@article{BorgettoTomlinMaxetal., author = {Borgetto, Bernhard and Tomlin, George S. and Max, Susanne and Gantschnig, Brigitte Elisabeth and Pfingsten, Andrea}, title = {Die Forschungspyramide. Teil 2: Methodologische Grundlagen: Kausalit{\"a}t und externe Evidenz}, series = {Ergoscience}, volume = {12}, journal = {Ergoscience}, number = {3}, publisher = {Springer}, address = {Berlin, Heidelberg}, doi = {10.1007/978-3-662-58314-2_58}, pages = {90 -- 101}, abstract = {Um die medizinische und therapeutische Versorgung von Patienten kontinuierlich zu optimieren, wird von Angeh{\"o}rigen der Gesundheitsberufe, therapeutischen Teams und Versorgungseinrichtungen gefordert, wissenschaftliche Erkenntnisse (externe Evidenz) in die t{\"a}gliche Praxis zu integrieren und auf den jeweiligen Patientenfall abzustimmen. Die Aufbereitung, Systematisierung und Bewertung der externen Evidenz orientiert sich dabei klassischerweise an eindimensionalen Evidenzhierarchien, die vorwiegend quantitativ-experimentelle Studiendesigns ber{\"u}cksichtigen. In diesem Beitrag wird die Orientierung an klassischen eindimensionalen Evidenzhierarchien kritisch hinterfragt. Als Alternative wird das Modell und die Systematik der Forschungspyramide vorgestellt, die Evidenz aus unterschiedlichen Forschungsans{\"a}tzen umfassend ber{\"u}cksichtigt und dennoch methodologisch streng beurteilt. Der Einbezug beobachtender und qualitativer Studien stellt dahingehend eine besondere Praxisn{\"a}he her.}, language = {de} } @article{BorgettoTomlinMaxetal., author = {Borgetto, Bernhard and Tomlin, George S. and Max, Susanne and Gantschnig, Brigitte Elisabeth and Pfingsten, Andrea}, title = {Die Forschungspyramide. Teil 3: Grundlagen der Anwendung f{\"u}r die kritische Evidenzbewertung}, series = {Ergoscience}, volume = {12}, journal = {Ergoscience}, number = {4}, publisher = {Schulz-Kirchner-Verlag}, doi = {10.2443/skv-s-2017-54020170401}, pages = {134 -- 143}, abstract = {Die Forschungspyramide ist ein Modell zur Bewertung und Zusammenf{\"u}hrung von externer Evidenz aus unterschiedlichen Forschungsans{\"a}tzen. Sie bietet eine Grundlage zur Aufbereitung und Systematisierung von Forschungsergebnissen, um, basierend auf wissenschaftlicher Evidenz, ergotherapeutische Fragestellungen zu beantworten und ergotherapeutische Entscheidungen in der allt{\"a}glichen Praxis zu treffen. Dieser Beitrag arbeitet die Grundlagen der praktischen Anwendung des Modells auf: die Evidenzbewertung im Modell der Forschungspyramide, die Bewertung der Durchf{\"u}hrungsqualit{\"a}t von quantitativen und qualitativen Studien und die Durchf{\"u}hrung von Pyramiden-Reviews. The Research Pyramid is a model that values and integrates external evidence from multiple research approaches. It provides a basis to collect and synthesize research findings for answering questions that emerge in occupational therapy practice and for subsequent decision making, based on research evidence. In this article, the application principles that underlie the model are presented: the principles of the appraisal of evidence according to the research pyramid, the procedural quality of quantitative and qualitative studies and the administration of pyramid reviews.}, language = {de} } @incollection{BorgettoTomlinMaxetal., author = {Borgetto, Bernhard and Tomlin, George S. and Max, Susanne and Brinkmann, Melanie and Spitzer, Lena and Pfingsten, Andrea}, title = {Evidenz in der Gesundheitsversorgung : Die Forschungspyramide}, series = {Gesundheitswissenschaften}, booktitle = {Gesundheitswissenschaften}, editor = {Haring (Hrsg.), Robin}, publisher = {Springer}, address = {Berlin, Heidelberg}, doi = {10.1007/978-3-662-54179-1_58-1}, pages = {643 -- 654}, abstract = {Um die medizinische und therapeutische Versorgung von Patienten kontinuierlich zu optimieren, wird von Angeh{\"o}rigen der Gesundheitsberufe, therapeutischen Teams und Versorgungseinrichtungen gefordert, wissenschaftliche Erkenntnisse (externe Evidenz) in die t{\"a}gliche Praxis zu integrieren und auf den jeweiligen Patientenfall abzustimmen. Die Aufbereitung, Systematisierung und Bewertung der externen Evidenz orientiert sich dabei klassischerweise an eindimensionalen Evidenzhierarchien, die vorwiegend quantitativ-experimentelle Studiendesigns ber{\"u}cksichtigen. In diesem Beitrag wird die Orientierung an klassischen eindimensionalen Evidenzhierarchien kritisch hinterfragt. Als Alternative wird das Modell und die Systematik der Forschungspyramide vorgestellt, die Evidenz aus unterschiedlichen Forschungsans{\"a}tzen umfassend ber{\"u}cksichtigt und dennoch methodologisch streng beurteilt. Der Einbezug beobachtender und qualitativer Studien stellt dahingehend eine besondere Praxisn{\"a}he her.