@article{ZacherlWopperSchwanzeretal., author = {Zacherl, Florian and Wopper, Christoph and Schwanzer, Peter and Rabl, Hans-Peter}, title = {Potential of the Synthetic Fuel Oxymethylene Ether (OME) for the Usage in a Single-Cylinder Non-Road Diesel Engine: Thermodynamics and Emissions}, series = {Energies}, volume = {15}, journal = {Energies}, number = {21}, publisher = {MDPI}, doi = {10.3390/en15217932}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-55350}, pages = {1 -- 26}, abstract = {Non-road sectors, such as agriculture and construction machinery, require high energy densities and flexibility in use, which is why diesel engines are mainly used. The use of climate-neutral fuels, produced from renewable energies, such as Oxymethylene Ether (OME) as a diesel substitute, can significantly reduce CO2 and pollutant emissions in these sectors. In addition to CO2 neutrality, OME also offers improved combustion characteristics compared to diesel fuel, eliminating the soot-NOx trade-off and thus enabling new opportunities in engine design and calibration. In this paper, the combustion of pure OME on a close-to-production, single-cylinder non-road diesel engine with a pump-line-nozzle injection system is analyzed. A variation of the center of combustion at constant power output was performed for diesel and OME at different operating points. Two injectors were investigated with OME. A study on ignition delay and a detailed thermodynamic analysis was carried out. In addition, the exhaust emissions CO, NOx, VOC, as well as particulate-matter, -number and -size distributions were measured. With OME, a significantly shorter ignition delay as well as a shortened combustion duration could be observed, despite a longer injection duration. In addition, the maximum injection pressure increases. VOC and CO emissions are reduced. Particulate matter was reduced by more than 99\% and particle number (>10 nm) was reduced by multiple orders of magnitude. The median of the particle size distribution shifts from 60 to 85 nm (diesel) into a diameter range of sub 23 nm (OME). A significant reduction of NOx emissions with OME enables new degrees of freedom in engine calibration and an efficiency advantage without hardware adaption.}, language = {en} } @article{StichelLaumerBaumuelleretal., author = {Stichel, Thomas and Laumer, Tobias and Baum{\"u}ller, Tobias and Amend, Philipp and Roth, Stephan}, title = {Powder Layer Preparation Using Vibration-controlled Capillary Steel Nozzles for Additive Manufacturing}, series = {Physics Procedia}, volume = {56}, journal = {Physics Procedia}, publisher = {Elsevier}, issn = {1875-3892}, doi = {10.1016/j.phpro.2014.08.158}, pages = {157 -- 166}, abstract = {In this report, the dry delivery of polyamide 12 powders by vibrating capillary steel nozzles is investigated and discussed regarding its potential for powder layer preparation in Laser Beam Melting. Therefore, a setup including a steel nozzle assembled on a piezoelectric actuator is presented, which enables the precise control over very small powder quantities by vibration excitation. An analysis reveals that the mass flow through the nozzle can be adjusted by the vibration modes in a certain range depending on the nozzle's specifications, whereas the vibration modes themselves show a complicated behaviour. Using a positioning system in combination with the vibrating nozzle, single-layer patterns consisting of polyamide 12 are produced and characterized regarding surface homogeneity and selectivity using a laser stripe sensor.}, language = {en} } @misc{SchliermannMarkovGlazer, author = {Schliermann, Rainer and Markov-Glazer, Alon}, title = {Zusammenh{\"a}nge zwischen habitueller Stressbew{\"a}ltigung und Burnout bzw. habituellem Wohlbefinden bei MannschaftssporttrainerInnen}, series = {Gelingende Entwicklung im Lebenslauf : Abstractband der 49. Jahrestagung der Arbeitsgemeinschaft f{\"u}r Sportpsychologie (asp) vom 25. bis 27. Mai 2017 in Bern}, journal = {Gelingende Entwicklung im Lebenslauf : Abstractband der 49. Jahrestagung der Arbeitsgemeinschaft f{\"u}r Sportpsychologie (asp) vom 25. bis 27. Mai 2017 in Bern}, editor = {Zuber, Claudia and Schmidt, Mirko and Wegner, Mirko and Conzelmann, Achim and Schmid, Julia}, publisher = {Universit{\"a}t Bern Bern Open Publishing}, address = {Bern}, isbn = {978-3-906813-42-4}, doi = {10.7892/boris.99636}, pages = {102 -- 102}, language = {de} } @misc{SchliermannHeydenreichBungteretal., author = {Schliermann, Rainer and Heydenreich, Patrick and Bungter, Tanja and Anneken, Volker}, title = {Analysis of motivational factors and physical activity and sport of people with visual impairments in vocational promotion centers [Abstract]}, series = {Proceedings 14th European Congress of Sport Psychology : Sport Psychology - Theories and Applications for Performance, Health and Humanity ; 14-19 July 2015, Bern, Switzerland}, journal = {Proceedings 14th European Congress of Sport Psychology : Sport Psychology - Theories and Applications for Performance, Health and Humanity ; 14-19 July 2015, Bern, Switzerland}, editor = {Schmid, Oliver and Seiler, Roland}, publisher = {University of Bern, Institut of Sport Science}, address = {Bern}, isbn = {978-3-033-05129-4}, pages = {230}, language = {en} } @misc{EgerBergstraesserDendorferetal., author = {Eger, Maximilian and Bergstraesser, Marcel and Dendorfer, Sebastian and Lenich, Andreas and Pfeifer, Christian}, title = {Influence of radial head prosthetic design on humeroradial stability: Validation of a test rig therefore}, series = {DOKU2022, Deutscher Kongress f{\"u}r Orthop{\"a}die und Unfallchirurgie, 25.-28. 10.2022, Berlin}, journal = {DOKU2022, Deutscher Kongress f{\"u}r Orthop{\"a}die und Unfallchirurgie, 25.-28. 10.2022, Berlin}, publisher = {German Medical Science GMS Publishing House}, address = {D{\"u}sseldorf}, doi = {10.3205/22dkou611}, url = {http://nbn-resolving.de/urn:nbn:de:0183-22dkou6115}, language = {en} } @article{Herrmann, author = {Herrmann, Frank}, title = {Using Optimization Models for Scheduling in Enterprise Resource Planning Systems}, series = {Systems}, volume = {4}, journal = {Systems}, number = {1}, doi = {10.3390/systems4010015}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-2036}, pages = {13}, abstract = {Companies often use specially-designed production systems and change them from time to time. They produce small batches in order to satisfy specific demands with the least tardiness. This imposes high demands on high-performance scheduling algorithms which can be rapidly adapted to changes in the production system. As a solution, this paper proposes a generic approach: solutions were obtained using a widely-used commercially-available tool for solving linear optimization models, which is available in an Enterprise Resource Planning System (in the SAP system for example) or can be connected to it. In a real-world application of a flow shop with special restrictions this approach is successfully used on a standard personal computer. Thus, the main implication is that optimal scheduling with a commercially-available tool, incorporated in an Enterprise Resource Planning System, may be the best approach.}, subject = {Enterprise-Resource-Planning}, language = {en} } @misc{OPUS4-641, title = {Regensburger Applied Research Conference 2020 (RARC 2020), July 31st}, editor = {Mottok, J{\"u}rgen and Ehrlich, Ingo and Haumer, Anton}, address = {Regensburg}, organization = {RARC <2020, Regensburg>}, doi = {10.35096/othr/pub-641}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-6417}, pages = {184}, abstract = {The Applied Research Conference which is held every year at another University of Applied Sciences in Bavaria is the main event for all students in the Master of Applied Research program. They come together to present their work in oral presentations and full papers, which are published in the proceedings, as well as poster presentations of the students after their 1st semester. For sure it is interesting for Professors and interested people to see the results of upcoming scientists and researchers. Due to the Corona pandemic, this year it is not possible to organize the conference as usual in presence. We have to refrain from face-to-face discussions, having together a cup of coffee. We as Professors at the OTH Regensburg wanted to give our students the chance to finish this semester successfully - despite all limitations due to the pandemic situation. Therefore we decided to organize the RARC 2020 - Regensburg Applied Research Conference 2020 - for the Master of Applied Research students of OTH Regensburg as an online conference. However, for a Technical University the situation is rather a challenge than a problem. Using a variety of online tools for teaching during this semester, we have enough experience to find a setup for RARC2020. We received 28 submissions for full papers, which were peer reviewed and 26 of them were accepted - you will find them in this proceedings, and they will be presented orally on July 31st, 2020. Additionally, there are 22 posters which will be presented on the same day. During the Plenary Opening Session, after a welcome by our President Prof. Dr. Wolfgang Baier we will have 3 Keynote speakers: Prof. Dr. phil. habil. Karsten Weber: Erkenntnistheorie f{\"u}r Ingenieure Prof. em. Georg Scharfenberg: 11 Years Master of Applied Research Alumnis Veronika Fetzer: Entrepreneurship}, language = {en} } @misc{NeidhartCaicedoBergforth, author = {Neidhart, Thomas and Caicedo, Jos{\´e} and Bergforth, Axel}, title = {Baugrundverbesserung mittels Kunstharzs{\"a}ulen zur Nachgr{\"u}ndung sich setzender Geb{\"a}ude}, series = {Vortr{\"a}ge der 38. Baugrundtagung, 25. bis 27. September 2024, Bremen}, journal = {Vortr{\"a}ge der 38. Baugrundtagung, 25. bis 27. September 2024, Bremen}, publisher = {Aktiv Druck \& Verlag GmbH}, address = {Ebelsbach}, organization = {Deutsche Gesellschaft f{\"u}r Geotechnik e.V. (DGGT)}, isbn = {978-3-932653-57-5}, doi = {10.35096/othr/pub-7765}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-77657}, pages = {89 -- 94}, abstract = {Im Beitrag werden neben der Herstellung und Wirkungsweise auch die Ergebnisse von Versuchen im Maßstab 1:1 an neuartigen Kunstharzs{\"a}ulen vorgestellt, die als ein minimalinvasives Injektionsverfahren speziell zur Nachgr{\"u}ndung und Stabilisierung bestehender Bauwerke auf setzungsempfindlichen Untergrund mit geringer Tragf{\"a}higkeit entwickelt wurde.