@article{MennCorstenLaueretal., author = {Menn, Lara and Corsten, Sabine and Lauer, Norina and Wallace, Sarah J.}, title = {The effectiveness of biographical approaches in long-term care: a systematic review}, series = {Gerontologist}, volume = {60}, journal = {Gerontologist}, number = {4}, doi = {10.1093/geront/gnz074}, pages = {309 -- 328}, abstract = {Background and Objectives Older adults in long-term residential aged care experience loneliness and reduced quality of life (QoL). Biographical approaches use the recall of the past events to increase self-efficacy, promote acceptance, and improve QoL. The aim of the systematic review was to examine the effectiveness of biographical approaches in improving the QoL of older adults in long-term residential aged care. Research Design and Methods This systematic review was conducted in accordance with PRISMA guidelines, using databases Medline, CINAHL, and the Cochrane Library. A 2-phase search strategy was used to identify research literature relating to the use of biographical interventions. Narrative analysis was used to synthesize results. Results Twenty-one studies met inclusion criteria for this review, comprising both group and individual interventions. The findings were inconsistent. Subjective elements of QoL of older adults improved in a narrow majority of the studies. Of a total of 21 outcomes investigated in group interventions, 11 resulted in significant improvements in QoL. The 16 outcomes of the individual interventions resulted in 10 significant improvements. The most significant influence was observed in life satisfaction. Group reminiscence also had a particularly strong influence on self-esteem. Discussion and Implications Although benefits were observed, it remains unclear why some interventions led to improvements in subjective elements of QoL and others did not. Exploration of the participant perspective through qualitative data collection and more detailed description of interventions in future studies could lead to a better understanding of the treatment components that are related to improved outcomes for older adults.}, language = {en} } @article{LauerCorsten, author = {Lauer, Norina and Corsten, Sabine}, title = {Quality of life in leaders and members of peer-led aphasia support groups - preliminary results of a systematic approach}, series = {Aphasiology}, volume = {32}, journal = {Aphasiology}, number = {sup1: International Aphasia Rehabilitation Conference (IARC)}, publisher = {Taylor\&Francis}, doi = {10.1080/02687038.2018.1485839}, pages = {119 -- 121}, language = {en} } @misc{MelznerPfeiferSuessetal., author = {Melzner, Maximilian and Pfeifer, Christian and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Muskuloskeletal analysis of elbow stability for common injury patterns}, series = {27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal}, journal = {27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal}, pages = {654}, language = {en} } @misc{LauerCorsten, author = {Lauer, Norina and Corsten, Sabine}, title = {Supporting peer-led aphasia support groups with a specific training program: a first proof of concept}, series = {International Aphasia Rehabilitation Conference, London}, journal = {International Aphasia Rehabilitation Conference, London}, language = {en} } @techreport{PfingstenBorgetto, author = {Pfingsten, Andrea and Borgetto, Bernhard}, title = {Efficacy and effectiveness of physical therapy in adults with rheumatoid arthritis}, edition = {Version: 14.05.2020}, abstract = {What is the efficacy of physical therapy in the treatment of rheumatoid arthritis? What is the effectiveness of physical therapy in the treatment of rheumatoid arthritis? Which differences do exist between efficacy and effectiveness of rheumatoid arthritis?