}, language = {de} } @article{SchuesslerPfingstenSchoettkerKoeniger, author = {Sch{\"u}ßler, Beate and Pfingsten, Andrea and Sch{\"o}ttker-K{\"o}niger, Thomas}, title = {Intertester-Reliabilit{\"a}t des Upper Limb Neural Tension Tests (ULNT) 1}, series = {manuelletherapie}, volume = {23}, journal = {manuelletherapie}, number = {2}, publisher = {Georg Thieme Verlag}, doi = {10.1055/A-0816-0000}, pages = {77 -- 82}, abstract = {Zur {\"U}berpr{\"u}fung der Nervenleitf{\"a}higkeit werden Kraft, Reflexe und Sensibilit{\"a}t getestet. Bei der Untersuchung der Mechanosensitivit{\"a}t eines Nervs kommen neurodynamische Tests zum Einsatz. Der Upper Limb Neural Tension Test (ULNT) 1 bestimmt die Mechanosensitivit{\"a}t des N. medianus. Ziel der Studie war die Untersuchung der Intertester-Reliabilit{\"a}t des ULNT 1 von nicht spezialisierten Physiotherapeuten bei Probanden mit unilateralen Nacken- und/oder Armsymptomen. Die Therapeuten beurteilten binar und metrisch die Kriterien patientenspezifische Symptome, strukturelle Differenzierung und Bewegungsausmaß sowie das Gesamtergebnis bei 33 Patienten mit unilateralen Nacken- und/oder Armsymptomen. Bei den binaren Daten bestimmte der Fleiss-Kappa und bei den metrischen Daten der Intraklassen-Korrelationskoeffizient die Reliabilit{\"a}t. Die zus{\"a}tzlich erstellten Regressionsmodelle sollten den Einfluss der einzelnen Beurteilungskriterien auf die Gesamtentscheidung herausfiltern. Mit Ausnahme der Reproduzierbarkeit patientenspezifischer Symptome scheint die Beurteilung des ULNT 1 durch nicht spezialisierte Therapeuten nur schlecht vergleichbar zu sein. Da die metrische Bewertungsweise die individuellen Schwellenwerte besser darstellt, ist diese der binaren vorzuziehen.}, language = {de} } @article{BorgettoRaebigerRotteneckeretal., author = {Borgetto, Bernhard and R{\"a}biger, Jutta and Rottenecker, Joachim and Hansen, Hilke and Pfingsten, Andrea and Wasner, Mieke}, title = {Akademisierung: Die vollst{\"a}ndige hochschulische Ausbildung in der Ergotherapie, Logop{\"a}die und Physiotherapie ist notwendig und machbar}, series = {physioscience}, volume = {15}, journal = {physioscience}, number = {1}, publisher = {Thieme}, doi = {10.1055/a-0832-9668}, pages = {41 -- 42}, abstract = {Im Jahr 2018 haben wir bildungs-, gesundheits- und berufspolitisch bewegte Zeiten durchlebt. Politische Spitzentreffen wechselten sich mit Informationsveranstaltungen f{\"u}r Parlamentarier ab, die Ausbildung und die berufliche Situation wurden in Trippelschritten reformiert, immer gerade nur so weit, wie es die Hoffnung auf Verringerung des politischen Drucks in Bund und L{\"a}ndern seitens der Regierenden als n{\"o}tig erscheinen l{\"a}sst. Die Ausbildungsflickschusterei in den Therapieberufen von der (Teil-)Abschaffung des Schulgeldes bis zur Zahlung einer Ausbildungsverg{\"u}tung f{\"u}r einen kleinen Teil der Sch{\"u}lerschaft scheint aber eher die Unruhe zu n{\"a}hren. In dieser Situation ist es etwas Besonderes, dass umfassende konzeptionelle Perspektiven zu den anstehenden Reformen der Ausbildung und Berufsgesetze entwickelt werden und eine breite verbandliche Unterst{\"u}tzung finden. Das Strategiepapier des Hochschulverbunds Gesundheitsfachberufe (HVG) und des Verbunds f{\"u}r Ausbildung und Studium in den Therapieberufen (VAST) begr{\"u}ndet und belegt die Notwendigkeit und Machbarkeit der vollst{\"a}ndigen hochschulischen Ausbildung in der Ergotherapie, Logop{\"a}die und Physiotherapie in prim{\"a}rqualifizierenden Studieng{\"a}ngen mit einem {\"U}bergangszeitraum von 10 - 15 Jahren. (Der HVG ist ein Zusammenschluss von 38 Hochschulen mit Therapiestudieng{\"a}ngen und 18 Berufsfachschulen, die in Kooperation mit Hochschulen Studieng{\"a}nge mitgestalten. In VAST sind derzeit 5 Schul- bzw. Lehrerverb{\"a}nde organisiert). Der Deutsche Verband f{\"u}r Physiotherapie (ZVK), der Bundesverband selbstst{\"a}ndiger Physiotherapeuten (IFK) und der Verband Physikalische Therapie (VPT) unterst{\"u}tzen dieses Ziel. Diese Einigkeit ist neu und sehr erfreulich; besonders bemerkenswert ist jedoch, dass auch die Mitgliedsverb{\"a}nde des VAST das Papier unterst{\"u}tzen. Die in VAST organisierten Schul- bzw. Lehrerverb{\"a}nde der Therapieberufe (u.a. der Verband der leitenden Lehrkr{\"a}fte in der Physiotherapie (VLL)) stellen damit die bisherige traditionelle Rolle der Schulen als Ausbildungsinstitutionen mit dem Ziel einer ad{\"a}quaten Weiterentwicklung der Ausbildung zur Disposition.