TY - CONF A1 - Ott, C. A1 - Rosengarth, K. A1 - Doenitz, Christian A1 - Hoehne, J. A1 - Wendl, C. A1 - Dodoo-Schittko, Frank A1 - Lang, E. A1 - Schmidt, Nils Ole A1 - Goldhacker, Markus T1 - Preoperative assessment of language dominance through combined resting-state and task-based functional magnetic resonance imaging T2 - Brain and Spine N2 - Background: Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years the resting-state fMRI (rs-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere. Methods: Twenty patients suffering from brain lesions close to supposed language relevant cortical areas were included. Rs-fMRI and task-based (tb-fMRI) were performed for the purpose of preoperative language assessment. Tb-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language critical and language supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the tb-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice-index. Results: The RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly. Conclusion: In general, the results suggest that determining language dominance in the human brain is feasible both with tb-fMRI and rs-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits. Y1 - 2021 UR - https://opus4.kobv.de/opus4-oth-regensburg/frontdoor/index/index/docId/4572 VL - 1 IS - Suppl. 2 PB - Elsevier ER -