@article{DillingerWeberMayeretal., author = {Dillinger, Andrea Elisabeth and Weber, Gregor R. and Mayer, Matthias and Schneider, Magdalena and G{\"o}ppner, Corinna and Ohlmann, Andreas and Shamonin (Chamonine), Mikhail and Monkman, Gareth J. and Fuchshofer, Rudolf and Keller, Kate and Lozano, Diana C. and Clark, Abbot}, title = {CCN2/CTGF-A Modulator of the Optic Nerve Head Astrocyte}, series = {Frontiers in cell and developmental biology (Front Cell Dev Biol.)}, volume = {10}, journal = {Frontiers in cell and developmental biology (Front Cell Dev Biol.)}, publisher = {frontiers}, doi = {10.3389/fcell.2022.864433}, pages = {864433}, abstract = {In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent deformation and to degeneration of ON axons. The remodeling process of the ECM causes changes in the biomechanical properties of the ONH and the peripapillary sclera, which is accompanied by an increased reactivity of the resident astrocytes. The molecular factors involved in the remodeling process belong to the Transforming growth factor (TGF)-β superfamily, especially TGF-β2. In previous publications we showed that TGF-β2 induced ECM alterations are mediated by Cellular Communication Network Factor (CCN)2/Connective Tissue Growth Factor (CTGF) and recently we showed that CCN2/CTGF is expressed by astrocytes of the ON under normal conditions. In this study we wanted to get a better understanding of the function of CCN2/CTGF under normal and pathologic conditions. To this end, we analyzed the glial lamina and peripapillary sclera of CCN2/CTGF overexpressing mice and studied the effect of CCN2/CTGF and increasing substratum stiffness on murine ON astrocytes in vitro. We observed enhanced astrocyte reactivity in the ONH, increased ECM protein synthesis in the peripapillary sclera and increased Ccn2/Ctgf expression in the ONH during the pathologic development in situ. CCN2/CTGF treatment of primary murine ON astrocytes induced a higher migration rate, and increase of ECM proteins including fibronectin, elastin and collagen type III. Furthermore, the astrocytes responded to stiffer substratum with increased glial fibrillary acidic protein, vimentin, actin and CCN2/CTGF synthesis. Finally, we observed the reinforced appearance of CCN2/CTGF in the lamina cribrosa of glaucomatous patients. We conclude that reactive changes in ONH astrocytes, induced by the altered biomechanical characteristics of the region, give rise to a self-amplifying process that includes increased TGF-β2/CCN2/CTGF signaling and leads to the synthesis of ECM molecules and cytoskeleton proteins, a process that in turn augments the stiffness at the ONH. Such a scenario may finally result in a vicious circle in the pathogenesis of POAG. The transgenic CTGF-overexpressing mouse model might be an optimal model to study the chronic pathological POAG changes in the ONH.}, language = {en} } @article{SavelevGlavanBurdinetal., author = {Savelev, Dmitrii V. and Glavan, Gašper and Burdin, Dmitrii A. and Belyaeva, Inna A. and Fetisov, Leonid Y. and Shamonin (Chamonine), Mikhail and Fetisov, Yuri K.}, title = {Enhancement of magnetoelectric effect in polymer composites at low resonance frequencies by operation in the transverse-transverse mode}, series = {Journal of Magnetism and Magnetic Materials}, volume = {598}, journal = {Journal of Magnetism and Magnetic Materials}, publisher = {Elsevier}, issn = {1873-4766}, doi = {10.1016/j.jmmm.2024.172020}, abstract = {The resonant direct magnetoelectric (ME) effect for a series of multilayer heterostructures comprising a magnetoactive elastomer (MAE) of different thicknesses and a commercially available piezoelectric polyvinylidene fluoride-based vibration sensor has been investigated in detail. The specimens were rigidly fixed at one end as cantilevers. The cantilevers were operated in the transverse-transverse (T-T) mode, where both magnetic and electric fields were perpendicular to the plane of a non-deformed heterostructure. It is shown that the ME voltage coefficient of considered heterostructures in the T-T mode can be about 20-fold higher than in the conventional longitudinal-transverse (L-T) mode. The highest ME voltage coefficient reached about 150 V/(Oe·cm) at the first bending oscillation mode for the sample with MAE layer thickness of 4 mm. Mechanism of the resonant ME effect in T-T mode is explained using theory of critical bending of MAE cantilevers. Magnetic fields, when the ME voltage reaches its maximum, strongly depended on the MAE layer thickness, and could be associated with the critical field, where the structure commences to strongly bend. The non-monotonous dependence of the resonance frequency of the first oscillation mode on magnetic field strength was observed. The shift of the resonance frequency in the maximum magnetic field reached up to roughly 100 \% in comparison with zero field.