}, language = {de} } @article{HaugSchnellScharfetal., author = {Haug, Sonja and Schnell, Rainer and Scharf, Anna and Altenbuchner, Amelie and Weber, Karsten}, title = {Bereitschaft zur Impfung mit einem COVID-19-Vakzin - Risikoeinsch{\"a}tzung, Impferfahrungen und Einstellung zu Behandlungsverfahren}, series = {Pr{\"a}vention und Gesundheitsf{\"o}rderung}, volume = {17}, journal = {Pr{\"a}vention und Gesundheitsf{\"o}rderung}, number = {4}, publisher = {Springer Nature}, doi = {10.1007/s11553-021-00908-y}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-154}, pages = {537 -- 544}, abstract = {Hintergrund Impfungen stellen eine bedeutende Pr{\"a}ventionsmaßnahme dar. Grundlegend f{\"u}r die Eind{\"a}mmung der Coronapandemie mittels Durchimpfung der Gesellschaft ist eine ausgepr{\"a}gte Impfbereitschaft. Ziel der Arbeit Die Impfbereitschaft mit einem COVID‑19-Vakzin (Impfstoff gegen das Coronavirus) und deren Einflussfaktoren werden anhand einer Zufallsstichprobe der Gesamtbev{\"o}lkerung in Deutschland untersucht. Material und Methoden Die Studie basiert auf einer telefonischen Zufallsstichprobe und ber{\"u}cksichtigt {\"a}ltere und vorerkrankte Personen ihrem Bev{\"o}lkerungsanteil entsprechend. Die Ein-Themen-Bev{\"o}lkerungsbefragung zur Impfbereitschaft (n = 2014) wurde im November/Dezember 2020 durchgef{\"u}hrt. Ergebnisse Die Impfbereitschaft in der Stichprobe liegt bei rund 67 \%. Vorerfahrungen mit Impfungen moderieren die Impfbereitschaft. Sie steigt bei Zugeh{\"o}rigkeit zu einer Risikogruppe. Der Glaube an die Wirksamkeit alternativer Heilmethoden und Bef{\"u}rwortung alternativer Behandlungsverfahren geht mit geringerer Impfbereitschaft einher. {\"A}ltere Menschen sind impfbereiter, kovariierend mit ihrer Einsch{\"a}tzung h{\"o}herer Gef{\"a}hrdung bei Erkrankung. Ebenso ist die Ablehnung einer Impfung mit der {\"U}bersch{\"a}tzung von Nebenwirkungen assoziiert. Schlussfolgerung Die Impfbereitschaft h{\"a}ngt mit Impferfahrungen und Einstellungen zu Gesundheitsbehandlungsverfahren allgemein zusammen. Die {\"U}bersch{\"a}tzung der H{\"a}ufigkeit ernsthafter Nebenwirkungen bei Impfungen weist auf weit verbreitete Fehlinformationen hin.}, language = {de} } @article{Herrmann, author = {Herrmann, Frank}, title = {The Smart Factory and Its Risks}, series = {Systems}, volume = {6}, journal = {Systems}, number = {4}, publisher = {MDPI}, doi = {10.3390/systems6040038}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-1793}, pages = {1 -- 15}, abstract = {In this paper, the risks of a Smart Factory are to be examined and structured in order to be able to evaluate the status of the Smart Factory. This thesis thus serves as an overview of the technical components of a Smart Factory and the associated risks. The study takes a holistic view of the smart factory. The results show that the greatest need for action lies in the technological field. Thus, the topics of standardization, information security, availability of IT infrastructure, availability of fast internet and complex systems were prioritized. The organizational and financial risks, which also play an important role in a Smart Factory transformation, are addressed.}, subject = {Smart Factory}, language = {en} } @article{ThielKratzerGrimmetal., author = {Thiel, Charlotte and Kratzer, Johanna and Grimm, Benedikt and Kr{\"a}nkel, Thomas and Gehlen, Christoph}, title = {Effect of Internal Moisture and Outer Relative Humidity on Concrete Carbonation}, series = {CivilEng}, volume = {4}, journal = {CivilEng}, number = {3}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/civileng3040058}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-56091}, pages = {1039 -- 1052}, abstract = {With steadily rising CO2 concentrations in the ambient air and fast-changing concretecompositions with reduced clinker contents, the availability of reliable and accelerated concrete car-bonation tests is of crucial importance to design durable structures. This paper focuses on the effectsof moisture under accelerated conditions and the effects of different CO2 exposure conditions. Mor-tar prisms incorporating three different cement types were cured and stored at either 50\% or 65\%relative humidity (RH). Afterwards, the prisms were carbonated at different ambient humidities(50, 57 and 65\%), different CO2 concentrations (0.04, 1 and 3 vol.\%) and complemented by a seriesof tests at increased gas pressure (2 barg). High-resolution test methods were used to explain theunderlying carbonation mechanisms. The results show that pre-conditioning for two weeks—ascurrently suggested by the European Standard—seems to be too short because the initial inner mois-ture content severely affects the carbonation rate. Relative humidity during carbonation of 57\% ledto higher carbonation rates compared to 50\% and 65\%. In addition, climate data needs to be period-ically (preferably permanently) recorded in research experiments and in laboratory testing to ensurefair interpretation of experimental results.}, language = {en} } @article{KaessStrahringerWestner, author = {K{\"a}ss, Sebastian and Strahringer, Susanne and Westner, Markus}, title = {Practitioners' Perceptions on the Adoption of Low Code Development Platforms}, series = {IEEE Access}, journal = {IEEE Access}, publisher = {IEEE}, issn = {2169-3536}, doi = {10.1109/ACCESS.2023.3258539}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-59170}, pages = {30}, abstract = {Organizations are under increasing pressure to develop applications within budget and time at high quality. Therefore, multiple organizations adopt Low Code Development Platforms (LCDP) to develop applications faster and cheaper compared to traditional application development. However, current research on LCDP adoption lacks empirical grounding as well as a deeper understanding of the importance of adoption drivers and inhibitors. We conducted semi-structured interviews and a Delphi study with seventeen experts to address these gaps. As a result, we identified twelve drivers and nineteen inhibitors for adopting LCDPs. We show that the experts have a consensus on the most and the least important drivers and inhibitors for LCDP adoption. Yet, the ranking of the drivers and inhibitors between the most and least important is highly context dependent. For some drivers and inhibitors, the experts' ranking is similar to academic literature, whereas, for others, it differs. In conclusion, the study at hand empirically validates drivers and inhibitors for LCDP adoption, adds six new drivers and six new inhibitors to the body of knowledge, and analyses the importance of these factors.}, language = {en} } @article{DotterHaugWeberetal., author = {Dotter, Caroline and Haug, Sonja and Weber, Karsten and Schnell, Rainer and Scharf, Anna and Altenburcher, Amelie}, title = {Analyzing factors determining vaccination willingness against COVID-19 in Germany 2020}, series = {Vaccine: X}, volume = {14}, journal = {Vaccine: X}, publisher = {Elsevier}, doi = {10.1016/j.jvacx.2023.100342}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-62900}, pages = {6}, abstract = {The study is based on a German single-topic population survey on vaccination willingness against COVID-19 (VWC) by the authors (2020, n = 2014). The single-topic survey allowed us to test several competing explanations for VWC, as discussed in the literature. The VWC in the sample was 67.3\%. Logistic regression was used to identify factors affecting VWC. Being at high risk from COVID-19 and having received flu vaccination have a positive impact on VWC. Perceived VWC of friends has a strong positive effect on respondents' VWC. Bivariate relationships of gender, age, and level of education with VWC were no longer significant in a multivariate analysis. Trust in alternative medicine and belief in conspiracy theories have a negative effect on VWC.}, language = {en} } @misc{OPUS4-266, title = {Angewandte Forschung in der Wirtschaftsinformatik: Prozesse, Technologien, Anwendungen, Systeme und Management}, editor = {Barton, Thomas and Erdlenbruch, Burkhard and Herrmann, Frank and M{\"u}ller, Christian}, publisher = {Verlag News \& Media}, address = {Berlin}, doi = {10.15771/978-3-936527-38-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-2660}, abstract = {Die Wirtschaftsinformatik, die von den Mitgliedern des Arbeitskreises Wirtschaftsinformatik an Fachhochschulen im deutschsprachigen Raum vertreten wird, basiert auf drei S{\"a}ulen, n{\"a}mlich der Informatik, der Betriebswirtschaft und der Wirtschaftsinformatik selbst, worunter Systeme zur Steuerung betriebswirtschaftlicher Prozesse verstanden werden - dies entspricht auch der Empfehlung der Gesellschaft f{\"u}r Informatik und liegt den Evaluierungen der Akkreditierungsverfahren zugrunde. Diese S{\"a}ulen inkludieren fast zwangsl{\"a}ufig eine substantielle Heterogenit{\"a}t an Projekten mit der industriellen Praxis wie auch in der Forschung. Die Einreichungen zur Tagung best{\"a}tigten diese Erwartung. Beispiele sind mehrere Arbeiten zur „Datenbank SAP HANA", zu (allgemeinen) Entwicklungsthemen wie zum „Datenbank-Join" oder der „Internetsuche" und zu IT-Systemen wie beispielsweise „F{\"u}nf Jahre produktiver Einsatz eines man- dantenf{\"a}higen Data-Warehouse-Systems". Andere Arbeiten befassen sich mit eher technischen Themen wie mobilen (End-)Ger{\"a}ten wie „Plattformunabh{\"a}ngiges, mobiles, integriertes Hochwassermeldesystem f{\"u}r Mittelhessen" oder „Electronic vs. Mobile Banking" und der Nutzung von Cloud wie beim „Aufbau einer ‚Private Cloud' mit OpenStack". Mehrere Arbeiten befassen sich mit der IT-Unterst{\"u}tzung logistischer Fragestellungen wie die „Ermittlung von prognoserelevanten Absatzzahlen in der Praxis eines großen Lebensmittelkonzerns", mit Prozessen wie „Business Process Excellence und der Zusammenhang mit dem Unternehmenserfolg" sowie mit Management wie „Faktoren f{\"u}r nachhaltigen Unternehmenserfolg".