@techreport{RabindranathBoeseProbstetal., author = {Rabindranath, Raman and B{\"o}se, Holger and Probst, J{\"o}rn and Schlunck, G{\"u}nther and Mayer, Matthias and Forster, Eva and Bentz, Alexander and Shamonin (Chamonine), Mikhail and Monkman, Gareth J.}, title = {EAP mit magnetisch steuerbarer Elastizit{\"a}t zur Interaktion mit Bindegewebszellen MagElan}, address = {Regensburg}, organization = {Hochschule f{\"u}r Angewandte Wissenschaften Regensburg / Fachbereich Elektro- und Informationstechnik}, pages = {37}, language = {de} } @article{DillingerWeberMayeretal., author = {Dillinger, Andrea Elisabeth and Weber, Gregor R. and Mayer, Matthias and Schneider, Magdalena and G{\"o}ppner, Corinna and Ohlmann, Andreas and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Fuchshofer, Rudolf and Keller, Kate and Lozano, Diana C. and Clark, Abbot}, title = {CCN2/CTGF-A Modulator of the Optic Nerve Head Astrocyte}, series = {Frontiers in cell and developmental biology (Front Cell Dev Biol.)}, volume = {10}, journal = {Frontiers in cell and developmental biology (Front Cell Dev Biol.)}, publisher = {frontiers}, doi = {10.3389/fcell.2022.864433}, pages = {864433}, abstract = {In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent deformation and to degeneration of ON axons. The remodeling process of the ECM causes changes in the biomechanical properties of the ONH and the peripapillary sclera, which is accompanied by an increased reactivity of the resident astrocytes. The molecular factors involved in the remodeling process belong to the Transforming growth factor (TGF)-β superfamily, especially TGF-β2. In previous publications we showed that TGF-β2 induced ECM alterations are mediated by Cellular Communication Network Factor (CCN)2/Connective Tissue Growth Factor (CTGF) and recently we showed that CCN2/CTGF is expressed by astrocytes of the ON under normal conditions. In this study we wanted to get a better understanding of the function of CCN2/CTGF under normal and pathologic conditions. To this end, we analyzed the glial lamina and peripapillary sclera of CCN2/CTGF overexpressing mice and studied the effect of CCN2/CTGF and increasing substratum stiffness on murine ON astrocytes in vitro. We observed enhanced astrocyte reactivity in the ONH, increased ECM protein synthesis in the peripapillary sclera and increased Ccn2/Ctgf expression in the ONH during the pathologic development in situ. CCN2/CTGF treatment of primary murine ON astrocytes induced a higher migration rate, and increase of ECM proteins including fibronectin, elastin and collagen type III. Furthermore, the astrocytes responded to stiffer substratum with increased glial fibrillary acidic protein, vimentin, actin and CCN2/CTGF synthesis. Finally, we observed the reinforced appearance of CCN2/CTGF in the lamina cribrosa of glaucomatous patients. We conclude that reactive changes in ONH astrocytes, induced by the altered biomechanical characteristics of the region, give rise to a self-amplifying process that includes increased TGF-β2/CCN2/CTGF signaling and leads to the synthesis of ECM molecules and cytoskeleton proteins, a process that in turn augments the stiffness at the ONH. Such a scenario may finally result in a vicious circle in the pathogenesis of POAG. The transgenic CTGF-overexpressing mouse model might be an optimal model to study the chronic pathological POAG changes in the ONH.}, language = {en} } @misc{ChavezVegaBoehmScharffetal., author = {Chavez Vega, Jhohan Harvey and B{\"o}hm, Valter and Scharff, Moritz and Prem, Nina and Monkman, Gareth J. and Becker, Tatiana I. and G{\"u}nther, L. and Alencastre, Jorge H. and Grieseler, R. and Zimmermann, Klaus}, title = {Magneto-active elastomer as viscoelastic foundation material for artificial tactile sensors with tuneable properties}, series = {Book of Abstracts of the 16th German Ferrofluid Workshop, Braunschweig, 18.-20.07.2018}, journal = {Book of Abstracts of the 16th German Ferrofluid Workshop, Braunschweig, 18.-20.07.2018}, pages = {16 -- 17}, language = {en} } @incollection{FuechtmeierEgersdoerferTumaetal., author = {F{\"u}chtmeier, Bernd and Egersd{\"o}rfer, Stefan and Tuma, G. and Monkman, Gareth J. and Nerlich, Michael}, title = {Development of a Robotic Navigation and Fracture Fixation System}, series = {Integration of Health Telematics into Medical Practice}, booktitle = {Integration of Health Telematics into Medical Practice}, editor = {Nerlich, Michael and Sch{\"a}chinger, Ulrich}, publisher = {IOS Press}, pages = {43 -- 49}, language = {en} } @article{PutzSchirmerSattleretal., author = {Putz, Christoph and Schirmer, Maximilian and Sattler, Robert and Monkman, Gareth J.}, title = {Fabrication of Bisphenol-free Boron-Siloxane Polymers}, series = {Materials Chemistry and Physics}, journal = {Materials Chemistry and Physics}, edition = {Journal Pre-proof}, publisher = {Elsevier}, doi = {10.1016/j.matchemphys.2025.130567}, abstract = {Interest in the preparation of magnetoactive boron-siloxane polymers (MBP) has been stimulated by recent scientific developments. However, recent regulations have prohibited the inclusion of Bisphenol-A normally employed in the manufacture of commercially available products. In the following publication, two different routes for the preparation of magnetoactive borosiloxane polymers have been taken. First, the possibilities of obtaining homogeneous mixtures of magnetoactive polymers by mixing the magnetic particles with the polymer using solid CO2 (dry ice) and stirring (shearing) are investigated. In the course of the work, an approach for the preparation of reference materials of different viscosities was made to prove the transferability to other elastomers. This is then followed by a brief review of the reaction of the polymer with different solvents in relation to the mixing with particles. In manually kneaded compounds, dispersions ranging from 0.00004 to 0.004 particles per mm3 are common. The process described in this work resulted in agglomerations of no greater than 0.00004 particles per mm3 A possible synthesis route for bisphenol-free boron-siloxanes is then considered, in which for the polymer matrix, polydimethylsilanes (dichloro(methyl)silane), boric acid and iron(III)chloride are used for this purpose by polycondensation.}, language = {en} }