@incollection{ScholzKrenkelTerekhovetal., author = {Scholz, Alexander-Wigbert K. and Krenkel, Lars and Terekhov, Maxim and Friedrich, Janet and Rivoire, Julien and K{\"o}brich, Rainer and Wolf, Ursula and Kalthoff, Daniel and David, Matthias and Wagner, Claus and Schreiber, Laura Maria}, title = {Magnetic Resonance Imaging and Computational Fluid Dynamics of High Frequency Oscillatory Ventilation (HFOV)}, series = {Fundamental Medical and Engineering Investigations on Protective Artificial Respiration}, volume = {116}, booktitle = {Fundamental Medical and Engineering Investigations on Protective Artificial Respiration}, editor = {Hirschel, Ernst Heinrich and Schr{\"o}der, Wolfgang and Fujii, Kozo and Haase, Werner and Leer, Bram and Leschziner, Michael A. and Pandolfi, Maurizio and Periaux, Jacques and Rizzi, Arthur and Roux, Bernard and Shokin, Yurii I. and Klaas, Michael and Koch, Edmund and Schr{\"o}der, Wolfgang}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-642-20325-1}, doi = {10.1007/978-3-642-20326-8_7}, pages = {107 -- 128}, abstract = {In order to better understand the mechanisms of gas transport during High Frequency Oscillatory Ventilation (HFOV) Magnetic Resonance Imaging (MRI) with contrast gases and numerical flow simulations based on Computational Fluid Dynamics(CFD) methods are performed. Validation of these new techniques is conducted by comparing the results obtained with simplified models of the trachea and a first lung bifurcation as well as in a cast model of the upper central airways with results achieved from conventional fluid mechanical measurement techniques like e.g. Laser Doppler Anemometry (LDA). Further it is demonstrated that MRI of experimental HFOV is feasible and that Hyperpolarized 3He allows for imaging the gas re-distribution inside the lung. Finally, numerical results of oscillatory flow in a 3rd generation model of the lung as well as the impact of endotracheal tubes on the flow regime development in a trachea model are presented.}, language = {en} }