}, language = {en} } @article{RoghaniRomeisGlavanetal., author = {Roghani, Mehran and Romeis, Dirk and Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail and Saphiannikova, Marina}, title = {Magnetically induced deformation of isotropic magnetoactive elastomers and its relation to the magnetorheological effect}, series = {Physical Review Applied}, volume = {23}, journal = {Physical Review Applied}, number = {3}, publisher = {American Physical Society (APS)}, issn = {2331-7019}, doi = {10.1103/PhysRevApplied.23.034041}, abstract = {Can isotropic magnetoactive elastomers (MAEs) undergo giant magnetically induced deformations and exhibit huge magnetorheological effects simultaneously? In this experimental and theoretical study, we reveal how the macroscopic deformation of MAEs relates to the process of particle restructuring caused by application of a magnetic field. For this purpose, MAE cylinders with different aspect ratios and particle loadings are studied in uniform magnetic fields. The axial deformations of the cylinders are acquired using an optical camera. A unified mean-field model proposed in previous studies is adapted to describe the transition of initially isotropic cylinders into transversely isotropic ones. This mechanical transition is caused by the rearrangement of particles into dense columnar structures aligned with the field and is believed to result in a huge magnetorheological effect. Our model however predicts less than a threefold increase in elastic moduli when evaluated along the field direction. This prediction is based on a careful examination of the shear moduli of studied MAEs and the columnar structures. A weak magnetorheological effect explains significant axial deformations measured in the field direction. A strong magnetorheological effect would hinder axial deformations due to an increase in the modulus by several orders of magnitude. Not only are the moduli and macroscopic deformations influenced by microstructure evolution, but so is the magnetization of particles, which increases as they rearrange into dense columns. With this study, we show that the unified mean-field model provides quantitative access to hidden material properties such as magnetization and stiffness in MAE samples with different shapes and evolving microstructures. Published by the American Physical Society 2025}, language = {en} } @misc{GlavanBelyaevaShamoninChamonine, author = {Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail}, title = {On the Piezomagnetism of Magnetoactive Elastomeric Cylinders in Uniform Magnetic Fields: Height Modulation in the Vicinity of an Operating Point by Time-Harmonic Fields [Data set]}, doi = {10.5281/zenodo.13834054}, language = {en} } @misc{GlavanBelyaevaShamoninChamonine, author = {Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail}, title = {Multiferroic Cantilevers Containing a Magnetoactive Elastomer: Magnetoelectric Response to Low-Frequency Magnetic Fields of Triangular and Sinusoidal Waveform [Data set]}, doi = {10.5281/zenodo.14651784}, language = {en} } @article{GlavanBelyaevaShamoninChamonine, author = {Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail}, title = {Multiferroic Cantilevers Containing a Magnetoactive Elastomer: Magnetoelectric Response to Low-Frequency Magnetic Fields of Triangular and Sinusoidal Waveform}, series = {Sensors}, volume = {22}, journal = {Sensors}, number = {10}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/s22103791}, pages = {1 -- 17}, abstract = {In this work, multiferroic cantilevers comprise a layer of a magnetoactive elastomer (MAE) and a commercially available piezoelectric polymer-based vibration sensor. The structures are fixed at one end in the horizontal plane and the magnetic field is applied vertically. First, the magnetoelectric (ME) response to uniform, triangle-wave magnetic fields with five different slew rates is investigated experimentally. Time and field dependences of the generated voltage, electric charge, and observed mechanical deflection are obtained and compared for four different thicknesses of the MAE layer. The ME responses to triangular and sinusoidal wave excitations are examined in contrast. Second, the ME response at low frequencies (≤3 Hz) is studied by the standard method of harmonic magnetic field modulation. The highest ME coupling coefficient is observed in the bias magnetic field strength of ≈73 kA/m and it is estimated to be about 3.3 ns/m (ME voltage coefficient ≈ 25 V/A) at theoretically vanishing modulation frequency (f→0 Hz). Presented results demonstrate that the investigated heterostructures are promising for applications as magnetic-field sensors and energy harvesting devices.}, language = {en} } @article{KrieglJezeršekKravanjaetal., author = {Kriegl, Raphael and Jezeršek, Matija and Kravanja, Gaia and Hribar, Luka and Mukhi, Soham and Kokot, Gašper and Drevenšek-Olenik, Irena and Shamonin (Chamonine), Mikhail}, title = {Tunable rebound of millimeter-sized rigid balls by magnetic actuation of elastomer-based surface microstructures}, series = {Smart Materials and Structures}, volume = {33}, journal = {Smart Materials and Structures}, number = {6}, publisher = {IOP Publishing}, doi = {10.1088/1361-665X/ad41a9}, abstract = {A novel method for controlling the rebound behavior of small balls made of Al2O3 with a radius of 2.381 mm is presented. It uses different types of micro-structured surfaces of soft magnetoactive elastomers. These surfaces were fabricated via laser micromachining and include fully ablated surfaces as well as micrometer-sized lamellas with a fixed width of 90 µm, height of 250 µm and three different gap sizes (15, 60 and 105 µm). The lamellas can change their orientation from edge-on to face-on configuration according to the direction of the external magnetic field from a permanent magnet. The orientation of the external magnetic field significantly influences the rebound behavior of the balls, from a coefficient of restitution e of to < 0.1. The highest relative change in the coefficient of restitution between zero field and face-on configuration of is observed for lamellas with a gap of 60 µm. Other characteristics of the ball rebound such as the penetration depth into an Magnetoactive elastomer and the maximum deceleration are investigated as well. The proposed method does not require a constant power supply due to the use of permanent magnets. It may find novel applications in the field of impact engineering.