@article{ZellnerHierlMuelleretal., author = {Zellner, Johannes and Hierl, Katja and Mueller, Michael and Pfeifer, Christian and Berner, Arne and Dienstknecht, Thomas and Krutsch, Werner and Geis, Sebastian and Gehmert, Sebastian and Kujat, Richard and Dendorfer, Sebastian and Prantl, Lukas and Nerlich, Michael and Angele, Peter}, title = {Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone}, series = {Journal of Biomedical Materials Research Part B Applied Biomaterials}, volume = {101}, journal = {Journal of Biomedical Materials Research Part B Applied Biomaterials}, number = {7}, editor = {Gilbert, Jeremy}, doi = {10.1002/jbm.b.32922}, pages = {1133 -- 1142}, abstract = {Meniscal tears in the avascular zone have a poor self-healing potential, however partial meniscectomy predisposes the knee for early osteoarthritis. Tissue engineering with mesenchymal stem cells and a hyaluronan collagen based scaffold is a promising approach to repair meniscal tears in the avascular zone. 4 mm longitudinal meniscal tears in the avascular zone of lateral menisci of New Zealand White Rabbits were performed. The defect was left empty, sutured with a 5-0 suture or filled with a hyaluronan/collagen composite matrix without cells, with platelet rich plasma or with autologous mesenchymal stem cells. Matrices with stem cells were in part precultured in chondrogenic medium for 14 days prior to the implantation. Menisci were harvested at 6 and 12 weeks. The developed repair tissue was analyzed macroscopically, histologically and biomechanically. Untreated defects, defects treated with suture alone, with cell-free or with platelet rich plasma seeded implants showed a muted fibrous healing response. The implantation of stem cell-matrix constructs initiated fibrocartilage-like repair tissue, with better integration and biomechanical properties in the precultured stem cell-matrix group. A hyaluronan-collagen based composite scaffold seeded with mesenchymal stem cells is more effective in the repair avascular meniscal tear with stable meniscus-like tissue and to restore the native meniscus.}, subject = {Meniskusschaden}, language = {en} } @article{MaurerSaiboldGerletal., author = {Maurer, Julia and Saibold, Anna and Gerl, Katharina and Koller, Michael and K{\"o}lbl, Oliver and Pukrop, Tobias and Windschuettl, Sandra and Einhell, Sabine and Herrmann-Johns, Anne and Raptis, Georgios and Mueller, Karolina}, title = {Systematic development of a patient-reported ONCOlogical-ROUTinE-Screening (ONCO-ROUTES) procedure at the University Cancer Center Regensburg}, series = {Journal of Cancer Research and Clinical Oncology}, volume = {150}, journal = {Journal of Cancer Research and Clinical Oncology}, number = {9}, publisher = {Springer Science and Business Media LLC}, issn = {1432-1335}, doi = {10.1007/s00432-024-05955-4}, abstract = {Purpose The evaluation of treatment success and progression in oncology patient-reported outcomes (PROs) is playing an increasingly important role. Meanwhile, PROs are a component of the certification requirements of the German Cancer Society for oncology centers. PROs are used to provide supportive therapy. There is currently no instrument that fully covers the requirements. At the University Hospital Regensburg (UKR), a digital ONCOlogical-ROUTinE-Screening (ONCO-ROUTES) procedure was developed in order to assess the need for supportive therapy in a standardized way and to provide patients with supportive interventions tailored to their needs. Methods On the basis of current requirements and guidelines, the development of ONCO-ROUTES was supported by experts in focus groups and interviews, and digitalization was carried out in connection with the IT infrastructure. Results A Needs-based, Quality-of-life (QoL) and Symptoms Screening (NQS2) tool already established in the routine at the UKR was further developed into ONCO-ROUTES, which is made up of the domains therapy phase, nutrition, tobacco use, alcohol use, quality of life, general condition/functional status, physical activity, psychooncology, social services, and further support needs. By linking the digitized questionnaire to the hospital information system, the results are available for immediate use in routine operations and thus for the referral of patients for further supportive therapy. Conclusion The digital PRO application ONCO-ROUTES is designed to involve patients in monitoring additional supportive needs and thus, improves supportive interdisciplinary treatment.}, language = {en} }