@article{HaugSchnellRaptisetal., author = {Haug, Sonja and Schnell, Rainer and Raptis, Georgios and Dotter, Caroline and Weber, Karsten}, title = {Wissen und Einstellung zur Speicherung und Nutzung von Gesundheitsdaten: Ergebnisse einer Bev{\"o}lkerungsbefragung}, series = {Zeitschrift f{\"u}r Evidenz, Fortbildung und Qualit{\"a}t im Gesundheitswesen}, journal = {Zeitschrift f{\"u}r Evidenz, Fortbildung und Qualit{\"a}t im Gesundheitswesen}, publisher = {Elsevier}, issn = {1865-9217}, doi = {10.1016/j.zefq.2023.11.001}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-67461}, pages = {50 -- 58}, abstract = {Hintergrund/Zielsetzung Der Beitrag befasst sich mit dem Wissenstand und der Einstellung der Bev{\"o}lkerung. Betrachtet werden die {\"U}bermittlung und Verf{\"u}gbarkeit von Gesundheitsdaten, Gesundheitsregister, die elektronische Patientenakte, Einwilligungsverfahren f{\"u}r die {\"U}bermittlung von Daten und der Zugriff auf Gesundheitsdaten zu Forschungszwecken. Methoden Die Studie basiert auf einer computergest{\"u}tzten Telefonbefragung (Dual-Frame) bei einer Zufallsstichprobe der Bev{\"o}lkerung in Deutschland im Zeitraum 01.-27.06.2022 (n = 1.308). Ergebnisse Der Wissensstand zur {\"U}bermittlung von Gesundheitsdaten an Krankenkassen ist hoch, wohingegen das Vorhandensein zentraler Sterbe-, Impf- und Gesundheitsregister sowie der Zugriff auf Gesundheitsdaten durch behandelnde {\"A}rztinnen und {\"A}rzte {\"u}bersch{\"a}tzt werden. Die Akzeptanz medizinischer Register ist sehr hoch. Die elektronische Patientenakte ist bei der H{\"a}lfte der Bev{\"o}lkerung unbekannt, die Nutzungsbereitschaft ist eher gering ausgepr{\"a}gt; bei der {\"U}bertragung von Daten wird eine Zustimmungsoption bevorzugt, und {\"u}ber achtzig Prozent w{\"u}rden die Daten der elektronischen Patientenakte zur Forschung freigeben. Drei Viertel w{\"u}rden ihre Gesundheitsdaten allgemein zur Forschung freigeben, insbesondere an Universit{\"a}ten in Deutschland, wobei meist Anonymit{\"a}t Bedingung ist. Die Bereitschaft zur Datenfreigabe steigt mit der H{\"o}he des Vertrauens in die Presse sowie in Universit{\"a}ten und Hochschulen, und sie sinkt, wenn ein Datenleck als schwerwiegend erachtet wird. Diskussion und Schlussfolgerung In Deutschland besteht, wie in anderen europ{\"a}ischen L{\"a}ndern, eine große Bereitschaft zur Freigabe von Gesundheitsdaten zu Forschungszwecken. Dagegen ist der Wunsch zur Nutzung der elektronischen Patientenakte eher gering. Ebenso niedrig ist die Akzeptanz einer Widerspruchsoption, die jedoch als Voraussetzung f{\"u}r eine erfolgreiche Einf{\"u}hrung einer elektronischen Patientenakte gilt. Vertrauen in die Forschung und staatliche Stellen, die Gesundheitsdaten verarbeiten, sind zentrale Faktoren.}, language = {en} } @article{ScharfHaugRitthaleretal., author = {Scharf, Anna and Haug, Sonja and Ritthaler, Markus and Raptis, Georgios}, title = {Chancen und Herausforderungen der Digitalisierung bei der Rehabilitation - Ergebnisse einer Befragung von Rehabilitationseinrichtungen}, series = {Die Rehabilitation: Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, volume = {62}, journal = {Die Rehabilitation: Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, number = {5}, publisher = {Thieme}, address = {Stuttgart}, doi = {10.1055/a-2123-1566}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-64726}, pages = {299 -- 307}, abstract = {Ziel der Studie: Ziel der Studie ist die Messung des Stands der Digitalisierung und die mit einer Anbindung an die Telematikinfrastruktur verbundenen Chancen und Herausforderungen f{\"u}r Rehabilitationseinrichtungen. Methodik: Teilstandardisierte Online-Befragung bei Tr{\"a}gern von Rehabilitationseinrichtungen in Bayern (n=33). Der Fragebogen mit 36 Fragen beinhaltet eine leicht ver{\"a}nderte Skala auf Basis des „Electronic Medical Record Adoption Model (EMRAM)". Ergebnisse: Der Digitalisierungsgrad wurde in 70 Prozent der Rehabilitationseinrichtungen mit Stufe 0 angegeben (Stufenmodell bis 7). Die {\"U}bermittlung patientenbezogener Daten (Eingang und Ausgang) erfolgt h{\"a}ufig analog, wohingegen die Verarbeitung innerhalb der Einrichtung in vielen