@article{BartschBehamGebhardtetal., author = {Bartsch, Alexander and Beham, Daniela and Gebhardt, Jakob and Ehrlich, Ingo and Schratzenstaller, Thomas and Monkman, Gareth J.}, title = {Mechanical Properties of NdPrFeB Based Magnetoactive Bisphenol-Free Boron-Silicate Polymers}, series = {Journal of Nanomedicine and Nanotechnology}, volume = {14}, journal = {Journal of Nanomedicine and Nanotechnology}, number = {6}, publisher = {Walsh Medical Media}, issn = {2157-7439}, doi = {10.35248/2157-7439.23.14.705}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-67425}, abstract = {Following a ban on many materials containing bisphenol-A, new bisphenol-free Boron silicates have been found as substitutes. The purpose of this study is to describe the mechanical properties of these bisphenol-free magnetoactive borosilicate polymers containing hard magnetic particles. Samples of 0\%, 33\% and 66\% by wt. were loaded for compression using a universal testing machine. The maximum forces occurring for different travel speeds were compared before and after post-magnetization treatments. The post-magnetization included 2 stages. In addition, the change in mechanical properties within 24 hours after the post-magnetization process was investigated. Furthermore, the influence of speed and particle content were investigated. In general, there is a correlation between the required compressive force and, the level of post-magnetization stress, the increase in travel speed and particle content in the boron silicate. Comparison of the non-post-magnetized and post-magnetized samples using two-tailed t-tests shows that the p-values for all weight fraction changes in NdPrFeB particles and travel speeds are less than 0.001. Also, a comparison between tests in which the traverse speed was varied also showed significant changes in the resulting compression forces. The same is valid for changes in the weight ratio of the NdPrFeB particles in the samples. For post-magnetized samples, no significant difference can be observed in the first 24 hours following magnetization. In summary, the material presents viscoelastic, plastic force-displacement behavior, which can be well recognized by its bi-linear curve shape. The investigation shows that borosilicate polymers based on NdPrFeB can have their mechanical behavior modified and controlled by post-magnetization processes. This opens new possibilities for many future applications.}, language = {en} } @article{DotterHaugWeberetal., author = {Dotter, Caroline and Haug, Sonja and Weber, Karsten and Schnell, Rainer and Scharf, Anna and Altenburcher, Amelie}, title = {Analyzing factors determining vaccination willingness against COVID-19 in Germany 2020}, series = {Vaccine: X}, volume = {14}, journal = {Vaccine: X}, publisher = {Elsevier}, doi = {10.1016/j.jvacx.2023.100342}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-62900}, pages = {6}, abstract = {The study is based on a German single-topic population survey on vaccination willingness against COVID-19 (VWC) by the authors (2020, n = 2014). The single-topic survey allowed us to test several competing explanations for VWC, as discussed in the literature. The VWC in the sample was 67.3\%. Logistic regression was used to identify factors affecting VWC. Being at high risk from COVID-19 and having received flu vaccination have a positive impact on VWC. Perceived VWC of friends has a strong positive effect on respondents' VWC. Bivariate relationships of gender, age, and level of education with VWC were no longer significant in a multivariate analysis. Trust in alternative medicine and belief in conspiracy theories have a negative effect on VWC.}, language = {en} } @inproceedings{Fuhrmann, author = {Fuhrmann, Thomas}, title = {Semi-Structured Lab Projects in Communication Engineering Education}, series = {2023 IEEE Global Engineering Education Conference (EDUCON), 01-04 May 2023, Kuwait}, booktitle = {2023 IEEE Global Engineering Education Conference (EDUCON), 01-04 May 2023, Kuwait}, publisher = {IEEE}, doi = {10.1109/EDUCON54358.2023.10125244}, pages = {1 -- 5}, abstract = {It is generally known that project-based learning is a very important part of engineering education to connect theoretical knowledge with practical work. Students learn to apply their knowledge to real-world challenges as it is the case in their later professional life. If students are not used to project work or the scientific topic is new and relatively complex, they may be overwhelmed. The consequence is that students achieve poor results, are frustrated, and therefore learning success is low. Semi-structured projects are introduced that combine the advantages of structured experiments with projects. The project work is structured into several parts with detailed descriptions of the tasks. In the end, students get similar results to doing a free project, but the success rate is higher due to higher guidance. Therefore, these semi-structured projects are seen to be an appropriate method to guide students to learn how to do project work. The feedback from most students is very positive. Some students with no previous lab experience complained about the project work and wished for more guidance to become familiar with lab work. In sum, the student feedback is encouraging to develop semi-structured projects further.}, language = {en} } @article{FoerstlSuessEnglertetal., author = {F{\"o}rstl, Nikolas and S{\"u}ß, Franz and Englert, Carsten and Dendorfer, Sebastian}, title = {Design of a reverse shoulder implant to measure shoulder stiffness during implant component positioning}, series = {Medical Engineering \& Physics}, volume = {121}, journal = {Medical Engineering \& Physics}, edition = {Journal Pre-proof}, publisher = {Elsevier}, doi = {10.1016/j.medengphy.2023.104059}, pages = {22}, abstract = {To avoid dislocation of the shoulder joint after reverse total shoulder arthroplasty, it is important to achieve sufficient shoulder stability when placing the implant components during surgery. One parameter for assessing shoulder stability can be shoulder stiffness. The aim of this research was to develop a temporary reverse shoulder implant prototype that would allow intraoperative measurement of shoulder stiffness while varying the position of the implant components. Joint angle and torque measurement techniques were developed to determine shoulder stiffness. Hall sensors were used to measure the joint angles by converting the magnetic flux densities into angles. The accuracy of the joint angle measurements was tested using a test bench. Torques were determined by using thin-film pressure sensors. Various mechanical mechanisms for variable positioning of the implant components were integrated into the prototype. The results of the joint angle measurements showed measurement errors of less than 5° in a deflection range of ±15° adduction/abduction combined with ±45° flexion/extension. The proposed design provides a first approach for intra-operative assessment of shoulder stiffness. The findings can be used as a technological basis for further developments.}, language = {en} } @article{GiordanoLauerLeuschetal., author = {Giordano, Katharina and Lauer, Norina and Leusch, Vera and Kreiter, Daniel and Corsten, Sabine}, title = {Tablet-based biography work in long-term care homes to support quality of life and prevent depression}, series = {Educational Gerontology}, journal = {Educational Gerontology}, publisher = {Taylor and Francis}, address = {London}, issn = {1521-0472}, doi = {10.1080/03601277.2023.2225362}, pages = {1 -- 14}, abstract = {Older adults in long-term care homes are at high risk of experiencing reduced quality of life (QoL) and depression. Technology-assisted biography work can have a positive impact on QoL and mood, but there is little research on its use with this target group. The purpose of this paper is to examine the effect of tablet-based biography work conducted by volunteers on the QoL of residents and volunteers. A pretest-posttest control group design with an intervention period of 3 months and a 3-month follow-up was used. Results show a significant increase in participation for volunteers and residents after the intervention, which is stable for residents until follow-up. Volunteers also show significant improvement in mental QoL immediately after the intervention. There were no significant effects for life satisfaction, self-esteem, or depression. No significant changes were found for the control group. Digitally conducted tablet-based biography work appears to have effects on QoL-associated outcomes.