}, language = {de} } @misc{ScheppachRauberMendeletal., author = {Scheppach, Markus W. and Rauber, David and Mendel, Robert and Palm, Christoph and Byrne, Michael F. and Messmann, Helmut and Ebigbo, Alanna}, title = {Detection Of Celiac Disease Using A Deep Learning Algorithm}, series = {Endoscopy}, volume = {53}, journal = {Endoscopy}, number = {S 01}, publisher = {Georg Thieme Verlag}, address = {Stuttgart}, doi = {10.1055/s-0041-1724970}, abstract = {Aims Celiac disease (CD) is a complex condition caused by an autoimmune reaction to ingested gluten. Due to its polymorphic manifestation and subtle endoscopic presentation, the diagnosis is difficult and thus the disorder is underreported. We aimed to use deep learning to identify celiac disease on endoscopic images of the small bowel. Methods Patients with small intestinal histology compatible with CD (MARSH classification I-III) were extracted retrospectively from the database of Augsburg University hospital. They were compared to patients with no clinical signs of CD and histologically normal small intestinal mucosa. In a first step MARSH III and normal small intestinal mucosa were differentiated with the help of a deep learning algorithm. For this, the endoscopic white light images were divided into five equal-sized subsets. We avoided splitting the images of one patient into several subsets. A ResNet-50 model was trained with the images from four subsets and then validated with the remaining subset. This process was repeated for each subset, such that each subset was validated once. Sensitivity, specificity, and harmonic mean (F1) of the algorithm were determined. Results The algorithm showed values of 0.83, 0.88, and 0.84 for sensitivity, specificity, and F1, respectively. Further data showing a comparison between the detection rate of the AI model and that of experienced endoscopists will be available at the time of the upcoming conference. Conclusions We present the first clinical report on the use of a deep learning algorithm for the detection of celiac disease using endoscopic images. Further evaluation on an external data set, as well as in the detection of CD in real-time, will follow. However, this work at least suggests that AI can assist endoscopists in the endoscopic diagnosis of CD, and ultimately may be able to do a true optical biopsy in live-time.}, language = {en} } @misc{RoemmeleMendelRauberetal., author = {R{\"o}mmele, Christoph and Mendel, Robert and Rauber, David and R{\"u}ckert, Tobias and Byrne, Michael F. and Palm, Christoph and Messmann, Helmut and Ebigbo, Alanna}, title = {Endoscopic Diagnosis of Eosinophilic Esophagitis Using a deep Learning Algorithm}, series = {Endoscopy}, volume = {53}, journal = {Endoscopy}, number = {S 01}, publisher = {Georg Thieme Verlag}, address = {Stuttgart}, doi = {10.1055/s-0041-1724274}, abstract = {Aims Eosinophilic esophagitis (EoE) is easily missed during endoscopy, either because physicians are not familiar with its endoscopic features or the morphologic changes are too subtle. In this preliminary paper, we present the first attempt to detect EoE in endoscopic white light (WL) images using a deep learning network (EoE-AI). Methods 401 WL images of eosinophilic esophagitis and 871 WL images of normal esophageal mucosa were evaluated. All images were assessed for the Endoscopic Reference score (EREFS) (edema, rings, exudates, furrows, strictures). Images with strictures were excluded. EoE was defined as the presence of at least 15 eosinophils per high power field on biopsy. A convolutional neural network based on the ResNet architecture with several five-fold cross-validation runs was used. Adding auxiliary EREFS-classification branches to the neural network allowed the inclusion of the scores as optimization criteria during training. EoE-AI was evaluated for sensitivity, specificity, and F1-score. In addition, two human endoscopists evaluated the images. Results EoE-AI showed a mean sensitivity, specificity, and F1 of 0.759, 0.976, and 0.834 respectively, averaged over the five distinct cross-validation runs. With the EREFS-augmented architecture, a mean sensitivity, specificity, and F1-score of 0.848, 0.945, and 0.861 could be demonstrated respectively. In comparison, the two human endoscopists had an average sensitivity, specificity, and F1-score of 0.718, 0.958, and 0.793. Conclusions To the best of our knowledge, this is the first application of deep learning to endoscopic images of EoE which were also assessed after augmentation with the EREFS-score. The next step is the evaluation of EoE-AI using an external dataset. We then plan to assess the EoE-AI tool on endoscopic videos, and also in real-time. This preliminary work is encouraging regarding the ability for AI to enhance physician detection of EoE, and potentially to do a true "optical biopsy" but more work is needed.