}, language = {en} } @misc{KoeglerIsmailRusavyetal., author = {K{\"o}gler, Michael and Ismail, Khaled M. and Rusavy, Zdenek and Kalis, Vladimir and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Influence of bed height and stance on accoucheurs lower back and glenohumeral load during simulated childbirth}, series = {31st meeting of Czech Urogynaecological Society, Prague, 2022}, journal = {31st meeting of Czech Urogynaecological Society, Prague, 2022}, language = {en} } @article{EigenbergerFelthausSchratzenstalleretal., author = {Eigenberger, Andreas and Felthaus, Oliver and Schratzenstaller, Thomas and Haerteis, Silke and Utpatel, Kirsten and Prantl, Lukas}, title = {The Effects of Shear Force-Based Processing of Lipoaspirates on White Adipose Tissue and the Differentiation Potential of Adipose Derived Stem Cells}, series = {cells}, volume = {11}, journal = {cells}, number = {16}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/cells11162543}, pages = {13}, abstract = {Autologous lipotransfer is a promising method for tissue regeneration, because white adipose tissue contains a heterogeneous cell population, including mesenchymal stem cells, endothelial cells, immune cells, and adipocytes. In order to improve the outcome, adipose tissue can be processed before application. In this study, we investigated changes caused by mechanical processing. Lipoaspirates were processed using sedimentation, first-time centrifugation, shear-force homogenization, and second-time centrifugation. The average adipocyte size, stromal vascular cell count, and adipocyte depot size were examined histologically at every processing step. In addition, the adipose derived stem cells (ADSCs) were isolated and differentiated osteogenically and adipogenically. While homogenization causes a disruption of adipocyte depots, the shape of the remaining adipocytes is not changed. On average, these adipocytes are smaller than the depot adipocytes, they are surrounded by the ECM, and therefore mechanically more stable. The volume loss of adipocyte depots leads to a significant enrichment of stromal vascular cells such as ADSCs. However, the mechanical processing does not change the potential of the ADSCs to differentiate adipogenically or steogenically. It thus appears that mechanically processed lipoaspirates are promising for the reparation of even mechanically stressed tissue as that found in nasolabial folds. The changes resulting from the processing correspond more to a filtration of mechanically less stable components than to a manipulation of the tissue.}, language = {en} } @article{GiordanoLauerLeuschetal., author = {Giordano, Katharina and Lauer, Norina and Leusch, Vera and Kreiter, Daniel and Corsten, Sabine}, title = {Tablet-based biography work in long-term care homes to support quality of life and prevent depression}, series = {Educational Gerontology}, journal = {Educational Gerontology}, publisher = {Taylor and Francis}, address = {London}, issn = {1521-0472}, doi = {10.1080/03601277.2023.2225362}, pages = {1 -- 14}, abstract = {Older adults in long-term care homes are at high risk of experiencing reduced quality of life (QoL) and depression. Technology-assisted biography work can have a positive impact on QoL and mood, but there is little research on its use with this target group. The purpose of this paper is to examine the effect of tablet-based biography work conducted by volunteers on the QoL of residents and volunteers. A pretest-posttest control group design with an intervention period of 3 months and a 3-month follow-up was used. Results show a significant increase in participation for volunteers and residents after the intervention, which is stable for residents until follow-up. Volunteers also show significant improvement in mental QoL immediately after the intervention. There were no significant effects for life satisfaction, self-esteem, or depression. No significant changes were found for the control group. Digitally conducted tablet-based biography work appears to have effects on QoL-associated outcomes.}, subject = {Biografieforschung}, language = {en} } @misc{AuerReinkerSuessetal., author = {Auer, Simon and Reinker, Lukas and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Comparing calculated and measured muscle activity of thigh muscles in dynamic motion.