}, subject = {Biografieforschung}, language = {en} } @inproceedings{GlemarecHoermannLaueretal., author = {Gl{\´e}marec, Yann and H{\"o}rmann, Amelie and Lauer, Norina and Buche, C{\´e}dric and Lugrin, Jean-Luc and Latoschik, Marc Erich}, title = {Towards Virtual Audience Simulation For Speech Therapy}, series = {Proceedings of the 23rd ACM International Conference on Intelligent Virtual Agents (IVA '23), W{\"u}rzburg, September 19 - 22, 2023}, booktitle = {Proceedings of the 23rd ACM International Conference on Intelligent Virtual Agents (IVA '23), W{\"u}rzburg, September 19 - 22, 2023}, publisher = {Association for Computing Machinery}, address = {New York}, isbn = {78-1-4503-9994-4}, doi = {10.1145/3570945.3607348}, pages = {1-3}, abstract = {The utilization of virtual reality (VR) technology has shown promise in various therapeutic applications, particularly in exposure therapy for reducing fear of certain situations objects or activities, e.g. fear of height, or negative evaluation of others in social situations. VR has been shown to yield positive outcomes in follow-up studies, and provides a safe and ecological therapeutic environment for therapists and their patients. This paper presents a collaborative effort to develop a VR speech therapy system which simulates a virtual audience for users to practice their public speaking skills. We describe a novel web-based graphica user interface that enables therapists to manage the therapy session using a simple timeline. Lastly, we present the results from a qualitative study with therapists and teachers with functional dysphonia, which highlight the potential of such an application to support and augment the therapists' work and the remaining challenges regarding the design of natural interactions, agent behaviours and scenario customisation for patients.}, subject = {Stimme}, language = {en} } @article{HaugSchnellRaptisetal., author = {Haug, Sonja and Schnell, Rainer and Raptis, Georgios and Dotter, Caroline and Weber, Karsten}, title = {Wissen und Einstellung zur Speicherung und Nutzung von Gesundheitsdaten: Ergebnisse einer Bev{\"o}lkerungsbefragung}, series = {Zeitschrift f{\"u}r Evidenz, Fortbildung und Qualit{\"a}t im Gesundheitswesen}, journal = {Zeitschrift f{\"u}r Evidenz, Fortbildung und Qualit{\"a}t im Gesundheitswesen}, publisher = {Elsevier}, issn = {1865-9217}, doi = {10.1016/j.zefq.2023.11.001}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-67461}, pages = {50 -- 58}, abstract = {Hintergrund/Zielsetzung Der Beitrag befasst sich mit dem Wissenstand und der Einstellung der Bev{\"o}lkerung. Betrachtet werden die {\"U}bermittlung und Verf{\"u}gbarkeit von Gesundheitsdaten, Gesundheitsregister, die elektronische Patientenakte, Einwilligungsverfahren f{\"u}r die {\"U}bermittlung von Daten und der Zugriff auf Gesundheitsdaten zu Forschungszwecken. Methoden Die Studie basiert auf einer computergest{\"u}tzten Telefonbefragung (Dual-Frame) bei einer Zufallsstichprobe der Bev{\"o}lkerung in Deutschland im Zeitraum 01.-27.06.2022 (n = 1.308). Ergebnisse Der Wissensstand zur {\"U}bermittlung von Gesundheitsdaten an Krankenkassen ist hoch, wohingegen das Vorhandensein zentraler Sterbe-, Impf- und Gesundheitsregister sowie der Zugriff auf Gesundheitsdaten durch behandelnde {\"A}rztinnen und {\"A}rzte {\"u}bersch{\"a}tzt werden. Die Akzeptanz medizinischer Register ist sehr hoch. Die elektronische Patientenakte ist bei der H{\"a}lfte der Bev{\"o}lkerung unbekannt, die Nutzungsbereitschaft ist eher gering ausgepr{\"a}gt; bei der {\"U}bertragung von Daten wird eine Zustimmungsoption bevorzugt, und {\"u}ber achtzig Prozent w{\"u}rden die Daten der elektronischen Patientenakte zur Forschung freigeben. Drei Viertel w{\"u}rden ihre Gesundheitsdaten allgemein zur Forschung freigeben, insbesondere an Universit{\"a}ten in Deutschland, wobei meist Anonymit{\"a}t Bedingung ist. Die Bereitschaft zur Datenfreigabe steigt mit der H{\"o}he des Vertrauens in die Presse sowie in Universit{\"a}ten und Hochschulen, und sie sinkt, wenn ein Datenleck als schwerwiegend erachtet wird. Diskussion und Schlussfolgerung In Deutschland besteht, wie in anderen europ{\"a}ischen L{\"a}ndern, eine große Bereitschaft zur Freigabe von Gesundheitsdaten zu Forschungszwecken. Dagegen ist der Wunsch zur Nutzung der elektronischen Patientenakte eher gering. Ebenso niedrig ist die Akzeptanz einer Widerspruchsoption, die jedoch als Voraussetzung f{\"u}r eine erfolgreiche Einf{\"u}hrung einer elektronischen Patientenakte gilt. Vertrauen in die Forschung und staatliche Stellen, die Gesundheitsdaten verarbeiten, sind zentrale Faktoren.}, language = {en} } @inproceedings{HauserGrabingerMottoketal., author = {Hauser, Florian and Grabinger, Lisa and Mottok, J{\"u}rgen and Jahn, Sabrina and Nadimpalli, Vamsi Krishna}, title = {The Expert's View: Eye Movement Modeling Examples in Software Engineering Education}, series = {Proceedings of the 5th European Conference on Software Engineering Education, Seeon/Germany, June 19 - 21, 2023}, booktitle = {Proceedings of the 5th European Conference on Software Engineering Education, Seeon/Germany, June 19 - 21, 2023}, publisher = {ACM}, isbn = {978-1-4503-9956-2}, doi = {10.1145/3593663.3593683}, pages = {148 -- 152}, abstract = {This study investigates the impact of eye movement modeling examples in Software Engineering education. Software Engineering is a highly visual domain. The daily tasks of a software engineer (e.g., formulating requirements, creating UML diagrams, or conducting a code review) require in many cases the use of certain visual strategies. Although these strategies can be found for experts, it has been observed in different eye tracking studies that students have difficulties in learning and applying them. To familiarize students with these visual strategies and to provide them with a better understanding for the cognitive processes involved, a total of seven eye movement modeling examples was created. The seven eye movement modeling examples cover relevant parts of an introductory Software Engineering lecture; they are focused on typical situations in which visual strategies are applied. The results of a questionnaire-based evaluation shows that students consider the eye movement modeling examples as useful, feel supported in their learning process, and would like to see more use of them in the Software Engineering lecture. Furthermore, the students suggested that eye movement modeling examples should also be used in other lectures.}, language = {en} } @article{KnoedlerKnoedlerKaukeNavarroetal., author = {Kn{\"o}dler, Leonard and Kn{\"o}dler, Samuel and Kauke-Navarro, Martin and Kn{\"o}dler, Christoph and H{\"o}fer, Simon and B{\"a}cher, Helena and Gassner, Ulrich M. and Machens, Hans-G{\"u}nther and Prantl, Lukas and Panayi, Adriana}, title = {Three-dimensional Medical Printing and Associated Legal Issues in Plastic Surgery: A Scoping Review}, series = {Plastic \& Reconstructive Surgery-Global Open}, volume = {11}, journal = {Plastic \& Reconstructive Surgery-Global Open}, number = {4}, publisher = {Wolters Kluwer}, issn = {2169-7574}, doi = {10.1097/GOX.0000000000004965}, abstract = {Three-dimensional printing (3DP) represents an emerging field of surgery. 3DP can facilitate the plastic surgeon's workflow, including preoperative planning, intraoperative assistance, and postoperative follow-up. The broad clinical application spectrum stands in contrast to the paucity of research on the legal framework of 3DP. This imbalance poses a potential risk for medical malpractice lawsuits. To address this knowledge gap, we aimed to summarize the current body of legal literature on medical 3DP in the US legal system. By combining the promising clinical use of 3DP with its current legal regulations, plastic surgeons can enhance patient safety and outcomes.}, language = {en} } @article{KnoedlerSchliermannKnoedleretal., author = {Kn{\"o}dler, Samuel and Schliermann, Rainer and Kn{\"o}dler, Leonard and Wu, Mengfan and Hansen, Frederik J. and Matar, Dany Y. and Obed, Doha and Vervoort, Dominique and Haug, Valentin and Hundeshagen, Gabriel and Paik, Angie and Kauke-Navarro, Martin and Kneser, Ulrich and Pomahac, Bohdan and Orgill, Dennis P. and Panayi, Adriana C.