were found to be better suited to represent the data. However, the data is too small for a detailed statement, especially for loads below 100\%. The results of this work can help to better assess the musculoskeletal effects of psychological stress on the musculoskeletal system and, if necessary, to develop ergonomic prevention strategies. By recognizing stress-related kinematic difference, as well as subsequent prompting of trunk movement, could help prevent long-term effects. When examining any situation, the combination of machine learning and musculoskeletal simulation tools can help examine and minimize the effects of psychological stress.}, language = {en} } @inproceedings{SuessKubowitschRasmussenetal., author = {S{\"u}ß, Franz and Kubowitsch, Simone and Rasmussen, John and Verkerke, Gijsbertus Jacob and Dendorfer, Sebastian}, title = {The influence of cognitive stress on muscle activation and spinal disc load}, series = {European Society of Biomechanics meeting 2019, Vienna, Austria}, booktitle = {European Society of Biomechanics meeting 2019, Vienna, Austria}, language = {en} } @inproceedings{SuessKubowitschVerkerkeetal., author = {S{\"u}ß, Franz and Kubowitsch, Simone and Verkerke, Gijsbertus Jacob and Dendorfer, Sebastian}, title = {Investigation of cognitive stress induced changes in spinal disc forces due to altered kinematics and muscle activity}, series = {World Congress Biomechanics, Dublin, 2018}, booktitle = {World Congress Biomechanics, Dublin, 2018}, language = {en} } @inproceedings{SuessKubowitschVerkerkeetal., author = {S{\"u}ß, Franz and Kubowitsch, Simone and Verkerke, Gijsbertus Jacob and Dendorfer, Sebastian}, title = {The influence of mental stress on spinal disc loading and muscle activity}, series = {23th Congress of the European Society of Biomechanics, Sevilla, Spain, 2017}, booktitle = {23th Congress of the European Society of Biomechanics, Sevilla, Spain, 2017}, language = {en} } @inproceedings{SuessKubowitschVerkerkeetal., author = {S{\"u}ß, Franz and Kubowitsch, Simone and Verkerke, Gijsbertus Jacob and Dendorfer, Sebastian}, title = {The influence of stress on spinal loading}, series = {ESEM webconference, Dez. 2017}, booktitle = {ESEM webconference, Dez. 2017}, language = {en} } @inproceedings{SuessPutzerDendorfer, author = {S{\"u}ß, Franz and Putzer, Michael and Dendorfer, Sebastian}, title = {Numerische und experimentelle Untersuchungen an der Wirbels{\"a}ule}, series = {Forschungssymposium Bad Abbach, Germany, 2015}, booktitle = {Forschungssymposium Bad Abbach, Germany, 2015}, language = {de} } @article{TauwaldErzingerQuadrioetal., author = {Tauwald, Sandra Melina and Erzinger, Florian and Quadrio, Maurizio and R{\"u}tten, Markus and Stemmer, Christian and Krenkel, Lars}, title = {Tomo-PIV in a patient-specific model of human nasal cavities: a methodological approach}, series = {Measurement Science and Technology}, volume = {35}, journal = {Measurement Science and Technology}, number = {5}, publisher = {IOP Publishing}, doi = {10.1088/1361-6501/ad282c}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-70393}, abstract = {The human nose serves as the primary gateway for air entering the respiratory system and plays a vital role in breathing. Nasal breathing difficulties are a significant health concern, leading to substantial healthcare costs for patients. Understanding nasal airflow dynamics is crucial for comprehending respiratory mechanisms. This article presents a detailed study using tomo-Particle Image Velocimetry (PIV) to investigate nasal airflow dynamics while addressing its accuracy. Embedded in the OpenNose project, the work described aims to provide a validation basis for different numerical approaches to upper airway flow. The study includes the manufacturing of a transparent silicone model based on a clinical CT scan, refractive index matching to minimize optical distortions, and precise flow rate adjustments based on physiological breathing cycles. This method allows for spatial high-resolution investigations in different regions of interest within the nasopharynx during various phases of the breathing cycle. The results demonstrate the accuracy of the investigations, enabling detailed analysis of flow structures and gradients. This spatial high-resolution tomo-PIV approach provides valuable insights into the complex flow phenomena occurring during the physiological breathing cycle in the nasopharynx. The study's findings contribute to advancements in non-free-of-sight experimental flow investigation of complex cavities under nearly realistic conditions. Furthermore, reliable and accurate experimental data is crucial for properly validating numerical approaches that compute this patient-specific flow for clinical purposes.