}, series = {27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal}, journal = {27th Congress of the European Society of Biomechanics, 26 - 29 June 2022, Porto, Portugal}, pages = {640}, language = {en} } @misc{PfingstenBorgettoTomlinetal., author = {Pfingsten, Andrea and Borgetto, Bernhard and Tomlin, George S. and Max, Susanne and Trickes, Claudia}, title = {The Research Pyramid. Establishing the value of evidence from multiple research approaches in a systematic review}, series = {World Physical Therapy Congress der World Confederation for Physical Therapy (WCPT), Amsterdam, 2011}, journal = {World Physical Therapy Congress der World Confederation for Physical Therapy (WCPT), Amsterdam, 2011}, abstract = {Goal: The Research Pyramid is a model that values and integrates external evidence from multiple research approaches: experimental and observational as well as quantitative and qualitative. It provides a basis to collect and synthesize research findings for answering questions that emerge in therapy practice and for subsequent decision making, based on research evidence.}, language = {en} } @misc{AltenbuchnerHaugMohretal., author = {Altenbuchner, Amelie and Haug, Sonja and Mohr, Christa and Scorna, Ulrike and Weber, Karsten}, title = {The impact of nurse advisors and online advice services on treatment adherence in multiple sclerosis (MS)}, series = {7th Joint European Committee for Treatment and Research in Multiple Sclerosis - Americas Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS-ACTRIMS), 25.-27.10.2017, Paris}, journal = {7th Joint European Committee for Treatment and Research in Multiple Sclerosis - Americas Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS-ACTRIMS), 25.-27.10.2017, Paris}, language = {en} } @article{MoragKieningerEissnertetal., author = {Morag, Sarah and Kieninger, Martin and Eissnert, Christoph and Auer, Simon and Dendorfer, Sebastian and Popp, Daniel and Hoffmann, Johannes and Kieninger, B{\"a}rbel}, title = {Comparison of different techniques for prehospital cervical spine immobilization: Biomechanical measurements with a wireless motion capture system}, series = {PLOS ONE}, volume = {18}, journal = {PLOS ONE}, number = {11}, publisher = {PLOS}, address = {San Francisco, California}, doi = {10.1371/journal.pone.0292300}, pages = {1 -- 14}, language = {en} } @article{MelznerSuessDendorfer, author = {Melzner, Maximilian and Suess, Franz and Dendorfer, Sebastian}, title = {The impact of anatomical uncertainties on the predictions of a musculoskeletal hand model - a sensitivity study}, series = {Computer Methods in Biomechanics and Biomedical Engineering}, volume = {25}, journal = {Computer Methods in Biomechanics and Biomedical Engineering}, number = {2}, publisher = {Taylor \& Francis}, issn = {1476-8259}, doi = {10.1080/10255842.2021.1940974}, pages = {156 -- 164}, abstract = {Outputs of musculoskeletal models should be considered probabilistic rather than deterministic as they are affected by inaccuracies and estimations associated with the development of the model. One of these uncertainties being critical for modeling arises from the determination of the muscles' line of action and the physiological cross-sectional area. Therefore, the aim of this study was to evaluate the outcome sensitivity of model predictions from a musculoskeletal hand model in comparison to the uncertainty of these input parameters. For this purpose, the kinematics and muscle activities of different hand movements (abduction of the fingers, abduction of the thumb, and flexion of the thumb) were recorded. One thousand simulations were calculated for each movement using the Latin hypercube sampling method with a corresponding variation of the muscle origin/insertion points and the cross-sectional area. Comparing the standard hand to simulations incorporating uncertainties of input parameters shows no major deviations in on- and off-set time point of muscle activities. About 60\% of simulations are located within a ± 30\% interval around the standard model concerning joint reaction forces. The comparison with the variation of the input data leads to the conclusion that the standard hand model is able to provide not over-scattered outcomes and, therefore, can be considered relatively stable. These results are of practical importance to the personalization of a musculoskeletal model with subject-specific bone geometries and hence changed muscle line of action.