}, title = {Impact of sarcopenia on outcomes in surgical patients: A systematic review and meta-analysis}, series = {International journal of surgery}, journal = {International journal of surgery}, edition = {accepted}, publisher = {Wolters Kluwer}, doi = {10.1097/JS9.0000000000000688}, pages = {71}, abstract = {BACKGROUND Surgeons have historically used age as a preoperative predictor of postoperative outcomes. Sarcopenia, the loss of skeletal muscle mass due to disease or biological age, has been proposed as a more accurate risk predictor. The prognostic value of sarcopenia assessment in surgical patients remains poorly understood. Therefore, we aimed to synthesize the available literature and investigate the impact of sarcopenia on peri- and postoperative outcomes across all surgical specialties. METHODS We systematically assessed the prognostic value of sarcopenia on postoperative outcomes by conducting a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching the PubMed/MEDLINE and EMBASE databases from inception to 1st October 2022. Our primary outcomes were complication occurrence, mortality, length of operation and hospital stay, discharge to home, and postdischarge survival rate at one, three, and five years. Subgroup analysis was performed by stratifying complications according to the Clavien-Dindo classification system. Sensitivity analysis was performed by focusing on studies with an oncological, cardiovascular, emergency, or transplant surgery population, and on those of higher quality or prospective study design. RESULTS A total of 294 studies comprising 97,643 patients, of which 33,070 had sarcopenia, were included in our analysis. Sarcopenia was associated with significantly poorer postoperative outcomes including greater mortality, complication occurrence, length of hospital stay, and lower rates of discharge to home (all P<0.00001). A significantly lower survival rate in patients with sarcopenia was noted at one, three, and five years (all P<0.00001) after surgery. Subgroup analysis confirmed higher rates of complications and mortality in oncological (both P<0.00001), cardiovascular (both P<0.00001), and emergency (P=0.03 and P=0.04, respectively) patients with sarcopenia. In the transplant surgery cohort, mortality was significantly higher in patients with sarcopenia (P<0.00001). Among all patients undergoing surgery for inflammatory bowel disease, the frequency of complications was significantly increased among sarcopenic patients (P=0.007). Sensitivity analysis based on higher-quality studies and prospective studies showed that sarcopenia remained a significant predictor of mortality and complication occurrence (all P<0.00001). CONCLUSION Sarcopenia is a significant predictor of poorer outcomes in surgical patients. Preoperative assessment of sarcopenia can help surgeons to identify patients at risk, critically balance eligibility, and refine perioperative management. Large-scale studies are required to further validate the importance of sarcopenia as a prognostic indicator of perioperative risk, especially in surgical sub-specialties.}, language = {en} } @article{KurfessCorstenNickeletal., author = {Kurfess, Christina and Corsten, Sabine and Nickel, Maren Tabea and Knieriemen, Marie and Kreiter, Daniel and Lauer, Norina}, title = {Peer-to-peer support: digital networking in aphasia to improve quality of life (PeerPAL)}, series = {Frontiers in Communication}, volume = {8}, journal = {Frontiers in Communication}, publisher = {Frontiers Media S.A.}, doi = {10.3389/fcomm.2023.1187233}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-64881}, abstract = {Background: People with aphasia (PWA) often suffer from reduced participation and quality of life. Nevertheless, there are currently only a few specific interventions that respond to this problem. Participation and quality of life could be increased by interacting with peers who have similar experiences. Digital social networks could stimulate an autonomous interaction. However, digital social networks need to be adapted to the specific needs of PWA. Therefore, a participatory, agile process involving the target group should be chosen to develop such a olution, i.e., an app. The research project consists of a total of three phases. In the first phase—app development—the app was developed and programmed including the target group. In the second phase—app testing—the usability and user-friendliness of the app were evaluated with four PWA. In the third phase—feasibility and preliminary effcacy—that will be described in the article, the impact of the app on PWA will be evaluated. Aims: The overarching aim of our study is to provide preliminary effcacy of the intervention. Digital social interaction with other PWA can lead to increased social integration. In addition to digital interaction, personal encounters between PWA should be encouraged. As a result, we expect an improvement in quality of life of PWA. Additionally, we focus on identification of the most appropriate measurements to discover changes associated with the intervention. Methods: The evaluation, which is described in this paper, takes place in a pre-test - post-test design with a total of n = 48 PWA. Participants will be recruited in regional clusters to facilitate face-to-face meetings. Half of the participants will be assigned to the delayed intervention group and the other half to the immediate intervention group. Participants in the delayed intervention group will go through a 3-month waiting period before using the app, while the participants of the immediate intervention group will start using the app for 3 months right away. Inclusion criteria are the presence of chronic aphasia (at least 6 months) and possession of a smartphone with internet access. Questionnaires on quality of life (SAQOL-39, GHQ-12), depression (GDS, DISCs), communicative participation (CPIB), and social support (F-SozU) will be conducted at inclusion (t0), after 3 months of app use (t1), and after another 3 months for follow-up (t2). Participants in the delayed intervention group will be assessed twice before the intervention, before the 3-month waiting period (t0a) and after the waiting period (t0b). In addition to the quantitative measures, interviews will take place with 6 to 8 selected participants after 3 months of app use. Responses will be analysed using Thematic Analysis. Discussion: The app will be the first social network tool that is systematically developed with PWA. Initial indications from the first phases are that the app can be used by PWA, so that the evaluation of this app version can take place in the third phase. Results of this study can provide an initial indication of whether social network support is a suitable intervention. Findings will help provide information on the feasibility of digital connectivity for PWA. Preliminary findings on its impact on the participation and quality of life of PWA could be made available.}, subject = {Aphasie}, language = {en} } @article{KaessStrahringerWestner, author = {K{\"a}ss, Sebastian and Strahringer, Susanne and Westner, Markus}, title = {A Multiple Mini Case Study on the Adoption of Low Code Development Platforms in Work Systems}, series = {IEEE Access}, journal = {IEEE Access}, publisher = {IEEE}, issn = {2169-3536}, doi = {10.1109/ACCESS.2023.3325092}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-65634}, pages = {118762 -- 118786}, abstract = {Although adopting Low Code Development Platforms (LCDPs) promises significant efficiency and effectiveness improvements for application development, its adoption still needs further empirical research. This paper uses a combinatorial approach to research LCDP adoption and presents the results of a multiple mini case study with 36 cases on LCDP adoption. A combination of the Socio-Technical Systems theory and the Technology-Organisational-Environment model is used as a theoretical lens. In this paper, we show that LCDP adoption is a multifaceted phenomenon and identify three archetypes for LCDP adoption (i.e., IT Resource Shortage Mitigators, Application Development Democratisers, and Synergy Realisers) and one archetype for LCDP non-adoption (i.e., Intricacy Adversaries). Each archetype can be interpreted as an individual path towards LCDP (non-)adoption. Based on these archetypes, we derive seven starting points for practitioners to adopt LCDPs in work systems. Moreover, by using the theoretical lenses, the paper shows that for an LCDP adoption to occur, an optimisation of the social and technical sub-systems is required.}, language = {en} } @article{KoeckStrieglKrausetal., author = {K{\"o}ck, Hannah and Striegl, Birgit and Kraus, Annalena and Zborilova, Magdalena and Christiansen, Silke H. and Sch{\"a}fer, Nicole and Gr{\"a}ssel, Susanne and Hornberger, Helga}, title = {In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes}, series = {Bioengineering}, volume = {10}, journal = {Bioengineering}, publisher = {MDPI}, doi = {10.3390/bioengineering10070767}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-61235}, pages = {1 -- 21}, abstract = {Osteoarthritis (OA) is a degenerative joint disease causing loss of articular cartilage and structural damage in all joint tissues. Given the limited regenerative capacity of articular cartilage, methods to support the native structural properties of articular cartilage are highly anticipated. The aim of this study was to infiltrate zwitterionic monomer solutions into human OA-cartilage explants to replace lost proteoglycans. The study included polymerization and deposition of methacryloyloxyethyl-phosphorylcholine- and a novel sulfobetaine-methacrylate-based monomer solution within ex vivo human OA-cartilage explants and the encapsulation of isolated chondrocytes within hydrogels and the corresponding effects on chondrocyte viability. The results demonstrated that zwitterionic cartilage-hydrogel networks are formed by infiltration. In general, cytotoxic effects of the monomer solutions were observed, as was a time-dependent infiltration behavior into the tissue accompanied by increasing cell death and penetration depth. The successful deposition of zwitterionic hydrogels within OA cartilage identifies the infiltration method as a potential future therapeutic option for the repair/replacement of OA-cartilage extracellular suprastructure. Due to the toxic effects of the monomer solutions, the focus should be on sealing the OA-cartilage surface, instead of complete infiltration. An alternative treatment option for focal cartilage defects could be the usage of monomer solutions, especially the novel generated sulfobetaine-methacrylate-based monomer solution, as bionic for cell-based 3D bioprintable hydrogels.