@misc{GschossmannDendorfer, author = {Gschoßmann, Lukas and Dendorfer, Sebastian}, title = {Personalized Rehabilitation after Total Knee Arthroplasty}, series = {32nd Annual Meeting of the European Orthopaedic Research Society (EORS 2024), 18 - 20 September 2024, Aalborg}, journal = {32nd Annual Meeting of the European Orthopaedic Research Society (EORS 2024), 18 - 20 September 2024, Aalborg}, language = {en} } @inproceedings{MelznerEngelhardtHavelkovaetal., author = {Melzner, Maximilian and Engelhardt, Lucas and Havelkova, Leonard and Simon, Ulrich and Dendorfer, Sebastian}, title = {A new musculoskeletal AnyBody detailed hand model validated by electromyography}, series = {16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) 2019, New York City, USA}, booktitle = {16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) 2019, New York City, USA}, abstract = {The AnyBody™ Modeling System (AMS) [1], is an universally used musculoskeletal simulation software using inverse dynamics. Until now, no complete human hand model is known in the AMS. Also considering other musculoskeletal software platforms, just one detailed entire hand model is recently published [2] but is only based on one subject. The aim of this work is to implement a full detailed hand model for the AMS including all extrinsic and intrinsic muscles using data by the UWB gained through an anatomical study of ten cadaver hands.}, language = {en} } @misc{AuerKrutschRenkawitzetal., author = {Auer, Simon and Krutsch, Werner and Renkawitz, Tobias and Kubowitsch, Simone and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Effect of mental demand on leg loading in highly dynamic motion}, series = {AnyBody online Webinar, Oct 2020}, journal = {AnyBody online Webinar, Oct 2020}, abstract = {Football players have a high risk of leg muscle injuries, especially when exposed to mental stress. Injuries to muscles of the thigh are common in amateur and professional football, representing almost a third of all injuries. These injuries occur primarily in non-contact situations and from overuse. They can lead to a range of costs, including financial costs associated with treatment as well as those associated with long-term recovery, and absence from training and/or competition. Further, there is a high risk of injury recurrence and subsequent injury.}, language = {en} } @article{AuerKrutschRenkawitzetal., author = {Auer, Simon and Krutsch, Werner and Renkawitz, Tobias and Kubowitsch, Simone and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Kognitiver Stress f{\"u}hrt zu unphysiologisch erh{\"o}hten Kniebelastungen im Profifußball}, series = {Sports Orthopaedics and Traumatology}, volume = {36}, journal = {Sports Orthopaedics and Traumatology}, number = {2}, publisher = {Elsevier}, doi = {10.1016/j.orthtr.2020.04.122}, pages = {202 -- 203}, language = {de} } @inproceedings{SuessKubowitschRasmussenetal., author = {S{\"u}ß, Franz and Kubowitsch, Simone and Rasmussen, John and Verkerke, Gijsbertus Jacob and Dendorfer, Sebastian}, title = {The influence of cognitive stress on muscle activation and spinal disc load}, series = {European Society of Biomechanics meeting 2019, Vienna, Austria}, booktitle = {European Society of Biomechanics meeting 2019, Vienna, Austria}, language = {en} } @misc{AurbachSuessDendorfer, author = {Aurbach, Maximilian and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {The impact of the hill type muscle model on the glenohumeral joint reaction force}, series = {16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) 2019, New York City, USA}, journal = {16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) 2019, New York City, USA}, language = {en} } @inproceedings{KubowitschDendorfer, author = {Kubowitsch, Simone and Dendorfer, Sebastian}, title = {Psychologie und Biomechanik - Integrierte Betrachtung von Muskelrekrutierung}, series = {Jahrestagung der Deutschen Gesellschaft f{\"u}r Biofeedback e. V., Regensburg, 2018}, booktitle = {Jahrestagung der Deutschen Gesellschaft f{\"u}r Biofeedback e. V., Regensburg, 2018}, language = {de} } @misc{Dendorfer, author = {Dendorfer, Sebastian}, title = {Virtuelle Modelle der oberen Extremit{\"a}t}, series = {22. Interdisziplin{\"a}res Symposium Medizin-Physiotherapie-Sportwissenschaften, 22.