@inproceedings{KhaledBruhnsReichlingetal., author = {Khaled, W. and Bruhns, Otto T. and Reichling, S. and B{\"o}se, Holger and Baumann, Michael and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Meier, Alexander and Klein, Dagmar and Freimuth, Herbert and Ermert, Helmut}, title = {A haptic system for virtual reality applications based on ultrasound elastography and electrorheological fluids}, series = {Acoustical Imaging (ACIM)}, volume = {27}, booktitle = {Acoustical Imaging (ACIM)}, publisher = {Springer}, address = {Dordrecht}, isbn = {978-90-481-6652-7}, issn = {0270-5117}, doi = {10.1007/978-1-4020-2402-3_85}, pages = {667 -- 674}, abstract = {Mechanical properties of biological tissue represent important diagnostic information and are of histological and pathological relevance. Malignant tumors are significantly stiffer and more immobile than surrounding healthy tissue. Hard calcifications in vessels occur due to arteriosclerosis. The problem is, that such information is usually not available or can only be obtained by manual palpation, which is subjective and limited in sensitivity. It requires intuitive assessment and does not allow quantitative documentation. Unfortunately, none of the established medical imaging equipment such as magnetic resonance imaging (MRI) or X-ray computed tomography (CT) can provide direct measure of tissue elasticity. On the one hand a suitable sensor is required for quantitative measurement of mechanical tissue properties. On the other hand there is also some need for a realistic haptic display of such tissue properties. Suitable actuator arrays with high spatial resolution acting in real time are required. A haptic sensor actuator system is presented in this paper including a sensitive sensor part and an actuator array for different applications. The mechanical consistency of an object is to be locally specified using a sensor system and represented perceptibly in a remote position on an actuator system for the user. The sensor system uses ultrasound (US) elastography, whereas the actuator array is based on electrorheological (ER) fluids.}, language = {en} } @inproceedings{KhaledBruhnsReichlingetal., author = {Khaled, W. and Bruhns, Otto T. and Reichling, S. and B{\"o}se, Holger and Baumann, Michael and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Meier, Alexander and Klein, Dagmar and Freimuth, Herbert and Ermert, Helmut}, title = {A haptic sensor-actuator-system based on ultrasound elastography and electrorheological fluids for virtual reality applications in medicine}, series = {CARS 2003 : computer assisted radiology and surgery ; proceedings of the 17th International Congress and Exhibition London, June 25 - 28, 2003}, booktitle = {CARS 2003 : computer assisted radiology and surgery ; proceedings of the 17th International Congress and Exhibition London, June 25 - 28, 2003}, publisher = {Elsevier}, address = {Amsterdam}, pages = {1354}, abstract = {Mechanical properties of biological tissue represent important diagnostic information and are of histological relevance (hard lesions, "nodes" in organs: tumors; calcifications in vessels: arteriosclerosis). The problem is, that such information is usually obtained by digital palpation only, which is limited with respect to sensitivity. It requires intuitive assessment and does not allow quantitative documentation. A suitable sensor is required for quantitative detection of mechanical tissue properties. On the other hand, there is also some need for a realistic mechanical display of those tissue properties. Suitable actuator arrays with high spatial resolution and real-time capabilities are required operating in a haptic sensor actuator system with different applications. The sensor system uses real time ultrasonic elastography whereas the tactile actuator is based on electrorheological fluids. Due to their small size the actuator array elements have to be manufactured by micro-mechanical production methods. In order to supply the actuator elements with individual high voltages a sophisticated switching and control concept have been designed. This haptic system has the potential of inducing real time substantial forces, using a compact lightweight mechanism which can be applied to numerous areas including intraoperative navigation, telemedicine, teaching, space and telecommunication.}, language = {en} } @article{KhaledErmertBruhnsetal., author = {Khaled, W. and Ermert, Helmut and Bruhns, Otto T. and Reichling, S. and B{\"o}se, Holger and Baumann, Michael and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Meier, Alexander and Klein, Dagmar and Freimuth, Herbert}, title = {Haptic sensor-actuator-system based on ultrasound elastography and electrorheological fluids for virtual reality applications in medicine}, series = {Studies in health technology and informatics, Medicine Meets Virtual Reality (MMVR)}, volume = {11}, journal = {Studies in health technology and informatics, Medicine Meets Virtual Reality (MMVR)}, number = {94}, publisher = {IOS Press}, pages = {144 -- 150}, abstract = {Mechanical properties of biological tissue represent important diagnostic information and are of histological relevance (hard lesions, "nodes" in organs: tumors; calcifications in vessels: arteriosclerosis). The problem is, that such information is usually obtained by digital palpation only, which is limited with respect to sensitivity. It requires intuitive assessment and does not allow quantitative documentation. A suitable sensor is required for quantitative detection of mechanical tissue properties. On the other hand, there is also some need for a realistic mechanical display of those tissue properties. Suitable actuator arrays with high spatial resolution and real-time capabilities are required operating in a haptic sensor actuator system with different applications. The sensor system uses real time ultrasonic elastography whereas the tactile actuator is based on electrorheological fluids. Due to their small size the actuator array elements have to be manufactured by micro-mechanical production methods. In order to supply the actuator elements with individual high voltages a sophisticated switching and control concept have been designed. This haptic system has the potential of inducing real time substantial forces, using a compact lightweight mechanism which can be applied to numerous areas including intraoperative navigation, telemedicine, teaching, space and telecommunication.