F{\"a}llen bereits {\"u}berwiegend digital ist. Beim Anschluss an die Telematikinfrastruktur wird hoher Aufwand bei der Installation, aber auch der Schulung des Personals und der Anpassung der Arbeitsorganisation gesehen. Schlussfolgerung: Durch {\"A}nderung der gesetzlich-finanziellen Lage in Deutschland er{\"o}ffnen sich f{\"u}r Rehabilitationseinrichtungen neue M{\"o}glichkeiten einer verst{\"a}rkten Digitalisierung. H{\"u}rden h{\"a}ngen mit Anforderungen an IT-Sicherheit, Schulung des Personals und sowie dem ebenfalls geringen Digitalisierungsstand bei Krankenh{\"a}usern und {\"A}rzt*innen sowie Patient*innen zusammen, die eine digitale Daten{\"u}bermittlung erschweren.}, language = {de} } @misc{HaugSchnellRaptisetal., author = {Haug, Sonja and Schnell, Rainer and Raptis, Georgios and Dotter, Caroline and Weber, Karsten}, title = {Projekt: Privacy und Willingness to share von Gesundheitsdaten (PWG): Fragebogen}, doi = {10.35096/othr/pub-6057}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-60575}, abstract = {Befragung zum Umgang mit Gesundheitsdaten Die Studie basiert auf einer computergest{\"u}tzten Telefonbefragung (Dual-Frame) bei einer Zufallsstichprobe der Bev{\"o}lkerung (innerhalb der via ADM-Telefonstichprobe rekrutierten Teilnehmer der infas-Mehrthemenbefragung) ab 18 Jahren in Deutschland, die im Zeitraum 01.-27.06.2022 erhoben wurden (n=1.308). Der Fragebogen besteht aus 46 standardisierten Fragen inkl. Soziodemografie und 69 Items. Einzelne Fragen wurden (teilweise {\"u}bersetzt und leicht abgewandelt) {\"u}bernommen aus anderen Studien.}, language = {de} } @misc{HaugSchnellRaptisetal., author = {Haug, Sonja and Schnell, Rainer and Raptis, Georgios and Dotter, Caroline and Weber, Karsten}, title = {Projekt: Privacy und Willingness to share von Gesundheitsdaten (PWG): Fragebogen}, doi = {10.35096/othr/pub-7680}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-76802}, abstract = {Survey on the acceptance of sharing health data. The study is based on a computer-assisted telephone survey (dual-frame) of a random sample of the population (within the participants of the infas multi-topic survey recruited via ADM telephone sample) aged 18 and over in Germany, which was collected in the period 01-27 June 2022 (n=1,308). The questionnaire consists of 46 standardised questions including socio-demographics and 69 items. Individual questions were taken (partially translated and slightly modified) from other studies. This document is the translation of the German language questionaire used in the field. The original document may be found here: https://doi.org/10.35096/othr/pub-6057.}, language = {en} } @article{HornRaptisFischeretal., author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta and Hentschel, Bettina and K{\"o}hler, U. and Richter, Christine E. and Martin, Rosemarie}, title = {CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance}, series = {Archives of Gynecology and Obstetrics}, volume = {273}, journal = {Archives of Gynecology and Obstetrics}, number = {2}, doi = {10.1007/s00404-005-0039-5}, pages = {104 -- 106}, abstract = {Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @inproceedings{WiesmaierLippertKaratsiolisetal., author = {Wiesmaier, Alexander and Lippert, Markus and Karatsiolis, Vangelis and Raptis, Georgios and Buchmann, Johannes}, title = {An Evaluated Certification Services System for the German National Root CA - Legally Binding and Trustworthy Transactions in E-Business and E-Government}, series = {Proceedings of The 2005 International Conference on E-Business, Enterprise Information Systems, E-Government, and Outsourcing, EEE 2005, Las Vegas, Nevada, USA, June 20-23, 2005}, booktitle = {Proceedings of The 2005 International Conference on E-Business, Enterprise Information Systems, E-Government, and Outsourcing, EEE 2005, Las Vegas, Nevada, USA, June 20-23, 2005}, publisher = {CSREA Press}, isbn = {1-932415-76-9}, pages = {103 -- 108}, language = {en} } @article{BuschDaumRaptis, author = {Busch, Ch. and Daum, H. and Raptis, Georgios}, title = {Merkmal Iris. K{\"o}nnen diese Augen l{\"u}gen?