-23.11.2019, Regensburg, Germany}, journal = {22. Interdisziplin{\"a}res Symposium Medizin-Physiotherapie-Sportwissenschaften, 22.-23.11.2019, Regensburg, Germany}, language = {de} } @inproceedings{AurbachWagnerSuessetal., author = {Aurbach, Maximilian and Wagner, Kilian and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Implementation and Validation of Human Kinematics Measured Using IMUs for Musculoskeletal Simulations by the Evaluation of Joint Reaction Forces}, series = {CMBEBIH 2017, Proceedings of the International Conference on Medical and Biological Engineering 2017, Sarajevo, Bosnia and Herzegovina}, volume = {Vol. 62}, booktitle = {CMBEBIH 2017, Proceedings of the International Conference on Medical and Biological Engineering 2017, Sarajevo, Bosnia and Herzegovina}, editor = {Badnjevic, Almir}, publisher = {Springer}, address = {Singapore}, doi = {10.1007/978-981-10-4166-2_31}, pages = {205 -- 211}, abstract = {The gold standard for the analysis of human kinematics and kinetics is a camera-based motion capture system in combination with force measurement platforms. Alternatively, inertial measurement units can be utilized to obtain human kinematics, while ground reaction forces are computed from full body dynamics. This setup represents a system independent from the spatial confinement of a gait laboratory. The aim of this study is the comparison of the two methods by the investigation of lower limb kinematics and the resulting joint reaction forces within the ankle-, knee- and hip joints. For this purpose, human motion during gait was captured simultaneously by both measurement techniques. 13 trials from 8 different test subjects were evaluated in total. IMU data was processed with a quaternion based Kalman Filter. The data sets were implemented into a musculoskeletal simulation program in order to drive a virtual human body model. Each sensor was aligned to the gravitational and magnetic field vectors of the earth. The angles of flexions, extensions and rotations were analyzed to determine kinematic differences. Joint reaction forces defined kinetic dissimilarities. The overall kinematic differences of both models yielded root mean square errors of 7.62°, 6.02°, 4.95°, 2.79°, 2.38° and 3.56° for ankle flexion, subtalar eversion, knee flexion, hip external rotation, hip abduction and hip flexion, respectively. The proximo-distal differences in force peaks between the models yielded overall for the ankle, 57.33 \%Bodyweight(BW) ± 46.86 \%BW (16.66 \%(Maximum peak to peak) ± 13.62 \%) for the knee 37.09 \%BW ± 29.33 \%BW (17.65 \% ± 15.44 \%) and 32.03 \%BW ± 24.33 \%BW (15.6 \% ± 12.54 \%) for the hip. The overall outcome of this work investigated an approach independent of the common setup of the gait laboratory, thus enabling a cheaper and more flexible technology as an alternative. However, kinematic and thus kinetic differences remain rather large. Future work aims to improve the contact criterion for the calculation of the ground reaction forces and the implementation of a full-body calibration algorithm for the IMU system in order to counteract magnetic field disturbances.}, subject = {Bewegungsapparat}, language = {en} } @inproceedings{HammerDendorfer, author = {Hammer, Joachim and Dendorfer, Sebastian}, title = {Cyclic loading and microstructure of cancellous bone}, series = {Journal of Biomechanics}, volume = {41}, booktitle = {Journal of Biomechanics}, number = {Suppl. 1, July 2008}, doi = {10.1016/S0021-9290(08)70409-3}, pages = {S410}, language = {en} } @inproceedings{Dendorfer, author = {Dendorfer, Sebastian}, title = {Biomechanical evaluation and optimisation of countermeasure exercises}, series = {ESA/ESTEC Bedrest Strategy Workshop, Noordwijk, NL, 2009}, booktitle = {ESA/ESTEC Bedrest Strategy Workshop, Noordwijk, NL, 2009}, language = {en} } @misc{AdlerFoerstlSuessetal., author = {Adler, Ina and F{\"o}rstl, Nikolas and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Biomechanical exposition of the factors influencing the pelvic floor muscle activity}, series = {ESB 2024, 29th Congress of the European Society of Biomechanics, 30 June-3 July 2024, Edinburgh, Scotland}, journal = {ESB 2024, 29th Congress of the European Society of Biomechanics, 30 June-3 July 2024, Edinburgh, Scotland}, abstract = {Introduction About 40 \% of the women worldwide suffer from