TY - JOUR A1 - Maerkl, Raphaela A1 - Rueckert, Tobias A1 - Rauber, David A1 - Gutbrod, Max A1 - Weber Nunes, Danilo A1 - Palm, Christoph T1 - Enhancing generalization in zero-shot multi-label endoscopic instrument classification T2 - International Journal of Computer Assisted Radiology and Surgery N2 - Purpose Recognizing previously unseen classes with neural networks is a significant challenge due to their limited generalization capabilities. This issue is particularly critical in safety-critical domains such as medical applications, where accurate classification is essential for reliability and patient safety. Zero-shot learning methods address this challenge by utilizing additional semantic data, with their performance relying heavily on the quality of the generated embeddings. Methods This work investigates the use of full descriptive sentences, generated by a Sentence-BERT model, as class representations, compared to simpler category-based word embeddings derived from a BERT model. Additionally, the impact of z-score normalization as a post-processing step on these embeddings is explored. The proposed approach is evaluated on a multi-label generalized zero-shot learning task, focusing on the recognition of surgical instruments in endoscopic images from minimally invasive cholecystectomies. Results The results demonstrate that combining sentence embeddings and z-score normalization significantly improves model performance. For unseen classes, the AUROC improves from 43.9% to 64.9%, and the multi-label accuracy from 26.1% to 79.5%. Overall performance measured across both seen and unseen classes improves from 49.3% to 64.9% in AUROC and from 37.3% to 65.1% in multi-label accuracy, highlighting the effectiveness of our approach. Conclusion These findings demonstrate that sentence embeddings and z-score normalization can substantially enhance the generalization performance of zero-shot learning models. However, as the study is based on a single dataset, future work should validate the method across diverse datasets and application domains to establish its robustness and broader applicability. KW - Generalized zero-shot learning KW - Sentence embeddings KW - Z-score normalization KW - Multi-label classification KW - Surgical instruments Y1 - 2025 UR - https://opus4.kobv.de/opus4-oth-regensburg/frontdoor/index/index/docId/8567 UR - https://nbn-resolving.org/urn:nbn:de:bvb:898-opus4-85674 N1 - Corresponding author der OTH Regensburg: Raphaela Maerkl VL - 20 SP - 1577 EP - 1587 PB - Springer Nature ER -