}, subject = {Wirtschaftsinformatik}, language = {de} } @misc{OPUS4-244, title = {Logistische Anwendungen in der Wirtschaftsinformatik}, editor = {Barton, Thomas and Erdlenbruch, Burkhard and Herrmann, Frank and M{\"u}ller, Christian}, publisher = {Verlag News \& Media}, address = {Berlin}, organization = {Arbeitskreis Wirtschaftsinformatik an Fachhochschulen (AKWI)}, isbn = {978-3-936527-24-7}, doi = {10.15771/978-3-936527-24-7}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-2448}, abstract = {Seit jeher zeichnet sich die Wirtschaftsinformatik durch eine große thematische Breite aus, da sie ihre Aufgabe in der Entwicklung und Anwendung von Theorien, Konzepten, Modellen, Methoden und Werkzeugen f{\"u}r die Analyse, Gestaltung und Nutzung von Informationssystemen sieht. Dabei greift die Wirtschaftsinformatik auch auf Ans{\"a}tze der Betriebswirtschaftslehre sowie der Informatik zur{\"u}ck, die sie erweitert, integriert und um eigene spezifische Ans{\"a}tze erg{\"a}nzt. Es freut uns mit diesem Tagungsband Forschungs- und Entwicklungsarbeiten vorstellen zu d{\"u}rfen, die belegen, dass und wie an Fachhochschulen an dieser Aufgabe der Wirtschaftsinformatik im Rahmen der Logistik gearbeitet wird. Eine grundlegende Aufgabe von Wirtschaftsinformatikern ist die Integration heterogener Softwaresysteme zur Unterst{\"u}tzung von Unternehmensprozessen. Ausgehend von einer Anforderungsspezifikation werden f{\"u}r Unternehmen geeignete Softwaresysteme beschafft. In dem Beitrag „Verkn{\"u}pfung von Softwarel{\"o}sungen in einem IT-Logistiknetzwerk" wird quasi der umgekehrten Aufgabestellung nachgegangen, wie n{\"a}mlich heterogene Systeme so verkn{\"u}pft werden k{\"o}nnen, dass mit ihnen gemeinsam Unternehmensprozesse unterst{\"u}tzt werden k{\"o}nnen. W{\"a}hrend in diesem Beitrag die technische Verkn{\"u}pfung {\"u}ber eine dedizierte Architektur nicht im Detail vorgestellt wird, ist sie Gegenstand in dem Beitrag „Ein Informationssystem f{\"u}r das RFID-gest{\"u}tzte Beh{\"a}ltermanagement". Konkret handelt es sich um den Architekturstil REST (Representational State Transfer). Prozessverbesserungen lassen sich durch die Nutzung von Simulations- und Optimierungsmodellen erreichen. Typischerweise werden diese als „stand-alone"- Systeme betrieben, und sie erhalten ihre Daten von einem ERP-, PPS- oder allgemein von einem „Decision Support"-System. Dies erfordert eine Schnittstelle. Einen Vorschlag enth{\"a}lt der Beitrag „Konzeption einer Datenschnittstelle f{\"u}r Klassen von Simulations- und Optimierungsmodellen". Beispiele f{\"u}r die L{\"o}sung von Optimierungsproblemen werden in den Beitr{\"a}gen „Einfuhrzollmanagement - neue Chancen und Herausforderungen f{\"u}r die Standortoptimierung" und „Gestaltung von Logistiknetzen mit der EDA-Heuristik" beschrieben. Kern des ersten Beitrags ist die Formulierung eines geeigneten Optimierungsmodells, welches mit einem rechnergest{\"u}tzter Optimierungssystem gel{\"o}st wird. Im zweiten Beitrag wird die L{\"o}sung von einem sehr anspruchsvollen Optimierungsproblem durch ein heuristisches Verfahren angen{\"a}hert. Ein wichtiges Themengebiet der Wirtschaftsinformatik ist die Verbindung von Gesch{\"a}ftsprozessmodellierung und Softwareentwicklung. Einen Ansatz dazu beschreibt der Beitrag „Modellgetriebene Softwareentwicklung auf der Grundlage realer Gesch{\"a}ftsprozessoptimierung". Generell zunehmende Bedeutung in der Wirtschaftsinformatik hat das Wissensmanagement. In dem Beitrag „Konzept, Methoden und offene Fragen f{\"u}r einen Web-Service zur Analyse des Wissensmanagement-Reifegrades in Logistikunternehmen" wird die Relevanz dieses Themas und sein Umsetzungsgrad bei Logistikunternehmen aus verschiedenen L{\"a}ndern erl{\"a}utert, und es wird ein Rahmenkonzept f{\"u}r ein Wissensmanagement in Logistikunternehmen in Form einer webbasierten Infrastruktur dargestellt.}, subject = {Informationstechnik}, language = {de} } @misc{OPUS4-222, title = {Management und IT. Tagungsband zur AKWI-Fachtagung vom 16. bis 18.09.2012 an der Hochschule Pforzheim (FH)}, editor = {Barton, Thomas and Erdlenbruch, Burkhard and Herrmann, Frank and M{\"u}ller, Christian and Schuler, Joachim}, publisher = {Verlag News \& Media}, address = {Berlin}, organization = {Arbeitskreis Wirtschaftsinformatik an Fachhochschulen (AKWI)}, isbn = {978-3-936527-30-8}, doi = {10.15771/978-3-936527-30-8}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-2225}, abstract = {Wirtschaftsinformatik befasst sich mit allen Themen, die an der Schnittstelle zwischen Informatik und Betriebswirtschaft anzutreffen sind. So geht es in der Wirtschaftsinformatik - basierend auf dem Wissen und dem Verstehen der betriebswirtschaftlichen Konzepte und Anwendungen - insbesondere darum, IT-Systeme f{\"u}r die betriebliche Praxis zu entwickeln, einzuf{\"u}hren und zu betreiben. Eine wissenschaftliche Fachtagung, die den Titel „Management und IT" tr{\"a}gt, setzt an einer solchen Beschreibung der Wirtschaftsinformatik an.}, subject = {Wirtschaftsinformatik}, language = {de} } @misc{OPUS4-216, title = {Herausforderungen an die Wirtschaftsinformatik: Integration und Konnexion}, editor = {Barton, Thomas and Erdlenbruch, Burkhard and Guckert, Michael and Herrmann, Frank and M{\"u}ller, Christian}, publisher = {Verlag News \& Media}, address = {Berlin}, isbn = {978-3-936527-36-0}, doi = {10.15771/978-3-936527-36-0}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-2165}, abstract = {Das aufgerufene Thema „Herausforderungen an die Wirtschaftsinformatik: Integration und Konnexion" provozierte Beitr{\"a}ge, die thematisch ein sehr breites Spektrum abdecken. Neben theoretischen Betrachtungen und Definitionen des sicher noch nicht final gepr{\"a}gten Begriffs der Konnexion gab es auch sehr praktische Beitr{\"a}ge wie die Darstellung von konkreten prototypischen Entwicklungsvorhaben. Auch das ist ein Indiz f{\"u}r die lebendige Landschaft der Wirtschaftsinformatik an den deutschsprachigen Hochschulen f{\"u}r Angewandte Wissenschaften.}, subject = {Wirtschaftsinformatik}, language = {de} } @misc{OPUS4-233, title = {Betriebliche Anwendungssysteme}, editor = {Barton, Thomas and Erdlenbruch, Burkhard and Herrmann, Frank and M{\"u}ller, Christian}, publisher = {Verlag News \& Media}, address = {Berlin}, organization = {Arbeitskreis Wirtschaftsinformatik an Fachhochschulen (AKWI)}, isbn = {978-3-936527-26-1}, doi = {10.15771/978-3-936527-26-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-2333}, abstract = {In heutigen Unternehmen werden im Kern alle Aufgaben durch Anwendungssysteme direkt oder durch diese unterst{\"u}tzt erledigt. Folglich beschreiben betriebliche Anwendungssysteme heute im Grunde, welche Aufgaben in Unternehmen {\"u}berhaupt zu l{\"o}sen sind und welche davon automatisiert und somit durch Software erledigt bzw. unterst{\"u}tzt werden k{\"o}nnen. Die Arbeit an und mit Betrieblichen Anwendungssystemen ist gekennzeichnet durch eine große thematische Breite und demonstriert die f{\"u}r die Wirtschaftsinformatik charakteristische Nutzung von Ans{\"a}tzen der Betriebswirtschaftslehre sowie der Informatik. Deswegen erwarteten die Herausgeber sehr heterogene Themenvorschl{\"a}ge und sie wurden nicht entt{\"a}uscht. Die letztlich ausgew{\"a}hlten Themen stellen aktuelle Entwicklungs- und anwendungsorientierte Forschungsprojekte zu Gesch{\"a}ftsprozessen, Standardsoftware, Softwareentwicklung und Betrieb von Anwendungssystemen vor. Dadurch beschreiben sie das heute existierende Berufsbild von Wirtschaftsinformatikern und -innen in der industriellen Praxis.}, language = {de} } @article{Richter, author = {Richter, Stefanie}, title = {Integrated Care for People with Dementia}, series = {Geriatrics}, volume = {2}, journal = {Geriatrics}, number = {1}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/geriatrics2010001}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-22091}, pages = {1 -- 13}, abstract = {This article presents results of the social-scientific evaluation of an established care model for people with dementia developed by the professionals as a result of acute problems in care in north-east Germany. In addition to the central elements of the model, the conditions of intersectoral and interprofessional cooperation as well as the qualification profile requirements of the professional groups involved are presented in detail. The results can give suggestions for the organization of integrated care for people with dementia in other countries. Further, the author would hereby like to highlight the gain from the scientific examination of solutions to problems in the field.}, subject = {Demenz}, language = {en} } @article{PangerlSukulRuecketal., author = {Pangerl, Jonas and Sukul, Pritam and R{\"u}ck, Thomas and Fuchs, Patricia and Weigl, Stefan and Miekisch, Wolfram and Bierl, Rudolf and Matysik, Frank-Michael}, title = {An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone}, series = {Photoacoustics}, volume = {38}, journal = {Photoacoustics}, publisher = {Elsevier}, issn = {2213-5979}, doi = {10.1016/j.pacs.2024.100604}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-71279}, pages = {12}, abstract = {n this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) - providing clinically relevant information about the human health. This is achieved via the development of a CO2-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 8.3 ppbV and an NNEA of 1.4E-9 Wcm 1Hz 0.5. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.}, language = {en} } @article{BauerSterner, author = {Bauer, Franz and Sterner, Michael}, title = {Impacts of lifestyle changes on energy demand and greenhouse gas emissions in Germany}, series = {Renewable and Sustainable Energy Reviews}, volume = {207}, journal = {Renewable and Sustainable Energy Reviews}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1364-0321}, doi = {10.1016/j.rser.2024.114944}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-77682}, pages = {17}, abstract = {Most energy scenario studies typically focus on technological options and fuel substitution for decarbonising future energy systems. Lifestyle changes are rarely considered, although they can significantly reduce energy demand and climate change mitigation efforts. By using an energy system model, this study shows that it is possible to reduce final energy demand in Germany by 61 \% in 2050 relative to 2019 levels, resulting in an annual per capita energy demand of 44 GJ for a representative country of the Global North. This goal can be achieved through a combination of technological measures and lifestyle changes without sacrificing a decent standard of living. Societal chances can eliminate reliance on not-yet-established negative emission technologies, reduce energy dependency, and reduce the need for energy-intensive hydrogen and e-fuels. Downsizing the energy system provides an opportunity for strengthening climate change mitigation, decrease material demand and reduce land use.}, language = {en} } @inproceedings{RuikenLandmannZoelleretal., author = {Ruiken, Axel and Landmann, Philipp and Z{\"o}ller, Ralf and Wolff, Thomas}, title = {Untersuchungen zum Tragverhalten von Einfach- und Mehrfachverbundankern im Zuge des BA 2/2 der A281 in Bremen}, series = {Vortr{\"a}ge der 38. Baugrundtagung, 25. bis 27. September 2024, Bremen}, booktitle = {Vortr{\"a}ge der 38. Baugrundtagung, 25. bis 27. September 2024, Bremen}, publisher = {Aktiv Druck \& Verlag GmbH}, address = {Ebelsbach}, organization = {Deutsche Gesellschaft f{\"u}r Geotechnik e.V. (DGGT)}, isbn = {978-3-932653-57-5}, doi = {10.35096/othr/pub-7766}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-77662}, pages = {129 -- 135}, abstract = {Im Vorfeld zum Neubau der A281 BA2/2 in Bremen wurden u.a. 14 Eignungsanker hergestellt und das Lastabtragsverhalten in den anstehenden Wesersanden ermittelt. Die Verpressk{\"o}rper wurden in Sanden mit mitteldichter und dichter Lagerung angeordnet und dabei die L{\"a}nge und Anzahl der Verpressk{\"o}rper systematisch variiert. Neben der Messung von Kraft und Verschiebung am Ankerkopf wurde mithilfe hochaufl{\"o}sender faseroptischer Instrumentierung von Verpressk{\"o}rpern und Ankerlitzen der Lastabtrag {\"u}ber den reinen Verpressk{\"o}rper hinaus {\"u}ber die gesamte Verbundl{\"a}nge ermittelt. Anhand der Ergebnisse wird die sukzessive Aktivierung der Baugrundwiderst{\"a}nde sichtbar. Die Ergebnisse zeigen einen n{\"a}herungsweise linearen Zusammenhang zwischen den untersuchten 6 m bis 12 m langen Verpressk{\"o}rpern und den ermittelten Herausziehwiderst{\"a}nden im Sand und somit ein deutlich g{\"u}nstigeres Lastabtragsverhalten, als es bisherige Erfahrungen gezeigt haben.}, language = {de} } @article{AlbrechtHellerbrandWeiningeretal., author = {Albrecht, Sophie Viktoria and Hellerbrand, Stefan and Weininger, Florian and Thiel, Charlotte}, title = {Strategies for Minimizing Environmental Impact in Construction: A Case Study of a Cementitious 3D Printed Lost Formwork for a Staircase}, series = {materials}, volume = {18}, journal = {materials}, publisher = {MDPI}, doi = {10.3390/ma18040825}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-79236}, pages = {18}, abstract = {The construction industry faces significant challenges, including environmental sustainability, rising material costs, and a shortage of skilled labor. Digital fabrication technologies offer innovative solutions to address these issues by reducing raw material consumption and waste generation. Among these, 3D printing technologies offer distinct advantages over traditional construction methods, particularly in handling complex geometries. However, the significant environmental impact of cement in 3D printed concrete, due to its high rheological and printability requirements, remains a concern. This study introduces a novel application of 3D printed permanent formwork in the construction of a winder staircase, assessed through an Environmental Life Cycle Assessment (LCA) from cradle to gate. By comparing the environmental impacts of various construction materials and processes, this study highlights the comparative advantages and disadvantages of conventional methods versus 3D printing. The LCA results reveal that traditional production methods, particularly those using plywood formwork, exhibit higher environmental impacts. In contrast, timber formwork performs better than most 3D printed mixtures in terms of Global Warming Potential (GWP), Acidification Potential (AP), and abiotic depletion potential (ADP). The findings of this study underscore the potential of additive manufacturing for sustainable construction, particularly through the use of low-clinker cement in 3D printed formwork, offering a promising pathway towards reducing the environmental footprint of construction activities}, language = {en} } @article{WestnerReichenederMatschi, author = {Westner, Markus and Reicheneder, Matthias and Matschi, Markus}, title = {From Captive Centers to Global Integration}, series = {Information Resources Management Journal}, volume = {38}, journal = {Information Resources Management Journal}, number = {1}, publisher = {IGI Global}, issn = {1533-7979}, doi = {10.4018/IRMJ.373322}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-80406}, pages = {25}, abstract = {Contemporary developments in virtual work and global talent management are transforming information technology (IT) nearshoring and offshoring practices, yet research on organizational responses remains limited. Through expert interviews with 33 IT executives (76\% chief information officers) from Germany's top 500 companies, this article examines organizational models, strategies, and good practices in IT nearshoring and offshoring. It reveals a shift from traditional captive centers toward fully integrated global teams, enabling high-value task delivery and reflecting increased workforce maturity. Companies are expanding their operations driven by talent needs rather than cost savings, with success factors including employee integration and robust on-site management. This study contributes to theory and practice by providing a framework for understanding organizational models in global IT delivery and offering actionable insights for executives, emphasizing workforce integration over geographical separation.}, subject = {Offshoring}, language = {en} } @article{HauslerHolznerEhrnspergeretal., author = {Hausler, Peter and Holzner, Lukas and Ehrnsperger, Matthias and Bierl, Rudolf}, title = {Evaluation of the creep strength of samples produced by fused deposition modeling}, series = {Open Engineering}, volume = {14}, journal = {Open Engineering}, number = {1}, publisher = {de Gruyter}, doi = {10.1515/eng-2024-0084}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-79760}, pages = {10}, abstract = {Data sheets for 3D printing materials typically include softening temperature, impact strength, tensile strength, and stiffness. However, creep strength, an important parameter for components used over an extended period, is usually not included. Nevertheless, this parameter is of significant importance for components that are used over an extended period of time.This study compares the long-term creep behavior of a selection of materials that are commonly used in fused deposition modeling 3D printing. The materials under investigation are acrylonitrile butadiene styrene, acrylonitrile styrene acrylate, polylactic acid, and polycarbonate. In addition, the influence of fiber reinforcements on these materials is also examined. A simple, reproducible test procedure is proposed for users to determine and compare creep resistance of materials. This enables developers to select materials suitable for their own requirements on creep resistance and allows 3D-printing users to compare different materials. Results suggest that fiber reinforcement generally improves creep stability in 3D-printing materials, with GreenTEC Pro Carbon and add:north PC Blend HT LCF showing the most promise in this study.}, language = {en} } @incollection{Leinweber, author = {Leinweber, Juliane}, title = {Digitale Versorgung in der Logop{\"a}die/Sprachtherapie Von der Pr{\"a}senz- und Videotherapie zur Teletherapie}, series = {Digitale Technik f{\"u}r ambulante Pflege und Therapie II - Impulse f{\"u}r die Praxis}, booktitle = {Digitale Technik f{\"u}r ambulante Pflege und Therapie II - Impulse f{\"u}r die Praxis}, editor = {Weber, Karsten and Haug, Sonja and Lauer, Norina and Mohr, Christa and Pfingsten, Andrea and Raptis, Georgios and Bahr, Gudrun}, publisher = {transcript}, address = {Bielefeld}, doi = {10.14361/9783839467275-012}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-65039}, pages = {145 -- 152}, language = {de} } @misc{OPUS4-7391, title = {Digitale Technik f{\"u}r ambulante Pflege und Therapie III}, editor = {Weber, Karsten and Haug, Sonja and Lauer, Norina and Mohr, Christa and Pfingsten, Andrea and Raptis, Georgios and Bahr, Gudrun}, edition = {1. Aufl.