}, language = {en} } @article{LingelHausPaschkeetal., author = {Lingel, Maximilian P. and Haus, Moritz and Paschke, Lukas and Foltan, Maik and Lubnow, Matthias and Gruber, Michael and Krenkel, Lars and Lehle, Karla}, title = {Clinical relevance of cell-free DNA during venovenous extracorporeal membrane oxygenation}, series = {Artificial organs}, volume = {47}, journal = {Artificial organs}, number = {11}, publisher = {Wiley}, issn = {1525-1594}, doi = {10.1111/aor.14616}, pages = {1720 -- 1731}, abstract = {BACKGROUND: Thrombosis remains a critical complication during venovenous extracorporeal membrane oxygenation (VV ECMO). The involvement of neutrophil extracellular traps (NETs) in thrombogenesis has to be discussed. The aim was to verify NETs in the form of cell-free DNA (cfDNA) in the plasma of patients during ECMO. METHODS: A fluorescent DNA-binding dye (QuantifFluor®, Promega) was used to detect cell-free DNA in plasma samples. cfDNA concentrations from volunteers (n = 21) and patients (n = 9) were compared and correlated with clinical/technical data before/during support, ECMO end and time of a system exchange. RESULTS: Before ECMO, patients with a median (IQR) age of 59 (51/63) years, SOFA score of 11 (10/15), and ECMO run time of 9.0 (7.0/19.5) days presented significantly higher levels of cfDNA compared to volunteers (6.4 (5.8/7.9) ng/μL vs. 5.9 (5.4/6.3) ng/μL; p = 0.044). Within 2 days after ECMO start, cfDNA, inflammatory, and hemolysis parameters remained unchanged, while platelets decreased (p = 0.005). After ECMO removal at the end of therapy, cfDNA, inflammation, and coagulation data (except antithrombin III) remained unchanged. The renewal of a system resulted in known alterations in fibrinogen, d-dimers, and platelets, while cfDNA remained unchanged. CONCLUSION: Detection of cfDNA in plasma of ECMO patients was not an indicator of acute and circuit-induced thrombogenesis.}, language = {en} } @article{MarkovGlazerElbeSchliermann, author = {Markov-Glazer, Alon and Elbe, Anne-Marie and Schliermann, Rainer}, title = {Sport psychology consultants' views on mental training with elite Deaf sport athletes}, series = {International Journal of Sport and Exercise Psychology}, journal = {International Journal of Sport and Exercise Psychology}, publisher = {Taylor \& Francis}, issn = {1557-251X}, doi = {10.1080/1612197X.2023.2245422}, pages = {1 -- 16}, abstract = {The elite sport movement for athletes with hearing impairments, namely Deaflympics, differs from the Paralympic and Olympic sport movements because it exhibits a variety of distinct sociocultural and organisational characteristics. Yet, mental training with Deaflympic athletes receives little to no attention from the scientific community. Little is known about sport psychology consultants' (SPCs) work with Deaflympic athletes. In this study, we explored SPCs' exposure to so called Deaf sport as well as their experiences, attitudes, and assumptions regarding the utility of psychological skills training (PST) with Deaflympic athletes. A self-constructed questionnaire with closed and semi-open questions was completed by 93 (58.8\% female) SPCs in European German-speaking countries. Analyses revealed SPCs had limited exposure to Deaflympic sport but indicated readiness to work with Deaflympic athletes. SPCs shared no reasons as to why PST skills and techniques would not be effective with Deaflympic athletes. However, SPCs regarded communication challenges as a major obstacle. We conclude that the integration of elite Deaf sport in SPCs' training programmes is vital, considering SPCs' lack of exposure and experience with Deaflympic athletes as well as their communication insecurities. In addition, further empirical research on PST effectiveness in Deaflympics athletes should provide the foundation for evidence-based utility of applied sport psychology in Deaflympic sport.}, language = {en} } @misc{MeinikheimMendelProbstetal., author = {Meinikheim, Michael and Mendel, Robert and Probst, Andreas and Scheppach, Markus W. and Schnoy, Elisabeth and Nagl, Sandra and R{\"o}mmele, Christoph and Prinz, Friederike and Schlottmann, Jakob and Golger, Daniela and Palm, Christoph and Messmann, Helmut and Ebigbo, Alanna}, title = {AI-assisted detection and characterization of early Barrett's neoplasia: Results of an Interim analysis}, series = {Endoscopy}, volume = {55}, journal = {Endoscopy}, number = {S02}, publisher = {Thieme}, doi = {10.1055/s-0043-1765437}, pages = {S169}, abstract = {Aims Evaluation of the add-on effect an artificial intelligence (AI) based clinical decision support system has on the performance of endoscopists with different degrees of expertise in the field of Barrett's esophagus (BE) and Barrett's esophagus-related neoplasia (BERN). Methods The support system is based on a multi-task deep learning model trained to solve a segmentation and several classification tasks. The training approach represents an extension of the ECMT semi-supervised learning algorithm. The complete system evaluates a decision tree between estimated motion, classification, segmentation, and temporal constraints, to decide when and how the prediction is highlighted to the observer. In our current study, ninety-six video cases of patients with BE and BERN were prospectively collected and assessed by Barrett's specialists and non-specialists. All video cases were evaluated twice - with and without AI assistance. The order of appearance, either with or without AI support, was assigned randomly. Participants were asked to detect and characterize regions of dysplasia or early neoplasia within the video sequences. Results Standalone sensitivity, specificity, and accuracy of the AI system were 92.16\%, 68.89\%, and 81.25\%, respectively. Mean sensitivity, specificity, and accuracy of expert endoscopists without AI support were 83,33\%, 58,20\%, and 71,48 \%, respectively. Gastroenterologists without Barrett's expertise but with AI support had a comparable performance with a mean sensitivity, specificity, and accuracy of 76,63\%, 65,35\%, and 71,36\%, respectively. Conclusions Non-Barrett's experts with AI support had a similar performance as experts in a video-based study.}, language = {en} } @inproceedings{MendelRauberPalm, author = {Mendel, Robert and Rauber, David and Palm, Christoph}, title = {Exploring the Effects of Contrastive Learning on Homogeneous Medical Image Data}, series = {Bildverarbeitung f{\"u}r die Medizin 2023: Proceedings, German Workshop on Medical Image Computing, July 2- 4, 2023, Braunschweig}, booktitle = {Bildverarbeitung f{\"u}r die Medizin 2023: Proceedings, German Workshop on Medical Image Computing, July 2- 4, 2023, Braunschweig}, publisher = {Springer Vieweg}, address = {Wiesbaden}, doi = {10.1007/978-3-658-41657-7}, pages = {128 -- 13}, abstract = {We investigate contrastive learning in a multi-task learning setting classifying and segmenting early Barrett's cancer. How can contrastive learning be applied in a domain with few classes and low inter-class and inter-sample variance, potentially enabling image retrieval or image attribution? We introduce a data sampling strategy that mines per-lesion data for positive samples and keeps a queue of the recent projections as negative samples. We propose a masking strategy for the NT-Xent loss that keeps the negative set pure and removes samples from the same lesion. We show cohesion and uniqueness improvements of the proposed method in feature space. The introduction of the auxiliary objective does not affect the performance but adds the ability to indicate similarity between lesions. Therefore, the approach could enable downstream auto-documentation tasks on homogeneous medical image data.