}, language = {de} } @inproceedings{KhaledReichlingBruhnsetal., author = {Khaled, W. and Reichling, S. and Bruhns, Otto T. and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Baumann, Michael and B{\"o}se, Holger and Klein, Dagmar and Freimuth, Herbert and Tunayar, A. and Lorenz, A. and Pessavento, A. and Ermert, Helmut}, title = {Palpation imaging using a haptic system for virtual reality applications in medicine}, series = {Perspective in image-guided surgery : proceedings of the Scientific Workshop on Medical Robotics, Navigation, and Visualization : RheinAhrCampus Remagen, Germany, 11-12 March}, booktitle = {Perspective in image-guided surgery : proceedings of the Scientific Workshop on Medical Robotics, Navigation, and Visualization : RheinAhrCampus Remagen, Germany, 11-12 March}, publisher = {World Scientific Publ.}, address = {Singapore}, pages = {407 -- 414}, language = {en} } @inproceedings{KhaledReichlingBruhnsetal., author = {Khaled, W. and Reichling, S. and Bruhns, Otto T. and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Baumann, Michael and B{\"o}se, Holger and Klein, Dagmar and Freimuth, Herbert and Tunayar, A. and Lorenz, A. and Pessavento, A. and Ermert, Helmut}, title = {Palpation Imaging using a Haptic System for Virtual Reality Applications in Medicine}, series = {Proceedings of the 12th Annual Medicine Meets Virtual Reality Conference: - Building a Better You: The Next Tools for Medical Education, Diagnosis, and Care. - Medicine Meets Virtual Reality (MMVR) - Newport Beach (California, USA). 2004}, booktitle = {Proceedings of the 12th Annual Medicine Meets Virtual Reality Conference: - Building a Better You: The Next Tools for Medical Education, Diagnosis, and Care. - Medicine Meets Virtual Reality (MMVR) - Newport Beach (California, USA). 2004}, language = {en} } @inproceedings{KhaledBruhnsReichlingetal., author = {Khaled, W. and Bruhns, Otto T. and Reichling, S. and B{\"o}se, Holger and Baumann, Michael and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Meier, Alexander and Freimuth, Herbert and Tunayar, A. and Ermert, Helmut}, title = {A New Haptic Sensor Actuator System for Virtual Reality Applications in Medicine}, series = {Medical Image Computing and Computer-Assisted Intervention - MICCAI 2003: 6th International Conference, Montr{\´e}al, Canada, November 15-18, 2003, Proceedings}, booktitle = {Medical Image Computing and Computer-Assisted Intervention - MICCAI 2003: 6th International Conference, Montr{\´e}al, Canada, November 15-18, 2003, Proceedings}, publisher = {Springer}, isbn = {978-3540204626}, pages = {132 -- 140}, language = {en} } @article{KhaledBruhnsReichlingetal., author = {Khaled, W. and Bruhns, Otto T. and Reichling, S. and B{\"o}se, Holger and Baumann, Michael and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Meier, Alexander and Klein, Dagmar and Freimuth, Herbert and Ermert, Helmut}, title = {A haptic system for virtual reality applications based on ultrasound elastography and electrorheological fluids}, series = {Acoustical Imaging}, journal = {Acoustical Imaging}, number = {27}, publisher = {Kluver Academic}, address = {Dordrecht \& New York}, doi = {10.1007/978-1-4020-2402-3_85}, pages = {667 -- 675}, language = {en} } @inproceedings{KhaledReichlingBruhnsetal., author = {Khaled, W. and Reichling, S. and Bruhns, Otto T. and Ermert, Helmut and Monkman, Gareth J. and Egersd{\"o}rfer, Stefan and Baumann, Michael and B{\"o}se, Holger and Freimuth, Herbert and Tunayar, A.}, title = {Palpation imaging using a haptic sensor actuator system for medical applications}, series = {Actuator 2004 : 9th International Conference on New Actuators \& 3rd International Exhibition on Smart Actuators and Drive Systems, 14-16 June 2004, Bremen, Germany}, booktitle = {Actuator 2004 : 9th International Conference on New Actuators \& 3rd International Exhibition on Smart Actuators and Drive Systems, 14-16 June 2004, Bremen, Germany}, publisher = {HVG Hanseatische Veranstaltungs-GmbH}, address = {Bremen}, pages = {379 -- 382}, language = {en} } @article{MayerRabindranathBoerneretal., author = {Mayer, Matthias and Rabindranath, Raman and B{\"o}rner, Juliane and H{\"o}rner, Eva and Bentz, Alexander and Salgado, Josefina and Han, Hong and B{\"o}se, Holger and Probst, J{\"o}rn and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Schlunck, G{\"u}nther}, title = {Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata}, series = {PLoS ONE}, volume = {8}, journal = {PLoS ONE}, number = {10}, publisher = {PLOS}, doi = {10.1371/journal.pone.0076196}, abstract = {Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young's modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.}, language = {en} } @article{ForsterMayerRabindranathetal., author = {Forster, Eva and Mayer, Matthias and Rabindranath, Raman and B{\"o}se, Holger and Schlunck, G{\"u}nther and Monkman, Gareth J. and Shamonin (Chamonine), Mikhail}, title = {Patterning of ultrasoft, agglutinative magnetorheological elastomers}, series = {Journal of applied polymer science}, volume = {128}, journal = {Journal of applied polymer science}, number = {4}, publisher = {Wiley}, address = {New York, NY}, doi = {10.1002/app.38500}, pages = {2508 -- 2515}, abstract = {A low-cost wax-cast molding technique for structuring ultrasoft (Young's modulus ≤ 40 kPa), agglutinative magnetorheological elastomer (MRE) material is presented. MRE structures ranging from a few millimeters down to the micrometer range with highly reproducible results are possible. Semitransparent MREs are also fabricated and their surfaces modified accordingly. This method opens new possibilities for MREs in biomedical engineering and microfluidic applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013}, language = {en} }