Pelvic Floor Dysfunctions [1]. In previous studies, musculoskeletal simulations helped to understand and facilitate the complex issues of musculoskeletal disorders in several different branches [2, 3]. A fundamental prerequisite for the generation of these models is to have a basic understanding of the stresses acting on the pelvic floor. The aim of this study is to investigate the biomechanical factors influencing the activity of the pelvic floor muscles by establishing a parameterised model. Methods To identify the factors that affect the pelvic floor muscles, the process is divided into several stages. The first step is to investigate the loads acting on the pelvic floor. For this, a simplified sagittal cross-sectional model of the upper body is analysed. The discretization of the abdominal cavity is presented with resulting force vectors representing the organs in the abdominal and pelvic region, the tensile force of the structures that fixate the organs as well as the intraabdominal pressure. A second step is the examination of the basic mechanics of the pelvic floor muscles. As the functional anatomy of these muscles demonstrate differences compared to other muscle groups [4], the understanding of how they differ is crucial for the construction of musculoskeletal models. After a static examination of loads on a simplified muscle model, an extended model including the physiological properties of a muscle must be involved in the considerations. Therefore, the influence of parameters such as the ideal muscle strength and fibre length, as well as elasticity or passive stiffness of the elements must be taken into account. The influencing factors of the variables can be analysed in a simplified pelvic floor muscle model by systematically changing the parameters. Results The process of analysing the factors influencing the activity of the pelvic floor muscles follows two main strategies. The review of the effects of the whole body identifies the forces acting on the pelvic floor muscles and effect their activity. With the examination of the basic mechanics of a simplified pelvic floor muscle model a better understanding is achieved of how the pelvic floor muscles absorb the loads acting in the body. Discussion This process results in the main influence factors on the activity of the pelvic floor. The consequent parameters form the basis for a biomechanically justified construction of musculoskeletal simulation models of the pelvic floor. Nevertheless, it must be considered, that these mechanical studies represent simplifications of the reality. References 1. Wang et al, Front Public Health, 10:975829, 2022. 2. Bulat et al., Curr Sports Med Rep, 18(6):210-216, 2019 3. Melzner et al., Eur J Obstet Gynecol Reprod Biol, 264:306-313, 2021 4. Ashton-Miller et al., Ann N Y Acad Sci, 1101:266-96, 2007}, language = {en} } @misc{AuerReinkerSuessetal., author = {Auer, Simon and Reinker, Lukas and S{\"u}ß, Franz and Kubowitsch, Simone and Krutsch, Werner and Weber, Markus and Renkawitz, Tobias and Dendorfer, Sebastian}, title = {Webcast: Effect of mental demand on leg loading in highly dynamic motion}, abstract = {Football players have a high risk of leg muscle injuries, especially when exposed to mental stress. Injuries to muscles of the thigh are common in amateur and professional football, representing almost a third of all injuries. These injuries occur primarily in non-contact situations and from overuse. They can lead to a range of costs, including financial costs associated with treatment as well as those associated with long-term recovery, and absence from training and/or competition. Further, there is a high risk of injury recurrence and subsequent injury.}, language = {en} } @article{DendorferMelzner, author = {Dendorfer, Sebastian and Melzner, Maximilian}, title = {R{\"u}ckenschmerzen bei Geburtshelfer:innen. Die Haltung macht's.