}, language = {en} } @unpublished{WeihererEigenbergerBrebantetal., author = {Weiherer, Maximilian and Eigenberger, Andreas and Br{\´e}bant, Vanessa and Prantl, Lukas and Palm, Christoph}, title = {Learning the shape of female breasts: an open-access 3D statistical shape model of the female breast built from 110 breast scans}, pages = {15}, abstract = {We present the Regensburg Breast Shape Model (RBSM) - a 3D statistical shape model of the female breast built from 110 breast scans, and the first ever publicly available. Together with the model, a fully automated, pairwise surface registration pipeline used to establish correspondence among 3D breast scans is introduced. Our method is computationally efficient and requires only four landmarks to guide the registration process. In order to weaken the strong coupling between breast and thorax, we propose to minimize the variance outside the breast region as much as possible. To achieve this goal, a novel concept called breast probability masks (BPMs) is introduced. A BPM assigns probabilities to each point of a 3D breast scan, telling how likely it is that a particular point belongs to the breast area. During registration, we use BPMs to align the template to the target as accurately as possible inside the breast region and only roughly outside. This simple yet effective strategy significantly reduces the unwanted variance outside the breast region, leading to better statistical shape models in which breast shapes are quite well decoupled from the thorax. The RBSM is thus able to produce a variety of different breast shapes as independently as possible from the shape of the thorax. Our systematic experimental evaluation reveals a generalization ability of 0.17 mm and a specificity of 2.8 mm for the RBSM. Ultimately, our model is seen as a first step towards combining physically motivated deformable models of the breast and statistical approaches in order to enable more realistic surgical outcome simulation.}, language = {en} } @misc{AuerReinkerSuessetal., author = {Auer, Simon and Reinker, Lukas and S{\"u}ß, Franz and Kubowitsch, Simone and Krutsch, Werner and Weber, Markus and Renkawitz, Tobias and Dendorfer, Sebastian}, title = {Webcast: Effect of mental demand on leg loading in highly dynamic motion}, abstract = {Football players have a high risk of leg muscle injuries, especially when exposed to mental stress. Injuries to muscles of the thigh are common in amateur and professional football, representing almost a third of all injuries. These injuries occur primarily in non-contact situations and from overuse. They can lead to a range of costs, including financial costs associated with treatment as well as those associated with long-term recovery, and absence from training and/or competition. Further, there is a high risk of injury recurrence and subsequent injury.}, language = {en} } @misc{MelznerEngelhardt, author = {Melzner, Maximilian and Engelhardt, Lucas}, title = {AnyBody Webcast - A new musculoskeletal AnyBody™ detailed hand model}, language = {en} } @misc{MelznerIsmailRušavyetal., author = {Melzner, Maximilian and Ismail, Khaled M. and Rušav{\´y}, Zdeněk and Kališ, Vladim{\´i}r and S{\"u}ß, Franz and Dendorfer, Sebastian}, title = {Musculoskeletal Lower Back Load of Accoucheurs During Delivery}, series = {26th Congress of the European Society of Biomechanics, July 11-14, 2021, Milan, Italy}, journal = {26th Congress of the European Society of Biomechanics, July 11-14, 2021, Milan, Italy}, address = {Milan}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-20208}, abstract = {With the progress in modern medicine, it was possible to significantly reduce the risks of birth for mother and child. One aspect that has received less attention so far is the risk of injury to the accoucheurs (obstetricians and midwives) during the birth process. Indeed, studies indicate that 92\% of midwives suffer from musculoskeletal disorders, with the lower back being the main cause of complaints (72\%). The aim of this study was to investigate two commonly used postural techniques used by accoucheurs during childbirth and to analyze the resulting load on the lower back using the AnyBodyTM musculoskeletal simulation software.