}, language = {en} } @article{MendelRauberSouzaJretal., author = {Mendel, Robert and Rauber, David and Souza Jr., Luis Antonio de and Papa, Jo{\~a}o Paulo and Palm, Christoph}, title = {Error-Correcting Mean-Teacher: Corrections instead of consistency-targets applied to semi-supervised medical image segmentation}, series = {Computers in Biology and Medicine}, volume = {154}, journal = {Computers in Biology and Medicine}, number = {March}, publisher = {Elsevier}, issn = {0010-4825}, doi = {10.1016/j.compbiomed.2023.106585}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-57790}, pages = {13}, abstract = {Semantic segmentation is an essential task in medical imaging research. Many powerful deep-learning-based approaches can be employed for this problem, but they are dependent on the availability of an expansive labeled dataset. In this work, we augment such supervised segmentation models to be suitable for learning from unlabeled data. Our semi-supervised approach, termed Error-Correcting Mean-Teacher, uses an exponential moving average model like the original Mean Teacher but introduces our new paradigm of error correction. The original segmentation network is augmented to handle this secondary correction task. Both tasks build upon the core feature extraction layers of the model. For the correction task, features detected in the input image are fused with features detected in the predicted segmentation and further processed with task-specific decoder layers. The combination of image and segmentation features allows the model to correct present mistakes in the given input pair. The correction task is trained jointly on the labeled data. On unlabeled data, the exponential moving average of the original network corrects the student's prediction. The combined outputs of the students' prediction with the teachers' correction form the basis for the semi-supervised update. We evaluate our method with the 2017 and 2018 Robotic Scene Segmentation data, the ISIC 2017 and the BraTS 2020 Challenges, a proprietary Endoscopic Submucosal Dissection dataset, Cityscapes, and Pascal VOC 2012. Additionally, we analyze the impact of the individual components and examine the behavior when the amount of labeled data varies, with experiments performed on two distinct segmentation architectures. Our method shows improvements in terms of the mean Intersection over Union over the supervised baseline and competing methods. Code is available at https://github.com/CloneRob/ECMT.}, language = {en} } @article{MoragKieningerEissnertetal., author = {Morag, Sarah and Kieninger, Martin and Eissnert, Christoph and Auer, Simon and Dendorfer, Sebastian and Popp, Daniel and Hoffmann, Johannes and Kieninger, B{\"a}rbel}, title = {Comparison of different techniques for prehospital cervical spine immobilization: Biomechanical measurements with a wireless motion capture system}, series = {PLOS ONE}, volume = {18}, journal = {PLOS ONE}, number = {11}, publisher = {PLOS}, address = {San Francisco, California}, doi = {10.1371/journal.pone.0292300}, pages = {1 -- 14}, language = {en} } @article{ReichDalferth, author = {Reich, Katrin and Dalferth, Matthias}, title = {From the Placement Paradigm to Sustainable Support of Companies in the Integration of People with High-Functioning Autism - Results of an Employer Survey}, series = {Die Rehabilitation: Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, journal = {Die Rehabilitation: Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, publisher = {Thieme}, issn = {0034-3536}, doi = {10.1055/a-1998-6630}, pages = {10}, abstract = {Im Rahmen des Projektes AUT-1A wurden 123 Arbeitgeber*innen mittels Fragebogen zu ihren Erfahrungen mit der Besch{\"a}ftigung von autistischen Mitarbeiter*innen befragt. Ziel war es, die besch{\"a}ftigungsf{\"o}rdernden und -hindernden Faktoren herauszuarbeiten. Die Studie deutet darauf hin, dass sich die berufliche Qualifizierung in den Berufsbildungswerken positiv auf die nachhaltige Besch{\"a}ftigung von Menschen mit Autismus-Spektrum-Diagnose (ASD) auswirkt, die Unterst{\"u}tzungsleistungen f{\"u}r Betriebe aber noch nicht hinreichend sind. Auch konnte eine mangelnde Aufkl{\"a}rung in Bezug auf eine autismusfreundliche Umgebungsgestaltung sowie eine mangelnde Aufkl{\"a}rung {\"u}ber die Diagnose Autismus der direkten Kolleg*innen herausgearbeitet werden.}, language = {en} } @article{ReinkerBlaesingBierletal., author = {Reinker, Lukas and Bl{\"a}sing, Dominic and Bierl, Rudolf and Ulbricht, Sabina and Dendorfer, Sebastian}, title = {Correlation of Acceleration Curves in Gravitational Direction for Different Body Segments during High-Impact Jumping Exercises}, series = {sensors}, volume = {23}, journal = {sensors}, number = {4}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/s23042276}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-58217}, abstract = {Osteoporosis is a common disease of old age. However, in many cases, it can be very well prevented and counteracted with physical activity, especially high-impact exercises. Wearables have the potential to provide data that can help with continuous monitoring of patients during therapy phases or preventive exercise programs in everyday life. This study aimed to determine the accuracy and reliability of measured acceleration data at different body positions compared to accelerations at the pelvis during different jumping exercises. Accelerations at the hips have been investigated in previous studies with regard to osteoporosis prevention. Data were collected using an IMU-based motion capture system (Xsens) consisting of 17 sensors. Forty-nine subjects were included in this study. The analysis shows the correlation between impacts and the corresponding drop height, which are dependent on the respective exercise. Very high correlations (0.83-0.94) were found between accelerations at the pelvis and the other measured segments at the upper body. The foot sensors provided very weak correlations (0.20-0.27). Accelerations measured at the pelvis during jumping exercises can be tracked very well on the upper body and upper extremities, including locations where smart devices are typically worn, which gives possibilities for remote and continuous monitoring of programs.}, language = {en} } @article{ReinkerDendorfer, author = {Reinker, Lukas and Dendorfer, Sebastian}, title = {Evaluation of acceleration patterns during high-impact jumping exercises}, series = {Gait \& Posture}, volume = {100}, journal = {Gait \& Posture}, number = {Supplement 1, March}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, doi = {10.1016/j.gaitpost.2022.11.051}, pages = {93 -- 94}, language = {en} } @article{RueweEigenbergerKleinetal., author = {Ruewe, Marc and Eigenberger, Andreas and Klein, Silvan and von Riedheim, Antonia and Gugg, Christine and Prantl, Lukas and Palm, Christoph and Weiherer, Maximilian and Zeman, Florian and Anker, Alexandra}, title = {Precise Monitoring of Returning Sensation in Digital Nerve Lesions by 3-D Imaging: A Proof-of-Concept Study}, series = {Plastic and Reconstructive Surgery}, volume = {152}, journal = {Plastic and Reconstructive Surgery}, number = {4}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia, Pa.}, organization = {American Society of Plastic Surgeons}, issn = {1529-4242}, doi = {10.1097/PRS.0000000000010456}, pages = {670e -- 674e}, abstract = {Digital nerve lesions result in a loss of tactile sensation reflected by an anesthetic area (AA) at the radial or ulnar aspect of the respective digit. Yet, available tools to monitor the recovery of tactile sense have been criticized for their lack of validity. However, the precise quantification of AA dynamics by three-dimensional (3-D) imaging could serve as an accurate surrogate to monitor recovery following digital nerve repair. For validation, AAs were marked on digits of healthy volunteers to simulate the AA of an impaired cutaneous innervation. Three dimensional models were composed from raw images that had been acquired with a 3-D camera (Vectra H2) to precisely quantify relative AA for each digit (3-D models, n= 80). Operator properties varied regarding individual experience in 3-D imaging and image processing. Additionally, the concept was applied in a clinical case study. Images taken by experienced photographers were rated better quality (p< 0.001) and needed less processing time (p= 0.020). Quantification of the relative AA was neither altered significantly by experience levels of the photographer (p= 0.425) nor the image assembler (p= 0.749). The proposed concept allows precise and reliable surface quantification of digits and can be performed consistently without relevant distortion by lack of examiner experience. Routine 3-D imaging of the AA has the great potential to provide visual evidence of various returning states of sensation and to convert sensory nerve recovery into a metric variable with high responsiveness to temporal progress.