Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain
- In a randomized controlled multiple cross-over trial, the effect of a single application of 1000 and 3000 F.I.P. bromelain on 6 cytokines, of male healthy volunteers was studied. The analysis of cytokines (Interferon gamma, IL-2, IL-6, IL8, IL-10, IL13 and MCP-1) was performed with the TrueCulture(tm) whole-blood culture system (EDI GmbH). With a single dose of 3000 F. I. P. bromelain, IFNgamma was found to be significantly stimulated in the afternoon hours compared to placebo (p = 0.043; Mixed Linear Model, Bonferroni adjusted).
- In einer randomisierten, controlleirten Cross-Over-Studie wurde der Effekt einer einmaligen Appliaktion von 1000 bzw. 3000 F. I. P. Bromelain (Ursapharm GmbH, Saarbrücken)untersucht. Endpunkte waren 6 Zytokine(Interferon gamma, IL-2, IL-6, IL8, IL-10, IL13 and MCP-1), die mittels TrueCulture-Test-System (EDI-GmbH, Reutlingen) analysiert wurden. Die Analyse mittels Gemischtem Linearen Model ergab, dass die Doseriung von 3000 F.I.P. Bromelain einen signifikanten Anstieg im Vergleich zu Plazebo bewirkte (p=0,043, Bonferroni-korrigiert).
Author: | Silke Müller, Reinhard März, Manfred Schmolz, Bernd Drewelow, Klaus Eschmann, Peter Meiser |
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URN: | urn:nbn:de:bvb:92-opus-1022 |
Document Type: | Preprint |
Language: | English |
Publishing Institution: | Technische Hochschule Nürnberg Georg Simon Ohm |
Creating Corporation: | Instiute of Clinical Pharmacology, Medical Faculty, University of Rostock |
Contributing Corporation: | EDI GmbH, Ursapharm |
Release Date: | 2013/04/19 |
Tag: | Immune System; antiinflammatory activity; bromelain; circadian rhythm; cytokines |
Note: | Originalversion zu finden in: Phytotherpy Research. 27(2013)2, S.199-204 http://onlinelibrary.wiley.com/doi/10.1002/ptr.4678/abstract |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |