@article{ZellnerHierlMuelleretal., author = {Zellner, Johannes and Hierl, Katja and Mueller, Michael and Pfeifer, Christian and Berner, Arne and Dienstknecht, Thomas and Krutsch, Werner and Geis, Sebastian and Gehmert, Sebastian and Kujat, Richard and Dendorfer, Sebastian and Prantl, Lukas and Nerlich, Michael and Angele, Peter}, title = {Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone}, series = {Journal of Biomedical Materials Research Part B Applied Biomaterials}, volume = {101}, journal = {Journal of Biomedical Materials Research Part B Applied Biomaterials}, number = {7}, editor = {Gilbert, Jeremy}, doi = {10.1002/jbm.b.32922}, pages = {1133 -- 1142}, abstract = {Meniscal tears in the avascular zone have a poor self-healing potential, however partial meniscectomy predisposes the knee for early osteoarthritis. Tissue engineering with mesenchymal stem cells and a hyaluronan collagen based scaffold is a promising approach to repair meniscal tears in the avascular zone. 4 mm longitudinal meniscal tears in the avascular zone of lateral menisci of New Zealand White Rabbits were performed. The defect was left empty, sutured with a 5-0 suture or filled with a hyaluronan/collagen composite matrix without cells, with platelet rich plasma or with autologous mesenchymal stem cells. Matrices with stem cells were in part precultured in chondrogenic medium for 14 days prior to the implantation. Menisci were harvested at 6 and 12 weeks. The developed repair tissue was analyzed macroscopically, histologically and biomechanically. Untreated defects, defects treated with suture alone, with cell-free or with platelet rich plasma seeded implants showed a muted fibrous healing response. The implantation of stem cell-matrix constructs initiated fibrocartilage-like repair tissue, with better integration and biomechanical properties in the precultured stem cell-matrix group. A hyaluronan-collagen based composite scaffold seeded with mesenchymal stem cells is more effective in the repair avascular meniscal tear with stable meniscus-like tissue and to restore the native meniscus.}, subject = {Meniskusschaden}, language = {en} } @misc{OPUS4-330, title = {Medicine Meets Engineering: Proceedings of the 2nd Conference on Applied Biomechanics Regensburg}, editor = {Hammer, Joachim and Nerlich, Michael and Dendorfer, Sebastian}, edition = {1. Aufl.}, publisher = {IOS Press, US}, isbn = {978-1586038281}, pages = {X, 247}, abstract = {Biomedical Engineering is defined as the science that integrates medical and engineering sciences to improve diagnosis and treatment of patients. Only by this integration progress can be achieved. Both medical and engineering sciences comprise a huge diversity in topics, so it is imaginable that Biomedical Engineering, combining these two science areas, is even more huge. Thanks to this megadisciplinary approach many breakthroughs can be achieved. More and more research groups realize this and start new research projects, which results in a rapid increase in knowledge in Biomedical Engineering. This will only benefit the main goal of Biomedical Engineering; improving diagnosis and treatment of patients when it is spread and applied. The 2nd Regensburg Applied Biomechanics conference is special in that it realized both the distribution of new knowledge and the essential integration of medical and engineering specialists. The conference dealt with the latest results in applied biomechanics, ranging from fundamental bone strength properties via bone remodeling phenomena to new implants that replace lost human functions. Also new research areas like robot surgery and tissue engineering were discussed.}, subject = {Biomechanik}, language = {en} } @misc{OPUS4-14, title = {Gute Technik f{\"u}r ein gutes Leben im Alter?}, editor = {Frommeld, Debora and Scorna, Ulrike and Haug, Sonja and Weber, Karsten}, publisher = {transcript Verlag}, address = {Bielefeld}, isbn = {978-3-8376-5469-1}, doi = {10.14361/9783839454695}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-149}, pages = {372}, abstract = {L{\"a}ngst gibt es altersgerechte digitale Assistenzsysteme. Doch sind Umfang und Geschwindigkeit ihrer Verbreitung sowohl in Pflegeeinrichtungen als auch in privaten Haushalten weitgehend unbekannt. Informationen zu tats{\"a}chlich eingesetzten Systemen, realisierten Ums{\"a}tzen und Marktvolumen sind kaum zu finden. Obwohl es viele Vermutungen hinsichtlich der Hindernisse bei der Einf{\"u}hrung altersgerechter Assistenzsysteme gibt, sind auch hier verl{\"a}ssliche Aussagen rar. Die Beitr{\"a}ge des Bandes liefern auf Basis empirischer Untersuchungen und theoretischer {\"U}berlegungen Antworten und zeigen auf, wie vielgestaltig die Faktoren sind, die die Diffusion altersgerechter Assistenzsysteme hemmen oder f{\"o}rdern.}, subject = {Alter}, language = {de} }