@misc{HornPippigRaptisetal., author = {Horn, L. C and Pippig, S. and Raptis, Georgios and Fischer, U. and Kohler, U. and Hentschel, B. and Martin, R.}, title = {00083 PAI-1 AND UFA AS PARAMETERS OF TUMORASSOCIATED PROTEOLYSIS IN CERVICAL CARCINOMA}, series = {International Journal of Gynecologic Cancer}, volume = {15}, journal = {International Journal of Gynecologic Cancer}, number = {Suppl 2}, publisher = {BMJ}, issn = {1048-891X}, doi = {10.1136/ijgc-00009577-200509001-00083}, language = {en} } @article{HornRaptisFischeretal., author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta and Hentschel, Bettina and K{\"o}hler, U. and Richter, Christine E. and Martin, Rosemarie}, title = {CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance}, series = {Archives of Gynecology and Obstetrics}, volume = {273}, journal = {Archives of Gynecology and Obstetrics}, number = {2}, doi = {10.1007/s00404-005-0039-5}, pages = {104 -- 106}, abstract = {Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{HornPippigRaptisetal., author = {Horn, Lars-Christian and Pippig, S. and Raptis, Georgios and Fischer, Uta and K{\"o}hler, U. and Hentschel, Bettina and Martin, Rosemarie}, title = {Clinical relevance of urokinase-type plasminogen activator and its inhibitor type-1 (PAI-1) in squamous cell carcinoma of the uterine cervix}, series = {Australian and New Zealand Journal of Obstetrics and Gynaecology}, volume = {42}, journal = {Australian and New Zealand Journal of Obstetrics and Gynaecology}, number = {4}, doi = {10.1111/j.0004-8666.2002.00385.x}, pages = {385 -- 388}, abstract = {Objective The expression of uPA and PAI-1 as parameters of tumour-associated proteolysis has been implicated in the process of tumour cell invasion and the metastatic process. However, there is limited information on the impact of these parameters in cervical carcinoma. Methods Quantitative levels for uPA (n = 114) and PAI-1 (n = 103) were researched in operatively treated, surgically staged squamous cell cancer of the uterine cervix, using an ELISA-technique. Results were assessed regarding their impact in predicting pelvic lymph nodes metastases, tumour recurrence rate and recurrence free survival (RFS) using uni- and multivariate analysis. Results Median levels of both parameters were significantly higher in tumour tissue than in normal cervical tissue (p < 0.001). Detection of uPA gave no useful prognostic information. PAI-1 concentration showed a positive correlation with advanced tumour stage (p = 0.008), but no significant correlation with nodal status (pN0: 2.6 vs. pN1: 4.0 ng/mg protein; p = 0.092). Using a cut-off level of 2.4 ng/mg protein, patients with elevated PAI-1 levels demonstrated reduced RFS (45.9 versus 52.9 months; p = 0.1). Multivariate analysis, including nodal status, tumour stage, lymphovascular space involvement and grading failed to demonstrate any prognostic impact of uPA and PAI-1. Conclusions The results indicate, that PAI-1 expression is of some prognostic impact in cervical cancer, indicating an association of elevated PAI levels with local tumour progression and reduced recurrence-free survival.}, subject = {Plasminogen human-Aktivator}, language = {en} } @inproceedings{HornPippigRaptisetal., author = {Horn, Lars-Christian and Pippig, S. and Raptis, Georgios and Fischer, Uta and K{\"o}hler, U. and Hentschel, Bettina and Martin, Rosemarie}, title = {Tumorassoziierte Proteolyse beim Zervixkarzinom}, series = {87. Tagung der Deutschen Gesellschaft f{\"u}r Pathologie, 14. Juni 2003}, booktitle = {87. Tagung der Deutschen Gesellschaft f{\"u}r Pathologie, 14. Juni 2003}, subject = {Geb{\"a}rmutterhalskrebs}, language = {de} } @article{FischerRaptisGessneretal., author = {Fischer, Uta and Raptis, Georgios and Geßner, W. and Roschlau, U. and Dressel, K. and Bilek, Karin and Horn, Lars-Christian}, title = {Epidemiologie und formale Pathogenese des Zervixkarzinoms}, series = {Zentralblatt f{\"u}r Gyn{\"a}kologie}, volume = {123}, journal = {Zentralblatt f{\"u}r Gyn{\"a}kologie}, number = {4}, pages = {198 -- 205}, subject = {Geb{\"a}rmutterhalskrebs}, language = {de} }