@article{EnglertAngeleFierlbecketal., author = {Englert, Carsten and Angele, Peter and Fierlbeck, J. and Dendorfer, Sebastian and Schubert, T. and M{\"u}ller, R. and Lienhard, S. and Zellner, Johannes and Nerlich, Michael and Neumann, Carsten}, title = {Conductive bone substitute material with variable antibiotic delivery}, series = {Der Unfallchirurg}, volume = {110}, journal = {Der Unfallchirurg}, number = {5}, publisher = {Springer}, doi = {10.1007/s00113-007-1229-3}, pages = {408 -- 413}, abstract = {A new bone substitute, consisting of hydroxylapatite and calcium sulphate, was prepared in two formulations and analysed for its mechanical strength and antibiotic elution.The bone substitute PerOssal has osteoconductive and degradable properties. The material has a built-in capillary structure, which results in an immediate fluid uptake. Antibiotics absorbed to the bone substitute resulted in a prolonged release rate. Mechanical strength was investigated by an unconfined compression test up to failure under both wet and dry conditions for both formulations of the bone substitute. Antibiotic release was analysed microbiologically for two antibiotics, vancomycin and gentamicin, over an elution period of 10 days using the agar diffusion method.The drug release analysis resulted in a prolonged release rate of both antibiotics over 10 days. In vitro the amount of gentamicin and vancomycin eluted at day 10. From one pellet still exceeded the minimal inhibitory concentration of most aetiologically important pathogens. Formulation two of the present bone substitute is significantly harder in both wet and dry conditions when compared to formulation one. Both formulations lose strength in the wet condition relative to their performance in the dry condition. However, formulation two is as hard under wet conditions as formulation one is when dry.PerOssal is a suitable new degradable osteoconductive bone substitute that can be loaded with antibiotic solutions, which are released in effective doses over 10 days. The mechanical strength of PerOssal is sufficient to support cancellous bone defects in non-weight-bearing areas or in combination with osteosynthesis.}, subject = {Knochenersatz}, language = {en} } @book{DehlingerBanarjeeBaurMelnyketal., author = {Dehlinger, Friedrich and Banarjee, M. and Baur-Melnyk, A. and Berth, A. and B{\"o}keler, Ulf W. and Brandt, Hanna and Brunnader, Lars and B{\"u}ttner, Carl Christopher and Clausen, J. and Eden, Lars and Englert, Carsten and Freislederer, F. and Grimm, C. and Grossmann, Irmgard and Jung, C. and Kopkow, Christian and Krifter, R.M. and Martetschl{\"a}ger, Frank and Mehrens, D. and Michalk, Katrin and M{\"u}ller-Rath, Ralf and Pfingsten, Andrea and Prill, Robert and Schmalzl, J. and W{\"o}rtler, K.}, title = {Schultersteife : eine S2e Leitlinie der Deutschen Gesellschaft f{\"u}r Orthop{\"a}die und Unfallchirurgie e.V. (DGOU) mit Beteiligung der Deutsche Vereinigung f{\"u}r Schulter- und Ellenbogenchirurgie e.V. (DVSE)}, edition = {Version 1.0}, publisher = {AWMF online}, address = {Berlin}, pages = {69}, abstract = {Bei der Schultersteife handelt es sich um ein h{\"a}ufiges Krankheitsbild in der Orthop{\"a}die bzw. Schulterchirurgie, das sowohl bei {\"A}rztinnen und {\"A}rzten (Allgemeinmedizinerinnen und mediziner, Fach{\"a}rztinnen und -{\"a}rzte) als auch bei sonstigem medizinischem Fachpersonal, z.B. der Physiotherapie oder Pflege, nur einen geringen Bekanntheitsgrad besitzt. Zielorientierung dieser Leitlinie war es, eine fundierte Hilfestellung und Richtlinie in Bezug auf das Krankheitsbild f{\"u}r {\"A}rztinnen, {\"A}rzte und medizinisches Fachpersonal zu schaffen, den aktuellen evidenz-basierten Wissensstand zu vermitteln und eine bessere Patientinnen- und Patientenversorgung zu erzielen, inkl. der intensiven Aufkl{\"a}rung der Betroffenen durch die behandelnden Berufsgruppen und - wenn von den Betroffenen gew{\"u}nscht - einer gemeinsamen Entscheidungsfindung bez{\"u}glich der Behandlung.}, language = {de} }