}, subject = {Biomechanik}, language = {en} } @article{MelznerEngelhardtSimonetal., author = {Melzner, Maximilian and Engelhardt, Lucas and Simon, Ulrich and Dendorfer, Sebastian}, title = {Electromyography-Based Validation of a Musculoskeletal Hand Model}, series = {Journal of Biomechanical Engineering}, volume = {144}, journal = {Journal of Biomechanical Engineering}, number = {2}, publisher = {American Society of Mechanical Engineers, ASME}, doi = {10.1115/1.4052115}, pages = {8}, abstract = {Regarding the prevention of injuries and rehabilitation of the human hand, musculoskeletal simulations using an inverse dynamics approach allow for insights of the muscle recruitment and thus acting forces on the hand. Currently, several hand models from various research groups are in use, which are mainly validated by the comparison of numerical and anatomical moment arms. In contrast to this validation and model-building technique by cadaver studies, the aim of this study is to further validate a recently published hand model [1] by analyzing numerically calculated muscle activities in comparison to experimentally measured electromyographical signals of the muscles. Therefore, the electromyographical signals of 10 hand muscles of five test subjects performing seven different hand movements were measured. The kinematics of these tasks were used as input for the hand model, and the numerical muscle activities were computed. To analyze the relationship between simulated and measured activities, the time difference of the muscle on- and off-set points was calculated, which resulted in a mean on- and off-set time difference of 0.58 s between the experimental data and the model. The largest differences were detected for movements that mainly addressed the wrist. One major issue comparing simulated and measured muscle activities of the hand is cross-talk. Nevertheless, the results show that the hand model fits the experiment quite accurately despite some limitations and is a further step toward patient-specific modeling of the upper extremity.}, subject = {Elektromyographie}, language = {en} } @article{FoerstlSuessEnglertetal., author = {F{\"o}rstl, Nikolas and S{\"u}ß, Franz and Englert, Carsten and Dendorfer, Sebastian}, title = {Design of a reverse shoulder implant to measure shoulder stiffness during implant component positioning}, series = {Medical Engineering \& Physics}, volume = {121}, journal = {Medical Engineering \& Physics}, edition = {Journal Pre-proof}, publisher = {Elsevier}, doi = {10.1016/j.medengphy.2023.104059}, pages = {22}, abstract = {To avoid dislocation of the shoulder joint after reverse total shoulder arthroplasty, it is important to achieve sufficient shoulder stability when placing the implant components during surgery. One parameter for assessing shoulder stability can be shoulder stiffness. The aim of this research was to develop a temporary reverse shoulder implant prototype that would allow intraoperative measurement of shoulder stiffness while varying the position of the implant components. Joint angle and torque measurement techniques were developed to determine shoulder stiffness. Hall sensors were used to measure the joint angles by converting the magnetic flux densities into angles. The accuracy of the joint angle measurements was tested using a test bench. Torques were determined by using thin-film pressure sensors. Various mechanical mechanisms for variable positioning of the implant components were integrated into the prototype. The results of the joint angle measurements showed measurement errors of less than 5° in a deflection range of ±15° adduction/abduction combined with ±45° flexion/extension. The proposed design provides a first approach for intra-operative assessment of shoulder stiffness. The findings can be used as a technological basis for further developments.}, language = {en} } @inproceedings{SuessMelznerDendorfer, author = {Suess, Franz and Melzner, Maximilian and Dendorfer, Sebastian}, title = {Towards ergonomics working - machine learning algorithms and musculoskeletal modeling}, series = {IOP Conference Series: Materials Science and Engineering}, volume = {1208}, booktitle = {IOP Conference Series: Materials Science and Engineering}, publisher = {IOP Publishing}, issn = {1757-899X}, doi = {10.1088/1757-899X/1208/1/012001}, abstract = {Ergonomic workplaces lead to fewer work-related musculoskeletal disorders and thus fewer sick days. There are various guidelines to help avoid harmful situations. However, these recommendations are often rather crude and often neglect the complex interaction of biomechanical loading and psychological stress. This study investigates whether machine learning algorithms can be used to predict mechanical and stress-related muscle activity for a standardized motion. For this purpose, experimental data were collected for trunk movement with and without additional psychological stress. Two different algorithms (XGBoost and TensorFlow) were used to model the experimental data. XGBoost in particular predicted the results very well. By combining it with musculoskeletal models, the method shown here can be used for workplace analysis but also for the development of real-time feedback systems in real workplace environments.