}, language = {en} } @misc{AuerReinkerDendorfer, author = {Auer, Simon and Reinker, Lukas and Dendorfer, Sebastian}, title = {Evaluation of muscle recruitment and muscle models in musculoskeletal simulation of dynamic motion}, series = {26th Congress of the European Society of Biomechanics, July 11-14, 2021, Milan, Italy}, journal = {26th Congress of the European Society of Biomechanics, July 11-14, 2021, Milan, Italy}, address = {Milan}, pages = {8}, abstract = {Musculoskeletal simulation plays an increasingly important role in sports biomechanics. In the last years, the field of application widened from orthopaedics and ergonomics to sports [1]. A muscle recruitment algorithm with a quadratic objective function is usually used to calculate muscle activity in dynamic movements. The agreement of calculated and measured thigh muscle activity has already been investigated [2]. They found a strong agreement for sprinting and running, while the correlation decreased for side-cutting manoeuvres. Nevertheless, the influence of different muscle recruitment criteria on muscle activity in dynamic musculoskeletal simulations is currently unknown. Hence, this study aimed to analyse the effect of different muscle recruitment criteria and muscle models on the correlation of numerical and measured muscle activity in highly dynamic movements.}, language = {en} } @unpublished{Weiss, author = {Weiß, Martin Georg}, title = {Optimization of Cartesian Tasks with Configuration Selection}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-20176}, abstract = {A basic task in the design of an industrial robot application is the relative placement of robot and workpiece. Process points are defined in Cartesian coordinates relative to the workpiece coordinate system, and the workpiece has to be located such that the robot can reach all points. Finding such a location is still an iterative procedure based on the developers' intuition. One difficulty is the choice of one of the several solutions of the backward transform of a typical 6R robot. We present a novel algorithm that simultaneously optimizes the workpiece location and the robot configuration at all process points using higher order optimization algorithms. A key ingredient is the extension of the robot with a virtual prismatic axis. The practical feasibility of the approach is shown with an example using a commercial industrial robot.}, subject = {Intralogistik}, language = {en} } @article{KlotzWestnerStrahringer, author = {Klotz, Stefan and Westner, Markus and Strahringer, Susanne}, title = {Critical Success Factors of Business-managed IT: It Takes Two to Tango}, series = {Information Systems Management}, volume = {39}, journal = {Information Systems Management}, number = {3}, publisher = {Taylor\&Francis}, doi = {10.1080/10580530.2021.1938300}, pages = {220 -- 240}, abstract = {This paper identifies critical success factors of Business-managed IT based on case study results. Four groups of critical success factors emerge: (1) general approach to Business-managed IT/Business-managed IT strategy, (2) Business-managed IT project prerequisites/Business-managed IT team, (3) Business-managed IT project execution and outcome, and (4) information technology management for Business-managed IT. The results suggest that bilateral responsibility between the business unit and the IT organization is the most favorable governance option for Business-managed IT.}, subject = {Betriebliches Informationssystem}, language = {en} } @inproceedings{BrosigWestnerStrahringer, author = {Brosig, Christoph and Westner, Markus and Strahringer, Susanne}, title = {Linking IT assets and competitive advantage - IT capabilities of servitized business models}, series = {34th Bled eConference Digital Support from Crisis to Progressive Change: June 27 - 30, 2021, Online: Conference Proceedings}, booktitle = {34th Bled eConference Digital Support from Crisis to Progressive Change: June 27 - 30, 2021, Online: Conference Proceedings}, editor = {Borštnar, Mirjana Kljajić}, isbn = {978-961-286-485-9}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-20158}, pages = {111 -- 123}, abstract = {This paper connects research from business model innovation and information systems by exploring critical IT capabilities for servitized business models. The adoption of servitized business models is a major business model innovation strategy. At the same time, digitalization drives the evolution of IT capabilities at these business models. Scholars argue that it remains unclear how IT capabilities enable servitized business models to build a competitive advantage by achieving cost advantages or differentiation. This paper explores IT capabilities that enable building a competitive advantage for servitized business models based on a qualitative analysis of multiple published case studies. The authors identify configurations of IT capabilities among servitized business models. The findings contribute to servitization research by exploring IT capabilities and how they are combined among servitized business models. The insights help practitioners deploy digital technologies and IT assets effectively as building blocks of IT capabilities to advance their servitized business model.