@article{HornFischerRaptisetal., author = {Horn, Lars-Christian and Fischer, Uta and Raptis, Georgios and Bilek, Karin and Hentschel, Bettina}, title = {Tumor size is of prognostic value in surgically treated FIGO stage II cervical cancer}, series = {Gynecologic Oncology}, volume = {107}, journal = {Gynecologic Oncology}, number = {2}, doi = {10.1016/j.ygyno.2007.06.026}, pages = {310 -- 315}, abstract = {Objectives Tumor size is a well recognized prognostic factor in early stage cervical carcinoma (CX). However, limited knowledge exists about the value of tumor size in surgically treated CX with extrauterine extension. Methods 245 cases of local advanced CX (FIGO stage IIA and IIB) who received upfront surgery were evaluated regarding tumor size, regarding the prediction of pelvic lymph node involvement and recurrence free and overall survival during a median follow-up time of 54 months (95\% CI 45.4-62.6 months). Tumors larger than 4 cm were defined as bulky stage disease. Results Bulky disease was seen in 46.1\% (113/245). 60.2\% of these patients showed pelvic lymph node involvement, compared to 42.4\% (56/132) in non-bulky tumors (p = 0.006; odds ratio: 2.2 [95\% CI: 1.3-3.6]). Patients with bulky tumors showed an increase of recurrent disease (40.2\% vs. 28.0\%; p = 0.045). The relative risk for recurrent disease was 1.97 (95\% CI: 1.3-3.0). The 5-year overall survival rate was significantly lower (67.7\% [95\% CI: 58.2-74.8] vs. 49.5\% [95\% CI: 36.8-59.1]; p = 0.0015). In multivariate analysis, tumor stage, pelvic lymph node involvement and maximal tumor size were independent prognostic factors. Conclusions The results suggest that tumor size, defining bulky disease as tumors larger than 4 cm, is of prognostic impact also in FIGO stage II cervical carcinomas. A revised FIGO/TNM classification system similar to the subgrouping of stage IB CX is recommended for stage II using a cut-off value of 4 cm as discriminator: stage IIA1 and stage IIB1 for tumors with ≤ 4 cm and IIA2 and IIB2 for tumors > 4 cm (i.e. bulky disease).}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{HornFischerHaneletal., author = {Horn, Lars-Christian and Fischer, Uta and Hanel, C. and Kuhn, H. and Raptis, Georgios and Bilek, Karin}, title = {p53 in surgically treated and pathologically staged cervical cancer}, series = {Pathology - Research and Practice}, volume = {197}, journal = {Pathology - Research and Practice}, number = {9}, pages = {605 -- 609}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{FischerRaptisGessneretal., author = {Fischer, Uta and Raptis, Georgios and Geßner, W. and Roschlau, U. and Dressel, K. and Bilek, Karin and Horn, Lars-Christian}, title = {Epidemiologie und formale Pathogenese des Zervixkarzinoms}, series = {Zentralblatt f{\"u}r Gyn{\"a}kologie}, volume = {123}, journal = {Zentralblatt f{\"u}r Gyn{\"a}kologie}, number = {4}, pages = {198 -- 205}, subject = {Geb{\"a}rmutterhalskrebs}, language = {de} } @article{HornRaptisFischeretal., author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta and Bilek, Karin}, title = {Standardised handling of hysterectomy specimen in cervical cancer - report of over 900 stage pT1b1- to pT2b-tumors}, series = {Pathology - Research and Practice}, volume = {196}, journal = {Pathology - Research and Practice}, pages = {450}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{HornRaptisFischeretal., author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta and Bilek, Karin}, title = {Impact of tumorload in surgically treated, histologically staged early cervical cancer: Multivariate analysis of 568 patients}, series = {International Journal of Gynecology \& Obstetrics}, volume = {70}, journal = {International Journal of Gynecology \& Obstetrics}, number = {Suppl. 1}, pages = {20 -- 21}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{HornRaptisFischeretal., author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta and Bilek, Karin}, title = {p53-tumorsuppressor gene in surgically treated histologically staged early cervical cancer}, series = {International Journal of Gynecology \& Obstetrics}, volume = {70}, journal = {International Journal of Gynecology \& Obstetrics}, number = {Suppl. 1}, pages = {112}, subject = {Tumorsuppressor-Gen}, language = {en} }