@article{MayerRabindranathBoerneretal., author = {Mayer, Matthias and Rabindranath, Raman and B{\"o}rner, Juliane and H{\"o}rner, Eva and Bentz, Alexander and Salgado, Josefina and Han, Hong and B{\"o}se, Holger and Probst, J{\"o}rn and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Schlunck, G{\"u}nther}, title = {Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata}, series = {PLoS ONE}, volume = {8}, journal = {PLoS ONE}, number = {10}, publisher = {PLOS}, doi = {10.1371/journal.pone.0076196}, abstract = {Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young's modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.}, language = {en} } @article{ForsterMayerRabindranathetal., author = {Forster, Eva and Mayer, Matthias and Rabindranath, Raman and B{\"o}se, Holger and Schlunck, G{\"u}nther and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail}, title = {Patterning of ultrasoft, agglutinative magnetorheological elastomers}, series = {Journal of applied polymer science}, volume = {128}, journal = {Journal of applied polymer science}, number = {4}, publisher = {Wiley}, address = {New York, NY}, doi = {10.1002/app.38500}, pages = {2508 -- 2515}, abstract = {A low-cost wax-cast molding technique for structuring ultrasoft (Young's modulus ≤ 40 kPa), agglutinative magnetorheological elastomer (MRE) material is presented. MRE structures ranging from a few millimeters down to the micrometer range with highly reproducible results are possible. Semitransparent MREs are also fabricated and their surfaces modified accordingly. This method opens new possibilities for MREs in biomedical engineering and microfluidic applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013}, language = {en} } @inproceedings{ForsterMayerRabindranathetal., author = {Forster, Eva and Mayer, Matthias and Rabindranath, Raman and Bentz, Alexander and B{\"o}se, Holger and Shamonin (Chamonine), Mikhail and Monkman, Gareth J.}, title = {Surface Control Magneto-Active Polymers (MAP)}, series = {EuroEAP 2011, First international conference on Electromechanically Active Polymer (EAP) transducers \& artificial muscles, Pisa, 8-9 June}, booktitle = {EuroEAP 2011, First international conference on Electromechanically Active Polymer (EAP) transducers \& artificial muscles, Pisa, 8-9 June}, abstract = {Smart materials change their properties with external energy supply. Besides the known ferro-fluids and Magneto Rheological Fluid (MRF) also the Electro Active Polymer (EAP) and Magneto Rheological Elastomer (MRE) belong to these intelligent materials. The latest generation of magnetic elastomers represents a new class of composite materials. This consists of small magnetized particles which are sized in the micron or even nanometer range that in turn is bounded in a highly elastic rubber matrix. These materials are very often called MRE. Only recently, it has managed to develop these materials even further, so that very soft composite materials with a young?s modulus up to 10 kPa are possible. These soft polymers could be named magneto-active polymers. The combination of polymers with magnetic materials show novel and often enhanced properties. A precisely controllable young?s modulus and hardness, giant and non-homogeneous deformation behavior and rapid response to the magnetic field opens up new possibilities for various applications. Since MAP represent a very new technology, the behavior of these materials as a function of their composition and external conditions so far are not yet sufficiently understood. Therefore, some fundamental studies are necessary. In this paper, the mechanical surface properties are studied using a micro hardness meter. This work shows the possibility to control mechanical properties at the surface of MAP with new developed magnetic systems.}, language = {en} } @inproceedings{MayerForsterRabindranathetal., author = {Mayer, Matthias and Forster, Eva and Rabindranath, Raman and Bentz, Alexander and B{\"o}se, Holger and Shamonin (Chamonine), Mikhail and Monkman, Gareth J.}, title = {Highly compliant Magneto-Active Polymers (MAPs)}, series = {Actuator'11, Bremen, May 2011}, booktitle = {Actuator'11, Bremen, May 2011}, language = {en} } @inproceedings{ForsterRabindranathMayeretal., author = {Forster, Eva and Rabindranath, Raman and Mayer, Matthias and Bentz, Alexander and B{\"o}se, Holger and Shamonin (Chamonine), Mikhail and Monkman, Gareth J.}, title = {Characterization of ultra soft Magneto-Active Polymers (MAPs)}, series = {Conference proceedings / INDUCTICA 2011, Berlin, Germany, 24 - 26 May}, booktitle = {Conference proceedings / INDUCTICA 2011, Berlin, Germany, 24 - 26 May}, language = {en} } @techreport{RabindranathBoeseProbstetal., author = {Rabindranath, Raman and B{\"o}se, Holger and Probst, J{\"o}rn and Schlunck, G{\"u}nther and Mayer, Matthias and Forster, Eva and Bentz, Alexander and Shamonin (Chamonine), Mikhail and Monkman, Gareth J.}, title = {EAP mit magnetisch steuerbarer Elastizit{\"a}t zur Interaktion mit Bindegewebszellen MagElan}, address = {Regensburg}, organization = {Hochschule f{\"u}r Angewandte Wissenschaften Regensburg / Fachbereich Elektro- und Informationstechnik}, pages = {37}, language = {de} }