@article{HornFischerRaptisetal., author = {Horn, Lars-Christian and Fischer, Uta and Raptis, Georgios and Bilek, Karin and Hentschel, Bettina and Richter, Christine E. and Braumann, Ulf Dietrich and Einenkel, Jens}, title = {Pattern of invasion is of prognostic value in surgically treated cervical cancer patients}, series = {Gynecologic Oncology}, volume = {103}, journal = {Gynecologic Oncology}, number = {3}, doi = {10.1016/j.ygyno.2006.05.046}, pages = {906 -- 911}, abstract = {Objectives: Different patterns of invasion (representing different grades of tumor cell dissociation) are associated with prognostic outcome in cancer. We evaluated the prognostic value of different patterns of invasion (PI) in cervical carcinomas (CX). Methods: Six hundred eleven surgically treated CX (FIGO IB to IIB) were re-evaluated histologically regarding the PI, using a three-level scoring system. Closed PI was defined as cohesive growth with well-delineated (pushing) borders. In finger-like PI the tumor grows in solid cords/trabecles. Highly dissociative growth in small groups or single cells was defined as spray-like PI. Types of PI were correlated to tumor stage, histo-morphologic factors and prognostic outcome. Results: Sixty percent of the tumors showed a spray-like PI, 30\% a finger-like PI and only 7.4\% were of the closed type. Spray-like PI showed a significant correlation with advanced stage disease, lymphovascular space involvement, poorly differentiated tumors and pelvic lymph node metastases. Spray-like PI was accompanied by a reduced 5-year overall survival when compared to the finger-like and closed PI (68.7\% vs. 80.9\% vs. 88.5\%; P=0.0004). The prognostic impact of the PI disappeared in node-positive patients (P=0.06) but persisted in patients without pelvic lymph node disease (P=0.03). In multivariate analysis, using COX regression model, the PI represented as independent prognostic factor. Conclusions: Spray-like PI (i.e., highest degree of tumor cell dissociation) is associated with advanced tumor stages, increased rate of recurrency and a reduced overall survival. In separate analysis of patients with and without lymph node metastases, the impact of PI persisted only in node-negative cases as a prognostic factor.}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{HornRaptisFischeretal., author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta and Hentschel, Bettina and K{\"o}hler, U. and Richter, Christine E. and Martin, Rosemarie}, title = {CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance}, series = {Archives of Gynecology and Obstetrics}, volume = {273}, journal = {Archives of Gynecology and Obstetrics}, number = {2}, doi = {10.1007/s00404-005-0039-5}, pages = {104 -- 106}, abstract = {Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} }