}, language = {en} } @misc{TauwaldKrenkel, author = {Tauwald, Sandra Melina and Krenkel, Lars}, title = {Elementary experimental setup for flow visualization in upper human respiratory tract}, series = {25th Congress of the European Society of Biomechanics, July 7-10, 2019, Vienna, Austria}, journal = {25th Congress of the European Society of Biomechanics, July 7-10, 2019, Vienna, Austria}, language = {en} } @article{TauwaldMichelBrandtetal., author = {Tauwald, Sandra Melina and Michel, Johanna and Brandt, Marie and Vielsmeier, Veronika and Stemmer, Christian and Krenkel, Lars}, title = {Experimental studies and mathematical modeling of the viscoelastic rheology of tracheobronchial mucus from respiratory healthy patients}, series = {Multidisciplinary Respiratory Medicine}, volume = {18}, journal = {Multidisciplinary Respiratory Medicine}, number = {1}, publisher = {PAGEPress}, address = {Pavia, Italy}, issn = {2049-6958}, doi = {10.4081/mrm.2023.923}, pages = {12}, abstract = {BACKGROUND: Tracheobronchial mucus plays a crucial role in pulmonary function by providing protection against inhaled pathogens. Due to its composition of water, mucins, and other biomolecules, it has a complex viscoelastic rheological behavior. This interplay of both viscous and elastic properties has not been fully described yet. In this study, we characterize the rheology of human mucus using oscillatory and transient tests. Based on the transient tests, we describe the material behavior of mucus under stress and strain loading by mathematical models. METHODS: Mucus samples were collected from clinically used endotracheal tubes. For rheological characterization, oscillatory amplitude-sweep and frequency-sweep tests, and transient creep-recovery and stress-relaxation tests were performed. The results of the transient test were approximated using the Burgers model, the Weibull distribution, and the six-element Maxwell model. The three-dimensional microstructure of the tracheobronchial mucus was visualized using scanning electron microscope imaging. RESULTS: Amplitude-sweep tests showed storage moduli ranging from 0.1 Pa to 10000 Pa and a median critical strain of 4 \%. In frequency-sweep tests, storage and loss moduli increased with frequency, with the median of the storage modulus ranging from 10 Pa to 30 Pa, and the median of the loss modulus from 5 Pa to 14 Pa. The Burgers model approximates the viscoelastic behavior of tracheobronchial mucus during a constant load of stress appropriately (R2 of 0.99), and the Weibull distribution is suitable to predict the recovery of the sample after the removal of this stress (R2 of 0.99). The approximation of the stress-relaxation test data by a six-element Maxwell model shows a larger fit error (R2 of 0.91). CONCLUSIONS: This study provides a detailed description of all process steps of characterizing the rheology of tracheobronchial mucus, including sample collection, microstructure visualization, and rheological investigation. Based on this characterization, we provide mathematical models of the rheological behavior of tracheobronchial mucus. These can now be used to simulate mucus flow in the respiratory system through numerical approaches.