}, subject = {Gesch{\"a}ftsmodell}, language = {en} } @article{WulfWestnerStrahringer, author = {Wulf, Frederik and Westner, Markus and Strahringer, Susanne}, title = {Cloud Computing Adoption: A Literature Review on What Is New and What We Still Need to Address}, series = {Communications of the Association for Information Systems}, volume = {48}, journal = {Communications of the Association for Information Systems}, number = {1}, publisher = {Association for Information Systems, AIS}, issn = {1529-3181}, doi = {10.17705/1CAIS.04843}, pages = {523 -- 561}, abstract = {Research on cloud computing (CC) recently emerged congruently with the technology's importance for organizations at a fast pace. This makes it difficult for practitioners to obtain a consolidated overview of what determines CC adoption based on the numerous papers in this regard. Moreover, for further research in the field to add value, it is necessary to identify what still needs to be addressed. In this vein, we conducted a descriptive review of 39 papers, integrating the results of a previous review on 23 papers from 2014, to compare findings across studies. We identify 44 determinant factors that exhibit consistent directional influence on the dependent meta-variable "CC adoption", extending previous literature reviews with regard to asset, client, and environmental characteristics. We then critically reviewed the research landscape to identify what is there, and what is not yet covered: Future research should specifically regard the adoption of Infrastructure-, Platform-, and Everything-as-a-Service, private, hybrid, and multi-cloud deployment, investigate vendor, solution, and individual characteristics, analyzing information systems, or the decision-maker.}, subject = {Cloud Computing}, language = {en} } @article{WuenscheBrinkmannPfingstenetal., author = {W{\"u}nsche, Isabel and Brinkmann, Melanie and Pfingsten, Andrea and Borgetto, Bernhard}, title = {Selbsthilfe von Menschen mit einer rheumatischen Erkrankung}, series = {internistische praxis}, volume = {61}, journal = {internistische praxis}, number = {1}, publisher = {Mediengruppe Oberfranken - Fachverlage}, issn = {0009-4846}, pages = {56 -- 67}, abstract = {Durch die wissenschaftlich fundierte Darstellung der Selbsthilfe (SH) bei rheumatischen Erkrankungen sollen m{\"o}gliche Handlungsunsicherheiten im Umgang mit Selbsthilfegruppen (SHG) in der t{\"a}glichen Praxis verringert werden. Welche Mechanismen in SHG wirken, wurde bisher nicht ausreichend wissenschaftlich untersucht. Im Zusammenhang mit dem gesicherten Wissen {\"u}ber die salutogenen und terti{\"a}rpr{\"a}ventiven Wirkungsweisen von Kommunikation und sozialen Bindungen, kann aus dem Stand der Selbsthilfeforschung jedoch ein allgemeines heuristisches Modell der Wirkung von SHG abgeleitet werden, welches kurz erl{\"a}utert wird. Von der Weltgesundheitsorganisation werden rheumatische Erkrankungen als mehr oder weniger klar definierte Erkrankungen der Gelenke, gelenkumgebenden Strukturen und Muskel- oder Bindegewebe beschrieben, die zu schmerzhaften, h{\"a}ufig chronischen Einschr{\"a}nkungen des Bewegungsapparates f{\"u}hren k{\"o}nnen. Neben der fach{\"a}rztlichen Versorgung besteht durch die Deutsche Rheuma-Liga (DRL) ein fl{\"a}chendeckendes SH-Angebot f{\"u}r Betroffene. Insbesondere SHG tragen zur gegenseitigen sozialen Unterst{\"u}tzung und zur Informationsaneignung bei den Betroffenen und in deren sozialen Umfeld bei. Sind die Ergebnisse und Schlussfolgerungen der Studien zu den Wirkungen von SH bei rheumatischen Erkrankungen aufgrund methodischer Schwierigkeiten der Wirkungsforschung auch limitiert, heben doch die meisten Forscher hervor, dass die Unterst{\"u}tzung durch SHG allein und in Kombination mit einer professionellen Versorgung neben vielen Einzelaspekten auch die Lebensqualit{\"a}t erh{\"o}ht.}, subject = {Rheumatismus}, language = {de} } @article{MelznerSuessDendorfer, author = {Melzner, Maximilian and Suess, Franz and Dendorfer, Sebastian}, title = {The impact of anatomical uncertainties on the predictions of a musculoskeletal hand model - a sensitivity study}, series = {Computer Methods in Biomechanics and Biomedical Engineering}, volume = {25}, journal = {Computer Methods in Biomechanics and Biomedical Engineering}, number = {2}, publisher = {Taylor \& Francis}, issn = {1476-8259}, doi = {10.1080/10255842.2021.1940974}, pages = {156 -- 164}, abstract = {Outputs of musculoskeletal models should be considered probabilistic rather than deterministic as they are affected by inaccuracies and estimations associated with the development of the model. One of these uncertainties being critical for modeling arises from the determination of the muscles' line of action and the physiological cross-sectional area. Therefore, the aim of this study was to evaluate the outcome sensitivity of model predictions