@misc{ScharfenbergMottokArtmannetal., author = {Scharfenberg, Georg and Mottok, J{\"u}rgen and Artmann, Christina and Hobelsberger, Martin and Paric, Ivan and Großmann, Benjamin and Pohlt, Clemens and Wackerbarth, Alena and Pausch, Uli and Heidrich, Christiane and Fadanelli, Martin and Elsner, Michael and P{\"o}cher, Daniel and Pittroff, Lenz and Beer, Stefan and Br{\"u}ckl, Oliver and Haslbeck, Matthias and Sterner, Michael and Thema, Martin and Muggenthaler, Nicole and Lenck, Thorsten and G{\"o}tz, Philipp and Eckert, Fabian and Deubzer, Michael and Stingl, Armin and Simsek, Erol and Kr{\"a}mer, Stefan and Großmann, Benjamin and Schlegl, Thomas and Niedersteiner, Sascha and Berlehner, Thomas and Joblin, Mitchell and Mauerer, Wolfgang and Apel, Sven and Siegmund, Janet and Riehle, Dirk and Weber, Joachim and Palm, Christoph and Zobel, Martin and Al-Falouji, Ghassan and Prestel, Dietmar and Scharfenberg, Georg and Mandl, Roland and Deinzer, Arnulf and Halang, W. and Margraf-Stiksrud, Jutta and Sick, Bernhard and Deinzer, Renate and Scherzinger, Stefanie and Klettke, Meike and St{\"o}rl, Uta and Wiech, Katharina and Kubata, Christoph and Sindersberger, Dirk and Monkman, Gareth J. and Dollinger, Markus and Dembianny, Sven and K{\"o}lbl, Andreas and Welker, Franz and Meier, Matthias and Thumann, Philipp and Swidergal, Krzysztof and Wagner, Marcus and Haug, Sonja and Vernim, Matthias and Seidenst{\"u}cker, Barbara and Weber, Karsten and Arsan, Christian and Schone, Reinhold and M{\"u}nder, Johannes and Schroll-Decker, Irmgard and Dillinger, Andrea Elisabeth and Fuchshofer, Rudolf and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail and Geith, Markus A. and Koch, Fabian and {\"U}hlin, Christian and Schratzenstaller, Thomas and Saßmannshausen, Sean Patrick and Auchter, Eberhard and Kriz, Willy and Springer, Othmar and Thumann, Maria and Kusterle, Wolfgang and Obermeier, Andreas and Udalzow, Anton and Schmailzl, Anton and Hierl, Stefan and Langer, Christoph and Schreiner, Rupert}, title = {Forschungsbericht 2015}, editor = {Baier, Wolfgang}, address = {Regensburg}, organization = {Ostbayerische Technische Hochschule Regensburg}, isbn = {978-3-00-048589-3}, doi = {10.35096/othr/pub-1386}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-13867}, language = {de} } @misc{MauererRexhepajMonkmanetal., author = {Mauerer, Wolfgang and Rexhepaj, Tanja and Monkman, Gareth J. and Sindersberger, Dirk and Diermeier, Andreas and Neidhart, Thomas and Wolfrum, Dominik and Sterner, Michael and Heberl, Michael and Nusko, Robert and Maier, Georg and Nagl, Klaus and Reuter, Monika and Hofrichter, Andreas and Lex, Thomas and Lesch, Florian and Kieninger, B{\"a}rbel and Szalo, Alexander Eduard and Zehner, Alexander and Palm, Christoph and Joblin, Mitchell and Apel, Sven and Ramsauer, Ralf and Lohmann, Daniel and Westner, Markus and Strasser, Artur and Munndi, Maximilian and Ebner, Lena and Elsner, Michael and Weiß, Nils and Segerer, Matthias and Hackenberg, Rudolf and Steger, Sebastian and Schmailzl, Anton and Dostalek, Michael and Armbruster, Dominik and Koch, Fabian and Hierl, Stefan and Thumann, Philipp and Swidergal, Krzysztof and Wagner, Marcus and Briem, Ulrich and Diermeier, Andreas and Spreitzer, Stefan and Beiderbeck, Sabrina and Hook, Christian and Zobel, Martin and Weber, Tim and Groß, Simon and Penzkofer, Rainer and Dendorfer, Sebastian and Schillitz, Ingo and Bauer, Thomas and Rudolph, Clarissa and Schmidt, Katja and Liebetruth, Thomas and Hamer, Markus and Haug, Sonja and Vernim, Matthias and Weber, Karsten and Saßmannshausen, Sean Patrick and Books, Sebastian and Neuleitner, Nikolaus and Rechenauer, Christian and Steffens, Oliver and Kusterle, Wolfgang and G{\"o}mmel, Roland and Wellnitz, Felix and Stierstorfer, Johannes and Stadler, Dominik and Hofmann, Matthias J. and Motschmann, Hubert and Shamonin (Chamonine), Mikhail and Bleicher, Veronika and Fischer, Sebastian and Hackenberg, Rudolf and Horn, Anton and Kawasch, Raphael and Petzenhauser, Michael and Probst, Tobias and Udalzow, Anton and Dams, Florian and Schreiner, Rupert and Langer, Christoph and Prommesberger, Christian and Ławrowski, Robert Damian}, title = {Forschungsbericht 2016}, editor = {Baier, Wolfgang}, address = {Regensburg}, organization = {Ostbayerische Technische Hochschule Regensburg}, doi = {10.35096/othr/pub-1384}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-13840}, language = {de} } @article{MayerRabindranathBoerneretal., author = {Mayer, Matthias and Rabindranath, Raman and B{\"o}rner, Juliane and H{\"o}rner, Eva and Bentz, Alexander and Salgado, Josefina and Han, Hong and B{\"o}se, Holger and Probst, J{\"o}rn and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Schlunck, G{\"u}nther}, title = {Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata}, series = {PLoS ONE}, volume = {8}, journal = {PLoS ONE}, number = {10}, publisher = {PLOS}, doi = {10.1371/journal.pone.0076196}, abstract = {Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young's modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.