}, publisher = {transcript}, address = {Bielefeld}, isbn = {978-3-8394-6728-2}, doi = {10.14361/9783839467282}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-73914}, abstract = {Dieser Artikel untersucht die Machbarkeit und Wirksamkeit einer physiotherapeutischen Tele-Intervention bei Schlaganfallpatient*innen. Die prospektive, nicht kontrollierte Interventionsstudie basiert auf einem Mixed-Methods-Design und analysiert funktionelle Ver{\"a}nderungen sowie die Lebensqualit{\"a}t der Teilnehmenden vor und nach der Intervention. Eingeschlossen wurden postakute und chronische Schlaganfallpatient*innen mit stabilen Krankheitsbildern, die in ihrem h{\"a}uslichen Umfeld lebten. Die Intervention bestand aus videobasierten Einzelsitzungen und einer optionalen Gruppenintervention, die Physiotherapie und Logop{\"a}die kombinierte. Die Ergebnisse zeigten signifikante Verbesserungen in der Arm-Hand-Funktion und der Teilhabef{\"a}higkeit. Die Teletherapie erwies sich als eine praktikable Erg{\"a}nzung zur traditionellen Rehabilitation, insbesondere in l{\"a}ndlichen Regionen, und f{\"o}rderte die Autonomie und das aktive Engagement der Patient*innen in ihrem Genesungsprozess. Die Studie belegt das Potenzial teletherapeutischer Maßnahmen zur {\"U}berbr{\"u}ckung von Versorgungsl{\"u}cken und zur Sicherstellung einer kontinuierlichen, hochfrequenten Rehabilitation.}, subject = {AAL-Technik}, language = {de} } @article{GradZentgrafSchultheissetal., author = {Grad, Marius and Zentgraf, Jan and Schultheiss, Ulrich and Esper, Lukas and Diemar, Andreas and Noster, Ulf and Spiess, Lothar}, title = {Effect of Carbon Content on the Phase Composition, Microstructure and Mechanical Properties of the TiC Layer Formed in Hot-Pressed Titanium-Steel Composites}, series = {Metals}, volume = {14}, journal = {Metals}, number = {9}, publisher = {MDPI AG}, issn = {2075-4701}, doi = {10.3390/met14090959}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-74617}, abstract = {During the hot pressing of pure titanium and different carbon steels in a temperature range of ϑ = 950-1050 °C, a compound layer up to dL≈10 μm thick is formed at the titanium-steel interface. With a higher carbon content of the used steel, the layer thickness increases. The carbon concentration within the layer is in the range of stoichiometry for TiC. Apart from TiC, no other phases can be detected by X-ray diffraction (XRD) measurements inside the formed layer. The calculation of the activation energy for the TiC layer formation is Q = 126.5-136.7 kJ mol-1 and is independent of the carbon content of the steel. The resulting microstructure has a grain size gradient, wherein the mechanical properties, such as hardness and Young's modulus, are almost constant. Statistical analysis using Response Surface Methodology (RSM) indicates that the carbon content of the steel has the most significant influence on layer thickness, followed by annealing temperature and annealing time. By selecting the appropriate carbon steel and the subsequent removal of the steel, it is possible to produce targeted TiC layers on titanium substrates, which holds enormous potential for this material in wear-intensive applications.}, language = {en} } @article{AltmannSchleglVolbert, author = {Altmann, Matthias and Schlegl, Peter and Volbert, Klaus}, title = {A low-power wireless system for energy consumption analysis at mains sockets}, series = {EURASIP Journal on Embedded Systems}, journal = {EURASIP Journal on Embedded Systems}, number = {1}, publisher = {Springer Nature}, doi = {10.1186/s13639-016-0041-y}, pages = {18}, abstract = {Introduction: Improving energy efficiency and reducing energy wastage is an important topic of our time. But it is quite difficult to figure out how much of our total electricity bill can be mapped to which device or at what time the device used it. We believe energy efficiency of normal households can be improved, if this kind of transparency would be available. In this article, we present a system for energy measurement at mains sockets to gain a transparent view of energy consumption for each device in a household. It consists of several smart energy measuring devices (SEMDs) that use a low-power radio protocol to dynamically build and connect to a radio network to transfer power usage date to a server. At the server, the data is stored and can be accessed via web interface. Results: Our primary goal was to build a back-end system for an energy metering platform with very low energy consumption. This platform can provide data for a variety of services that enables users (the consumers) to understand and improve their energy consumption behavior and increase overall energy efficiency of their households.}, language = {en} } @article{MayerRabindranathBoerneretal., author = {Mayer, Matthias and Rabindranath, Raman and B{\"o}rner, Juliane and H{\"o}rner, Eva and Bentz, Alexander and Salgado, Josefina and Han, Hong and B{\"o}se, Holger and Probst, J{\"o}rn and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Schlunck, G{\"u}nther}, title = {Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata}, series = {PLoS ONE}, volume = {8}, journal = {PLoS ONE}, number = {10}, publisher = {PLOS}, doi = {10.1371/journal.pone.0076196}, abstract = {Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young's modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.}, language = {en} } @article{ReinkerBlaesingBierletal., author = {Reinker, Lukas and Bl{\"a}sing, Dominic and Bierl, Rudolf and Ulbricht, Sabina and Dendorfer, Sebastian}, title = {Correlation of Acceleration Curves in Gravitational Direction for Different Body Segments during High-Impact Jumping Exercises}, series = {sensors}, volume = {23}, journal = {sensors}, number = {4}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/s23042276}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-58217}, abstract = {Osteoporosis is a common disease of old age. However, in many cases, it can be very well prevented and counteracted with physical activity, especially high-impact exercises. Wearables have the potential to provide data that can help with continuous monitoring of patients during therapy phases or preventive exercise programs in everyday life. This study aimed to determine the accuracy and reliability of measured acceleration data at different body positions compared to accelerations at the pelvis during different jumping exercises. Accelerations at the hips have been investigated in previous studies with regard to osteoporosis prevention. Data were collected using an IMU-based motion capture system (Xsens) consisting of 17 sensors. Forty-nine subjects were included in this study. The analysis shows the correlation between impacts and the corresponding drop height, which are dependent on the respective exercise. Very high correlations (0.83-0.94) were found between accelerations at the pelvis and the other measured segments at the upper body. The foot sensors provided very weak correlations (0.20-0.27). Accelerations measured at the pelvis during jumping exercises can be tracked very well on the upper body and upper extremities, including locations where smart devices are typically worn, which gives possibilities for remote and continuous monitoring of programs.}, language = {en} } @article{RusavyCechovaDendorferetal., author = {Rusavy, Zdenek and Cechova, Hana and Dendorfer, Sebastian and Kalis, Vladimir and Ismail, Khaled M.}, title = {Is the Finnish grip tight enough? A manometric study of two manual perineal protection techniques}, series = {Acta Obstetricia et Gynecologica Scandinavica}, journal = {Acta Obstetricia et Gynecologica Scandinavica}, edition = {Early view}, publisher = {Wiley}, doi = {10.1111/aogs.15033}, language = {en} } @article{SchmitzNeumannNeumannetal., author = {Schmitz, Paul and Neumann, Christoph Cornelius and Neumann, Carsten and Nerlich, Michael and Dendorfer, Sebastian}, title = {Biomechanical analysis of iliac crest loading following cortico-cancellous bone harvesting}, series = {Journal of Orthopaedic Surgery and Research}, volume = {13}, journal = {Journal of Orthopaedic Surgery and Research}, number = {108}, publisher = {Springer Nature}, doi = {10.1186/s13018-018-0822-1}, pages = {1 -- 8}, abstract = {Background Iliac crest bone harvesting is a frequently performed surgical procedure widely used to treat bone defects. The objective of this study is to assess the biomechanical quantities related to risk for pelvic fracture after harvesting an autologous bone graft at the anterior iliac crest. Methods Finite element models with a simulated harvest site (sized 15 × 20 mm, 15 × 35 mm, 30 × 20 mm and 30 × 35 mm) in the iliac wing are created. The relevant loading case is when the ipsilateral leg is lifted off the ground. Musculoskeletal analysis is utilized to compute the muscle and joint forces involved in this motion. These forces are used as boundary conditions for the finite element analyses. Bone tissue stress is analyzed. Results Critical stress peaks are located between the anterior superior iliac spine (ASIS) and the anterior edge of the harvest site. Irrespective of the graft size, the iliac wing does not show any significant stress peaks with the harvest site being 20 to 25 mm posterior to the ASIS. The harvest area itself inhibits the distribution of the forces applied on the ASIS to extend to the posterior iliac wing. This leads to a lack of stress posterior to the harvest site. A balanced stress distribution with no stress peaks appears when the bone graft is taken below the iliac crest. Conclusion A harvest site located at least 20 to 25 mm posterior to the ASIS should be preferred to minimize the risk of iliac fatigue fracture.