}, language = {en} } @misc{RueckertRiederRauberetal., author = {R{\"u}ckert, Tobias and Rieder, Maximilian and Rauber, David and Xiao, Michel and Humolli, Eg and Feussner, Hubertus and Wilhelm, Dirk and Palm, Christoph}, title = {Augmenting instrument segmentation in video sequences of minimally invasive surgery by synthetic smoky frames}, series = {International Journal of Computer Assisted Radiology and Surgery}, volume = {18}, journal = {International Journal of Computer Assisted Radiology and Surgery}, number = {Suppl 1}, publisher = {Springer Nature}, doi = {10.1007/s11548-023-02878-2}, pages = {S54 -- S56}, language = {en} } @inproceedings{SchaefferHerrmannBoehm, author = {Schaeffer, Leon and Herrmann, David and B{\"o}hm, Valter}, title = {Concept of a wrist Hand Orthosis based on a prestressed compliant structure}, series = {Proceedings of the 7th International Conference on Biomedical Engineering and Applications (ICBEA), Hangzhou, China, 21-23 April 2023}, booktitle = {Proceedings of the 7th International Conference on Biomedical Engineering and Applications (ICBEA), Hangzhou, China, 21-23 April 2023}, publisher = {IEEE}, doi = {10.1109/ICBEA58866.2023.00024}, pages = {98 -- 103}, abstract = {In the treatment of hand injuries in the context of orthopedic care, movable wrist hand orthoses are used in numerous instances. Early motion therapy is in most cases advantageous for adequate, rapid and successful long-term healing of the hand. Conventional dynamic wrist hand orthoses can only be used for movement therapy to a limited extent since they represent the wrist as a simple rotating joint and neglect the complexity of the hand movement possibilities. In this paper, a preliminary concept for dynamic wrist hand orthoses based on prestressed compliant structures is presented. The distinctive feature of this concept lies in the enabling of multiaxial motion capabilities of the human hand without applying conventional joints. According to the concept the wrist region is surrounded by a prestressed compliant structure. Besides the derivation and description of the concept, a first three-dimensional computer-aided design is shown. Additionally, the necessary steps in the development of such a novel dynamic wrist orthosis are discussed.}, language = {en} } @inproceedings{SchaefferHerrmannBoehm, author = {Schaeffer, Leon and Herrmann, David and B{\"o}hm, Valter}, title = {Preliminary theoretical considerations of a hand orthosis based on a prestressed, compliant structure}, series = {Proceedings of the 2023 International Symposium on Medical Robotics (ISMR), Atlanta, 19-21 April 2023}, booktitle = {Proceedings of the 2023 International Symposium on Medical Robotics (ISMR), Atlanta, 19-21 April 2023}, publisher = {IEEE}, doi = {10.1109/ISMR57123.2023.10130230}, pages = {1 -- 7}, abstract = {In the treatment of hand injuries in the context of orthopedic care, movable hand orthoses are used in many cases. Early motion therapy is in most cases advantageous for adequate, rapid, and successful long-term healing of the hand. Conventional mobile hand orthoses can only be used for movement therapy to a limited extent since they represent the wrist as a simple rotating joint and neglect the complexity of the movement possibilities of the hand. In this paper, a novel concept for movable hand orthoses based on prestressed compliant structures is presented. The advantage with this concept is that it replicates the multiaxial motion capabilities without the need for conventional joints. Besides the derivation and description of the concept, a first three-dimensional CAD design is shown. Additionally, the next planned steps in the development of such a novel dynamic hand orthosis are described.}, language = {en} } @inproceedings{SchaefferHerrmannBoehm, author = {Schaeffer, Leon and Herrmann, David and B{\"o}hm, Valter}, title = {Theoretical considerations on a 2D compliant tensegrity joint in context of a biomedical application}, series = {Engineering for a changing world : 60th ISC, Ilmenau Scientific Colloquium, Technische Universit{\"a}t Ilmenau, September 4-8, 2023}, booktitle = {Engineering for a changing world : 60th ISC, Ilmenau Scientific Colloquium, Technische Universit{\"a}t Ilmenau, September 4-8, 2023}, publisher = {Technische Universit{\"a}t Ilmenau}, address = {Ilmenau}, doi = {10.22032/dbt.58879}, pages = {1 -- 15}, abstract = {In this paper, a two-dimensional compliant tensegrity joint was investigated for potential biomedical applications such as orthotics or exoskeletons. The structure consists of two compressed members connected by five compliant tensioned members. The concept is based on the tensegrity principle, which allows the realization of dynamic orthoses without conventional hinge joints. Another advantage is the adaptability to the individual needs of the patient through a suitable design of the structure and the careful selection of the characteristics of the elements. Using geometric nonlinear analysis, the mechanical behavior of the structure was investigated, focusing on mechanical compliance. The main objective was to determine the influence of the initial length and stiffness of the tensioned members and the influence of the magnitude of external forces on the overall stiffness of the movable member of the structure. The results highlight the significant impact of member parameters on the structure's stiffness and movability under varying load magnitudes. The research laid the foundation for future development of dynamic orthoses based on this structure.}, language = {en} } @article{SchaefferHerrmannSchratzenstalleretal., author = {Schaeffer, Leon and Herrmann, David and Schratzenstaller, Thomas and Dendorfer, Sebastian and B{\"o}hm, Valter}, title = {Preliminary theoretical considerations on the stiffness characteristics of a tensegrity joint for the use in dynamic orthoses}, series = {Journal of Medical Robotics Research}, journal = {Journal of Medical Robotics Research}, publisher = {World Scientific}, doi = {10.1142/S2424905X23400081}, abstract = {Early motion therapy plays an important role for effective long-term healing of joint injuries. In many cases, conventional dynamic orthoses fail to address the intricate movement possibilities of the underlying joints, limited by their simplistic joint representations, often represented by revolute joints, enabling rotations by only one axis. In this paper, a two-dimensional compliant tensegrity joint for use in biomedical applications is investigated. It consists of two compressed members and five compliant tensioned members. Relative movement possibilities are realized by the intrinsic compliance of the structure. In the development of these systems, the first step is the determination of the static stable equilibrium. This analysis is conducted in this paper by considering the potential energy approach or by using the geometric nonlinear finite element method. The mechanical behavior of the structure is assessed with a specific emphasis on its mechanical compliance. The primary objective of this study is the investigation of the influence of structural parameters on the overall stiffness and movability of the structure. The results underscore the significant effect of member parameters on the stiffness and movability of the compliant tensegrity joint, particularly under varying load magnitudes. These findings provide insights for optimizing the joint's performance, contributing to its potential application in advanced orthotic and exoskeleton devices.}, language = {en} } @misc{ScheppachRauberStallhoferetal., author = {Scheppach, Markus and Rauber, David and Stallhofer, Johannes and Muzalyova, Anna and Otten, Vera and Manzeneder, Carolin and Schwamberger, Tanja and Wanzl, Julia and Schlottmann, Jakob and Tadic, Vidan and Probst, Andreas and Schnoy, Elisabeth and R{\"o}mmele, Christoph and Fleischmann, Carola and Meinikheim, Michael and Miller, Silvia and M{\"a}rkl, Bruno and Palm, Christoph and Messmann, Helmut and Ebigbo, Alanna}, title = {Performance comparison of a deep learning algorithm with endoscopists in the detection of duodenal villous atrophy (VA)}, series = {Endoscopy}, volume = {55}, journal = {Endoscopy}, number = {S02}, publisher = {Thieme}, doi = {10.1055/s-0043-1765421}, pages = {S165}, abstract = {Aims VA is an endoscopic finding of celiac disease (CD), which can easily be missed if pretest probability is low. In this study, we aimed to develop an artificial intelligence (AI) algorithm for the detection of villous atrophy on endoscopic images. Methods 858 images from 182 patients with VA and 846 images from 323 patients with normal duodenal mucosa were used for training and internal validation of an AI algorithm (ResNet18). A separate dataset was used for external validation, as well as determination of detection performance of experts, trainees and trainees with AI support. According to the AI consultation distribution, images were stratified into "easy" and "difficult". Results Internal validation showed 82\%, 85\% and 84\% for sensitivity, specificity and accuracy. External validation showed 90\%, 76\% and 84\%. The algorithm was significantly more sensitive and accurate than trainees, trainees with AI support and experts in endoscopy. AI support in trainees was associated with significantly improved performance. While all endoscopists showed significantly lower detection for "difficult" images, AI performance remained stable. Conclusions The algorithm outperformed trainees and experts in sensitivity and accuracy for VA detection. The significant improvement with AI support suggests a potential clinical benefit. Stable performance of the algorithm in "easy" and "difficult" test images may indicate an advantage in macroscopically challenging cases.