}, language = {en} } @article{ForsterMayerRabindranathetal., author = {Forster, Eva and Mayer, Matthias and Rabindranath, Raman and B{\"o}se, Holger and Schlunck, G{\"u}nther and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail}, title = {Patterning of ultrasoft, agglutinative magnetorheological elastomers}, series = {Journal of applied polymer science}, volume = {128}, journal = {Journal of applied polymer science}, number = {4}, publisher = {Wiley}, address = {New York, NY}, doi = {10.1002/app.38500}, pages = {2508 -- 2515}, abstract = {A low-cost wax-cast molding technique for structuring ultrasoft (Young's modulus ≤ 40 kPa), agglutinative magnetorheological elastomer (MRE) material is presented. MRE structures ranging from a few millimeters down to the micrometer range with highly reproducible results are possible. Semitransparent MREs are also fabricated and their surfaces modified accordingly. This method opens new possibilities for MREs in biomedical engineering and microfluidic applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013}, language = {en} } @article{DillingerMayerSchneideretal., author = {Dillinger, Andrea Elisabeth and Mayer, Matthias and Schneider, Magdalena and Weber, Gregor R. and Goeppner, Corinna and Tamm, Ernst R. and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Fuchshofer, Rudolf}, title = {Reactive changes in optic nerve astrocytes are mediated by CTGF, TGF beta 2 and increasing substratum stiffness}, series = {Investigative ophthalmology \& visual science}, volume = {56}, journal = {Investigative ophthalmology \& visual science}, number = {7}, publisher = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC}, abstract = {Purpose: Patients with primary open-angle glaucoma (POAG) show a stiffer peripapillary sclera, reactive astrocytes and a remodeled lamina cribrosa (LC). The changes are thought to be mediated by TGFβ2 and its downstream mediator CTGF. Recently we developed a murine glaucoma model by overexpressing CTGF in the anterior eye (βb1CTGF). In this study we investigated the glial lamina region of βb1CTGF mice, and the changes of astrocytes in response to CTGF and TGFβ2 as well as increasing substratum stiffness. Methods: Tangential sections of the glial LC of 2-month-old βb1CTGF mice and their wild-type littermates (WT) were stained with phalloidin and antibodies against GFAP, CTGF and fibronectin (FN). Murine optic nerve (ON) astrocytes from CD1 mice were isolated, cultured and characterized by GFAP staining. The astrocytes were treated with TGFβ2 (1ng/ml) and CTGF (50ng/ml and 100ng/ml). In addition, the cells were seeded on PDMS substrata with different stiffness (10, 30 and 60 kPa). Treated cells were analyzed by Western blotting, real-time RT-PCR and immunohistochemistry. Wound healing assays were performed to analyze migration rate following growth factor treatment. Results: βb1CTGF mice showed a massive increase in CTGF and GFAP in the glial LC when compared with WT mice. Moreover, an increase in FN staining and phalloidin-labeled actin was observed in the peripapillary sclera. Murine ON astrocytes reacted on increased substrate stiffness by increasing the synthesis of GFAP, vimentin and CTGF. Treatment of the cells with TGFβ2 and CTGF led to an enhanced migration rate. In addition, treatment resulted in an increased expression and synthesis of ECM proteins, including FN, tropoelastin, collagen type I and III. The in vitro findings correlated with those seen in the glaucoma mouse model. Conclusions: We conclude that changes in the ECM of LC and peripapillary sclera alter their biomechanical properties and thereby induce reactive changes in resident astrocytes. The reactive changes induced by higher stiffness of their surrounding ECM give rise to a self-amplifying process that includes increased TGFβ2/CTGF signaling and leads to synthesis of ECM and cytoskeletal proteins, a process that in turn augments the stiffness at the optic nerve head (ONH). Such a scenario may finally result in a vicious circle as the causative mechanism for ONH deformation in POAG.