from a musculoskeletal hand model in comparison to the uncertainty of these input parameters. For this purpose, the kinematics and muscle activities of different hand movements (abduction of the fingers, abduction of the thumb, and flexion of the thumb) were recorded. One thousand simulations were calculated for each movement using the Latin hypercube sampling method with a corresponding variation of the muscle origin/insertion points and the cross-sectional area. Comparing the standard hand to simulations incorporating uncertainties of input parameters shows no major deviations in on- and off-set time point of muscle activities. About 60\% of simulations are located within a ± 30\% interval around the standard model concerning joint reaction forces. The comparison with the variation of the input data leads to the conclusion that the standard hand model is able to provide not over-scattered outcomes and, therefore, can be considered relatively stable. These results are of practical importance to the personalization of a musculoskeletal model with subject-specific bone geometries and hence changed muscle line of action.}, subject = {Biomechanik}, language = {en} } @article{SouzaJrMendelStrasseretal., author = {Souza Jr., Luis Antonio de and Mendel, Robert and Strasser, Sophia and Ebigbo, Alanna and Probst, Andreas and Messmann, Helmut and Papa, Jo{\~a}o Paulo and Palm, Christoph}, title = {Convolutional Neural Networks for the evaluation of cancer in Barrett's esophagus: Explainable AI to lighten up the black-box}, series = {Computers in Biology and Medicine}, volume = {135}, journal = {Computers in Biology and Medicine}, publisher = {Elsevier}, issn = {0010-4825}, doi = {10.1016/j.compbiomed.2021.104578}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-20126}, pages = {1 -- 14}, abstract = {Even though artificial intelligence and machine learning have demonstrated remarkable performances in medical image computing, their level of accountability and transparency must be provided in such evaluations. The reliability related to machine learning predictions must be explained and interpreted, especially if diagnosis support is addressed. For this task, the black-box nature of deep learning techniques must be lightened up to transfer its promising results into clinical practice. Hence, we aim to investigate the use of explainable artificial intelligence techniques to quantitatively highlight discriminative regions during the classification of earlycancerous tissues in Barrett's esophagus-diagnosed patients. Four Convolutional Neural Network models (AlexNet, SqueezeNet, ResNet50, and VGG16) were analyzed using five different interpretation techniques (saliency, guided backpropagation, integrated gradients, input × gradients, and DeepLIFT) to compare their agreement with experts' previous annotations of cancerous tissue. We could show that saliency attributes match best with the manual experts' delineations. Moreover, there is moderate to high correlation between the sensitivity of a model and the human-and-computer agreement. The results also lightened that the higher the model's sensitivity, the stronger the correlation of human and computational segmentation agreement. We observed a relevant relation between computational learning and experts' insights, demonstrating how human knowledge may influence the correct computational learning.}, subject = {Deep Learning}, language = {en} } @article{HaugVetterWeber, author = {Haug, Sonja and Vetter, Miriam and Weber, Karsten}, title = {Geb{\"a}udesanierung zwischen Energieeffizienz und Sozialvertr{\"a}glichkeit}, series = {TATuP - Zeitschrift f{\"u}r Technikfolgenabsch{\"a}tzung in Theorie und Praxis}, volume = {29}, journal = {TATuP - Zeitschrift f{\"u}r Technikfolgenabsch{\"a}tzung in Theorie und Praxis}, number = {3}, publisher = {oekom-Verlag}, issn = {2567-8833}, doi = {10.14512/tatup.29.3.56}, pages = {56 -- 63}, abstract = {Die Akzeptanz unter Bewohnern und Bewohnerinnen gewinnt bei hoch komplexen, technisch anspruchsvollen energetischen Sanierungen als „Innovationsmotor" zunehmend an Relevanz. Der Beitrag basiert auf zwei Fallstudien zur partizipativen Nutzereinbindung bei energetischen Sanierungen im genossenschaftlichen Wohnbau historischer Stadtquartiere in Regensburg. Neben einer sozialvertr{\"a}glichen Sanierung wurde jeweils ein hohes Maß an Energieeffizienz bei den technischen L{\"o}sungen ange-strebt. Haushaltsbefragungen und qualitative Interviews zeigen die hohe Akzeptanz von Sanierungsmaßnahmen, sofern die Senkung der Energiekosten die erh{\"o}hte Miete kompensiert. Abschließend werden Akzeptanzfaktoren wie Partizipation, Vertrauen, Sozialvertr{\"a}glichkeit und Autarkie er{\"o}rtert.