}, series = {Spektrum der Wissenschaft}, journal = {Spektrum der Wissenschaft}, number = {7}, pages = {81 -- 82}, subject = {Biometrie}, language = {de} } @misc{Raptis, author = {Raptis, Georgios}, title = {M{\"o}gliche Auswirkungen der eIDAS-Verordnung auf die Telematikinfrastruktur und die eArztausweise}, series = {CAST-Workshop PKI, Darmstadt, 29.01.2015}, journal = {CAST-Workshop PKI, Darmstadt, 29.01.2015}, subject = {Europ{\"a}ische Union }, language = {de} } @book{SauerWolfBuchetal., author = {Sauer, S. and Wolf, Th. and Buch, M. and Raptis, Georgios}, title = {Sichere Client-Server-Architekturen f{\"u}r E-Government}, pages = {192}, subject = {Client-Server-Konzept}, language = {de} } @misc{Raptis, author = {Raptis, Georgios}, title = {HPCs als Basis f{\"u}r den elektronischen Arztausweis}, series = {Smartcard-Workshops, Fraunhofer SIT, 07.02.2006}, journal = {Smartcard-Workshops, Fraunhofer SIT, 07.02.2006}, subject = {Arzt}, language = {de} } @masterthesis{Raptis, type = {Bachelor Thesis}, author = {Raptis, Georgios}, title = {Klassifikation, Anwendungen und Sicherheitskonzept von Trustcentern}, subject = {Trust Center}, language = {de} } @misc{Raptis, author = {Raptis, Georgios}, title = {Datenschutzfragen zur Telemedizin}, series = {Fachtagung Datenschutz in der Medizin - Update 2015 I, Hamburg 03.02.2015}, journal = {Fachtagung Datenschutz in der Medizin - Update 2015 I, Hamburg 03.02.2015}, subject = {Telemedizin}, language = {de} } @article{Raptis, author = {Raptis, Georgios}, title = {Kryptographischer Langzeitschutz}, series = {KES - The Information Security Journal}, volume = {1}, journal = {KES - The Information Security Journal}, pages = {55 -- 62}, subject = {Kryptologie}, language = {de} } @article{Raptis, author = {Raptis, Georgios}, title = {Computer k{\"o}nnen {\"A}rzte nicht ersetzen}, series = {Technology Review}, volume = {11}, journal = {Technology Review}, pages = {82}, language = {de} } @article{HornFischerRaptisetal., author = {Horn, Lars-Christian and Fischer, Uta and Raptis, Georgios and Bilek, Karin and Hentschel, Bettina and Richter, Christine E. and Braumann, Ulf Dietrich and Einenkel, Jens}, title = {Pattern of invasion is of prognostic value in surgically treated cervical cancer patients}, series = {Gynecologic Oncology}, volume = {103}, journal = {Gynecologic Oncology}, number = {3}, doi = {10.1016/j.ygyno.2006.05.046}, pages = {906 -- 911}, abstract = {Objectives: Different patterns of invasion (representing different grades of tumor cell dissociation) are associated with prognostic outcome in cancer. We evaluated the prognostic value of different patterns of invasion (PI) in cervical carcinomas (CX). Methods: Six hundred eleven surgically treated CX (FIGO IB to IIB) were re-evaluated histologically regarding the PI, using a three-level scoring system. Closed PI was defined as cohesive growth with well-delineated (pushing) borders. In finger-like PI the tumor grows in solid cords/trabecles. Highly dissociative growth in small groups or single cells was defined as spray-like PI. Types of PI were correlated to tumor stage, histo-morphologic factors and prognostic outcome. Results: Sixty percent of the tumors showed a spray-like PI, 30\% a finger-like PI and only 7.4\% were of the closed type. Spray-like PI showed a significant correlation with advanced stage disease, lymphovascular space involvement, poorly differentiated tumors and pelvic lymph node metastases. Spray-like PI was accompanied by a reduced 5-year overall survival when compared to the finger-like and closed PI (68.7\% vs. 80.9\% vs. 88.5\%; P=0.0004). The prognostic impact of the PI disappeared in node-positive patients (P=0.06) but persisted in patients without pelvic lymph node disease (P=0.03). In multivariate analysis, using COX regression model, the PI represented as independent prognostic factor. Conclusions: Spray-like PI (i.e., highest degree of tumor cell dissociation) is associated with advanced tumor stages, increased rate of recurrency and a reduced overall survival. In separate analysis of patients with and without lymph node metastases, the impact of PI persisted only in node-negative cases as a prognostic factor.