}, language = {en} } @misc{TauwaldQuadrioRuettenetal., author = {Tauwald, Sandra Melina and Quadrio, Maurizio and R{\"u}tten, Markus and Stemmer, Christian and Krenkel, Lars}, title = {High Spatial Resolution Tomo-PIV of the Nasopharynx Focussing on the Physiological Breathing Cycle}, series = {23. DGLR Fach-Symposium Str{\"o}mungen mit Abl{\"o}sung, 09./10. November 2022, Berlin, Deutschland}, journal = {23. DGLR Fach-Symposium Str{\"o}mungen mit Abl{\"o}sung, 09./10. November 2022, Berlin, Deutschland}, address = {G{\"o}ttingen}, organization = {Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt e.V. / Arbeitsgemeinschaft Str{\"o}mungen mit Abl{\"o}sung, AG STAB}, abstract = {Investigations of complex patient-specific flow in the nasopharynx requires high resolution numerical calculations validated by reliable experiments. When building the validation base and the benchmark of computational fluid dynamics, an experimental setup of the nasal airways was developed. The applied optical measurement technique of tomo-PIV supplies information on the governing flow field in three dimensions. This paper presents tomo-PIV measurements of the highly complex patient-specific geometry of the human trachea. A computertomographic scan of a person's head builds the basis of the experimental silicone model of the nasal airways. An optimised approach for precise refractive index matching avoids optical distortions even in highly complex non-free-of-sight 3D geometries. A linear-motor-driven pump generates breathing scenarios, based on measured breathing cycles. Adjusting of the CCD cameras' double-frame-rate PIV-Δt enables the detailed analysis of flow structures during different cycle phases. Merging regions of interest enables high spatial resolution acquisition of the flow field.}, language = {en} } @inproceedings{TauwaldQuadrioRuettenetal., author = {Tauwald, Sandra Melina and Quadrio, Maurizio and R{\"u}tten, Markus and Stemmer, Christian and Krenkel, Lars}, title = {High Spatial Resolution Tomo-PIV of the Trachea Focussing on the Physiological Breathing Cycle}, series = {New Results in Numerical and Experimental Fluid Mechanics XIV - Contributions to the 23nd STAB/DGLR Symposium}, booktitle = {New Results in Numerical and Experimental Fluid Mechanics XIV - Contributions to the 23nd STAB/DGLR Symposium}, publisher = {Springer}, abstract = {Investigations of complex patient-specific flow in the nasopharynx requires high resolution numerical calculations validated by reliable experiments. When building the validation base and the benchmark of computational fluid dynamics, an experimental setup of the nasal airways was developed. The applied optical measurement technique of tomo-PIV supplies information on the governing flow field in three dimensions. This paper presents tomo-PIV measurements of the highly complex patient-specific geometry of the human trachea. A computertomographic scan of a person's head builds the basis of the experimental silicone model of the nasal airways. An optimised approach for precise refractive index matching avoids optical distortions even in highly complex non-free-of-sight 3D geometries. A linear-motor-driven pump generates breathing scenarios, based on measured breathing cycles. Adjusting of the CCD cameras' double-frame-rate PIV-Δt enables the detailed analysis of flow structures during different cycle phases. Merging regions of interest enables high spatial resolution acquisition of the flow field.}, language = {en} } @techreport{TenhagenTissenFimmetal., author = {Tenhagen, Anne and Tißen, Damaris and Fimm, Bruno and Heim, Stefan and Lauer, Norina}, title = {Normwerterhebung und Testg{\"u}tekriterien des Screenings f{\"u}r Auditive Verarbeitungsst{\"o}rungen nach Lauer bei siebenj{\"a}hrigen Kindern}, doi = {10.35096/othr/pub-1462}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-14629}, pages = {15}, abstract = {Im Rahmen der Diagnostik einer Auditiven Verarbeitungs- und Wahrnehmungsst{\"o}rung (AVWS) konzipierte Lauer (2014) ein im deutschsprachigen Raum verbreitetes Screening, welches erste Einsch{\"a}tzungen auditiver Teilleistungen bei Kindern zul{\"a}sst und bei Auff{\"a}lligkeiten eine weiterf{\"u}hrende multiprofessionelle Diagnostik indiziert. F{\"u}r das Screening wurden in zwei Masterarbeiten (Diesburg, 2017; Tenhagen, 2018) erste Normwerte generiert, die auf den Rohwerten von 200 siebenj{\"a}hrigen Kindern basieren. Sowohl die Einfl{\"u}sse von Mehrsprachigkeit, Geschlecht und Schulklasse als auch die Reliabilit{\"a}t und Validit{\"a}t des Verfahrens wurden initial {\"u}berpr{\"u}ft. Die erstellten Normwerttabellen bieten den Durchf{\"u}hren-den einen Vergleich der Testleistungen zu Gleichaltrigen und damit eine sinnvolle Interpretation und h{\"o}here Aussagekraft des Screenings. Die Normierung weiterer Altersgruppen wird f{\"u}r die Zukunft empfohlen.