}, language = {en} } @article{SorokinStepanovShamoninChamonineetal., author = {Sorokin, Vladislav V. and Stepanov, Gennady V. and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Khokhlov, Alexei R. and Kramarenko, Elena Yu}, title = {Hysteresis of the viscoelastic properties and the normal force in magnetically and mechanically soft magnetoactive elastomers: Effects of filler composition, strain amplitude and magnetic field}, series = {Polymer}, volume = {76}, journal = {Polymer}, publisher = {Elsevier}, doi = {10.1016/j.polymer.2015.08.040}, pages = {191 -- 202}, abstract = {Hysteresis in dynamic modulus, loss factor and normal forces of magnetoactive elastomers (MAEs) comprising various proportions of small (3-5 mu m) and large (50-60 mu m) ferromagnetic particles are experimentally studied using dynamic torsion performed at a fixed oscillation frequency in varying DC magnetic fields. It is shown that hysteresis is a characteristic feature of MAEs observed both under increasing/decreasing magnetic field strength and increasing/decreasing strain amplitude. This hysteresis is attributed to the specific rearrangement of the magnetic filler network under simultaneously applied magnetic field and shear deformation. Rheological properties of the magnetic filler network formed in the magnetic field and, therefore, the rheological properties of MAEs depend strongly on the filler composition and the magnetic field magnitude. Larger magnetic particles and higher magnetic fields provide stronger magnetic networks. Both factors result in the extension of the linear viscoelastic regime to larger strain amplitudes and lead to higher values of shear storage and loss moduli. It is found that the hysteresis width maximises at an intermediate magnetic field where it is attributed to the balance between elastic and magnetic particle interactions. This is apparently where the most significant restructuring of the magnetic network occurs. The hysteresis width decreases with increasing fraction of large particles in the magnetic filler. The loss factor grows significantly when the magnetic network is physically broken by large strains gamma > 1\%. A huge (more than one order of magnitude) increase of normal force at maximum magnetic field strengths is observed. It is predicted that any physical quantity depending on the internal structuring of the magnetic filler should demonstrate hysteresis either with a changing magnetic field and constant deformation amplitude or under variable deformation in a constant magnetic field. (C) 2015 Elsevier Ltd. All rights reserved.}, language = {en} } @article{KreitmeierChashinFetisovetal., author = {Kreitmeier, Florian and Chashin, Dmitri V. and Fetisov, Yuri K. and Fetisov, Leonid Y. and Schulz, Irene and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail}, title = {Nonlinear Magnetoelectric Response of Planar Ferromagnetic-Piezoelectric Structures to Sub-Millisecond Magnetic Pulses}, series = {Sensors}, volume = {12}, journal = {Sensors}, number = {11}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/s121114821}, pages = {14821 -- 14837}, abstract = {The magnetoelectric response of bi- and symmetric trilayer composite structures to pulsed magnetic fields is experimentally investigated in detail. The structures comprise layers of commercially available piezoelectric (lead zirconate titanate) and magnetostrictive (permendur or nickel) materials. The magnetic-field pulses have the form of a half-wave sine function with duration of 450 µs and amplitudes ranging from 500 Oe to 38 kOe. The time dependence of the resulting voltage is presented and explained by theoretical estimations. Appearance of voltage oscillations with frequencies much larger than the reciprocal pulse length is observed for sufficiently large amplitudes (~1-10 kOe) of the magnetic-field pulse. The origin of these oscillations is the excitation of bending and planar acoustic oscillations in the structures. Dependencies of the magnetoelectric voltage coefficient on the excitation frequency and the applied magnetic field are calculated by digital signal processing and compared with those obtained by the method of harmonic field modulation. The results are of interest for developing magnetoelectric sensors of pulsed magnetic fields as well as for rapid characterization of magnetoelectric composite structures.}, language = {en} } @article{SorokinEckerStepanovetal., author = {Sorokin, Vladislav V. and Ecker, Eva and Stepanov, Gennady V. and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Kramarenko, Elena Yu and Khokhlov, Alexei R.