}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @article{HornFischerRaptisetal., author = {Horn, Lars-Christian and Fischer, Uta and Raptis, Georgios and Bilek, Karin and Hentschel, Bettina}, title = {Tumor size is of prognostic value in surgically treated FIGO stage II cervical cancer}, series = {Gynecologic Oncology}, volume = {107}, journal = {Gynecologic Oncology}, number = {2}, doi = {10.1016/j.ygyno.2007.06.026}, pages = {310 -- 315}, abstract = {Objectives Tumor size is a well recognized prognostic factor in early stage cervical carcinoma (CX). However, limited knowledge exists about the value of tumor size in surgically treated CX with extrauterine extension. Methods 245 cases of local advanced CX (FIGO stage IIA and IIB) who received upfront surgery were evaluated regarding tumor size, regarding the prediction of pelvic lymph node involvement and recurrence free and overall survival during a median follow-up time of 54 months (95\% CI 45.4-62.6 months). Tumors larger than 4 cm were defined as bulky stage disease. Results Bulky disease was seen in 46.1\% (113/245). 60.2\% of these patients showed pelvic lymph node involvement, compared to 42.4\% (56/132) in non-bulky tumors (p = 0.006; odds ratio: 2.2 [95\% CI: 1.3-3.6]). Patients with bulky tumors showed an increase of recurrent disease (40.2\% vs. 28.0\%; p = 0.045). The relative risk for recurrent disease was 1.97 (95\% CI: 1.3-3.0). The 5-year overall survival rate was significantly lower (67.7\% [95\% CI: 58.2-74.8] vs. 49.5\% [95\% CI: 36.8-59.1]; p = 0.0015). In multivariate analysis, tumor stage, pelvic lymph node involvement and maximal tumor size were independent prognostic factors. Conclusions The results suggest that tumor size, defining bulky disease as tumors larger than 4 cm, is of prognostic impact also in FIGO stage II cervical carcinomas. A revised FIGO/TNM classification system similar to the subgrouping of stage IB CX is recommended for stage II using a cut-off value of 4 cm as discriminator: stage IIA1 and stage IIB1 for tumors with ≤ 4 cm and IIA2 and IIB2 for tumors > 4 cm (i.e. bulky disease).}, subject = {Geb{\"a}rmutterhalskrebs}, language = {en} } @inproceedings{HoehRaptis, author = {H{\"o}h, H. and Raptis, Georgios}, title = {Applications of the Erbium: YAG Laser in Ophthalmology - Cataracta-, Glaukoma-, Eyelid-Surgery and pars plana Vitrectomy}, abstract = {Recent developments in lasers have provided us the possibility of laser ocular surgery. The xenon, argon, neodymium:YAG and dye lasers have been successfully used in out-patient clinics. The excimer laser has been attracting researchers' interest in the new application of laser to cornea and lens. The erbium:YAG laser emits a 2.94-microns beam that can ablate the transparent ocular tissues such as lenses and corneas. The author has applied this laser to the cornea, lens, vitreous and other ocular tissues. The erbium:YAG laser beam was directed through a 1.5-meter-long, 200-microns-diameter fiberoptic guide. The radiant energy measured about 50 mJ at the end of the probe. The laser was emitted as a 400-microsecond pulse. Freshly enucleated rabbit eyes were used in this study. Laser burns were applied to the tissue surface at various energy settings. At minimal power, the tissues were coagulated by the erbium:YAG laser application. At a power of more than 636-954 mJ/mm2, tissue began to evaporate; the tissue loss was observed under a surgical light microscope. Corneal photoablation, lens ablation, iridotomy, trabeculotomy, cutting of the vitreous and retinal ablation were easily performed. Like the excimer laser, the erbium:YAG laser is a potential tool for ocular surgery.}, subject = {Augenchirurgie}, language = {en} } @article{ChaloupkaRaptisZachetal., author = {Chaloupka, I. and Raptis, Georgios and Zach, A. and Br{\"a}ndlin, K. and Meier-Ewert, H.