}, language = {en} } @misc{ScheppachMendelProbstetal., author = {Scheppach, Markus W. and Mendel, Robert and Probst, Andreas and Rauber, David and Rueckert, Tobias and Meinikheim, Michael and Palm, Christoph and Messmann, Helmut and Ebigbo, Alanna}, title = {Real-time detection and delineation of tissue during third-space endoscopy using artificial intelligence (AI)}, series = {Endoscopy}, volume = {55}, journal = {Endoscopy}, number = {S02}, publisher = {Thieme}, doi = {10.1055/s-0043-1765128}, pages = {S53 -- S54}, abstract = {Aims AI has proven great potential in assisting endoscopists in diagnostics, however its role in therapeutic endoscopy remains unclear. Endoscopic submucosal dissection (ESD) is a technically demanding intervention with a slow learning curve and relevant risks like bleeding and perforation. Therefore, we aimed to develop an algorithm for the real-time detection and delineation of relevant structures during third-space endoscopy. Methods 5470 still images from 59 full length videos (47 ESD, 12 POEM) were annotated. 179681 additional unlabeled images were added to the training dataset. Consequently, a DeepLabv3+ neural network architecture was trained with the ECMT semi-supervised algorithm (under review elsewhere). Evaluation of vessel detection was performed on a dataset of 101 standardized video clips from 15 separate third-space endoscopy videos with 200 predefined blood vessels. Results Internal validation yielded an overall mean Dice score of 85\% (68\% for blood vessels, 86\% for submucosal layer, 88\% for muscle layer). On the video test data, the overall vessel detection rate (VDR) was 94\% (96\% for ESD, 74\% for POEM). The median overall vessel detection time (VDT) was 0.32 sec (0.3 sec for ESD, 0.62 sec for POEM). Conclusions Evaluation of the developed algorithm on a video test dataset showed high VDR and quick VDT, especially for ESD. Further research will focus on a possible clinical benefit of the AI application for VDR and VDT during third-space endoscopy.}, subject = {Speiser{\"o}hrenkrankheit}, language = {en} } @article{ScheppachRauberStallhoferetal., author = {Scheppach, Markus W. and Rauber, David and Stallhofer, Johannes and Muzalyova, Anna and Otten, Vera and Manzeneder, Carolin and Schwamberger, Tanja and Wanzl, Julia and Schlottmann, Jakob and Tadic, Vidan and Probst, Andreas and Schnoy, Elisabeth and R{\"o}mmele, Christoph and Fleischmann, Carola and Meinikheim, Michael and Miller, Silvia and M{\"a}rkl, Bruno and Stallmach, Andreas and Palm, Christoph and Messmann, Helmut and Ebigbo, Alanna}, title = {Detection of duodenal villous atrophy on endoscopic images using a deep learning algorithm}, series = {Gastrointestinal Endoscopy}, journal = {Gastrointestinal Endoscopy}, publisher = {Elsevier}, doi = {10.1016/j.gie.2023.01.006}, abstract = {Background and aims Celiac disease with its endoscopic manifestation of villous atrophy is underdiagnosed worldwide. The application of artificial intelligence (AI) for the macroscopic detection of villous atrophy at routine esophagogastroduodenoscopy may improve diagnostic performance. Methods A dataset of 858 endoscopic images of 182 patients with villous atrophy and 846 images from 323 patients with normal duodenal mucosa was collected and used to train a ResNet 18 deep learning model to detect villous atrophy. An external data set was used to test the algorithm, in addition to six fellows and four board certified gastroenterologists. Fellows could consult the AI algorithm's result during the test. From their consultation distribution, a stratification of test images into "easy" and "difficult" was performed and used for classified performance measurement. Results External validation of the AI algorithm yielded values of 90 \%, 76 \%, and 84 \% for sensitivity, specificity, and accuracy, respectively. Fellows scored values of 63 \%, 72 \% and 67 \%, while the corresponding values in experts were 72 \%, 69 \% and 71 \%, respectively. AI consultation significantly improved all trainee performance statistics. While fellows and experts showed significantly lower performance for "difficult" images, the performance of the AI algorithm was stable. Conclusion In this study, an AI algorithm outperformed endoscopy fellows and experts in the detection of villous atrophy on endoscopic still images. AI decision support significantly improved the performance of non-expert endoscopists. The stable performance on "difficult" images suggests a further positive add-on effect in challenging cases.}, language = {en} } @article{SommoggyGrepmeierApfelbacheretal., author = {Sommoggy, Julia and Grepmeier, Eva-Maria and Apfelbacher, Christian and Brandstetter, Susanne and Curbach, Janina}, title = {Pediatricians' experiences of managing outpatient care during the COVID-19 pandemic: A qualitative study in Germany}, series = {Frontiers in Pediatrics}, volume = {11}, journal = {Frontiers in Pediatrics}, publisher = {frontiers}, doi = {10.3389/fped.2023.1127238}, pages = {11}, abstract = {Background: Pediatricians are important sources of information for parents regarding their children's health. During the COVID-19 pandemic, pediatricians faced a variety of challenges regarding information uptake and transfer to patients, practice organization and consultations for families. This qualitative study aimed at shedding light on German pediatricians' experiences of providing outpatient care during the first year of the pandemic. Methods: We conducted 19 semi-structured, in-depth interviews with pediatricians in Germany from July 2020 to February 2021. All interviews were audio recorded, transcribed, pseudonymized, coded, and subjected to content analysis. Results: Pediatricians felt able to keep up to date regarding COVID-19 regulations. However, staying informed was time consuming and onerous. Informing the patients was perceived as strenuous, especially when political decisions had not been officially communicated to pediatricians or if the recommendations were not supported by the professional judgment of the interviewees. Some felt that they were not taken seriously or adequately involved in political decisions. Parents were reported to consider pediatric practices as sources of information also for non-medical inquiries. Answering these questions was time consuming for the practice personnel and involved non-billable hours. Practices had to adapt their set-up and organization immediately to the new circumstances of the pandemic, which proved costly and laborious as well. Some changes in the organization of routine care, such as the separation of appointments for patients with acute infection from preventive appointments, were perceived as positive and effective by some study participants. Telephone and online consultations were established at the beginning of the pandemic and considered helpful for some situations, whereas for others these methods were deemed insufficient (e.g. for examinations of sick children). All pediatricians reported reduced utilization mainly due to a decline in acute infections. However, preventive medical check-ups and immunization appointments were reported to be mostly attended. Conclusion: Positive experiences of reorganizing pediatric practice should be disseminated as "best practices" in order to improve future pediatric health services. Further research could show how some of these positive experiences in reorganizing care during the pandemic are to be maintained by pediatricians in the future.}, language = {en} } @inproceedings{StelzerTauwaldVielsmeieretal., author = {Stelzer, Vera and Tauwald, Sandra Melina and Vielsmeier, Veronika and Cieplik, Fabian and Kandulski, Arne and Schneider-Brachert, Wulf and W{\"u}nsch, Olaf and R{\"u}tten, Markus and Krenkel, Lars}, title = {Generation and Distribution of Surgical Smoke During High Frequency Electrocauterization}, series = {New Results in Numerical and Experimental Fluid Mechanics XIV. STAB/DGLR Symposium 2022}, booktitle = {New Results in Numerical and Experimental Fluid Mechanics XIV. STAB/DGLR Symposium 2022}, editor = {Dillman, Andreas and Heller, Gerd and Kraemer, Ewald and Wagner, Claus and Weiss, Julien}, publisher = {Springer Nature Switzerland AG}, address = {Cham, Switzerland}, isbn = {978-3-031-40481-8}, doi = {10.1007/978-3-031-40482-5_53}, pages = {559 -- 568}, abstract = {Surgical Smoke is generated during the cauterization of tissue with high-frequency (HF) devices and consists of 95\% water vapor and 5\% cellular debris. When the coagulation tweezers, which are supplied with HF voltage by the HF device, touch tissue, the electric circuit is closed, and smoke is generated by the heat. In-vivo investigations are performed during tracheotomies where surgical smoke is produced during coagulation of tissue. Furthermore, in-vitro parametric studies to investigate the particle number and size distribution and the spatial distribution of surgical smoke with laser light sheet technique are conducted. With higher power of the HF device, the particles generated are larger in size and the total number of particles generated is also higher. Adding artificial saliva to the tissue shows even higher particle counts. The study by laser light sheet also confirms this. The resulting characteristic size distribution, which may include viruses and bacterial components, confirms considering the risk arising from surgical smoke. Furthermore, the experiments will provide the database for further numerical investigations.