}, title = {Experimental study of the magnetic field enhanced Payne effect in magnetorheological elastomers}, series = {Soft Matter}, volume = {10}, journal = {Soft Matter}, number = {43}, publisher = {ROYAL Society of CHEMISTRY}, doi = {10.1039/c4sm01738b}, pages = {8765 -- 8776}, abstract = {The dynamic modulus and the loss factor of magnetorheological elastomers (MREs) of various compositions and anisotropies are studied by dynamic torsion oscillations performed in the absence and in the presence of an external magnetic field. The emphasis is on the Payne effect, i.e. the dependence of the elastomer magnetorheological characteristics on the strain amplitude and their evolution with cyclically increasing and decreasing strain amplitudes. MREs are based on two silicone matrices differing in storage modulus (soft, G' similar to 10(3) Pa, and hard, G' similar to 10(4) Pa, matrices). For each matrix, the concentration of carbonyl iron particles with diameters of 3-5 mu m was equal to 70 and 82 mass\% (22 and 35 vol\%, respectively) in the composite material. Samples for each filler content, isotropic and aligned-particles, are investigated. It is found that the Payne effect significantly increases in the presence of an external magnetic field and varies with the cyclical loading which reaches saturation after several cycles. The results are interpreted as the processes of formation-destruction-reformation of the internal filler structure under the simultaneously applied mechanical force and magnetic field. Impacts of matrix elasticity and magnetic interactions on the filler alignment are elucidated.}, language = {en} } @inproceedings{EgersdoerferZeidlerWieseretal., author = {Egersd{\"o}rfer, Stefan and Zeidler, A. and Wieser, A. and Trompier, F. and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail}, title = {A portable accident dosimeter using tooth enamel}, series = {Proceedings of the 7th International Symposium on EPR Dosimetry and Applications and the 2nd International Conference on Biodosimetry held at the Uniformed Services University of the Health Sciences, Bethesda, MD, USA, 10-13 July 2006}, booktitle = {Proceedings of the 7th International Symposium on EPR Dosimetry and Applications and the 2nd International Conference on Biodosimetry held at the Uniformed Services University of the Health Sciences, Bethesda, MD, USA, 10-13 July 2006}, publisher = {Pergamon}, address = {Oxford}, language = {en} } @article{SorokinStepanovShamoninChamonineetal., author = {Sorokin, Vladislav V. and Stepanov, Gennady V. and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Kramarenko, Elena Yu}, title = {Magnetorheological behavior of magnetoactive elastomers filled with bimodal iron and magnetite particles}, series = {Smart materials and structures}, volume = {26}, journal = {Smart materials and structures}, number = {3}, publisher = {IOP Publishing}, doi = {10.1088/1361-665X/26/3/035019}, abstract = {Magnetoactive elastomers (MAE) based on soft silicone matrices, filled with various proportions of large diameter ( approximately 50 mu m) iron and small diameter ( approximately 0.5 mu m) magnetite particles are synthesized. Their rheological behavior in homogeneous magnetic fields up to 600 mT is studied in detail. The addition of small magnetite particles facilitates fabrication of uniformly distributed magnetic elastomer composites by preventing aggregation and sedimentation of large particles during curing. It is shown that using the proposed bimodal filler particles it is possible to tailor various magnetorheological (MR) properties which can be useful for different target applications. In particular, either absolute or relative magnetorheological effects can be tuned. The value of the damping factor as well as the range of deformation amplitudes for the linear viscoelastic regime can be chosen. The interdependencies between different MR properties of bimodal MAEs are considered. The results are discussed in the model framework of particle network formation under the simultaneous influence of external magnetic fields and mechanical deformation.