}, title = {Rolle der quantitativen CMV-DNA-Bestimmungen in der Diagnostik und Therapie der Cytomegalovirusinfektion bei immunsupprimierten Patienten}, series = {Jahrestagung der Gesellschaft f{\"u}r Virologie in Wien, April 2000}, journal = {Jahrestagung der Gesellschaft f{\"u}r Virologie in Wien, April 2000}, subject = {Cytomegalie-Virus}, language = {de} } @inproceedings{HornPippigRaptisetal., author = {Horn, Lars-Christian and Pippig, S. and Raptis, Georgios and Fischer, Uta and K{\"o}hler, U. and Hentschel, Bettina and Martin, Rosemarie}, title = {Tumorassoziierte Proteolyse beim Zervixkarzinom}, series = {87. Tagung der Deutschen Gesellschaft f{\"u}r Pathologie, 14. Juni 2003}, booktitle = {87. Tagung der Deutschen Gesellschaft f{\"u}r Pathologie, 14. Juni 2003}, subject = {Geb{\"a}rmutterhalskrebs}, language = {de} } @misc{HornRaptisFischer, author = {Horn, Lars-Christian and Raptis, Georgios and Fischer, Uta}, title = {Famili{\"a}res Zervixkarzinom - Erste Ergebnisse}, series = {54. Kongress der Deutschen Gesellschaft f{\"u}r Gyn{\"a}kologie und Geburtshilfe}, journal = {54. Kongress der Deutschen Gesellschaft f{\"u}r Gyn{\"a}kologie und Geburtshilfe}, subject = {Geb{\"a}rmutterhalskrebs}, language = {de} } @misc{Raptis, author = {Raptis, Georgios}, title = {{\"U}bersicht {\"u}ber die neuen Technischen Richtlinien des BSI zum ersetzenden Scannen und zur Langzeitarchivierung}, series = {Telemed 2014, Berlin, 14.10.2014}, journal = {Telemed 2014, Berlin, 14.10.2014}, language = {de} } @misc{Raptis, author = {Raptis, Georgios}, title = {Die elektronische Gesundheitskarte}, series = {7. Kommunikationsforum "Industry meets Medicine", Olpe, 5.11.2014}, journal = {7. Kommunikationsforum "Industry meets Medicine", Olpe, 5.11.2014}, subject = {Elektronische Gesundheitskarte}, language = {de} } @inproceedings{SpychalskiRodeRitthaleretal., author = {Spychalski, Dominik and Rode, Olaf and Ritthaler, Markus and Raptis, Georgios}, title = {Conceptual Design and Analysis of a Mobile Digital Identity for eHealth Applications}, series = {2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI): 27-30 July 2021, Athens, Greece}, booktitle = {2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI): 27-30 July 2021, Athens, Greece}, publisher = {IEEE}, issn = {2641-3604}, doi = {10.1109/BHI50953.2021.9508554}, pages = {1 -- 4}, abstract = {As mobile technology continues to improve, more and more professional services are being offered as mobile apps. This paradigm shift also affects eHealth applications. Digital identities in nation-wide eHealth infrastructures are often realized via smart cards, which however, do not support mobile applications well. In this paper we propose a concept of a mobile eID for eHealth based on smartphones with embedded secure hardware, an mobile authenticator app and an account manager as well as an Identity Provider (IdP) as backend services. The practical applicability of the concept is shown using the example of the German eHealth infrastructure. Our method generates a cryptographic key pair in secure hardware on the user's smartphone, registers it on the IdP and uses it to authenticate on the IdP. The security of the private key and the integrity of the smartphone is also validated and attestated. The user's established smartcard-based identity "Electronic Health Card" (EHC) forms the trust anchor. To authenticate against specialist eHealth apps the IdP issues standard-compliant OAuth2.0/OIDC tokens with a limited period of validity. Furthermore, in our security analysis we demonstrate that based on specific security requirements for smartphones and operating systems, at least the eIDAS security level "substantial" related to the technical security aspects of the system can be achieved. On the basis of this research German legislation was adjusted and "digital identities" supplementary to the smartcard-based EHC will be issued from 2023 in the German eHealth infrastructure.}, language = {en} } @misc{Raptis, author = {Raptis, Georgios}, title = {Vernetzung und ubiquit{\"a}re Informationsverarbeitung - technisch-organisatorischer Datenschutz in der Arztpraxis}, series = {2. Fachtagung der Gesellschaft f{\"u}r Datenschutz und Datensicherheit e.V. (GDD), Berlin, 13.05.2014, zertifiziert von der {\"A}rztekammer Berlin}, journal = {2. Fachtagung der Gesellschaft f{\"u}r Datenschutz und Datensicherheit e.V. (GDD), Berlin, 13.05.2014, zertifiziert von der {\"A}rztekammer Berlin}, subject = {Arztpraxis}, language = {de} }