}, subject = {Altbaumodernisierung}, language = {de} } @article{HaugVetter, author = {Haug, Sonja and Vetter, Miriam}, title = {Altersgerechtes Wohnen im Quartier}, series = {Standort - Zeitschrift f{\"u}r angewandte Geographie}, volume = {45}, journal = {Standort - Zeitschrift f{\"u}r angewandte Geographie}, publisher = {Springer Nature}, issn = {1432-220X}, doi = {10.1007/s00548-020-00678-3}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:898-opus4-20050}, pages = {11 -- 17}, abstract = {Im Alter nimmt das Quartier aufgrund geringerer Aktionsradien an Bedeutung zu. Der Beitrag befasst sich mit der Frage, welche Besonderheiten sich bei Senioren-Haushalten im Hinblick auf Wohnen und soziale Teilhabe zeigen. Aus dem Projekt MAGGIE werden Ergebnisse einer schriftlichen Haushaltsbefragung (N=195) in der Wohngenossenschaft Margaretenau Regensburg dargestellt. Hierbei wird auf die aktuelle und zuk{\"u}nftige Wohnsituation, den Ver{\"a}nderungsbedarf, den Wunsch nach Gemeinschaftsangeboten und die soziale Einbettung eingegangen. Es zeigt sich eine geringe Ver{\"a}nderungsbereitschaft und ein {\"u}berdurchschnittlich hohes Maß an lokalem Sozialkapital. Am Ende werden Schlussfolgerungen f{\"u}r das Sanierungs- und Quartiersmanagement gezogen.}, subject = {Alter}, language = {de} } @article{MilewskiHaug, author = {Milewski, Nadja and Haug, Sonja}, title = {Religious Diversity and Women's Attitudes Toward Using Assisted Reproductive Technologies}, series = {Journal of Religion and Demography}, volume = {7}, journal = {Journal of Religion and Demography}, number = {1}, publisher = {Brill}, issn = {2589-742X}, doi = {10.1163/2589742X-12347104}, pages = {150 -- 168}, abstract = {This study examines women's attitudes toward the own use of assisted reproductive technologies (ART) by their religious affiliation in Germany. The social relevance of ART is increasing in Western countries due to overall low birth rates, a high rate of childlessness, and a gap between the desired and the actual numbers of children. Previous literature has been scarce, however, on attitudes toward ART, and religious diversity has not been included in studies on ART. Our analysis is based on data collected in a pilot study in 2014 and 2015. The sample includes 944 women aged 18 to 50 living in Germany. The results show that Muslim women were significantly more likely than Christian women to say they would consider using ART; having no religious affiliation was associated with the least open attitude toward ART usage.}, subject = {Reproduktionsmedizin}, language = {de} } @article{WeberSuessJerabeketal., author = {Weber, Markus and Suess, Franz and Jerabek, Seth and Meyer, Matthias and Grifka, Joachim and Renkawitz, Tobias and Dendorfer, Sebastian}, title = {Kinematic pelvic tilt during gait alters functional cup position in total hip arthroplasty}, series = {Journal of Orthopaedic Research}, volume = {40}, journal = {Journal of Orthopaedic Research}, number = {4}, publisher = {Wiley}, issn = {1554-527X}, doi = {10.1002/jor.25106}, pages = {846 -- 853}, abstract = {Static pelvic tilt impacts functional cup position in total hip arthroplasty (THA). In the current study we investigated the effect of kinematic pelvic changes on cup position. In the course of a prospective controlled trial postoperative 3D-computed tomography (CT) and gait analysis before and 6 and 12 months after THA were obtained in 60 patients. Kinematic pelvic motion during gait was measured using Anybody Modeling System. By fusion with 3D-CT, the impact of kinematic pelvic tilt alterations on cup anteversion and inclination was calculated. Furthermore, risk factors correlating with high pelvic mobility were evaluated. During gait a high pelvic range of motion up to 15.6° exceeding 5° in 61.7\% (37/60) of patients before THA was found. After surgery, the pelvis tilted posteriorly by a mean of 4.0 ± 6.6° (p < .001). The pelvic anteflexion led to a mean decrease of -1.9 ± 2.2° (p < .001) for cup inclination and -15.1 ± 6.1° (p < .001) for anteversion in relation to the anterior pelvic plane (APP). Kinematic pelvic changes resulted in a further change up to 2.3° for inclination and up to 12.3° for anteversion. In relation to the preoperative situation differences in postoperative cup position ranged from -4.4 to 4.6° for inclination and from -7.8 to 17.9° for anteversion, respectively. Female sex (p < .001) and normal body weight (p < .001) correlated with high alterations in pelvic tilt. Kinematic pelvic changes highly impact cup anteversion in THA. Surgeons using the APP as reference should aim for a higher anteversion of about 15° due to the functional anteflexion of the pelvis during gait.}, subject = {H{\"u}ftgelenkprothese}, language = {en} }