}, language = {en} } @article{EbigboPalmMessmann, author = {Ebigbo, Alanna and Palm, Christoph and Messmann, Helmut}, title = {Barrett esophagus: What to expect from Artificial Intelligence?}, series = {Best Practice \& Research Clinical Gastroenterology}, volume = {52-53}, journal = {Best Practice \& Research Clinical Gastroenterology}, number = {June-August}, publisher = {Elsevier}, issn = {1521-6918}, doi = {10.1016/j.bpg.2021.101726}, abstract = {The evaluation and assessment of Barrett's esophagus is challenging for both expert and nonexpert endoscopists. However, the early diagnosis of cancer in Barrett's esophagus is crucial for its prognosis, and could save costs. Pre-clinical and clinical studies on the application of Artificial Intelligence (AI) in Barrett's esophagus have shown promising results. In this review, we focus on the current challenges and future perspectives of implementing AI systems in the management of patients with Barrett's esophagus.}, subject = {Deep Learning}, language = {en} } @article{ArribasAntonelliFrazzonietal., author = {Arribas, Julia and Antonelli, Giulio and Frazzoni, Leonardo and Fuccio, Lorenzo and Ebigbo, Alanna and van der Sommen, Fons and Ghatwary, Noha and Palm, Christoph and Coimbra, Miguel and Renna, Francesco and Bergman, Jacques J.G.H.M. and Sharma, Prateek and Messmann, Helmut and Hassan, Cesare and Dinis-Ribeiro, Mario J.}, title = {Standalone performance of artificial intelligence for upper GI neoplasia: a meta-analysis}, series = {Gut}, volume = {70}, journal = {Gut}, number = {8}, publisher = {BMJ}, address = {London}, doi = {10.1136/gutjnl-2020-321922}, pages = {1458 -- 1468}, abstract = {Objective: Artificial intelligence (AI) may reduce underdiagnosed or overlooked upper GI (UGI) neoplastic and preneoplastic conditions, due to subtle appearance and low disease prevalence. Only disease-specific AI performances have been reported, generating uncertainty on its clinical value. Design: We searched PubMed, Embase and Scopus until July 2020, for studies on the diagnostic performance of AI in detection and characterisation of UGI lesions. Primary outcomes were pooled diagnostic accuracy, sensitivity and specificity of AI. Secondary outcomes were pooled positive (PPV) and negative (NPV) predictive values. We calculated pooled proportion rates (\%), designed summary receiving operating characteristic curves with respective area under the curves (AUCs) and performed metaregression and sensitivity analysis. Results: Overall, 19 studies on detection of oesophageal squamous cell neoplasia (ESCN) or Barrett's esophagus-related neoplasia (BERN) or gastric adenocarcinoma (GCA) were included with 218, 445, 453 patients and 7976, 2340, 13 562 images, respectively. AI-sensitivity/specificity/PPV/NPV/positive likelihood ratio/negative likelihood ratio for UGI neoplasia detection were 90\% (CI 85\% to 94\%)/89\% (CI 85\% to 92\%)/87\% (CI 83\% to 91\%)/91\% (CI 87\% to 94\%)/8.2 (CI 5.7 to 11.7)/0.111 (CI 0.071 to 0.175), respectively, with an overall AUC of 0.95 (CI 0.93 to 0.97). No difference in AI performance across ESCN, BERN and GCA was found, AUC being 0.94 (CI 0.52 to 0.99), 0.96 (CI 0.95 to 0.98), 0.93 (CI 0.83 to 0.99), respectively. Overall, study quality was low, with high risk of selection bias. No significant publication bias was found. Conclusion: We found a high overall AI accuracy for the diagnosis of any neoplastic lesion of the UGI tract that was independent of the underlying condition. This may be expected to substantially reduce the miss rate of precancerous lesions and early cancer when implemented in clinical practice.