}, subject = {Beckenkammknochen}, language = {en} } @article{VoellnerWeberWeberetal., author = {V{\"o}llner, Florian and Weber, Tim A. and Weber, Markus and Renkawitz, Tobias and Dendorfer, Sebastian and Grifka, Joachim and Craiovan, Benjamin}, title = {A simple method for determining ligament stiffness during total knee arthroplasty in vivo}, series = {Scientific Reports}, volume = {9}, journal = {Scientific Reports}, publisher = {Nature}, doi = {10.1038/s41598-019-41732-x}, pages = {1 -- 8}, abstract = {A key requirement in both native knee joints and total knee arthroplasty is a stable capsular ligament complex. However, knee stability is highly individual and ranges from clinically loose to tight. So far, hardly any in vivo data on the intrinsic mechanical of the knee are available. This study investigated if stiffness of the native ligament complex may be determined in vivo using a standard knee balancer. Measurements were obtained with a commercially available knee balancer, which was initially calibrated in vitro. 5 patients underwent reconstruction of the force-displacement curves of the ligament complex. Stiffness of the medial and lateral compartments were calculated to measure the stability of the capsular ligament complex. All force-displacement curves consisted of a non-linear section at the beginning and of a linear section from about 80 N onwards. The medial compartment showed values of 28.4 ± 1.2 N/mm for minimum stiffness and of 39.9 ± 1.1 N/mm for maximum stiffness; the respective values for the lateral compartment were 19.9 ± 0.9 N/mm and 46.6 ± 0.8 N/mm. A commercially available knee balancer may be calibrated for measuring stiffness of knee ligament complex in vivo, which may contribute to a better understanding of the intrinsic mechanical behaviour of knee joints.}, subject = {Biomechanische Analyse}, language = {en} } @article{PutzerAuerMalpicaetal., author = {Putzer, Michael and Auer, Stefan and Malpica, William and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {A numerical study to determine the effect of ligament stiffness on kinematics of the lumbar spine during flexion}, series = {BMC Musculoskeletal Disorders}, volume = {17}, journal = {BMC Musculoskeletal Disorders}, number = {95}, doi = {10.1186/s12891-016-0942-x}, abstract = {Background There is a wide range of mechanical properties of spinal ligaments documented in literature. Due to the fact that ligaments contribute in stabilizing the spine by limiting excessive intersegmental motion, those properties are of particular interest for the implementation in musculoskeletal models. The aim of this study was to investigate the effect of varying ligament stiffness on the kinematic behaviour of the lumbar spine. Methods A musculoskeletal model with a detailed lumbar spine was modified according to fluoroscopic recordings and corresponding data files of three different subjects. For flexion, inverse dynamics analysis with a variation of the ligament stiffness matrix were conducted. The influence of several degrees of ligament stiffness on the lumbar spine model were investigated by tracking ligament forces, disc forces and resulting moments generated by the ligaments. Additionally, the kinematics of the motion segments were evaluated. Results An increase of ligament stiffness resulted in an increase of ligament and disc forces, whereas the relative change of disc force increased at a higher rate at the L4/L5 level (19 \%) than at the L3/L4 (10 \%) level in a fully flexed posture. The same behaviour applied to measured moments with 67 \% and 45 \%. As a consequence, the motion deflected to the lower levels of the lumbar spine and the lower discs had to resist an increase in loading. Conclusions Higher values of ligament stiffness over all lumbar levels could lead to a shift of the loading and the motion between segments to the lower lumbar levels. This could lead to an increased risk for the lower lumbar parts.}, language = {en} } @article{WeberDendorferGrifkaetal., author = {Weber, Tim A. and Dendorfer, Sebastian and Grifka, Joachim and Verkerke, Gijsbertus Jacob and Renkawitz, Tobias}, title = {Does Computer-Assisted Femur First THR Improve Musculoskeletal Loading Conditions?}, series = {BioMed Research International}, volume = {2015}, journal = {BioMed Research International}, editor = {Takagi, Michiaki}, doi = {10.1155/2015/625317}, pages = {ID 625317}, abstract = {We have developed a novel, computer-assisted operation method for minimal-invasive total hip replacement (THR) following the concept of "femur first/combined anteversion," which incorporates various aspects of performing a functional optimization of the prosthetic stem and cup position (CAS FF). The purpose of this study is to assess whether the hip joint reaction forces and patient's gait parameters are being improved by CAS FF in relation to conventional THR (CON). We enrolled 60 patients (28 CAS FF/32 CON) and invited them for gait analysis at three time points (preoperatively, postop six months, and postop 12 months). Data retrieved from gait analysis was processed using patient-specific musculoskeletal models. The target parameters were hip reaction force magnitude (hrf), symmetries, and orientation with respect to the cup. Hrf in the CAS FF group were closer to a young healthy normal. Phase-shift symmetry showed an increase in the CAS FF group. Hrf orientation in the CAS FF group was closer to optimum, though no edge or rim-loading occurred in the CON group as well. The CAS FF group showed an improved hrf orientation in an early stage and a trend to an improved long-term outcome.}, subject = {H{\"u}ftgelenkprothese}, language = {en} } @article{WeberMerleNawabietal., author = {Weber, Markus and Merle, Christian and Nawabi, Danyal H. and Dendorfer, Sebastian and Grifka, Joachim and Renkawitz, Tobias}, title = {Inaccurate offset restoration in total hip arthroplasty results in reduced range of motion}, series = {Scientific Reports}, volume = {10}, journal = {Scientific Reports}, number = {13208}, publisher = {Nature}, doi = {10.1038/s41598-020-70059-1}, pages = {9}, abstract = {Offset restoration in total hip arthroplasty (THA) is associated with postoperative range of motion (ROM) and gait kinematics. We aimed to research into the impact of high offset (HO) and standard stems on postoperative ROM. 121 patients received cementless THA through a minimally-invasive anterolateral approach. A 360° hip ROM analysis software calculated impingement-free hip movement based on postoperative 3D-CTs compared to ROM values necessary for activities of daily living (ADL). The same model was then run a second time after changing the stem geometry between standard and HO configuration with the implants in the same position. HO stems showed higher ROM for all directions between 4.6 and 8.9° (p < 0.001) compared with standard stems but with high interindividual variability. In the subgroup with HO stems for intraoperative offset restoration, the increase in ROM was even higher for all ROM directions with values between 6.1 and 14.4° (p < 0.001) compared to offset underrestoration with standard stems. Avoiding offset underrestoration resulted in a higher amount of patients of over 20\% for each ROM direction that fulfilled the criteria for ADL (p < 0.001). In contrast, in patients with standard stems for offset restoration ROM did increase but not clinically relevant by offset overcorrection for all directions between 3.1 and 6.1° (p < 0.001). Offset overcorrection by replacing standard with HO stems improved ROM for ADL in a low number of patients below 10\% (p > 0.03). Patient-individual restoration of offset is crucial for free ROM in THA. Both over and underrestoration of offset should be avoided.}, language = {en} } @article{ScheerKubowitschDendorferetal., author = {Scheer, Clara and Kubowitsch, Simone and Dendorfer, Sebastian and Jansen, Petra}, title = {Happy Enough to Relax? How Positive and Negative Emotions Activate Different Muscular Regions in the Back - an Explorative Study}, series = {Frontiers in Psychology}, volume = {Volume 12}, journal = {Frontiers in Psychology}, number = {May 2021}, publisher = {Frontiers Media}, issn = {1664-1078}, doi = {10.3389/fpsyg.2021.511746}, abstract = {Embodiment theories have proposed a reciprocal relationship between emotional state and bodily reactions. Besides large body postures, recent studies have found emotions to affect rather subtle bodily expressions, such as slumped or upright sitting posture. This study investigated back muscle activity as an indication of an effect of positive and negative emotions on the sitting position. The electromyography (EMG) activity of six back muscles was recorded in 31 healthy subjects during exposure to positive and negative affective pictures. A resting period was used as a control condition. Increased muscle activity patterns in the back were found during the exposure to negative emotional stimuli, which was mainly measured in the lumbar and thorax regions. The positive emotion condition caused no elevated activity. The findings show that negative emotions lead to increased differential muscle activity in the back and thus corroborate those of previous research that emotion affects subtle bodily expressions.}, language = {en} } @incollection{GreinerLauer, author = {Greiner, Nina and Lauer, Norina}, title = {Informierte Einwilligung bei Aphasie}, series = {Digitale Technik f{\"u}r ambulante Pflege und Therapie: Herausforderungen, L{\"o}sungen, Anwendungen und Forschungsperspektiven}, booktitle = {Digitale Technik f{\"u}r ambulante Pflege und Therapie: Herausforderungen, L{\"o}sungen, Anwendungen und Forschungsperspektiven}, editor = {Weber, Karsten and Haug, Sonja and Lauer, Norina and Meussling-Sentpali, Annette and Mohr, Christa and Pfingsten, Andrea and Raptis, Georgios and Bahr, Gudrun}, edition = {1. Aufl.