@article{MeinikheimMendelPalmetal.2024, author = {Meinikheim, Michael and Mendel, Robert and Palm, Christoph and Probst, Andreas and Muzalyova, Anna and Scheppach, Markus Wolfgang and Nagl, Sandra and Schnoy, Elisabeth and R{\"o}mmele, Christoph and Schulz, Dominik Andreas Helmut Otto and Schlottmann, Jakob and Prinz, Friederike and Rauber, David and R{\"u}ckert, Tobias and Matsumura, Tomoaki and Fern{\´a}ndez-Esparrach, Gl{\`o}ria and Parsa, Nasim and Byrne, Michael F and Messmann, Helmut and Ebigbo, Alanna}, title = {Effect of AI on performance of endoscopists to detect Barrett neoplasia: A Randomized Tandem Trial}, series = {Endoscopy}, journal = {Endoscopy}, publisher = {Georg Thieme Verlag}, issn = {0013-726X}, doi = {10.1055/a-2296-5696}, year = {2024}, abstract = {Background and study aims To evaluate the effect of an AI-based clinical decision support system (AI) on the performance and diagnostic confidence of endoscopists during the assessment of Barrett's esophagus (BE). Patients and Methods Ninety-six standardized endoscopy videos were assessed by 22 endoscopists from 12 different centers with varying degrees of BE experience. The assessment was randomized into two video sets: Group A (review first without AI and second with AI) and group B (review first with AI and second without AI). Endoscopists were required to evaluate each video for the presence of Barrett's esophagus-related neoplasia (BERN) and then decide on a spot for a targeted biopsy. After the second assessment, they were allowed to change their clinical decision and confidence level. Results AI had a standalone sensitivity, specificity, and accuracy of 92.2\%, 68.9\%, and 81.6\%, respectively. Without AI, BE experts had an overall sensitivity, specificity, and accuracy of 83.3\%, 58.1 and 71.5\%, respectively. With AI, BE nonexperts showed a significant improvement in sensitivity and specificity when videos were assessed a second time with AI (sensitivity 69.7\% (95\% CI, 65.2\% - 74.2\%) to 78.0\% (95\% CI, 74.0\% - 82.0\%); specificity 67.3\% (95\% CI, 62.5\% - 72.2\%) to 72.7\% (95 CI, 68.2\% - 77.3\%). In addition, the diagnostic confidence of BE nonexperts improved significantly with AI. Conclusion BE nonexperts benefitted significantly from the additional AI. BE experts and nonexperts remained below the standalone performance of AI, suggesting that there may be other factors influencing endoscopists to follow or discard AI advice.}, language = {en} }