}, language = {en} } @article{StollMayerMonkmanetal., author = {Stoll, Andrea and Mayer, Matthias and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail}, title = {Evaluation of highly compliant magneto-active elastomers with colossal magnetorheological response}, series = {Journal of applied polymer science}, journal = {Journal of applied polymer science}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-4628}, doi = {10.1002/app.39793}, abstract = {Highly compliant elastomers with a shear storage modulus as low as 25 Pa are prepared using commercially available silicone, plasticizer, and tactile mutator silicone additive. They are used as matrix material for magneto-active elastomers (MAEs) with carbonyl iron contents between 0 and 85 wt \%. In the absence of an external magnetic field, the storage modulus of MAEs based on two selected mixtures ranges between ~100 Pa and ~2000 Pa. Addition of a mutator to the matrix mixture results in a long post-cure period depending on the curing temperature and the initial mixture. In the presence of a magnetic field, the presented MAEs exhibit a strong magneto-induced change in storage modulus resulting in a colossal magnetorheological effect of >106 \% which is ~30 times higher than previously reported values. The results are of interest in applications using such elastomers as cell substrates with magnetically tunable rigidity.}, language = {en} } @inproceedings{KreitmeierSchulzMonkmanetal., author = {Kreitmeier, Florian and Schulz, Irene and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail and Fetisov, Yuri K. and Chashin, Dmitri V. and Fetisov, Leonid Y.}, title = {Observation of Nonlinear Magnetoelectric Response to Magnetic Pulses in Layered Magnetostrictive-Piezoelectric Structures}, publisher = {IEEE}, doi = {10.1109/ISAF.2012.6297739}, abstract = {A detailed experimental study of the magnetoelectric response of planar bi- and symmetric trilayer composite structures to magnetic field pulses is reported. The structures consist of layers of commercially available piezoelectric (lead zirconate titanate) and magnetostrictive (permendur or nickel) materials. The magnetic-field pulses have the form of a half-wave sine function with duration of 450 μs and amplitude from 500 Oe up to 38 kOe. The measurement method is explained and the measured time dependence of the resulting voltage is presented. The most interesting case, when pulse amplitudes are sufficiently large (~ 1-10 kOe) and various types of acoustic oscillation with frequencies much larger than the reciprocal pulse length are excited in the structures, is considered. The dependencies of the magnetoelectric voltage coefficient on the excitation frequency and the applied magnetic field are calculated. By digital signal processing the results are compared with those obtained by the method of harmonic field modulation (HFM). The findings are of interest for developing magnetoelectric sensors for pulsed magnetic fields as well as for rapid characterization of magnetoelectric composite structures.}, language = {en} } @misc{LautenschlaegerLeisDendorferetal., author = {Lautenschl{\"a}ger, Toni and Leis, Alexander and Dendorfer, Sebastian and Palm, Christoph and Schreiner, Rupert and Langer, Christoph and Prommesberger, Christian and Ławrowski, Robert Damian and Dams, Florian and Bornmann, Benjamin and Navitski, Aliaksandr and Serbun, Pavel and M{\"u}ller, G{\"u}nter and Liebetruth, Thomas and Kohlert, Dieter and Pernsteiner, Jochen and Schreier, Franz and Heerklotz, Sabrina and Heerklotz, Allwin and Boos, Alexander and Herwald, Dominik and Monkman, Gareth J. and Treiber, Daniel and Mayer, Matthias and H{\"o}rner, Eva and Bentz, Alexander and Shamonin (Chamonine), Mikhail and Johansen, S{\o}ren Peter and Reichel, Marco and Stoll, Andrea and Briem, Ulrich and Dullien, Silvia and Renkawitz, Tobias and Weber, Tim and Dendorfer, Sebastian and Grifka, Joachim and Penzkofer, Rainer and Barnsteiner, K. and Jovanovik, M. and Wernecke, P. and V{\"o}gele, A. and Bachmann, T. and Pl{\"o}tz, Martin and Schliekmann, Claus and Wels, Harald and Helmberger, Paul and Kaspar, Marcel and H{\"o}nicka, M. and Schrammel, Siegfried and Enser, Markus and Schmidmeier, Monika and Schroll-Decker, Irmgard and Haug, Sonja and Gelfert, Verena and Vernim, Matthias}, title = {Forschungsbericht 2012}, editor = {Baier, Wolfgang}, address = {Regensburg}, organization = {Ostbayerische Technische Hochschule Regensburg}, doi = {10.35096/othr/pub-783}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-7834}, pages = {64}, language = {de} } @misc{SorokinStepanovVasilievetal., author = {Sorokin, Vladislav V. and Stepanov, Gennady V. and Vasiliev, V. G. and Kramarenko, Elena Yu and Mayer, Matthias and Shamonin (Chamonine), Mikhail and Monkman, Gareth J.}, title = {Investigation of Dynamic Modulus and Normal Force of Magnetorheological Elastomers with Soft and Hard Magnetic Fillers}, series = {NANO 2014, July 13 - 18, 2014, Moscow ; Section 06 - Polymer, Organic and Other Soft Matter Materials}, journal = {NANO 2014, July 13 - 18, 2014, Moscow ; Section 06 - Polymer, Organic and Other Soft Matter Materials}, address = {Moscow}, language = {en} }