}, publisher = {transcript}, address = {Bielefeld}, isbn = {978-3-8394-6235-5}, doi = {10.14361/9783839462355-007}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-55107}, publisher = {Ostbayerische Technische Hochschule Regensburg}, pages = {137 -- 154}, abstract = {Nach einer Einf{\"u}hrung in die Grundlagen der informierten Einwilligung werden Empfehlungen zur Durchf{\"u}hrung zusammengefasst und Besonderheiten im Hinblick auf die Gestaltung des Einwilligungsprozesses bei Personen mit Aphasie herausgearbeitet. Zuletzt wird das aphasiefreundliche Vorgehen im Projekt DeinHaus 4.0 Oberpfalz kurz skizziert.}, subject = {Informed consent}, language = {de} } @article{BraunKunklerKellner, author = {Braun, Maximilian and Kunkler, Jan and Kellner, Florian}, title = {Towards Sustainable Cities: Utilizing Floating Car Data to Support Location-Based Road Network Performance Measurements}, series = {Sustainability}, volume = {12}, journal = {Sustainability}, number = {19}, publisher = {MDPI}, doi = {10.3390/su12198145}, abstract = {Road network performance (RNP) is a key element for urban sustainability as it has a significant impact on economy, environment, and society. Poor RNP can lead to traffic congestion, which can lead to higher transportation costs, more pollution and health issues regarding the urban population. To evaluate the effects of the RNP, the involved stakeholders need a real-world data base to work with. This paper develops a data collection approach to enable location-based RNP analysis using publicly available traffic information. Therefore, we use reachable range requests implemented by navigation service providers to retrieve travel times, travel speeds, and traffic conditions. To demonstrate the practicability of the proposed methodology, a comparison of four German cities is made, considering the network characteristics with respect to detours, infrastructure, and traffic congestion. The results are combined with cost rates to compare the economical dimension of sustainability of the chosen cities. Our results show that digitization eases the assessment of traffic data and that a combination of several indicators must be considered depending on the relevant sustainability dimension decisions are made from.}, language = {en} } @article{KunklerBraunKellner, author = {Kunkler, Jan and Braun, Maximilian and Kellner, Florian}, title = {Speed Limit Induced CO2 Reduction on Motorways: Enhancing Discussion Transparency through Data Enrichment of Road Networks}, series = {Sustainability}, volume = {13}, journal = {Sustainability}, number = {1}, publisher = {MDPI}, doi = {10.3390/su13010395}, abstract = {Considering climate change, recent political debates often focus on measures to reduce CO2 emissions. One key component is the reduction of emissions produced by motorized vehicles. Since the amount of emission directly correlates to the velocity of a vehicle via energy consumption factors, a general speed limit is often proposed. This article presents a methodology to combine openly available topology data of road networks from OpenStreetMap (OSM) with pay-per-use API traffic data from TomTom to evaluate such measures transparently by analyzing historical real-world circumstances. From our exemplary case study of the German motorway network, we derive that most parts of the motorway network on average do not reach their maximum allowed speed throughout the day due to traffic, construction sites and general road utilization by network participants. Nonetheless our findings prove that the introduction of a speed limit of 120 km per hour on the German autobahn would restrict 50.74\% of network flow kilometers for a CO2 reduction of 7.43\% compared to the unrestricted state.}, language = {en} } @article{LienlandZeng, author = {Lienland, Bernhard and Zeng, Li}, title = {A Review and Comparison of Genetic Algorithms for the 0-1 Multidimensional Knapsack Problem}, series = {International Journal of Operations Research and Information Systems (IJORIS)}, volume = {6}, journal = {International Journal of Operations Research and Information Systems (IJORIS)}, number = {2}, publisher = {IGI Global}, issn = {1947-9328}, doi = {10.4018/ijoris.2015040102}, pages = {11}, abstract = {The 0-1 multidimensional knapsack problem (MKP) is a well-known combinatorial optimization problem with several real-life applications, for example, in project selection. Genetic algorithms (GA) are effective heuristics for solving the 0-1 MKP. Multiple individual GAs with specific characteristics have been proposed in literature. However, so far, these approaches have only been partially compared in multiple studies with unequal conditions. Therefore, to identify the "best" genetic algorithm, this article reviews and compares 11 existing GAs. The authors' tests provide detailed information on the GAs themselves as well as their performance. The authors validated fitness values and required computation times in varying problem types and environments. Results demonstrate the superiority of one GA.}, language = {en} } @article{KellnerOttoBrabaender, author = {Kellner, Florian and Otto, Andreas and Brab{\"a}nder, Christian}, title = {Bringing infrastructure into pricing in road freight transportation - A measuring concept based on navigation service data}, series = {Transportation Research Procedia}, volume = {25}, journal = {Transportation Research Procedia}, publisher = {Elsevier}, doi = {10.1016/j.trpro.2017.05.458}, pages = {794 -- 805}, abstract = {Differences in road infrastructure, such as capacity, congestion, speed limits affect the productivity and the costs of short-distance freight operations. This article introduces a novel methodology that is based on navigation service data to measure the effects in terms of cost per kilometer using navigation and shipment data. The methodology is applied to five terminals of a forwarding cooperation and has been able to document significant differences in cost per kilometer across the terminals. The research results can be used by logistics service providers to better understand how productivity and thus profitability is affected by the quality of the transportation infrastructure in the particular areas they operate in. Furthermore, the insights will help these companies for better, i.e. cost-based pricing and will allow to document why and where prices need to be adapted.}, language = {en} } @article{Kellner, author = {Kellner, Florian}, title = {Exploring the impact of traffic congestion on CO2 emissions in freight distribution networks}, series = {Logistics Research}, volume = {9}, journal = {Logistics Research}, publisher = {Springer Nature}, doi = {10.1007/s12159-016-0148-5}, abstract = {This research quantifies the impact that regular road traffic congestion has on the CO2 emissions of a real-world distribution network, and it studies the consequences when the number of distribution centers changes. For this purpose, this study makes use of a network model allowing for a detailed representation of all relevant transport operations, including production flows between factories and distribution centers, line haul shipments between distribution centers and customers, and round/delivery trips between transshipment points and retailer locations for the last mile. The processed trip and traffic information does not rely on standard traffic data collection approaches, such as interviews, in situ technologies, or floating car data, but the road traffic data are retrieved from an online navigation service, such as Bing Maps, Google Maps, Inrix, Here, and TomTom. This study proves that online navigation services may considerably contribute to future research projects analyzing CO2 sensitivities and greenhouse gas cutting opportunities in logistics networks.}, language = {en} } @article{KraftQuaysonKellner, author = {Kraft, Sarah Katharina and Quayson, Matthew and Kellner, Florian}, title = {Assessing the German Act on Corporate Due Diligence Obligations in Supply Chains: a perspective from the smallholder cocoa farmer}, series = {Frontiers in Sustainability}, volume = {5}, journal = {Frontiers in Sustainability}, publisher = {frontiers}, doi = {10.3389/frsus.2024.1376619}, abstract = {This research examines the potential outputs, outcomes, and impacts of the German Act on Corporate Due Diligence Obligations in Supply Chains (LkSG) on the smallholder cocoa farmers in West Africa. The study primarily relies on a literature review and an impact pathway to conduct a systematic analysis to identify the potential effects of the LkSG on smallholder cocoa farmers. The findings indicate that some, but not all of the risks addressed by the LkSG align with those faced by smallholder cocoa farmers and their families. Additionally, the research also reveals weaknesses, particularly in managing environmental risks, which the LkSG does not adequately cover. Our findings show that in the short- and medium-term, the LkSG has no potential effects on smallholder cocoa farmers. Furthermore, the potential positive impacts of the law on smallholder cocoa farmers will take a long time to realize, as the LkSG considers primarily tier-1 suppliers. Companies in Germany might reassess their supply chains to strive for an LkSG-risk-free supply chain, which could in the long term have sustained impacts on smallholder cocoa farmers. However, we recommend a comprehensive risk analysis of the cocoa supply chain to enhance the human rights of cocoa farmers.}, language = {en} } @article{KraftKellner, author = {Kraft, Sarah Katharina and Kellner, Florian}, title = {Can Blockchain Be a Basis to Ensure Transparency in an Agricultural Supply Chain?