}, series = {Deutsche Hebammen-Zeitschrift}, volume = {74}, journal = {Deutsche Hebammen-Zeitschrift}, number = {11}, publisher = {Staude}, address = {Hannover}, issn = {0012-026X}, pages = {60 -- 62}, abstract = {F{\"u}r Mutter und Kind konnte das Risiko der Geburt durch die Weiterentwicklung der Medizin drastisch reduziert werden. Doch wie ist es um das Wohl derer bestellt, die die Geb{\"a}rende unterst{\"u}tzen? Eine Studie der Ostbayerischen Technischen Hochschule Regensburg hat sich mit den muskuloskelettalen Beschwerden von Geburtshelfer:innen auseinandergesetzt}, language = {de} } @article{VisscherWyssSinghetal., author = {Visscher, Rosa and Wyss, C. and Singh, Navrag B. and Taylor, William R. and Dendorfer, Sebastian and Rutz, E. and Brunner, Reinald}, title = {Influence of TAL-TATS surgery on energy production of Tricepts Surae - A musculoskeletal modeling evaluation}, series = {Gait \& Posture}, volume = {81}, journal = {Gait \& Posture}, number = {Suppl. 1}, publisher = {Elsevier}, doi = {10.1016/j.gaitpost.2020.08.090}, pages = {381 -- 382}, language = {en} } @misc{GschossmannSteinDendorfer, author = {Gschoßmann, Lukas and Stein, Leonhard and Dendorfer, Sebastian}, title = {Subject Specific Scaling Of Muscle Strengths In The Lower Extremity For Musculoskeletal Models}, series = {ESB 2024, 29th Congress of the European Society of Biomechanics, 30 June-3 July 2024, Edinburgh, Scotland}, journal = {ESB 2024, 29th Congress of the European Society of Biomechanics, 30 June-3 July 2024, Edinburgh, Scotland}, language = {en} } @inproceedings{SuessMelznerDendorfer, author = {Suess, Franz and Melzner, Maximilian and Dendorfer, Sebastian}, title = {Towards ergonomics working - machine learning algorithms and musculoskeletal modeling}, series = {IOP Conference Series: Materials Science and Engineering}, volume = {1208}, booktitle = {IOP Conference Series: Materials Science and Engineering}, publisher = {IOP Publishing}, issn = {1757-899X}, doi = {10.1088/1757-899X/1208/1/012001}, abstract = {Ergonomic workplaces lead to fewer work-related musculoskeletal disorders and thus fewer sick days. There are various guidelines to help avoid harmful situations. However, these recommendations are often rather crude and often neglect the complex interaction of biomechanical loading and psychological stress. This study investigates whether machine learning algorithms can be used to predict mechanical and stress-related muscle activity for a standardized motion. For this purpose, experimental data were collected for trunk movement with and without additional psychological stress. Two different algorithms (XGBoost and TensorFlow) were used to model the experimental data. XGBoost in particular predicted the results very well. By combining it with musculoskeletal models, the method shown here can be used for workplace analysis but also for the development of real-time feedback systems in real workplace environments.}, language = {en} } @inproceedings{AurbachJungtaeublSpickaetal., author = {Aurbach, Maximilian and Jungt{\"a}ubl, Dominik and Spicka, Jan and Dendorfer, Sebastian}, title = {EMG-based validation of musculoskeletal models considering crosstalk}, series = {World Congress Biomechanics, 28-30 June 2018, Dublin}, booktitle = {World Congress Biomechanics, 28-30 June 2018, Dublin}, doi = {10.1109/BIOMDLORE.2018.8467211}, abstract = {BACKGROUND: Validation and verification of multibody musculoskeletal models sEMG is a difficult process because of the reliability of sEMG data and the complex relationship of muscle force and sEMG. OBJECTIVE: This work aims at comparing experimentally recorded and simulated muscle activities considering a numerical model for crosstalk. METHODS: For providing an experimentally derived reference data set, subjects were performing elevations of the arm, where the activities of the contemplated muscle groups were measured by sEMG sensors. Computed muscle activities were further processed and transformed into an artificial electromyographical signal, which includes a numerical crosstalk model. In order to determine whether the crosstalk model provides a better agreement with the measured muscle activities, the Pearson correlation coefficient has been computed as a qualitative way of assessing the curve progression of the data sets. RESULTS: The results show an improvement in the correlation coefficient between the experimental data and the simulated muscle activities when taking crosstalk into account. CONCLUSIONS: Although the correlation coefficient increased when the crosstalk model was utilized, it is questionable if the discretization of both, the crosstalk and the musculoskeletal model, is accurate enough.