}, language = {en} } @inproceedings{GlemarecHoermannLaueretal., author = {Gl{\´e}marec, Yann and H{\"o}rmann, Amelie and Lauer, Norina and Buche, C{\´e}dric and Lugrin, Jean-Luc and Latoschik, Marc Erich}, title = {Towards Virtual Audience Simulation For Speech Therapy}, series = {Proceedings of the 23rd ACM International Conference on Intelligent Virtual Agents (IVA '23), W{\"u}rzburg, September 19 - 22, 2023}, booktitle = {Proceedings of the 23rd ACM International Conference on Intelligent Virtual Agents (IVA '23), W{\"u}rzburg, September 19 - 22, 2023}, publisher = {Association for Computing Machinery}, address = {New York}, isbn = {78-1-4503-9994-4}, doi = {10.1145/3570945.3607348}, pages = {1-3}, abstract = {The utilization of virtual reality (VR) technology has shown promise in various therapeutic applications, particularly in exposure therapy for reducing fear of certain situations objects or activities, e.g. fear of height, or negative evaluation of others in social situations. VR has been shown to yield positive outcomes in follow-up studies, and provides a safe and ecological therapeutic environment for therapists and their patients. This paper presents a collaborative effort to develop a VR speech therapy system which simulates a virtual audience for users to practice their public speaking skills. We describe a novel web-based graphica user interface that enables therapists to manage the therapy session using a simple timeline. Lastly, we present the results from a qualitative study with therapists and teachers with functional dysphonia, which highlight the potential of such an application to support and augment the therapists' work and the remaining challenges regarding the design of natural interactions, agent behaviours and scenario customisation for patients.}, subject = {Stimme}, language = {en} } @misc{StelzerRuettenKrenkel, author = {Stelzer, Vera and R{\"u}tten, Markus and Krenkel, Lars}, title = {Numerical Investigation of a 3D Dragonfly Wing Captured with a High-Resolution Micro-CT}, series = {8th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2022, 5-9 June 2022, Oslo, Norway}, journal = {8th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2022, 5-9 June 2022, Oslo, Norway}, abstract = {The special wing geometry of dragonflies consisting of veins and a membrane forming a corrugated profile leads to special aerodynamic characteristics. To capture the governing flow regimes of a dragonfly wing in detail, a realistic wing model has to be investigated. Therefore, this study aimed to analyze the aerodynamic characteristics of a 3D dragonfly wing reconstructed from a high-resolution micro-CT scan. Afterwards, a spatially high discretized mesh was generated using the mesh generator CENTAUR™ 14.5.0.2 (CentaurSoft, Austin, TX, US) to finally conduct Computational Fluid Dynamics (CFD) investigations in Fluent® 2020 R2 (ANSYS, Inc., Canonsburg, PA, US). Due to the small dimensions of the wing membrane, only the vein structure of a Camacinia Gigantea was captured at a micro-CT voxel size of 7 microns. The membrane was adapted and connected to the vein structure using a Boolean union operation. Occurring nconsistencies after combining the veins and the membrane were corrected using an adapted pymesh script [1]. As an initial study, only one quarter of the wing (outer wing section) was investigated to reduce the required computational effort. The resulting hybrid mesh consisting of 10 pseudo-structured prism layers along the wing surface and tetrahedra in the farfield area has 43 mio. nodes. The flow around the wing was considered to be incompressible and laminar using transient calculations. When the flow passes the vein structures, steady vortices occur in the corrugation valleys leading to recirculation zones. Therefore, the dragonfly wing resembles the profile of an airfoil. This leads to comparable lift coefficients of dragonfly wings and airfoil profiles at significantly reduced structural weight. The reconstructed geometry also included naturally occurring triangular prismlike serrated structures at the leading edge of the wing, which have comparable effects to micro vortex generators and might stabilize the recirculation zones. Further work aims to investigate the aerodynamic properties of a complete dragonfly wing during wing flapping.}, language = {en} }