}, series = {Sustainability}, volume = {14}, journal = {Sustainability}, number = {13}, publisher = {MDPI}, doi = {10.3390/su14138044}, abstract = {Many supply chains within developing countries lack transparency and are fraught with fraud, corruption, and a substantial number of intermediaries. For several decades, the cocoa sector has faced multiple social, economic, and environmental challenges, some of which include the issue of child labor and very low incomes for farmers, leading to poor living conditions. Blockchain technology has a high potential to reduce—or completely eradicate—some of these hurdles. In this article, we present a blockchain-based solution based on the open-source framework Hyperledger Fabric for the cocoa supply chain to promote transparency and reduce fraud. In doing so, we explicitly describe how farmers can be directly integrated into the whole blockchain solution considering the limited infrastructure, knowledge, and technologies available to them. Since about 70\% of all cocoa worldwide is produced in West Africa, this case study uses the cocoa sector in Ghana as an example.}, language = {en} } @article{KunklerKellner, author = {Kunkler, Jan and Kellner, Florian}, title = {Sustainable City Evaluation Using the Database for Estimation of Road Network Performance}, series = {Sustainability}, volume = {15}, journal = {Sustainability}, number = {1}, publisher = {MDPI}, doi = {10.3390/su15010733}, abstract = {This article introduces the Database for Estimation of Road Network Performance (DERNP) to enable wide-scale estimation of relevant Road Network Performance (RNP) factors for major German cities. The methodology behind DERNP is based on a randomized route sampling procedure that utilizes the Worldwide Harmonized Light Vehicles Test Procedure (WLTP) in combination with the tile-based HERE Maps Traffic API v7 and a digital elevation model provided by the European Union's Earth Observation Programme Copernicus to generate a large set of independent and realistic routes throughout OpenStreetMap road networks. By evaluating these routes using the PHEMLight5 framework, a comprehensive list of RNP parameters is estimated and translated into polynomial regression models for general usage. The applicability of these estimations is demonstrated based on a case study of four major German cities. This case study considers network characteristics in terms of detours, infrastructure, traffic congestion, fuel consumption, and CO2 emissions. Our results show that DERNP and its underlying randomized route sampling methodology overcomes major limitations of previous wide-scale RNP approaches, enabling efficient, easy-to-use, and region-specific RNP comparisons.}, language = {en} } @article{PhilippdeSomerFoltanetal., author = {Philipp, Alois and de Somer, Filip and Foltan, Maik and Bredthauer, Andre and Krenkel, Lars and Zeman, Florian and Lehle, Karla}, title = {Life span of different extracorporeal membrane systems for severe respiratory failure in the clinical practice}, series = {PLOS ONE}, volume = {13}, journal = {PLOS ONE}, number = {6}, publisher = {PLOS}, doi = {10.1371/journal.pone.0198392}, pages = {1 -- 10}, abstract = {Over the past decade, veno-venous extracorporeal membrane oxygenation (vvECMO) has been increasingly utilized in respiratory failure in patients. This study presents our institution´s experience focusing on the life span of ECMO systems reflecting the performance of a particular system. A retrospective review of our ECMO database identified 461 adult patients undergoing vvECMO (2010-2017). Patients that required more than one system and survived the first exchange >24 hours (n = 139) were included. Life span until the first exchange and exchange criteria were analyzed for all systems (PLS, Cardiohelp HLS-set, both Maquet Cardiopulmonary, Rastatt, Germany; Deltastream/Hilite7000LT, iLA-activve, Xenios/NovaLung, Heilbronn, Germany; ECC.O5, LivaNova, Mirandola, Italy). At our ECMO center, the frequency of a system exchange was 30\%. The median (IQR) life span was 9 (6-12) days. There was no difference regarding the different systems (p = 0.145 and p = 0.108, respectively). However, the Deltastream systems were exchanged more frequently due to elective technical complications (e. g. worsened gas transfer, development of coagulation disorder, increased bleedings complications) compared to the other exchanged systems (p = 0.013). In summary, the used ECMO systems are safe and effective for acute respiratory failure. There is no evidence for the usage of a specific system. Only the increased predictability of an imminent exchange preferred the usage of a Deltastream system. However, the decision to use a particular system should not depend solely on the possible criteria for an exchange.}, language = {en} } @article{DiermeierSindersbergerKrenkeletal., author = {Diermeier, Andreas and Sindersberger, Dirk and Krenkel, Lars and Rosell, X. C. and Monkman, Gareth J.}, title = {Controllable Magnetoactive Polymer Conduit}, series = {The Open Mechanical Engineering Journal}, volume = {12}, journal = {The Open Mechanical Engineering Journal}, number = {1}, publisher = {Bentham}, pages = {192 -- 200}, abstract = {Objective: Magneto-active Polymers (MAP) are smart materials whose mechanical characteristics, such as elastic and shear moduli, may be controllable by means of an externally applied magnetic field. Methods: Various additives may be used to influence the characteristics of the polymer matrix whilst a suspension of soft and/or hard magnetic particles determine the magnetic properties of the composite. Both pre-cure and post-cure magnetization is possible. Results: A range of control strategies have been investigated for evaluation of the system using fluids of differing kinematic viscosity. Conclusion: Depending on the degree of magnetic field homogeneity, magneto-deformation and magnetostriction contribute to MAP actuation. This paper presents a novel application in the form of a peristaltic MAP tube system, applicable to flow control and pumping of hemorheological fluids in blood circulatory systems for biomedical research purposes.}, language = {en} } @article{KoeckStrieglKrausetal., author = {K{\"o}ck, Hannah and Striegl, Birgit and Kraus, Annalena and Zborilova, Magdalena and Christiansen, Silke H. and Sch{\"a}fer, Nicole and Gr{\"a}ssel, Susanne and Hornberger, Helga}, title = {In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes}, series = {Bioengineering}, volume = {10}, journal = {Bioengineering}, publisher = {MDPI}, doi = {10.3390/bioengineering10070767}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-61235}, pages = {1 -- 21}, abstract = {Osteoarthritis (OA) is a degenerative joint disease causing loss of articular cartilage and structural damage in all joint tissues. Given the limited regenerative capacity of articular cartilage, methods to support the native structural properties of articular cartilage are highly anticipated. The aim of this study was to infiltrate zwitterionic monomer solutions into human OA-cartilage explants to replace lost proteoglycans. The study included polymerization and deposition of methacryloyloxyethyl-phosphorylcholine- and a novel sulfobetaine-methacrylate-based monomer solution within ex vivo human OA-cartilage explants and the encapsulation of isolated chondrocytes within hydrogels and the corresponding effects on chondrocyte viability. The results demonstrated that zwitterionic cartilage-hydrogel networks are formed by infiltration. In general, cytotoxic effects of the monomer solutions were observed, as was a time-dependent infiltration behavior into the tissue accompanied by increasing cell death and penetration depth. The successful deposition of zwitterionic hydrogels within OA cartilage identifies the infiltration method as a potential future therapeutic option for the repair/replacement of OA-cartilage extracellular suprastructure. Due to the toxic effects of the monomer solutions, the focus should be on sealing the OA-cartilage surface, instead of complete infiltration. An alternative treatment option for focal cartilage defects could be the usage of monomer solutions, especially the novel generated sulfobetaine-methacrylate-based monomer solution, as bionic for cell-based 3D bioprintable hydrogels.}, language = {en} } @article{MuellerHornberger, author = {M{\"u}ller, Wolf-Dieter and Hornberger, Helga}, title = {The Influence of MgH2 on the Assessment of Electrochemical Data to Predict the Degradation Rate of Mg and Mg Alloys}, series = {International Journal of Molecular Science}, volume = {15}, journal = {International Journal of Molecular Science}, doi = {10.3390/ijms150711456}, pages = {11456 -- 11472}, abstract = {Mg and Mg alloys are becoming more and more of interest for several applications. In the case of biomaterial applications, a special interest exists due to the fact that a predictable degradation should be given. Various investigations were made to characterize and predict the corrosion behavior in vitro and in vivo. Mostly, the simple oxidation of Mg to Mg2+ ions connected with adequate hydrogen development is assumed, and the negative difference effect (NDE) is attributed to various mechanisms and electrochemical results. The aim of this paper is to compare the different views on the corrosion pathway of Mg or Mg alloys and to present a neglected pathway based on thermodynamic data as a guideline for possible reactions combined with experimental observations of a delay of visible hydrogen evolution during cyclic voltammetry. Various reaction pathways are considered and discussed to explain these results, like the stability of the Mg+ intermediate state, the stability of MgH2 and the role of hydrogen overpotential. Finally, the impact of MgH2 formation is shown as an appropriate base for the prediction of the degradation behavior and calculation of the corrosion rate of Mg and Mg alloys.}, language = {en} }