}, language = {en} } @misc{SuessMelznerDendorfer, author = {Suess, Franz and Melzner, Maximilian and Dendorfer, Sebastian}, title = {Towards Ergonomic working - machine learning algorithms and musculoskeletal modeling}, series = {RIM 2021, 13th International Scientific Conference on Manufacturing Engineering, 29 Sept. - 1 Oct 2021, Sarajevo, Bosnia and Herzegovina}, journal = {RIM 2021, 13th International Scientific Conference on Manufacturing Engineering, 29 Sept. - 1 Oct 2021, Sarajevo, Bosnia and Herzegovina}, language = {en} } @techreport{PutzerRasmussenEhrlichetal., author = {Putzer, Michael and Rasmussen, John and Ehrlich, Ingo and Gebbeken, Norbert and Dendorfer, Sebastian}, title = {Muskuloskelettale Simulation zur Untersuchung des Einflusses geometrischer Parameter der Wirbelk{\"o}rper auf die Belastung der Lendenwirbels{\"a}ule}, series = {Forschungsbericht 2013 / Ostbayerische Technische Hochschule Regensburg}, journal = {Forschungsbericht 2013 / Ostbayerische Technische Hochschule Regensburg}, editor = {Baier, Wolfgang}, address = {Regensburg}, organization = {Ostbayerische Technische Hochschule Regensburg}, pages = {60 -- 61}, language = {de} } @misc{Dendorfer, author = {Dendorfer, Sebastian}, title = {Sturz- und Frakturpr{\"a}vention: Use it or lose it!}, series = {10 Jahre Alterstraumatologie Caritas Krankenhaus St. Josef Regensburg}, journal = {10 Jahre Alterstraumatologie Caritas Krankenhaus St. Josef Regensburg}, language = {de} } @inproceedings{DendorferEnglert, author = {Dendorfer, Sebastian and Englert, Carsten}, title = {Forces on a clavicles midshaft fracture and influence of fracture type}, series = {AO Symposium, Regensburg, 2009}, booktitle = {AO Symposium, Regensburg, 2009}, language = {en} } @article{FoerstlSuessEnglertetal., author = {F{\"o}rstl, Nikolas and S{\"u}ß, Franz and Englert, Carsten and Dendorfer, Sebastian}, title = {Design of a reverse shoulder implant to measure shoulder stiffness during implant component positioning}, series = {Medical Engineering \& Physics}, volume = {121}, journal = {Medical Engineering \& Physics}, edition = {Journal Pre-proof}, publisher = {Elsevier}, doi = {10.1016/j.medengphy.2023.104059}, pages = {22}, abstract = {To avoid dislocation of the shoulder joint after reverse total shoulder arthroplasty, it is important to achieve sufficient shoulder stability when placing the implant components during surgery. One parameter for assessing shoulder stability can be shoulder stiffness. The aim of this research was to develop a temporary reverse shoulder implant prototype that would allow intraoperative measurement of shoulder stiffness while varying the position of the implant components. Joint angle and torque measurement techniques were developed to determine shoulder stiffness. Hall sensors were used to measure the joint angles by converting the magnetic flux densities into angles. The accuracy of the joint angle measurements was tested using a test bench. Torques were determined by using thin-film pressure sensors. Various mechanical mechanisms for variable positioning of the implant components were integrated into the prototype. The results of the joint angle measurements showed measurement errors of less than 5° in a deflection range of ±15° adduction/abduction combined with ±45° flexion/extension. The proposed design provides a first approach for intra-operative assessment of shoulder stiffness. The findings can be used as a technological basis for further developments.}, language = {en} } @inproceedings{MuehlingEnglertDendorfer, author = {Muehling, M. and Englert, Carsten and Dendorfer, Sebastian}, title = {Influence of biceps tenotomy and tenodesis on post-operative shoulder strength}, series = {Jahrestagung der Deutschen Gesellschaft f{\"u}r Biomechanik, March 2017, Hannover, Germany}, booktitle = {Jahrestagung der Deutschen Gesellschaft f{\"u}r Biomechanik, March 2017, Hannover, Germany}, language = {en} } @inproceedings{EnglertMuellerDendorfer, author = {Englert, Carsten and M{\"u}ller, F. and Dendorfer, Sebastian}, title = {Einfluss der Muskelkr{\"a}fte, des Bewegungsausmaßes und der Bruchform auf die Kraft{\"u}bertragung des Implantat-Knochenverbundes am Beispiel der Claviculafraktur im mittleren Drittel}, series = {17. Jahreskongress der Deutschen Vereinigung f{\"u}r Schulter- und Ellenbogenchirurgie (DVSE), Rosenheim 2010}, booktitle = {17. Jahreskongress der Deutschen Vereinigung f{\"u}r Schulter- und Ellenbogenchirurgie (DVSE), Rosenheim 2010}, abstract = {Fragestellung Es soll in dieser Computersimulationsstudie untersucht werden, wie der Osteosyntheseverbund Platte mit Schrauben im Verbund mit einer im mittleren Drittel gebrochenen Clavicula durch das Bewegungsausmaß in vivo belastet ist. Was sind die grundlegenden Kr{\"a}fte die auf Clavicula und Implantat wirken und welchen Einfl uss hat die Bruchform. Methodik Die Muskel- und Gelenkkr{\"a}fte sowie die Belastung des Implantatverbundes wurden mit einer muskuloskelletalen Simulationssoftware (AnyBody Technology, V.4) berechnet. Hierf{\"u}r wurden mit einem komplexen Model des menschlichen K{\"o}rpers folgende Bewegungen analysiert: eine Flexion von 160° und Abduktion 160° mit einem Gewicht von 2 kg in der Hand. Aus CT-Patientendaten wurden zwei dreidimensionale Modelle des Clavicula-Implantat Verbundes gebildet, die sich in der Frakturform unterscheiden (Querfraktur und vertikale Fraktur). In beiden Modellen wurde eine Claviculaosteosynthese in superiorer Position mit einer 6 Loch LCP mit 2 Schrauben pro Hauptfragment verwendet. Die Materialeigenschaften wurden aus der Dichte des Materials sowie aus Literaturdaten verwendet. Die Muskel- und Gelenkkr{\"a}fte aus der muskuloskelletalen Berechnung wurden auf das Finite Elemente Modell {\"u}bertragen und die Spannungen und Dehnungen des Implantat-Knochenverbundes wurden berechnet. Ergebnisse Es zeigte sich, dass die simulierte in vivo Belastung stark abh{\"a}ngig vom Flexionswinkel ist. Das Implantat ist in der superioren Lage auf Biegung belastet, welche maximale Werte im {\"U}berschulterniveau erreicht. Die Bruchform mit anatomischer Reposition und Kontakt der Hauptfragmente zueinander f{\"u}hrt zu einer deutlichen Entlastung des Osteosyntheseverbundes im Vergleich zu einer Bruchform mit vertikaler Fraktur. Schlussfolgerung Aus den Analysen ist eine Positionierung der Plattenosteosynthese f{\"u}r die im mittleren Drittel frakturierte Clavicula in anterior-superiorer Lage w{\"u}nschenswert. Die anatomische Reposition entlastet den Osteosyntheseverbund und sollte m{\"o}glichst erreicht werden. Die Nachbehandlung sollte ein Bewegungsausmaß f{\"u}r den Arm f{\"u}r 4 Wochen f{\"u}r einfache Bruchformen auf 70° Flexion und Abduktion limitieren und f{\"u}r komplexe Bruchformen diese Limitierung ausgedehnt werden.}, language = {de} } @article{PfeiferMuellerPrantletal., author = {Pfeifer, Christian and M{\"u}ller, Michael and Prantl, Lukas and Berner, Arne and Dendorfer, Sebastian and Englert, Carsten}, title = {Cartilage labelling for mechanical testing in T-peel configuration}, series = {International Orthopaedics}, volume = {36}, journal = {International Orthopaedics}, number = {7}, publisher = {Springer}, doi = {10.1007/s00264-011-1468-3}, pages = {1493 -- 1499}, abstract = {PURPOSE: The purpose of this study was to find a suitable method of labelling cartilage samples for the measurement of distraction distances in biomechanical testing. METHODS: Samples of bovine cartilage were labelled using five different methods: hydroquinone and silver nitrate (AgNO3), potassium permanganate (KMnO4) with sodium thiosulphate (Na2S2O3), India ink, heat, and laser energy. After the labelling, we analysed the cartilage samples with regard to cytotoxity by histochemical staining with ethidiumbromide homodimer (EthD-1) and calcein AM. Furthermore, we tested cartilages labelled with India ink and heat in a T-peel test configuration to analyse possible changes in the mechanical behaviour between marked and unlabelled samples. RESULTS: Only the labelling methods with Indian ink or a heated needle showed acceptable results in the cytotoxity test with regard to labelling persistence, accuracy, and the influence on consistency and viability of the chondrocytes. In the biomechanical T-peel configuration, heat-labelled samples collapsed significantly earlier than unlabelled samples. CONCLUSION: Labelling bovine cartilage samples with Indian ink in biomechanical testing is a reliable, accurate, inexpensive, and easy-to-perform method. This labelling method influenced neither the biomechanical behaviour nor the viability of the tissue compared to untreated bovine cartilage.}, subject = {Knorpel}, language = {en} }