}, subject = {Wahrnehmungsst{\"o}rung}, language = {de} } @misc{ThalerHeese, author = {Thaler, Philip and Heese, Carl}, title = {Rezension vom 17.03.2021 zu. Heinz Becker. Die große Welt und die kleine Paula. Eine Geschichte der Behinderung. Beltz Verlag (Weinheim, Basel) 2020. ISBN 978-3-7799-6274-8}, series = {socialnet Rezensionen}, journal = {socialnet Rezensionen}, language = {de} } @misc{ThalerHeese, author = {Thaler, Philipp and Heese, Carl}, title = {Rezension vom 17.04.2020 zu: Harlich H. Stavemann, Wiebke Bergmann: Auf ins Leben! Wie Kinder lernen, selbstsicher, motiviert und zuversichtlich zu sein. dgvt-Verlag (T{\"u}bingen) 2019. ISBN 978-3-87159-230-0}, series = {socialnet Rezensionen}, journal = {socialnet Rezensionen}, issn = {2190-9245}, language = {de} } @misc{ThalerHeese, author = {Thaler, Philipp and Heese, Carl}, title = {Rezension vom 01.07.2019 zu: Effer-Uhe, Daniel; Mohnert, Alica: Psychologie f{\"u}r Juristen; Nomos Verlagsgesellschaft (Baden-Baden) 2019. ISBN 978-3-8487-4629-3}, series = {Socialnet Rezensionen}, journal = {Socialnet Rezensionen}, language = {de} } @article{ThalerHeese, author = {Thaler, Tilman and Heese, Carl}, title = {Schul- und Organisationsentwicklung. Zur Kooperation der Schule mit der Jugendhilfe}, series = {Jugendhilfe}, volume = {58}, journal = {Jugendhilfe}, number = {3}, pages = {230 -- 235}, abstract = {Die Organisationsentwicklung (OE) ist der Innovationsmotor der Schule und hat sich in den vergangenen zwei Jahrzehnten dort fest etablieren k{\"o}nnen. Sie ist auch das geeignete Instrument, um die Kooperation zwischen Schule und Jugendhilfe voranzubringen. Leider wird sie als solches nur selten eingesetzt, stattdessen ist die Schulentwicklung (SE) h{\"a}ufig mit internen schulischen Themen befasst. Im Folgenden wird die Etablierung der OE in der Schule nachgezeichnet und es wird dabei gezeigt, wie der thematische Fokus nur verz{\"o}gert auch die externen Kooperationen in einem vollen Umfang einbezogen hat. Die Entwicklung f{\"u}hrte aber dorthin, dass mittlerweile ein ad{\"a}quates theoretisches Verst{\"a}ndnis von kooperativen Beziehungen entstanden ist und dass auch flankierende rechtliche Rahmenbedingungen geschaffen wurden, so dass die Praxis der SE den Spielraum f{\"u}r eine Verbindung von Schulp{\"a}dagogik und Sozialp{\"a}dagogik nur zu nutzen br{\"a}uchte. Wie man dabei vorgehen k{\"o}nnte, wird abschließend skizziert.}, language = {de} } @unpublished{ThausHofrichterLubnowetal., author = {Thaus, Christopher and Hofrichter, Elena and Lubnow, Matthias and Krenkel, Lars and Lehle, Karla}, title = {Hemocompatibility of Membrane Lung Components from Extracorporeal Membrane Oxygenation with Different Antithrombogenic Coatings}, doi = {10.20944/preprints202412.0615.v1}, pages = {1 -- 11}, abstract = {Thrombus formation within extracorporeal membrane oxygenation (ECMO) devices remained a critical complication. One reason seems to be the contact of blood with large artificial surfaces within the membrane lung (ML). The aim was to test the hemocompatibility of different na{\"i}ve ECMO materials. Blood and platelets from five healthy volunteers were incubated with gas exchange (GF) and heat exchange fibers (HE) from four different commercial available new MLs representing different antithrombogenic coatings. Adherent platelets were stained with rhodamine-phalloidin. Surface coverage was quantified with ImageJ. Non-adherent platelets were stained with antibodies (CD62P, PAC-1, CD61) and fibrinogen to detect platelet activation with flow cytometry. Hemolysis of red blood cells after material contact was detected. All ECMO-materials were non-hemolytic and did not induce platelet activation. However, platetelet adhesion (median (IQR)) was significantly elevated on uncoated GFs made of polymethylpentene (GF-PMP; 12 (7-19)\%) and on GFs from the Hilite-MLs (GF-Hilite; 13 ((8-19)\%) compared to the other materials. In vitro testing of platelet adhesion disclosed significant differences of ECMO-materials with different antithrombogenic surface coatings. Instead, circulating platelets remained non-activated. ECMO-materials and its coatings were non-hemolytic. Finally, this study confirmed the good hemocompatibility of GFs and HEs from commerciall available MLs.}, language = {en} }