}, language = {en} } @article{TauwaldMichelBrandtetal., author = {Tauwald, Sandra Melina and Michel, Johanna and Brandt, Marie and Vielsmeier, Veronika and Stemmer, Christian and Krenkel, Lars}, title = {Experimental studies and mathematical modeling of the viscoelastic rheology of tracheobronchial mucus from respiratory healthy patients}, series = {Multidisciplinary Respiratory Medicine}, volume = {18}, journal = {Multidisciplinary Respiratory Medicine}, number = {1}, publisher = {PAGEPress}, address = {Pavia, Italy}, issn = {2049-6958}, doi = {10.4081/mrm.2023.923}, pages = {12}, abstract = {BACKGROUND: Tracheobronchial mucus plays a crucial role in pulmonary function by providing protection against inhaled pathogens. Due to its composition of water, mucins, and other biomolecules, it has a complex viscoelastic rheological behavior. This interplay of both viscous and elastic properties has not been fully described yet. In this study, we characterize the rheology of human mucus using oscillatory and transient tests. Based on the transient tests, we describe the material behavior of mucus under stress and strain loading by mathematical models. METHODS: Mucus samples were collected from clinically used endotracheal tubes. For rheological characterization, oscillatory amplitude-sweep and frequency-sweep tests, and transient creep-recovery and stress-relaxation tests were performed. The results of the transient test were approximated using the Burgers model, the Weibull distribution, and the six-element Maxwell model. The three-dimensional microstructure of the tracheobronchial mucus was visualized using scanning electron microscope imaging. RESULTS: Amplitude-sweep tests showed storage moduli ranging from 0.1 Pa to 10000 Pa and a median critical strain of 4 \%. In frequency-sweep tests, storage and loss moduli increased with frequency, with the median of the storage modulus ranging from 10 Pa to 30 Pa, and the median of the loss modulus from 5 Pa to 14 Pa. The Burgers model approximates the viscoelastic behavior of tracheobronchial mucus during a constant load of stress appropriately (R2 of 0.99), and the Weibull distribution is suitable to predict the recovery of the sample after the removal of this stress (R2 of 0.99). The approximation of the stress-relaxation test data by a six-element Maxwell model shows a larger fit error (R2 of 0.91). CONCLUSIONS: This study provides a detailed description of all process steps of characterizing the rheology of tracheobronchial mucus, including sample collection, microstructure visualization, and rheological investigation. Based on this characterization, we provide mathematical models of the rheological behavior of tracheobronchial mucus. These can now be used to simulate mucus flow in the respiratory system through numerical approaches.}, language = {en} } @inproceedings{TauwaldQuadrioRuettenetal., author = {Tauwald, Sandra Melina and Quadrio, Maurizio and R{\"u}tten, Markus and Stemmer, Christian and Krenkel, Lars}, title = {High Spatial Resolution Tomo-PIV of the Trachea Focussing on the Physiological Breathing Cycle}, series = {New Results in Numerical and Experimental Fluid Mechanics XIV - Contributions to the 23nd STAB/DGLR Symposium}, booktitle = {New Results in Numerical and Experimental Fluid Mechanics XIV - Contributions to the 23nd STAB/DGLR Symposium}, publisher = {Springer}, abstract = {Investigations of complex patient-specific flow in the nasopharynx requires high resolution numerical calculations validated by reliable experiments. When building the validation base and the benchmark of computational fluid dynamics, an experimental setup of the nasal airways was developed. The applied optical measurement technique of tomo-PIV supplies information on the governing flow field in three dimensions. This paper presents tomo-PIV measurements of the highly complex patient-specific geometry of the human trachea. A computertomographic scan of a person's head builds the basis of the experimental silicone model of the nasal airways. An optimised approach for precise refractive index matching avoids optical distortions even in highly complex non-free-of-sight 3D geometries. A linear-motor-driven pump generates breathing scenarios, based on measured breathing cycles. Adjusting of the CCD cameras' double-frame-rate PIV-Δt enables the detailed analysis of flow structures during different cycle phases. Merging regions of interest enables high spatial resolution acquisition of the flow field.}, language = {en} } @article{WeberKrugHaugetal., author = {Weber, Karsten and Krug, Henriette and Haug, Sonja and K{\"u}hn, Andrea A. and Scharf, Anna}, title = {External Observations and Subjective Experiences: Metaphors Used by DBS Patients}, series = {AJOB Neuroscience}, volume = {14}, journal = {AJOB Neuroscience}, number = {3}, publisher = {Taylor\&Francis}, doi = {10.1080/21507740.2023.2246219}, pages = {323 -- 325}, language = {en} } @article{WeihererEigenbergerEggeretal., author = {Weiherer, Maximilian and Eigenberger, Andreas and Egger, Bernhard and Br{\´e}bant, Vanessa and Prantl, Lukas and Palm, Christoph}, title = {Learning the shape of female breasts: an open-access 3D statistical shape model of the female breast built from 110 breast scans}, series = {The Visual Computer}, volume = {39}, journal = {The Visual Computer}, number = {4}, publisher = {Springer Nature}, doi = {10.1007/s00371-022-02431-3}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-30506}, pages = {1597 -- 1616}, abstract = {We present the Regensburg Breast Shape Model (RBSM)—a 3D statistical shape model of the female breast built from 110 breast scans acquired in a standing position, and the first publicly available. Together with the model, a fully automated, pairwise surface registration pipeline used to establish dense correspondence among 3D breast scans is introduced. Our method is computationally efficient and requires only four landmarks to guide the registration process. A major challenge when modeling female breasts from surface-only 3D breast scans is the non-separability of breast and thorax. In order to weaken the strong coupling between breast and surrounding areas, we propose to minimize the variance outside the breast region as much as possible. To achieve this goal, a novel concept called breast probability masks (BPMs) is introduced. A BPM assigns probabilities to each point of a 3D breast scan, telling how likely it is that a particular point belongs to the breast area. During registration, we use BPMs to align the template to the target as accurately as possible inside the breast region and only roughly outside. This simple yet effective strategy significantly reduces the unwanted variance outside the breast region, leading to better statistical shape models in which breast shapes are quite well decoupled from the thorax. The RBSM is thus able to produce a variety of different breast shapes as independently as possible from the shape of the thorax. Our systematic experimental evaluation reveals a generalization ability of 0.17 mm and a specificity of 2.8 mm. To underline the expressiveness of the proposed model, we finally demonstrate in two showcase applications how the RBSM can be used for surgical outcome simulation and the prediction of a missing breast from the remaining one. Our model is available at https://www.rbsm.re-mic.de/.}, language = {en} } @article{WinklerWestner, author = {Winkler, Fabian and Westner, Markus}, title = {A Systematic Literature Review of DevOps Success Factors and Adoption Models}, series = {SOICT '23: Proceedings of the 12th International Symposium on Information and Communication Technology. Ho Chi Minh City, Vietnam, 7-8 December 2023}, journal = {SOICT '23: Proceedings of the 12th International Symposium on Information and Communication Technology. Ho Chi Minh City, Vietnam, 7-8 December 2023}, publisher = {ACM}, isbn = {979-8-4007-0891-6}, doi = {10.1145/3628797.3628883}, pages = {525 -- 532}, abstract = {This paper investigates DevOps adoption, emphasizing its cultural dimensions in the context of the information systems domain. Utilizing a robust systematic literature review methodology, we discerned nine salient success factors and delineated three stage models instrumental for a smooth transition into DevOps-centric projects. Despite the increasing breadth of research in the DevOps area, the absence of a consolidated definition remains a challenge, underscoring the importance of a unified interpretative framework. This research notably extends the current body of knowledge by focusing on the cultural dynamics of DevOps adoption. As a result, it offers a refined lens through which both practitioners involved in the adoption process and academic researchers can comprehend the nuances and implications of cultural shifts in the evolving landscape of DevOps within information systems.}, language = {en} }