}, language = {en} } @misc{GlavanBelyaevaShamoninChamonineetal., author = {Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail and Ruwisch, Kevin and Wollschl{\"a}ger, Joachim}, title = {Magnetoelectric Response of Laminated Cantilevers Comprising a Magnetoactive Elastomer and a Piezoelectric Polymer, in Pulsed Uniform Magnetic Fields [Data set]}, doi = {10.5281/zenodo.14652152}, language = {en} } @misc{GlavanBelyaevaShamoninChamonine, author = {Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail}, title = {Transient Response of Macroscopic Deformation of Magnetoactive Elastomeric Cylinders in Uniform Magnetic Fields [Data set]}, doi = {10.5281/zenodo.10679499}, language = {en} } @article{GlavanBelyaevaShamoninChamonine, author = {Glavan, Gašper and Belyaeva, Inna A. and Shamonin (Chamonine), Mikhail}, title = {Transient Response of Macroscopic Deformation of Magnetoactive Elastomeric Cylinders in Uniform Magnetic Fields}, series = {Polymers}, volume = {16}, journal = {Polymers}, number = {5, Special Issue Magnetic Polymer Composites: Design and Application II}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2073-4360}, doi = {10.3390/polym16050586}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-71067}, pages = {17}, abstract = {Significant deformations of bodies made from compliant magnetoactive elastomers (MAE) in magnetic fields make these materials promising for applications in magnetically controlled actuators for soft robotics. Reported experimental research in this context was devoted to the behaviour in the quasi-static magnetic field, but the transient dynamics are of great practical importance. This paper presents an experimental study of the transient response of apparent longitudinal and transverse strains of a family of isotropic and anisotropic MAE cylinders with six different aspect ratios in time-varying uniform magnetic fields. The time dependence of the magnetic field has a trapezoidal form, where the rate of both legs is varied between 52 and 757 kA/(s·m) and the maximum magnetic field takes three values between 153 and 505 kA/m. It is proposed to introduce four characteristic times: two for the delay of the transient response during increasing and decreasing magnetic field, as well as two for rise and fall times. To facilitate the comparison between different magnetic field rates, these characteristic times are further normalized on the rise time of the magnetic field ramp. The dependence of the normalized characteristic times on the aspect ratio, the magnetic field slew rate, maximum magnetic field values, initial internal structure (isotropic versus anisotropic specimens) and weight fraction of the soft-magnetic filler are obtained and discussed in detail. The normalized magnetostrictive hysteresis loop is introduced, and used to explain why the normalized delay times vary with changing experimental parameters.}, language = {en} } @article{StrausKravanjaKriegletal., author = {Straus, Izidor and Kravanja, Gaia and Kriegl, Raphael and Shamonin (Chamonine), Mikhail and Drevenšek-Olenik, Irena and Jezeršek, Matija and Kokot, Gašper}, title = {Laser Micromachining for Polymer Surface Topography Designt}, series = {JoVE journal : engineering}, journal = {JoVE journal : engineering}, publisher = {JoVE}, doi = {10.3791/68126}, pages = {15}, abstract = {Soft magnetoactive elastomers (MAEs) are smart materials that respond to external magnetic fields by dynamically altering their mechanical properties. They are composed of magnetically responsive microparticles embedded within a soft polymer matrix, exhibiting an effective shear modulus of up to 100 kPa. In recent decades, MAEs' bulk properties have been successfully exploited for applications such as dynamic vibration damping, vibration sensing, and actuation in soft robotics. Recent research has shifted to their surface properties, revealing promising results on tunable surface features such as roughness, adhesion, and wetting. Even the transport of small solid and fluid objects was demonstrated. The associated surface effects can be significantly enhanced through the precise engineering of surface topography. In this article, an efficient laser micromachining technique, with a resolution of 15 µm, is presented, which enables rapid prototyping of MAE surfaces. It allows the creation of various complex shapes and offers functionality beyond the one achievable with traditional molding techniques. Additionally, the approach is versatile and can be applied to any polymer that sufficiently absorbs the laser light. As an example, a lamellar surface micro-pattern fabrication process and its characterization by optical and scanning electron microscopies are shown. Its response to a magnetic field is demonstrated. The technique provides a flexible and fast solution for optimizing polymer surface design across a wide range of applications.}, language = {en} }